Fetal Blood

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  Subject Areas on Research

  • 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A cord blood transplant recipient with Mycobacterium mucogenicum central venous catheter infection after infusion of tap water. 
  • A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery. 
  • A potential biomarker in the cord blood of preterm infants who develop retinopathy of prematurity. 
  • A review of the impact of phenylephrine administration on maternal hemodynamics and maternal and neonatal outcomes in women undergoing cesarean delivery under spinal anesthesia. 
  • A staging system for infantile Krabbe disease to predict outcome after unrelated umbilical cord blood transplantation. 
  • Absolute values of dendritic cell subsets in bone marrow, cord blood, and peripheral blood enumerated by a novel method. 
  • Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens. 
  • Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis. 
  • Analysis of bisphenol A diglycidyl ether (BADGE) and its hydrolytic metabolites in biological specimens by high-performance liquid chromatography and tandem mass spectrometry. 
  • Anesthetic technique for cesarean delivery and neonatal acid-base status: a retrospective database analysis. 
  • Antigen-specific T-lymphocyte function after cord blood transplantation. 
  • Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide. 
  • Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight. 
  • Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System. 
  • Banking and transplantation of unrelated donor umbilical cord blood: status of the National Heart, Lung, and Blood Institute-sponsored trial. 
  • Banking or Bankrupting: Strategies for Sustaining the Economic Future of Public Cord Blood Banks. 
  • Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells. 
  • Brain anomalies in children exposed prenatally to a common organophosphate pesticide. 
  • CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules. 
  • Chagas Disease Screening in Maternal Donors of Publicly Banked Umbilical Cord Blood, United States. 
  • Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. 
  • Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. 
  • Characterization of umbilical cord blood-derived late outgrowth endothelial progenitor cells exposed to laminar shear stress. 
  • Coexistent naïve phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. 
  • Comparison of cytomegalovirus polymerase chain reaction and serology for screening umbilical cord blood components. 
  • Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age. 
  • Comparison of midazolam and thiopental for rapid sequence anesthetic induction for elective cesarean section. 
  • Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro. 
  • Concentrations of protease inhibitors in cord blood after in utero exposure. 
  • Cord Blood Transplantation Study (COBLT): cord blood bank standard operating procedures. 
  • Cord blood for brain injury. 
  • Cord blood is the optimal graft source for the treatment of pediatric patients with lysosomal storage diseases: clinical outcomes and future directions. 
  • Cord blood stem cells. 
  • Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. 
  • DNA methylation at imprint regulatory regions in preterm birth and infection. 
  • Development and validation of a rapid, aldehyde dehydrogenase bright-based cord blood potency assay. 
  • Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues. 
  • Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34. 
  • Does maternal platelet-associated or platelet-bindable IgG correlate with levels in umbilical cord blood or colostrum during normal pregnancy? 
  • Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress. 
  • Effect of HLA-matching recipients to donor noninherited maternal antigens on outcomes after mismatched umbilical cord blood transplantation for hematologic malignancy. 
  • Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. 
  • Effect of maternal anemia at high altitude on infant hematocrit and oxygenation. 
  • Eighth Annual International Umbilical Cord Blood Transplantation Symposium, San Francisco, California, June 3-5, 2010. 
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. 
  • Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. 
  • Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status. 
  • Ethical aspects of banking placental blood for transplantation. 
  • Ethical issues in umbilical cord blood banking. Working Group on Ethical Issues in Umbilical Cord Blood Banking. 
  • Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the 'next' humoral barrier to xenotransplantation? 
  • Ex Vivo Expansion or Manipulation of Stem Cells to Improve Outcome of Umbilical Cord Blood Transplantation. 
  • Ex vivo expansion of murine and human hematopoietic stem cells. 
  • Ex vivo expansion, maturation, and activation of umbilical cord blood-derived T lymphocytes with IL-2, IL-12, anti-CD3, and IL-7. Potential for adoptive cellular immunotherapy post-umbilical cord blood transplantation. 
  • Extensive haplotype diversity in African American mothers and their cord blood units. 
  • Family-directed umbilical cord blood banking. 
  • Gastric graft-versus-host disease: a blinded histologic study. 
  • Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. 
  • Gene products promoting remyelination are up-regulated in a cell therapy product manufactured from banked human cord blood. 
  • Globoid cell leukodystrophy (Krabbe disease): normal umbilical cord blood galactocerebrosidase activity and polymorphic mutations. 
  • Graft-versus-leukemia-induced complete remission following unrelated umbilical cord blood transplantation for acute leukemia. 
  • Guidelines for the development and validation of new potency assays for the evaluation of umbilical cord blood. 
  • Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia. 
  • Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. 
  • Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. 
  • High levels of granulocyte and granulocyte-macrophage colony-stimulating factors in cord blood of normal full-term neonates. 
  • How transplant centers deal with the dextran shortage: recommendations for comparing alternatives. 
  • Human herpesvirus 6 limbic encephalitis after stem cell transplantation. 
  • Human umbilical cord blood-derived endothelial cells reendothelialize vein grafts and prevent thrombosis. 
  • Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cells. 
  • Idiopathic hyperammonemia following an unrelated cord blood transplant for mucopolysaccharidosis I. 
  • Immune reconstitution after unrelated cord blood transplantation. 
  • Immune reconstitution in children after unrelated cord blood transplantation. 
  • Immunoblot analysis of anti-Ureaplasma urealyticum antibody in pregnant women and newborn infants. 
  • Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation. 
  • In reply. 
  • In vitro autoantibody production by normal adult and cord blood B cells. 
  • In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes. 
  • Induction of uterine prostaglandin H synthase 2 by estradiol following fetal adrenalectomy. 
  • Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation. 
  • Internalization of FimH+ Escherichia coli by the human mast cell line (HMC-1 5C6) involves protein kinase C. 
  • Isolation and expansion of oligodendrocyte progenitor cells from cryopreserved human umbilical cord blood. 
  • Isolation of early hematopoietic cells, including megakaryocyte progenitors, in the ALDH-bright cell population of cryopreserved, banked UC blood. 
  • Isolation of functional human endothelial cells from small volumes of umbilical cord blood. 
  • Isolation of oligodendrocyte-like cells from human umbilical cord blood. 
  • Lack of circulating megakaryoblasts in newborn peripheral blood: development and validation of a sensitive flow cytometric detection method. 
  • Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis. 
  • Low incidence of Epstein-Barr virus-associated posttransplantation lymphoproliferative disorders in 272 unrelated-donor umbilical cord blood transplant recipients. 
  • Macrophage-mediated fungistasis: requirement for a macromolecular component in serum. 
  • Maternal BMI and Glycemia Impact the Fetal Metabolome. 
  • Maternal and preterm fetal sheep responses to dexmedetomidine. 
  • Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. 
  • Measurements from normal umbilical cord blood of four lysosomal enzymatic activities: alpha-L-iduronidase (Hurler), galactocerebrosidase (globoid cell leukodystrophy), arylsulfatase A (metachromatic leukodystrophy), arylsulfatase B (Maroteaux-Lamy). 
  • Mechanically ventilated pediatric stem cell transplant recipients: effect of cord blood transplant and organ dysfunction on outcome. 
  • Metal ion levels in maternal and placental blood after metal-on-metal total hip arthroplasty. 
  • Mitogenic stimulation of human B lymphocytes by the mannose-specific adhesin on Escherichia coli type 1 fimbriae. 
  • Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis. 
  • Multi-site evaluation of the BD Stem Cell Enumeration Kit for CD34(+) cell enumeration on the BD FACSCanto II and BD FACSCalibur flow cytometers. 
  • Multiparameter-fluorescence activated cell sorting analysis of retroviral vector gene transfer into primitive umbilical cord blood cells. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Nutritional regulation of insulin-like growth factor-binding protein gene expression in the ovine fetus and pregnant ewe. 
  • Optimization of informed consent for umbilical cord blood banking. 
  • Optimizing donor selection for public cord blood banking: influence of maternal, infant, and collection characteristics on cord blood unit quality. 
  • Outcomes among 562 recipients of placental-blood transplants from unrelated donors. 
  • Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. 
  • Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection. 
  • Pharmacokinetic profile and placental transfer of a single intravenous injection of [(14)C]chlorpyrifos in pregnant rats. 
  • Pharmacokinetics of didanosine in antepartum and postpartum human immunodeficiency virus--infected pregnant women and their neonates: an AIDS clinical trials group study. 
  • Phosphorus 31 magnetic resonance spectroscopy of human placenta and quantitation with perchloric acid extracts. 
  • Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. 
  • Placental lactogen and growth hormone receptors in human fetal tissues: relationship to fetal plasma human placental lactogen concentrations and fetal growth. 
  • Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells. 
  • Point-of-Care Rapid-Seeding Ventricular Assist Device with Blood-Derived Endothelial Cells to Create a Living Antithrombotic Coating. 
  • Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited metabolic diseases. 
  • Predictors of gastrostomy placement in children with inherited metabolic diseases treated by umbilical cord blood transplantation. 
  • Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine dose. 
  • Pregnancy lactogens in the rat conceptus and fetus: circulating levels, distribution of binding, and expression of receptor messenger ribonucleic acid. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Prenatal diagnosis using fetal cells from the maternal circulation. 
  • Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany. 
  • Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. 
  • Racial diversity with high nucleated cell counts and CD34 counts achieved in a national network of cord blood banks. 
  • Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood. 
  • Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. 
  • Results of a prospective multicentre myeloablative double-unit cord blood transplantation trial in adult patients with acute leukaemia and myelodysplasia. 
  • Results of the cord blood transplantation (COBLT) study unrelated donor banking program. 
  • Retroviral vector-mediated gene transfer into umbilical cord blood-derived megakaryocyte and platelet progenitors. 
  • Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors. 
  • S-Nitrosylated fetal hemoglobin in neonatal human blood. 
  • Sequential myeloablative autologous stem cell transplantation and reduced intensity allogeneic hematopoietic cell transplantation is safe and feasible in children, adolescents and young adults with poor-risk refractory or recurrent Hodgkin and non-Hodgkin lymphoma. 
  • Sources of human and murine hematopoietic stem cells. 
  • State of the art in umbilical cord transplantation. 
  • Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity. 
  • Storage of newborn stem cells for future use. 
  • Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen. 
  • T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children. 
  • T-Cell recovery in adults and children following umbilical cord blood transplantation. 
  • Telomerase activity in normal leukocytes and in hematologic malignancies. 
  • The Cord Blood Apgar: a novel scoring system to optimize selection of banked cord blood grafts for transplantation (CME). 
  • The prevalence of human immunodeficiency virus in patients and their spouses entering a large in vitro fertilization program. 
  • The role of tandem mass spectrometry in the diagnosis of fatty acid oxidation disorders. 
  • The transition from fetal to neonatal circulation: normal responses and implications for infants with heart disease. 
  • The use of umbilical cord blood in mismatched related and unrelated hemopoietic stem cell transplantation. 
  • Thyroid hormone levels in term and preterm neonates. 
  • Transplantation of cord-blood cells. 
  • Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease. 
  • Treatment of infants with complete DiGeorge anomaly. 
  • Umbilical Cord Blood-Derived Mononuclear Cells Exhibit Pericyte-Like Phenotype and Support Network Formation of Endothelial Progenitor Cells In Vitro. 
  • Umbilical cord blood donation: public or private? 
  • Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. 
  • Umbilical cord blood gas assessment of twins. 
  • Umbilical cord blood gases for term healthy newborns. 
  • Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation. 
  • Umbilical cord blood stem cells: application for the treatment of patients with hemoglobinopathies. 
  • Umbilical cord blood: a guide for primary care physicians. 
  • Umbilical cord blood: a novel alternative source of hematopoietic stem cells for bone marrow transplantation. 
  • Umbilical cord blood: biology and transplantation. 
  • Umbilical cord thiocyanate and thyroid function in intrauterine growth-restricted infants of the smoking gravida. 
  • Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience. 
  • Unrelated placental blood in marrow transplantation. 
  • Unrelated umbilical cord blood transplantation for an infant with beta-thalassemia major. 
  • Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood. 
  • Update on umbilical cord blood transplantation. 
  • Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury. 
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  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology