Folic Acid

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  Subject Areas on Research

  • 5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer. 
  • A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. 
  • A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. 
  • A mathematical model of the folate cycle: new insights into folate homeostasis. 
  • A population model of folate-mediated one-carbon metabolism. 
  • Acceptance of a Polypill approach to prevent cardiovascular disease among a sample of U.S. physicians. 
  • Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery. 
  • Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. 
  • Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity. 
  • Analysis of Homeostatic Mechanisms in Biochemical Networks. 
  • Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study. 
  • Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults. 
  • BP, cardiovascular disease, and death in the Folic Acid for Vascular Outcome Reduction in Transplantation trial. 
  • Biosynthesis and processing of the molybdenum cofactors. 
  • Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. 
  • Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. 
  • Comparison of fresh frozen serum to traditional proficiency testing material in a College of American Pathologists survey for ferritin, folate, and vitamin B12. 
  • Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. 
  • Correlates of intake of folic acid-containing supplements among pregnant women. 
  • Determination of total folate in plant material by chemical conversion into para-aminobenzoic acid followed by high performance liquid chromatography combined with on-line postcolumn derivatization and fluorescence detection. 
  • Development of biomarkers to optimize pediatric patient management: what makes children different? 
  • Dietary folate intake and lung cancer risk in former smokers: a case-control analysis. 
  • Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion. 
  • Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits. 
  • Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study. 
  • Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort. 
  • Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a cross-sectional hospital-based study. 
  • Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria. 
  • Folate and unipolar depression. 
  • Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate. 
  • Folate fortification of rice by metabolic engineering. 
  • Folate intake, markers of folate status and oral clefts: An updated set of systematic reviews and meta-analyses. 
  • Folate intake, markers of folate status and oral clefts: is the evidence converging? 
  • Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression. 
  • Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics. 
  • Folate targeting of drug carriers: a mathematical model. 
  • Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. 
  • Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic. 
  • Folic Acid Fortification and Women's Folate Levels in Selected Communities in Brazil - A First Look. 
  • Folic acid supplementation and chronic kidney disease progression. 
  • Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). 
  • Folic acid throughout pregnancy: too much? 
  • Free and total para-aminobenzoic acid analysis in plants with high-performance liquid chromatography/tandem mass spectrometry. 
  • Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. 
  • Genetic studies in neural tube defects. NTD Collaborative Group. 
  • Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival. 
  • Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. 
  • High dosage folic acid supplementation, oral cleft recurrence and fetal growth. 
  • High-risk gestational trophoblastic neoplasia with brain metastases: individualized multidisciplinary therapy in the management of four patients. 
  • Homeostasis and dynamic stability of the phenotype link robustness and plasticity. 
  • Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. 
  • Identification of novel candidate risk genes for myelomeningocele within the glucose homeostasis/oxidative stress and folate/one-carbon metabolism networks. 
  • Imaging biomarker roadmap for cancer studies. 
  • Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. 
  • In silico experimentation with a model of hepatic mitochondrial folate metabolism. 
  • Investigation of the extraction behavior of the main monoglutamate folates from spinach by liquid chromatography-electrospray ionization tandem mass spectrometry. 
  • Is weekly iron and folic acid supplementation as effective as daily supplementation for decreasing incidence of anemia in adolescent girls? 
  • Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate 
  • Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight. 
  • Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. 
  • Maternal dietary patterns are associated with risk of neural tube and congenital heart defects. 
  • Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico. 
  • Mathematical analysis of the regulation of competing methyltransferases. 
  • Mathematical model insights into arsenic detoxification. 
  • Mathematical modeling of cell metabolism 
  • Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. 
  • Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers. 
  • Mathematical models of folate-mediated one-carbon metabolism. 
  • Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. 
  • Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. 
  • Methionine metabolism in health and cancer: a nexus of diet and precision medicine. 
  • Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. 
  • Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. 
  • Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. 
  • Modeling folate, one-carbon metabolism, and DNA methylation. 
  • Molecular mechanisms underlying the potentially adverse effects of folate. 
  • Natural food folate and late-life depression. 
  • Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. 
  • Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. 
  • O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • One-carbon metabolism during the menstrual cycle and pregnancy 
  • Oral cleft prevention program (OCPP). 
  • Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. 
  • Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. 
  • Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium. 
  • Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes. 
  • Physiological anaemia of infancy and the anaemia of prematurity. 
  • Plasma FGF23 levels increase rapidly after acute kidney injury. 
  • Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis. 
  • Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study. 
  • Prevention of fumonisin B1-induced neural tube defects by folic acid. 
  • Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial. 
  • Reduction of folic acid-induced acute tubular injury by diuresis: an experimental model. 
  • Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation. 
  • Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study. 
  • Role of enzyme-bound 5,10-methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase. 
  • Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. 
  • Safety events in kidney transplant recipients: results from the folic Acid for vascular outcome reduction in transplant trial. 
  • Second trimester folate status and preterm birth. 
  • Sex differences in hepatic one-carbon metabolism. 
  • Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. 
  • Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells. 
  • The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies. 
  • The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber. 
  • The biological significance of substrate inhibition: a mechanism with diverse functions. 
  • The folate cofactor of Escherichia coli DNA photolyase acts catalytically. 
  • The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. 
  • The polypill to prevent cardiovascular disease: physicians' perspectives. 
  • The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants. 
  • The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. 
  • The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. 
  • The role of zinc and iron-folic acid supplementation on early child temperament and eating behaviors in rural Nepal: a randomized controlled trial. 
  • Use of pathway information in molecular epidemiology. 
  • Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging. 
  • pH stability of individual folates during critical sample preparation steps in prevision of the analysis of plant folates. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Mattingly, Jonathan Christopher, James B. Duke Distinguished Professor, Mathematics
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics