Fibronectins

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  Subject Areas on Research

  • 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. 
  • A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. 
  • A serum-free defined culture system which maintains follicle-stimulating hormone responsiveness and differentiation of porcine granulosa cells. 
  • A six-armed oligomer isolated from cell surface fibronectin preparations. 
  • Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies. 
  • Acute histologic effects of extraesophageal reflux on vocal fold healing. 
  • Adherence of streptococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa to fibronectin-coated and uncoated epithelial cells. 
  • Anatomy and physiology of cervical ripening. 
  • Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis. 
  • Assays to measure plasma membrane and cytoskeletal changes in interferon-treated cells. 
  • Association of age-dependent liver injury and fibrosis with immune cell populations. 
  • Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin. 
  • Binding of hexabrachion (tenascin) to the extracellular matrix and substratum and its effect on cell adhesion. 
  • Binding of tenascin-C to soluble fibronectin and matrix fibrils. 
  • Bioactive sutures for tendon repair: assessment of a method of delivering pluripotential embryonic cells. 
  • Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin. 
  • Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. 
  • Bolus magnesium infusion in humans is associated with predominantly unfavourable changes in platelet aggregation and certain haemostatic factors. 
  • Bonds between fibronectin and fibronectin-binding proteins on Staphylococcus aureus and Lactococcus lactis. 
  • C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. 
  • CLT1 targets bladder cancer through integrin α5β1 and CLIC3. 
  • Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle. 
  • Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. 
  • Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. 
  • Characterization of three restricted specificity monoclonal antibodies raised against the human glioma cell line D-54 MG. 
  • Clinical utility of fetal fibronectin for predicting preterm birth. 
  • Cloning and analysis of a Candida albicans gene that affects cell surface hydrophobicity. 
  • Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells. 
  • Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates. 
  • Complement activation influences Staphylococcus aureus adherence to endothelial cells. 
  • Construction, imaging, and analysis of FRET-based tension sensors in living cells. 
  • Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism. 
  • Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants. 
  • Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor? 
  • Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine. 
  • Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. 
  • Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. 
  • Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Designing an extracellular matrix protein with enhanced mechanical stability. 
  • Differential adhesion of rat colon carcinoma cells to fibronectin in relation to their tumorigenicity. 
  • Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells. 
  • Differential uptake of DNA-poly(ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces. 
  • Directed cell migration on fibronectin gradients: effect of gradient slope. 
  • Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin. 
  • Dissociation rate constants of human fibronectin binding to fibronectin-binding proteins on living Staphylococcus aureus isolated from clinical patients. 
  • Distribution of type VI collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein. 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress. 
  • Dynamic seeding of perfusing human umbilical vein endothelial cells (HUVECs) onto dual-function cell adhesion ligands: Arg-Gly-Asp (RGD)-streptavidin and biotinylated fibronectin. 
  • Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein. 
  • Effect of fibronectin amount and conformation on the strength of endothelial cell adhesion to HEMA/EMA copolymers. 
  • Effect of receptor-ligand affinity on the strength of endothelial cell adhesion. 
  • Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. 
  • Effects of a novel Mac-1 inhibitor, NPC 15669, on hemostatic parameters during preconditioned myocardial infarction. 
  • Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine. 
  • Electron microscopy of fibrinogen, its plasmic fragments and small polymers. 
  • Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells. 
  • Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB. 
  • Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. 
  • Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated. 
  • Expression of human fetal brain antigens by human tumors of neuroectodermal origin as defined by monoclonal antibodies. 
  • Expression of renin-angiotensin system and extracellular matrix genes in cardiovascular cells and its regulation through AT1 receptor. 
  • Fate of antigen in xenotransplantation: implications for acute vascular rejection and accommodation. 
  • Fetal fibronectin as a marker to discriminate between ectopic and intrauterine pregnancies. 
  • Fibronectin Conformation and Assembly: Analysis of Fibronectin Deletion Mutants and Fibronectin Glomerulopathy (GFND) Mutants. 
  • Fibronectin aggregation and assembly: the unfolding of the second fibronectin type III domain. 
  • Fibronectin and avidin-biotin as a heterogeneous ligand system for enhanced endothelial cell adhesion. 
  • Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. 
  • Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas. 
  • Fibronectin in extended and compact conformations. Electron microscopy and sedimentation analysis. 
  • Fibronectin is an immunosuppressive substance associated with epithelial ovarian cancer. 
  • Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. 
  • Fibronectin isoforms in megakaryocytes. 
  • Fibronectin molecule visualized in electron microscopy: a long, thin, flexible strand. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity. 
  • Flow and high affinity binding affect the elastic modulus of the nucleus, cell body and the stress fibers of endothelial cells. 
  • Force measurements of the alpha5beta1 integrin-fibronectin interaction. 
  • Functional heterogeneity of type 1 fimbriae of Escherichia coli. 
  • Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. 
  • Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. 
  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics. 
  • Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. 
  • Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. 
  • Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. 
  • Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C. 
  • HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression. 
  • HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase. 
  • Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish. 
  • Hemostatic changes after dietary coenzyme Q10 supplementation in swine. 
  • Hemostatic changes after early versus late intracoronary magnesium during acute myocardial infarction in swine. 
  • Heterogeneity of Genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. 
  • Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. 
  • Hydralazine differentially increases mRNAs for the alpha and beta subunits of prolyl 4-hydroxylase whereas it decreases pro alpha 1(I) collagen mRNAs in human skin fibroblasts. 
  • Identification and isolation of differentially expressed genes from very small tissue samples. 
  • Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein. 
  • Improving endothelial cell adhesion to vascular graft surfaces: clinical need and strategies. 
  • Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes. 
  • Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts. 
  • Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine. 
  • Irisin - a myth rather than an exercise-inducible myokine. 
  • Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy. 
  • Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. 
  • Measurement of cell migration on surface-bound fibronectin gradients. 
  • Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Medulloblastoma cell-substrate interaction in vitro. 
  • Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations. 
  • Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin. 
  • Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with "Corner Fractures". 
  • Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries. 
  • Normal function and lack of fibronectin accumulation in kidneys of Clara cell secretory protein/uteroglobin deficient mice. 
  • P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression. 
  • Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. 
  • Plasma fibronectin during myocardial ischemia-reperfusion: effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. 
  • Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. 
  • Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. 
  • Potential pathogenicity of deglycosylated IgG cross reactive with streptokinase and fibronectin in the serum of patients with rheumatoid arthritis. 
  • Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption. 
  • Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility. 
  • Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation. 
  • Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. 
  • Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains? 
  • Pulmonary and pleural leukocytes from F344 rats produce elevated levels of fibronectin following inhalation of refractory ceramic fibers. 
  • Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a synthetic vitreous fiber. II. Pathobiologic responses. 
  • Quantification of in vitro endothelial cell adhesion to vascular graft material. 
  • Quantitation of cell area on glass and fibronectin-coated surfaces by digital image analysis. 
  • Quantitative analysis of variable-angle total internal reflection fluorescence microscopy (VA-TIRFM) of cell/substrate contacts. 
  • Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid. 
  • Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. 
  • Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells. 
  • Reichert's membrane as a model for studying the biosynthesis and assembly of basement membrane components. 
  • Relationship between 3T3 cell spreading and the strength of adhesion on glass and silane surfaces. 
  • Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. 
  • Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds. 
  • Role of endothelial cell-substrate contact area and fibronectin-receptor affinity in cell adhesion to HEMA/EMA copolymers. 
  • Role of fibronectin in topographical guidance of neurite extension on electrospun fibers. 
  • Selective neuronal cell attachment to a covalently patterned monoamine on fluorinated ethylene propylene films. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. 
  • Smooth muscle cell rigidity and extracellular matrix organization influence endothelial cell spreading and adhesion formation in coculture. 
  • Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. 
  • Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING. 
  • Streptavidin binding and endothelial cell adhesion to biotinylated fibronectin. 
  • Streptokinase and human fibronectin share a common epitope: implications for regulation of fibrinolysis and rheumatoid arthritis. 
  • Stretching fibronectin. 
  • Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin. 
  • Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. 
  • Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • Surface proteins of a transitional carcinoma cell line (KS-31E). 
  • Synergistic effect of high-affinity binding and flow preconditioning on endothelial cell adhesion. 
  • Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes. 
  • Synthesis and localization of two sulphated glycoproteins associated with basement membranes and the extracellular matrix. 
  • Synthesis and secretion of von Willebrand factor and fibronectin in megakaryocytes at different phases of maturation. 
  • Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin. 
  • The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The biology of malignant gliomas--a comprehensive survey. 
  • The compact conformation of fibronectin is determined by intramolecular ionic interactions. 
  • The effect of fluid shear stress upon cell adhesion to fibronectin-treated surfaces. 
  • The effects of nicotine on vascular smooth muscle cell chemotaxis induced by thrombospondin-1 and fibronectin. 
  • The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. 
  • The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner. 
  • The molecular elasticity of the extracellular matrix protein tenascin. 
  • The production of transforming growth factor-beta activity by rat granulosa cell cultures. 
  • The role of soluble components in ambient fine particles-induced changes in human lungs and blood. 
  • The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. 
  • The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. 
  • The tyrosine corner: a feature of most Greek key beta-barrel proteins. 
  • Thrombospondin as a component of the extracellular matrix of epiretinal membranes: comparisons with cellular fibronectin. 
  • Topical fibronectin and corneal epithelial wound healing in the rabbit. 
  • Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. 
  • Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin. 
  • Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. 
  • Tumor-promoting phorbol esters induce rapid internalization of the C3b receptor via a cytoskeleton-dependent mechanism. 
  • TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells. 
  • Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy. 
  • Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers. 
  • Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. 
  • Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth. 
  • Visualization of purified fibronectin-transglutaminase complexes. 
  • miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics