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Subject Areas on Research
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5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.
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A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice.
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A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist.
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A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension.
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A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.
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A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.
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A regenerative microchannel device for recording multiple single-unit action potentials in awake, ambulatory animals.
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A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.
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Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.
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Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9.
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Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures.
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Alpha2-adrenergic receptors in human dorsal root ganglia: predominance of alpha2b and alpha2c subtype mRNAs.
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An in vitro bioassay for neurite growth using cryostat sections of nervous tissue as a substratum.
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Anisotropic scaffolds facilitate enhanced neurite extension in vitro.
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Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.
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CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension.
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CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain.
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Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy.
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Capsaicin activated currents in rat dorsal root ganglion cells.
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Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.
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Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.
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Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain.
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Central and peripheral expression of galanin in response to inflammation.
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Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.
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DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.
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Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root Ganglia.
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Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies.
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Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.
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Dorsal root entry zone lesions for the treatment of postherpetic neuralgia.
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Dorsal root ganglia neurite extension is inhibited by mechanical and chondroitin sulfate-rich interfaces.
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Dorsal root ganglia pulsed radiofrequency treatment alters the spinal immune environment.
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Double-labeling of saphenous nerve neuron pools: a model for determining the accuracy of axon regeneration at the single neuron level.
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Dysautonomia in Guillain-Barré syndrome with dorsal root ganglioneuropathy, wallerian degeneration, and fatal myocarditis.
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ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.
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Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation.
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Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes.
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Effect of growth factors on substance P mRNA expression in axotomized dorsal root ganglia.
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Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord.
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Emerging role of Toll-like receptors in the control of pain and itch.
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Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons.
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Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel.
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Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain.
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Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation.
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Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation.
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Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence.
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Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.
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GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.
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Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy.
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Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy.
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Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.
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Geometrical differences among homologous neurons in mammals.
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Global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain.
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Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
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Hydrogel-based three-dimensional matrix for neural cells.
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IL-23 Enhances C-Fiber-Mediated and Blue Light-Induced Spontaneous Pain in Female Mice.
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Identification of a peripheral nerve neurite growth-promoting activity by development and use of an in vitro bioassay.
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Identification of acetylcholine receptors in adult rat trigeminal ganglion neurons.
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Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2.
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Identifying local and descending inputs for primary sensory neurons.
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Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats.
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Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice.
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Implanted neural interfaces: biochallenges and engineered solutions.
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Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist.
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Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction.
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Influence of Touch-Spun Nanofiber Diameter on Contact Guidance during Peripheral Nerve Repair.
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Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
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Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice.
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Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.
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L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow.
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Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons.
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Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro.
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Latex nanosphere delivery system (LNDS): novel nanometer-sized carriers of fluorescent dyes and active agents selectively target neuronal subpopulations via uptake and retrograde transport.
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Locally synthesized phosphatidylcholine, but not protein, undergoes rapid retrograde axonal transport in the rat sciatic nerve.
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Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels.
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Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
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Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.
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Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.
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Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees.
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Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension.
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Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons.
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Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
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Nerve growth factor and its low-affinity receptor promote Schwann cell migration.
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Neurite outgrowth is enhanced by anti-idiotypic monoclonal antibodies to the ganglioside GM1.
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Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia.
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Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy.
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Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates.
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Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity.
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Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
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New modalities of neurostimulation: high frequency and dorsal root ganglion.
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Nociceptors are interleukin-1beta sensors.
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Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption.
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Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.
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Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.
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PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.
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Pain regulation by non-neuronal cells and inflammation.
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Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules.
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Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes.
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Persistent innervation of mammalian sympathetic neurones by native and foreign fibres.
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Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
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Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.
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Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system.
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Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL.
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Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity.
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Prominent expression of bFGF in dorsal root ganglia after axotomy.
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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
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Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
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Regenerative scaffold electrodes for peripheral nerve interfacing.
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Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons.
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Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
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Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.
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Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains.
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Retrograde axonal transport of locally synthesized phosphoinositides in the rat sciatic nerve.
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Role of fibronectin in topographical guidance of neurite extension on electrospun fibers.
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SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
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STING suppresses bone cancer pain via immune and neuronal modulation.
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Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain.
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Sustained release of nerve growth factor from biodegradable polymer microspheres.
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TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation.
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TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.
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TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms.
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TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone.
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Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
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Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain.
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The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.
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The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.
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The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold.
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The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.
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The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
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The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models.
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The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs.
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Theoretical analysis of lipid transport in sciatic nerve.
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Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.
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Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain.
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Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.
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Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases.
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Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.
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Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.
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Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
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Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier.
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Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.
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Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.
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Unfocused laser illumination kills dye-targeted mouse neurons by selective photothermolysis.
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Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.
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Urethral flow-responsive afferents in the cat sacral dorsal root ganglia.
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VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.
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Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter.
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Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice.
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Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus.
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aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy.
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beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue.
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p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.
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p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.
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Keywords of People