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Subject Areas on Research
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2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
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A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase.
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A serum-free defined culture system which maintains follicle-stimulating hormone responsiveness and differentiation of porcine granulosa cells.
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A six-armed oligomer isolated from cell surface fibronectin preparations.
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A tactile response in Staphylococcus aureus.
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Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies.
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Acute histologic effects of extraesophageal reflux on vocal fold healing.
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Adherence of streptococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa to fibronectin-coated and uncoated epithelial cells.
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Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs.
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Anatomy and physiology of cervical ripening.
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Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis.
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Assays to measure plasma membrane and cytoskeletal changes in interferon-treated cells.
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Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent.
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Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin.
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Balloon catheterization induced arterial expression of embryonic fibronectins.
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Binding of hexabrachion (tenascin) to the extracellular matrix and substratum and its effect on cell adhesion.
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Binding of tenascin-C to soluble fibronectin and matrix fibrils.
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Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.
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Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications.
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Biomaterial-mediated retroviral gene transfer using self-assembled monolayers.
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Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer.
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Bolus magnesium infusion in humans is associated with predominantly unfavourable changes in platelet aggregation and certain haemostatic factors.
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Bonds between fibronectin and fibronectin-binding proteins on Staphylococcus aureus and Lactococcus lactis.
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C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.
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CDK5 regulates cell adhesion and migration in corneal epithelial cells.
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CLT1 targets bladder cancer through integrin α5β1 and CLIC3.
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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.
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Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle.
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Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.
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Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.
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Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins.
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Cellular response to phase-separated blends of tyrosine-derived polycarbonates.
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Changes of Circulating Irisin and High-Sensitivity C-Reactive Protein Levels in Morbidly Obese Individuals with Type 2 Diabetes After Roux-en-Y Gastric Bypass.
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Characterization of three restricted specificity monoclonal antibodies raised against the human glioma cell line D-54 MG.
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Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
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Clinical utility of fetal fibronectin for predicting preterm birth.
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Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells.
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Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates.
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Construction, imaging, and analysis of FRET-based tension sensors in living cells.
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Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism.
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Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants.
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Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor?
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Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine.
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Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.
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Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone.
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Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA.
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Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis.
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Designing an extracellular matrix protein with enhanced mechanical stability.
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Differential adhesion of rat colon carcinoma cells to fibronectin in relation to their tumorigenicity.
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Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells.
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Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces
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Directed cell migration on fibronectin gradients: effect of gradient slope.
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Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin.
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Dissociation rate constants of human fibronectin binding to fibronectin-binding proteins on living Staphylococcus aureus isolated from clinical patients.
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Distribution of type VI collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein.
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Domain unfolding plays a role in superfibronectin formation.
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Dual action of TGF-beta1 on nasal-polyp derived fibroblasts.
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Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.
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Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress.
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Dynamic seeding of perfusing human umbilical vein endothelial cells (HUVECs) onto dual-function cell adhesion ligands: Arg-Gly-Asp (RGD)-streptavidin and biotinylated fibronectin.
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Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein.
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Effect of fibronectin amount and conformation on the strength of endothelial cell adhesion to HEMA/EMA copolymers.
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Effect of receptor-ligand affinity on the strength of endothelial cell adhesion.
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Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion.
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Effects of a novel Mac-1 inhibitor, NPC 15669, on hemostatic parameters during preconditioned myocardial infarction.
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Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine.
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Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials.
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Electron microscopy of fibrinogen, its plasmic fragments and small polymers.
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Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro.
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Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells.
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Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB.
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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.
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Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin.
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Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated.
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Expression of human fetal brain antigens by human tumors of neuroectodermal origin as defined by monoclonal antibodies.
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Expression of renin-angiotensin system and extracellular matrix genes in cardiovascular cells and its regulation through AT1 receptor.
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Fibronectin Conformation and Assembly: Analysis of Fibronectin Deletion Mutants and Fibronectin Glomerulopathy (GFND) Mutants.
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Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy.
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Fibronectin aggregation and assembly: the unfolding of the second fibronectin type III domain.
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Fibronectin and avidin-biotin as a heterogeneous ligand system for enhanced endothelial cell adhesion.
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Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.
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Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas.
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Fibronectin in extended and compact conformations. Electron microscopy and sedimentation analysis.
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Fibronectin in the tendon-synovial complex: quantitation in vivo and in vitro by ELISA and relative mRNA levels by polymerase chain reaction and northern blot.
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Fibronectin is an immunosuppressive substance associated with epithelial ovarian cancer.
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Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.
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Fibronectin isoforms in megakaryocytes.
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Fibronectin molecule visualized in electron microscopy: a long, thin, flexible strand.
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Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury.
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Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity.
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Flow and high affinity binding affect the elastic modulus of the nucleus, cell body and the stress fibers of endothelial cells.
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Force measurements of the alpha5beta1 integrin-fibronectin interaction.
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Functional heterogeneity of type 1 fimbriae of Escherichia coli.
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Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin.
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Gastrulation in the sea urchin embryo requires the deposition of crosslinked collagen within the extracellular matrix.
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Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics.
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Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR.
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Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
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Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
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Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C.
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HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression.
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HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase.
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Hemostatic changes after dietary coenzyme Q10 supplementation in swine.
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Hemostatic changes after early versus late intracoronary magnesium during acute myocardial infarction in swine.
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Heterogeneity of Genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas.
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Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody.
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Hydralazine differentially increases mRNAs for the alpha and beta subunits of prolyl 4-hydroxylase whereas it decreases pro alpha 1(I) collagen mRNAs in human skin fibroblasts.
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Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability
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Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein.
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Impact of polymer-bound iodine on fibronectin adsorption and osteoblast cell morphology in radiopaque medical polymers: tyrosine-derived polycarbonate blends as a model system.
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Improving endothelial cell adhesion to vascular graft surfaces: clinical need and strategies.
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Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes.
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Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts.
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Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.
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Irisin - a myth rather than an exercise-inducible myokine.
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Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow.
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Localization of a cryptic binding site for tenascin on fibronectin.
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Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy.
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Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine.
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Measurement of cell migration on surface-bound fibronectin gradients.
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Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone.
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Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
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Medulloblastoma cell-substrate interaction in vitro.
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Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations.
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Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin.
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Molecular cloning and nucleotide sequence of a cDNA clone coding for the cell attachment domain in human fibronectin.
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Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells.
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Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
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Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension.
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Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with "Corner Fractures".
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Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries.
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Overexpression of cell surface cytokeratin 8 in multidrug-resistant MCF-7/MX cells enhances cell adhesion to the extracellular matrix.
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P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury.
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PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells.
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Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression.
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Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.
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Plasma fibronectin during myocardial ischemia-reperfusion: effects of magnesium, diltiazem, and a novel Mac-1 inhibitor.
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Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes.
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Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.
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Potential pathogenicity of deglycosylated IgG cross reactive with streptokinase and fibronectin in the serum of patients with rheumatoid arthritis.
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Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption
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Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility.
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Progress and Challenges in the Biology of FNDC5 and Irisin.
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Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation.
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Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor.
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Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains?
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Pulmonary and pleural leukocytes from F344 rats produce elevated levels of fibronectin following inhalation of refractory ceramic fibers.
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Pulmonary and pleural responses in Fischer 344 rats following short-term inhalation of a synthetic vitreous fiber. II. Pathobiologic responses.
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Quantification of in vitro endothelial cell adhesion to vascular graft material.
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Quantifying cellular traction forces in three dimensions.
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Quantitation of cell area on glass and fibronectin-coated surfaces by digital image analysis.
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Quantitative analysis of variable-angle total internal reflection fluorescence microscopy (VA-TIRFM) of cell/substrate contacts.
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Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid.
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Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells.
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Reichert's membrane as a model for studying the biosynthesis and assembly of basement membrane components.
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Relationship between 3T3 cell spreading and the strength of adhesion on glass and silane surfaces.
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Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.
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Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds.
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Role of endothelial cell-substrate contact area and fibronectin-receptor affinity in cell adhesion to HEMA/EMA copolymers.
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Role of fibronectin in topographical guidance of neurite extension on electrospun fibers.
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Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.
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Selective neuronal cell attachment to a covalently patterned monoamine on fluorinated ethylene propylene films.
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Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs.
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Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice.
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Smooth muscle cell rigidity and extracellular matrix organization influence endothelial cell spreading and adhesion formation in coculture.
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Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
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Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING.
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Streptavidin binding and endothelial cell adhesion to biotinylated fibronectin.
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Streptokinase and human fibronectin share a common epitope: implications for regulation of fibrinolysis and rheumatoid arthritis.
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Stretching fibronectin.
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Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin.
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Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
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Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes.
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Surface proteins of a transitional carcinoma cell line (KS-31E).
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Synergistic effect of high-affinity binding and flow preconditioning on endothelial cell adhesion.
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Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes.
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Synthesis and localization of two sulphated glycoproteins associated with basement membranes and the extracellular matrix.
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Synthesis and secretion of von Willebrand factor and fibronectin in megakaryocytes at different phases of maturation.
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Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin.
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The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue.
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The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
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The biology of malignant gliomas--a comprehensive survey.
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The compact conformation of fibronectin is determined by intramolecular ionic interactions.
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The effect of fluid shear stress upon cell adhesion to fibronectin-treated surfaces.
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The effects of nicotine on vascular smooth muscle cell chemotaxis induced by thrombospondin-1 and fibronectin.
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The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator.
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The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner.
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The molecular elasticity of the extracellular matrix protein tenascin.
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The production of transforming growth factor-beta activity by rat granulosa cell cultures.
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The role of soluble components in ambient fine particles-induced changes in human lungs and blood.
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The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding.
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The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation.
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The tyrosine corner: a feature of most Greek key beta-barrel proteins.
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Topical fibronectin and corneal epithelial wound healing in the rabbit.
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Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice.
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Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin.
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Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation.
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TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.
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Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy.
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Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.
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Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X.
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Visualization of purified fibronectin-transglutaminase complexes.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Liu, Yutao,
Adjunct Assistant Professor in the Department of Medicine,
Medicine, Medical Genetics