Fibrosis

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  Subject Areas on Research

  • A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease. 
  • A multicenter trial of recombinant human interferon gamma in patients with systemic sclerosis: effects on cutaneous fibrosis and interleukin 2 receptor levels. 
  • A reappraisal of loop diuretic choice in heart failure patients. 
  • A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. 
  • Accessory fibrotic lateral rectus muscles in exotropic Duane syndrome with severe retraction and upshoot. 
  • Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. 
  • Actions of thrombin in the interstitium. 
  • Actual 10-Year Survivors After Resection of Hepatocellular Carcinoma. 
  • Acute kidney injury to chronic kidney disease transition: insufficient cellular stress response. 
  • Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats. 
  • Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring. 
  • Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis. 
  • Allograft airway fibrosis in the pulmonary milieu: a disorder of tissue remodeling. 
  • Anchoring Hepatic Gene Expression with Development of Fibrosis and Neoplasia in a Toxicant-induced Fish Model of Liver Injury 
  • Anterior interosseus nerve injury following elbow arthroscopy. 
  • Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye. 
  • Atypical lymphocytic angiitis of the optic nerve and central nervous system. 
  • B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model. 
  • Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin. 
  • Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure. 
  • Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β. 
  • Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. 
  • Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. 
  • C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. 
  • CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. 
  • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. 
  • Calcifying fibrous pseudotumor of pleura. A report of three cases of a newly described entity involving the pleura. 
  • Calcifying fibrous pseudotumor of pleura: radiologic features in three cases. 
  • Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. 
  • Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies. 
  • Characterization of implantable biosensor membrane biofouling. 
  • Chest case of the day. Fibrosing mediastinitis. 
  • Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition. 
  • Clinical phenotype and linkage analysis of the congenital fibrosis of the extraocular muscles in an Indian family. 
  • Clinicopathologic correlation of an epiretinal membrane associated with a recurrent macular hole. 
  • Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16. 
  • Collapsing glomerulopathy in 19 patients with systemic lupus erythematosus or lupus-like disease. 
  • Comparative studies of prosthetic materials in the left atrium of the dog. 
  • Comparison of MR imaging sequences for liver and head and neck interventions: is there a single optimal sequence for all purposes? 
  • Comparison of pulmonary and pleural responses of rats and hamsters to inhaled refractory ceramic fibers. 
  • Computational modeling of cardiac fibroblasts and fibrosis. 
  • Computed tomography findings in liver fibrosis and cirrhosis. 
  • Congenital unilateral fibrosis, blepharoptosis, and enophthalmos syndrome. 
  • Contrast-enhanced magnetic resonance imaging identifies focal regions of intramyocardial fibrosis in patients with severe aortic valve disease: Correlation with quantitative histopathology. 
  • Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer. 
  • Cyclosporine therapy and the development of interstitial fibrosis in renal allografts. 
  • Delayed enhancement cardiac MR imaging in noncompaction of left ventricular myocardium. 
  • Diagnosis and initial management of nonmalignant diseases related to asbestos. 
  • Diagnosis of diffuse malignant mesothelioma: experience of a US/Canadian Mesothelioma Panel. 
  • Differentiation of radiation fibrosis from recurrent neoplasia: a role for 31P MR spectroscopy? 
  • Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. 
  • Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. 
  • Dynamic indocyanine green angiography-guided focal thermal laser treatment of fibrotic choroidal neovascularization. 
  • Effect of erionite on the pleural mesothelium of the Fischer 344 rat. 
  • Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations. 
  • Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury. 
  • Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. 
  • Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis. 
  • Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach. 
  • Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. 
  • Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. 
  • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. 
  • Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. 
  • Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. 
  • Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve. 
  • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 
  • Extracellular superoxide dismutase regulates cardiac function and fibrosis. 
  • Female pattern hair loss and its relationship to permanent/cicatricial alopecia: a new perspective. 
  • FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus. 
  • Fibropolycystic liver disease: CT and MR imaging findings. 
  • Fibrosing mediastinitis. 
  • Fibrosis-related biomarkers and large and small vessel disease: the Cardiovascular Health Study. 
  • Fibrovascular ingrowth as a cause of Ahmed glaucoma valve failure in children. 
  • From the archives of the AFIP: Localized fibrous tumor of the pleura. 
  • Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University. 
  • Functional problems and arthrofibrosis following total knee arthroplasty. 
  • Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community. 
  • Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Glucocorticoid-treated mice are an inappropriate positive control for long-term preclinical studies in the mdx mouse. 
  • Halofuginone inhibits collagen deposition in fibrous capsules around implants. 
  • Heart regeneration in zebrafish. 
  • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. 
  • Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function. 
  • High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study. 
  • High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. 
  • Hypothesis: iron chelation plays a vital role in neutrophilic inflammation. 
  • IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha. 
  • Implant healing in experimental animal models of diabetes. 
  • Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1. 
  • Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. 
  • Increased lipofuscin on endomyocardial biopsy predicts greater cardiac improvement in adolescents and young adults. 
  • Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload. 
  • Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. 
  • Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice. 
  • Inhibition of epidural scar formation after lumbar laminectomy in the rat. 
  • Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice. 
  • Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects. 
  • Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. 
  • Interplay between vesicoureteric reflux and kidney infection in the development of reflux nephropathy in mice. 
  • Iron and Iron-Related Proteins in Asbestosis. 
  • Left Atrial Structure and Function in Heart Failure with Preserved Ejection Fraction: A RELAX Substudy. 
  • Linking immune responses with fibrosis in allergic eye disease. 
  • Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice. 
  • Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. 
  • Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. 
  • Mechanisms of fiber-induced diseases: implications for the safety evaluation of synthetic vitreous fibers. 
  • Medical Facts versus Value Judgments--Toward Preference-Sensitive Guidelines. 
  • Melanocytic nevi with nonsurgical trauma: a histopathologic study. 
  • Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice. 
  • Modeling dynamics in diseased cardiac tissue: Impact of model choice. 
  • Modulation of IL-33/ST2 system in postinfarction heart failure: correlation with cardiac remodelling markers. 
  • Molecular evaluation of BK polyomavirus nephropathy. 
  • Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo. 
  • Multiplex protein analysis to determine fibrosis stage and progression in patients with chronic hepatitis C. 
  • Myocardial Damage Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Uncommon in Peripartum Cardiomyopathy. 
  • Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. 
  • NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. 
  • Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10). 
  • Nephrogenic systemic fibrosis after exposure to gadolinium in patients with renal failure. 
  • Nephrogenic systemic fibrosis: possible association with a predisposing infection. 
  • Neural misdirection in congenital ocular fibrosis syndrome: implications and pathogenesis. 
  • Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression. 
  • Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model. 
  • Osteoradionecrosis mimicking metastatic epidural spinal cord compression. 
  • Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. 
  • Pannus-related prosthetic valve dysfunction and life-threatening aortic regurgitation. 
  • Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction. 
  • Pathologic response to preoperative chemotherapy in colorectal liver metastases: fibrosis, not necrosis, predicts outcome. 
  • Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome. 
  • Percutaneous stenting of right pulmonary artery stenosis in fibrosing mediastinitis. 
  • Percutaneous vascular stent implantation as treatment for central vascular obstruction due to fibrosing mediastinitis. 
  • Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis. 
  • Phase II trial of postoperative adjuvant intraperitoneal cisplatin and fluorouracil and systemic fluorouracil chemotherapy in patients with resected gastric cancer. 
  • Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis. 
  • Positron emission tomography in the pretreatment evaluation and follow-up of non-small cell lung cancer patients treated with radiotherapy: preliminary findings. 
  • Predictors of Post-Operative Pain Relief in Patients with Chronic Pancreatitis Undergoing the Frey or Whipple Procedure. 
  • Presence of mechanical dyssynchrony in Duchenne muscular dystrophy. 
  • Primary autoimmune myelofibrosis: definition of a distinct clinicopathologic syndrome. 
  • Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease. 
  • Prognostic value of left ventricular apical tissue removed for HeartMate II left ventricular assist device placement. 
  • Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition. 
  • Prostacyclin protects against elevated blood pressure and cardiac fibrosis. 
  • Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. 
  • Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis. 
  • Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice. 
  • Radiation-induced hypoxia may perpetuate late normal tissue injury. 
  • Relationship between histopathology and in vitro clonogenicity in breast cancer. 
  • Relationship of smoking and fibrosis in patients with chronic hepatitis C. 
  • Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. 
  • Relaxin suppresses atrial fibrillation in aged rats by reversing fibrosis and upregulating Na+ channels. 
  • Relief of superior vena cava syndrome due to fibrosing mediastinitis using the Palmaz stent. 
  • Remodeling and reparation of the cardiovascular system. 
  • Role of TGF-beta1 in renal parenchymal scarring following childhood urinary tract infection. 
  • Role of transforming growth factor beta in human disease. 
  • STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. 
  • Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests. 
  • Scleroderma and IgG4-related disease. 
  • Second glaucoma drainage devices in refractory pediatric glaucoma: failure by fibrovascular ingrowth. 
  • Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. 
  • Serum apolipoprotein C-III is independently associated with chronic hepatitis C infection and advanced fibrosis. 
  • Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni. 
  • Smad3 Loss is Associated with Aortic Dilation and Spontaneous Aortic Rupture in Lean and in Obese Diabetic Db/db Mice 
  • Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice. 
  • Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy. 
  • Surgical treatment of strabismus secondary to glaucoma drainage device. 
  • TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. 
  • Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. 
  • The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. 
  • The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. 
  • The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. 
  • The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. 
  • The role of cardiovascular MRI in heart failure and the cardiomyopathies. 
  • The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. 
  • The use of lipid microtubes as a novel slow-release delivery system for laryngeal injection. 
  • Tissue prolapse and stresses in stented coronary arteries: A computer model for multi-layer atherosclerotic plaque. 
  • Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat. 
  • Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity. 
  • Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. 
  • Ultrastructural studies of unstable angina in living man. 
  • Urinary bladder organ hypertrophy is partially regulated by Akt1-mediated protein synthesis pathway. 
  • Use of cardiac magnetic resonance imaging to evaluate cardiac structure, function and fibrosis in children with infantile Pompe disease on enzyme replacement therapy. 
  • Use of radionuclide measurements of left ventricular function for prognosis in patients with coronary artery disease. 
  • Validation of sub-segmental visual scoring for the quantification of ischemic and nonischemic myocardial fibrosis using late gadolinium enhancement MRI. 
  • Vasopressin receptor antagonists. 
  • [Renal erythropoietin-producing cells and kidney disease]. 
  • [Renal fibrosis and anemia]. 
  • miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. 
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  Keywords of People

  • Abbruzzese, James, D. C. I. Professor of Medical Oncology, Medicine, Medical Oncology
  • Barker, Piers Christopher Andrew, Professor of Pediatrics, Pediatrics, Cardiology
  • Buckley, Anne Frances, Assistant Professor of Pathology, Pathology
  • Charles, Hal Cecil, Associate Professor of Radiology, Radiology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Professor of Radiology, Physics
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Mentz, Robert John, Assistant Professor of Medicine, Medicine, Cardiology
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Patz Jr., Edward F., James and Alice Chen Professor of Radiology, Pathology
  • Sparks, Matthew A., Assistant Professor of Medicine, Medicine, Nephrology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery