Free Radicals

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  Subject Areas on Research

  • 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. 
  • A chemically competent thiosulfuranyl radical on the Escherichia coli class III ribonucleotide reductase. 
  • A free radical mechanism of prostaglandin synthase-dependent aminopyrine demethylation. 
  • A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. 
  • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. 
  • A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine. 
  • Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. 
  • Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. 
  • An apoptotic model for nitrosative stress. 
  • Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. 
  • Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid. 
  • Brain resuscitation. Medical management and innovations. 
  • Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes. 
  • Citrate and vitamin E blunt the shock wave-induced free radical surge in an in vitro cell culture model. 
  • Competitive apnea and its effect on the human brain: focus on the redox regulation of blood-brain barrier permeability and neuronal-parenchymal integrity. 
  • Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. 
  • Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. 
  • Consequences of chemical modifications on the free radical reactions of human hemoglobin. 
  • Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells. 
  • Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. 
  • Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. 
  • Current status of antioxidant therapy for Alzheimer's Disease. 
  • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. 
  • Cyclosporine increases hepatocyte synthesis of the immunosuppressive free radical nitric oxide. 
  • Early AGEing and Alzheimer's. 
  • Environmental toxins induce intracellular responses of airway epithelium through reactive species of oxygen and nitrogen. Roger S. Mitchell Lecture. 
  • Equilibration of tyrosyl radicals (Y356•, Y731•, Y730•) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase. 
  • Evidence for a radical mechanism of halogenation of monochlorodimedone catalyzed by chloroperoxidase. 
  • Evidence for formation of superoxide and formate radicals in Methanobacterium formicicum. 
  • Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging. 
  • Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity. 
  • Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. 
  • Free radicals and antioxidants at a glance using EPR spectroscopy. 
  • Free radicals formed by exposure of pyrimidine solids to sodium atoms: an electron spin resonance study. 
  • Free radicals mediate postshock contractile impairment in cardiomyocytes--translating experimental studies into clinical practice. 
  • Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+]. 
  • Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. 
  • Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. 
  • Glutathione in calf trabecular meshwork and its relation to aqueous humor outflow facility. 
  • Hemoglobin-based oxygen carriers (HBOCs): structural alterations that affect free radical generation. 
  • Hyperfractionated irradiation and concurrent cisplatin in brain stem tumors: a Pediatric Oncology Group pilot study (9139). 
  • Hyperoxia during reperfusion is a factor in reperfusion injury. 
  • Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies. 
  • Hypothesis: iron chelation plays a vital role in neutrophilic inflammation. 
  • Identification and quantification of regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein. 
  • In vivo assessment of free radical activity during shock wave lithotripsy using a microdialysis system: the renoprotective action of allopurinol. 
  • Increased survival of skin flaps by scavengers of superoxide radical. 
  • Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis. 
  • Investigation of photoexcited states in porcine eumelanin through their transient radical products. 
  • Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes. 
  • Ischemia/reperfusion injury in microvascular surgery. 
  • L-arginine enhances injury in the isolated rabbit lung during hyperoxia. 
  • Letter: Singlet oxygen decontaminating activity of erythrocuprein (superoxide dismutase). 
  • Mechanisms of the antioxidant effects of nitric oxide. 
  • Melatonin increases both life span and tumor incidence in female CBA mice. 
  • Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. 
  • Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. 
  • NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation. 
  • Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. 
  • Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. 
  • Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. 
  • Oxidation-reduction reactions of hemeproteins. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Problems concerning the biochemical action of superoxide dismutase (erythrocuprein). 
  • Pushing the boundaries of intrinsically stable radicals: inverse design using the thiadiazinyl radical as a template. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Raising the bar: how HIF-1 helps determine tumor radiosensitivity. 
  • Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals. 
  • Reproduction and survival in Mediterranean fruit flies: a "protein and energy" free radical model of aging. 
  • Response of platelets exposed to potassium tetraperoxochromate, an extracellular source of singlet oxygen, hydroxyl radicals, superoxide anions and hydrogen-peroxide. 
  • Shock wave lithotripsy causes ipsilateral renal injury remote from the focal point: the role of regional vasoconstriction. 
  • Singlet oxygen and superoxide dismutase (cuprein). 
  • Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation. 
  • Spontaneous tumor cell killing by human blood monocytes and human peritoneal macrophages: lack of alteration by endotoxin or quenchers of reactive oxygen species. 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states. 
  • Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. 
  • Superoxidized states of Escherichia coli sulfite reductase heme protein subunit. 
  • Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic. 
  • The effect of xanthine/xanthine oxidase generated reactive oxygen species on synaptic transmission. 
  • The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after myocardial ischemia-reperfusion. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • The role of oxidative stress in cerebral aneurysm formation and rupture. 
  • The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. 
  • Two crystal forms of bovine superoxide dismutase. 
  • Ultraviolet light and free radicals: an immunologic theory of epidermal carcinogenesis. 
  • Urinary biomarkers of oxidative status in a clinical model of oxidative assault. 
  • Vitamin E treatment of tardive dyskinesia. 
  • [In vitro studies on antioxidant and antimicrobial activities of polysaccharide from Lycoris aurea]. 
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  Keywords of People

  • Miller Jr., Francis Joseph, Professor of Medicine, Pharmacology & Cancer Biology
  • Zhong, Pei, Professor in the Department of Mechanical Enginnering and Materials Science, Mechanical Engineering and Materials Science