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Subject Areas on Research
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5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer.
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A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers.
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A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
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A mathematical model of the folate cycle: new insights into folate homeostasis.
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A population model of folate-mediated one-carbon metabolism.
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Acceptance of a Polypill approach to prevent cardiovascular disease among a sample of U.S. physicians.
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Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery.
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Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation.
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Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.
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Analysis of Homeostatic Mechanisms in Biochemical Networks.
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Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study.
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Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults.
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BP, cardiovascular disease, and death in the Folic Acid for Vascular Outcome Reduction in Transplantation trial.
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Biosynthesis and processing of the molybdenum cofactors.
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Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.
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Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid.
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Comparison of fresh frozen serum to traditional proficiency testing material in a College of American Pathologists survey for ferritin, folate, and vitamin B12.
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Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
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Correlates of intake of folic acid-containing supplements among pregnant women.
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Determination of total folate in plant material by chemical conversion into para-aminobenzoic acid followed by high performance liquid chromatography combined with on-line postcolumn derivatization and fluorescence detection.
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Development of biomarkers to optimize pediatric patient management: what makes children different?
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Dietary folate intake and lung cancer risk in former smokers: a case-control analysis.
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Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion.
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Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits.
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Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study.
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Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.
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Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a cross-sectional hospital-based study.
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Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria.
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Folate and unipolar depression.
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Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate.
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Folate fortification of rice by metabolic engineering.
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Folate intake, markers of folate status and oral clefts: An updated set of systematic reviews and meta-analyses.
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Folate intake, markers of folate status and oral clefts: is the evidence converging?
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Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression.
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Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
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Folate targeting of drug carriers: a mathematical model.
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Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis.
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Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic.
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Folic Acid Fortification and Women's Folate Levels in Selected Communities in Brazil - A First Look.
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Folic acid supplementation and chronic kidney disease progression.
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Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).
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Folic acid throughout pregnancy: too much?
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Free and total para-aminobenzoic acid analysis in plants with high-performance liquid chromatography/tandem mass spectrometry.
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Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize.
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Genetic studies in neural tube defects. NTD Collaborative Group.
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Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.
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Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.
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High dosage folic acid supplementation, oral cleft recurrence and fetal growth.
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High-risk gestational trophoblastic neoplasia with brain metastases: individualized multidisciplinary therapy in the management of four patients.
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Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
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Homeostasis and dynamic stability of the phenotype link robustness and plasticity.
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Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial.
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Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation.
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Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress.
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Identification of novel candidate risk genes for myelomeningocele within the glucose homeostasis/oxidative stress and folate/one-carbon metabolism networks.
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Imaging biomarker roadmap for cancer studies.
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Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.
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In silico experimentation with a model of hepatic mitochondrial folate metabolism.
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Investigation of the extraction behavior of the main monoglutamate folates from spinach by liquid chromatography-electrospray ionization tandem mass spectrometry.
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Is weekly iron and folic acid supplementation as effective as daily supplementation for decreasing incidence of anemia in adolescent girls?
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Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate
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Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.
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Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.
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Maternal dietary patterns are associated with risk of neural tube and congenital heart defects.
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Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico.
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Mathematical analysis of the regulation of competing methyltransferases.
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Mathematical model insights into arsenic detoxification.
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Mathematical modeling of cell metabolism
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Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis.
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Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers.
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Mathematical models of folate-mediated one-carbon metabolism.
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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
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Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease.
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Methionine metabolism in health and cancer: a nexus of diet and precision medicine.
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Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model.
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Methotrexate recognition by the human reduced folate carrier SLC19A1.
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Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.
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Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs.
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Modeling folate, one-carbon metabolism, and DNA methylation.
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Molecular mechanisms underlying the potentially adverse effects of folate.
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Natural food folate and late-life depression.
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Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.
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Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.
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Nutrition and hearing loss: a neglected cause and global health burden.
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O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines.
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One-carbon metabolism and epigenetics: understanding the specificity.
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One-carbon metabolism during the menstrual cycle and pregnancy
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Oral cleft prevention program (OCPP).
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Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency.
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Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil.
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Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium.
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Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.
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Plasma FGF23 levels increase rapidly after acute kidney injury.
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Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.
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Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study.
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Prevention of fumonisin B1-induced neural tube defects by folic acid.
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Reduction of folic acid-induced acute tubular injury by diuresis: an experimental model.
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Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation.
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Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study.
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Role of enzyme-bound 5,10-methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase.
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Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians.
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Safety events in kidney transplant recipients: results from the folic Acid for vascular outcome reduction in transplant trial.
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Second trimester folate status and preterm birth.
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Sex differences in hepatic one-carbon metabolism.
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Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate.
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Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells.
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The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
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The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber.
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The biological significance of substrate inhibition: a mechanism with diverse functions.
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The folate cofactor of Escherichia coli DNA photolyase acts catalytically.
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The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.
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The polypill to prevent cardiovascular disease: physicians' perspectives.
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The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.
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The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model.
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The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.
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The role of zinc and iron-folic acid supplementation on early child temperament and eating behaviors in rural Nepal: a randomized controlled trial.
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Use of pathway information in molecular epidemiology.
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Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging.
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Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.
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pH stability of individual folates during critical sample preparation steps in prevision of the analysis of plant folates.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Mattingly, Jonathan Christopher,
Kimberly J. Jenkins Distinguished University Professor of New Technologies,
Mathematics
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Moorman, Patricia Gripka,
Professor Emeritus in Family Medicine and Community Health,
Duke Cancer Institute
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Stinnett, Sandra Sue,
Associate Professor of Biostatistics & Bioinformatics,
Biostatistics & Bioinformatics