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Subject Areas on Research
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A colorimetric assay for releasable plasminogen activator.
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A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function.
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ATP-regulated activity of the plasmin-streptokinase complex: a novel mechanism involving phosphorylation of streptokinase.
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Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide.
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Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor.
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Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin.
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Antifibrinolytic therapy: new data and new concepts.
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Application of a plasmin generation assay to define pharmacodynamic effects of tranexamic acid in women undergoing cesarean delivery.
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Assessment of retinal morphology with spectral and time domain OCT in the phase III trials of enzymatic vitreolysis.
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Association between anatomical resolution and functional outcomes in the mivi-trust studies using ocriplasmin to treat symptomatic vitreomacular adhesion/vitreomacular traction, including when associated with macular hole.
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Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.
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BASELINE CHARACTERISTICS OF VITREOMACULAR TRACTION PROGRESSING TO FULL-THICKNESS MACULAR OR LAMELLAR HOLES IN THE PHASE III TRIALS OF ENZYMATIC VITREOLYSIS.
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Binding and endocytosis of alpha 2-macroglobulin-plasmin complexes.
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Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin.
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Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse.
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Cell migration through defined, synthetic ECM analogs.
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Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.
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Characterization of alpha 2-macroglobulin-plasmin complexes: complete subunit cleavage alters receptor recognition in vivo and in vitro.
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Characterization of prorenin activation using a synthetic peptide substrate.
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Characterization of vitreoretinal interface disorders using OCT in the interventional phase 3 trials of ocriplasmin.
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Circulating biomarkers for abdominal aortic aneurysm: what did we learn in the last decade?
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Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes.
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Degradation of von Willebrand factor in patients with acquired clinical conditions in which there is heightened proteolysis.
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EVALUATION OF FULL-FIELD ELECTRORETINOGRAM REDUCTIONS AFTER OCRIPLASMIN TREATMENT: Results of the OASIS Trial ERG Substudy.
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Effect of methylamine and plasmin on the conformation of human alpha 2-macroglobulin as revealed by differential scanning calorimetric analysis.
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Efficacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials.
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Electron microscopic identification of exposed plasmin epitopes in alpha 2-macroglobulin-plasmin complex using monoclonal antibody-colloidal gold adducts.
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Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia.
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Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin.
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Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis.
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Fibrinolysis and fibrinogenolysis by Val442-plasmin.
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High dose factor VIIa improves clot structure and stability in a model of haemophilia B.
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In vitro preparation of nonenzymatically glucosylated human transferrin, alpha 2-macroglobulin, and fibrinogen with preservation of function.
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In vitro studies of acantholysis of keratinocytes induced by pemphigus antibody.
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Inflammatory, hemostatic, and other novel biomarkers for diabetic retinopathy: the multi-ethnic study of atherosclerosis.
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Inhibition of platelet-derived growth factor-BB-induced fibroblast proliferation by plasmin-activated alpha 2-macroglobulin is mediated via an alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein-dependent mechanism.
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Ionic modulation of the effects of heparin on plasminogen activation by tissue plasminogen activator: the effects of ionic strength, divalent cations, and chloride.
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Keratinocyte urokinase-type plasminogen activator is secreted as a single chain precursor.
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Lipoprotein (a) promotes plasmin inhibition by alpha 2-antiplasmin.
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Lipoprotein (a) regulates plasmin generation and inhibition.
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Lipoprotein (a): purification and kinetic analysis.
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Mechanism of activation of human plasminogen by the activator complex, streptokinase-plasmin.
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Mechanism of ancrod anticoagulation. A direct proteolytic effect on fibrin.
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Model of alpha 2-macroglobulin structure and function.
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Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding.
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Plasmin-mediated proteolysis of vascular endothelial cell heparin releasable tissue factor pathway inhibitor.
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Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration.
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Proteolysis of von Willebrand factor after thrombolytic therapy in patients with acute myocardial infarction.
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Purification and characterization of human alpha 2-macroglobulin conformational variants by non-ideal high performance size-exclusion chromatography.
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Purification and some properties of the Glu- and Lys-human plasmin heavy chains.
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Reaction of human alpha 2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure.
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Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma.
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Specificity of alpha 2-macroglobulin covalent cross-linking for the active domain of proteinases.
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Subfoveal Lucency after Treatment of Vitreomacular Traction without Macular Hole in the Phase 3 Trials of Ocriplasmin Vitreolysis.
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Substructure of human von Willebrand factor.
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Successful treatment of acute vascular insufficiency in a hand by intra-arterial fibrinolysin, heparin, and reserpine. Case report.
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Symmetry of the inhibitory unit of human alpha 2-macroglobulin.
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The effect of plasmin on the subunit structure of human fibrin.
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The effect of plasmin on the subunit structure of human fibrinogen.
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The effect of substituted laminin A chain-derived peptides on the conformation and activation kinetics of plasminogen.
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The role of inter-alpha-trypsin inhibitor and other proteinase inhibitors in the plasma clearance of neutrophil elastase and plasmin.
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The temperature-dependent reaction between alpha 2-macroglobulin and streptokinase-plasmin(ogen) complex.
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The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface.
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Thromboxane A2modulates the fibrinolytic system in glomerular mesangial cells.
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Why is lipoprotein(a) relevant to thrombosis?
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tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.