Formaldehyde

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  Subject Areas on Research

  • A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer. 
  • A method of assessing air toxics concentrations in urban areas using mobile platform measurements. 
  • A methodology for utilization of predictive genomic signatures in FFPE samples. 
  • Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies. 
  • Accuracy of BRCA1 and BRCA2 founder mutation analysis in formalin-fixed and paraffin-embedded (FFPE) tissue. 
  • Acoustic radiation force impulse imaging of thermally- and chemically-induced lesions in soft tissues: preliminary ex vivo results. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. 
  • Active staining of mouse embryos for magnetic resonance microscopy. 
  • Air concentrations of VOCs in portable and traditional classrooms: results of a pilot study in Los Angeles County. 
  • Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. 
  • Antinociceptive activity of Syzygium jambos leaves extract on rats. 
  • Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors. 
  • Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts. 
  • Complement-mediated, infection-enhancing antibodies in plasma from vaccinated macaques before and after inoculation with live simian immunodeficiency virus. 
  • Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies. 
  • Concentration of lead in various endodontic filling materials. 
  • Consequences of chemical modifications on the free radical reactions of human hemoglobin. 
  • Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. 
  • Development of a tracheal implant xenograft model to expose human bronchial epithelial cells to toxic gases. 
  • Differential Health Effects of Constant versus Intermittent Exposure to Formaldehyde in Mice: Implications for Building Ventilation Strategies. 
  • Directed evolution of the surface chemistry of the reporter enzyme beta-glucuronidase. 
  • Effects of formaldehyde gas on the respiratory tract of rhesus monkeys. Pathology and cell proliferation. 
  • Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Fixation of Mycobacterium leprae in unstained smears prior to shipment or storage: evaluation of formaldehyde using Mycobacterium tuberculosis as indicator of efficacy. 
  • Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment. 
  • Formaldehyde case reports. 
  • Formaldehyde concentrations in the blood of rhesus monkeys after inhalation exposure. 
  • Formaldehyde-induced mutagenesis in Saccharomyces cerevisiae: molecular properties and the roles of repair and bypass systems. 
  • From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia. 
  • Gene expression analysis of messenger RNP complexes. 
  • Genome-wide localization of replication factors. 
  • Hand dermatitis: a focus on allergic contact dermatitis to biocides. 
  • Histochemistry of autonomic nerves in wing vessels of Pteropus giganteus (Flying-fox), and the effects of denervation. 
  • How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1. 
  • Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content. 
  • Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas. 
  • Induction of mucosal antibody responses by microsphere-encapsulated formalin-inactivated simian immunodeficiency virus in a male urethral challenge model. 
  • Integrative molecular profiling of routine clinical prostate cancer specimens. 
  • Magnetic resonance imaging of chronic myocardial infarcts in formalin-fixed human autopsy hearts. 
  • Microglial reactions after subcutaneous formalin injection into the rat hind paw. 
  • Microwave-stimulated recovery of myosin-V immunoreactivity from formalin-fixed, paraffin-embedded human CNS. 
  • Molecular biologic substaging of stage I NSCLC through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue. 
  • Molecular subtype classification of formalin-fixed, paraffin-embedded diffuse large B-cell lymphoma samples on the ICEPlex® system. 
  • Mosquito coil emissions and health implications. 
  • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. 
  • Optical mapping of protein-DNA complexes on chromatin fibers. 
  • Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues. 
  • Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis. 
  • Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. 
  • Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction. 
  • Policy guidelines for the utilization of formalin-fixed, paraffin-embedded tissue sections: the UNC SPORE experience. University of North Carolina Specialized Program of Research Excellence. 
  • Quantitative analysis of gas-phase formaldehyde molecular species at equilibrium with formalin solution. 
  • Reduced antigenicity of formaldehyde-fixed arterial allografts and their potential clinical application. 
  • Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin. 
  • Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo. 
  • Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays. 
  • Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms. 
  • Simple fixation and storage protocol for preserving the internal structure of intact human donor lenses and extracted human nuclear cataract specimens. 
  • Social modulation of pain as evidence for empathy in mice. 
  • Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells. 
  • Sources of volatile organic compounds in suburban homes in Shanghai, China, and the impact of air filtration on compound concentrations. 
  • Storing paraformaldehyde-fixed whole blood patient samples after chronic platelet glycoprotein IIb/IIIa blockade: core laboratory considerations. 
  • Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. 
  • TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. 
  • The fractions of respiratory tract cells at risk in formaldehyde carcinogenesis. 
  • The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. 
  • The use of diaminobenzidine for spectrophotometric and acrylamide gel detection of sulfite oxidase and its applicability to hydrogen peroxide-generating enzymes. 
  • Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord. 
  • Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues. 
  • [Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain]. 
  • [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. 
  • [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. 
  • [Intrathecal administration of HSV-I amplicon vector-mediated HPPE gene therapy of nocicepion in rats with formalin pain]. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory