Ganglia, Spinal

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  Subject Areas on Research

  • 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. 
  • A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice. 
  • A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension. 
  • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. 
  • A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo. 
  • A regenerative microchannel device for recording multiple single-unit action potentials in awake, ambulatory animals. 
  • A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. 
  • Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures. 
  • Alpha2-adrenergic receptors in human dorsal root ganglia: predominance of alpha2b and alpha2c subtype mRNAs. 
  • An in vitro bioassay for neurite growth using cryostat sections of nervous tissue as a substratum. 
  • Anisotropic scaffolds facilitate enhanced neurite extension in vitro. 
  • Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. 
  • CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. 
  • Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy. 
  • Capsaicin activated currents in rat dorsal root ganglion cells. 
  • Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain. 
  • Central and peripheral expression of galanin in response to inflammation. 
  • Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root Ganglia. 
  • Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. 
  • Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. 
  • Dorsal root entry zone lesions for the treatment of postherpetic neuralgia. 
  • Dorsal root ganglia neurite extension is inhibited by mechanical and chondroitin sulfate-rich interfaces. 
  • Dorsal root ganglia pulsed radiofrequency treatment alters the spinal immune environment. 
  • Double-labeling of saphenous nerve neuron pools: a model for determining the accuracy of axon regeneration at the single neuron level. 
  • Dysautonomia in Guillain-Barré syndrome with dorsal root ganglioneuropathy, wallerian degeneration, and fatal myocarditis. 
  • ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia. 
  • Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. 
  • Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes. 
  • Effect of growth factors on substance P mRNA expression in axotomized dorsal root ganglia. 
  • Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord. 
  • Emerging role of Toll-like receptors in the control of pain and itch. 
  • Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons. 
  • Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel. 
  • Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. 
  • Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation. 
  • Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. 
  • Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. 
  • Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy. 
  • Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. 
  • Geometrical differences among homologous neurons in mammals. 
  • Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. 
  • Hydrogel-based three-dimensional matrix for neural cells. 
  • Identification of a peripheral nerve neurite growth-promoting activity by development and use of an in vitro bioassay. 
  • Identification of acetylcholine receptors in adult rat trigeminal ganglion neurons. 
  • Identification of putative direct effectors for G alpha o, using yeast two-hybrid method. 
  • Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2. 
  • Identifying local and descending inputs for primary sensory neurons. 
  • Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats. 
  • Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice. 
  • Implanted neural interfaces: biochallenges and engineered solutions. 
  • Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist. 
  • Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. 
  • Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice. 
  • Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion. 
  • L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. 
  • Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons. 
  • Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro. 
  • Latex nanosphere delivery system (LNDS): novel nanometer-sized carriers of fluorescent dyes and active agents selectively target neuronal subpopulations via uptake and retrograde transport. 
  • Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. 
  • Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. 
  • Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. 
  • Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. 
  • Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons. 
  • Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. 
  • Nerve growth factor and its low-affinity receptor promote Schwann cell migration. 
  • Neurite outgrowth is enhanced by anti-idiotypic monoclonal antibodies to the ganglioside GM1. 
  • Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. 
  • Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy. 
  • Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates. 
  • Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • New modalities of neurostimulation: high frequency and dorsal root ganglion. 
  • Nociceptors are interleukin-1beta sensors. 
  • Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption. 
  • Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. 
  • Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. 
  • PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. 
  • Pain regulation by non-neuronal cells and inflammation. 
  • Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules. 
  • Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes. 
  • Persistent innervation of mammalian sympathetic neurones by native and foreign fibres. 
  • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. 
  • Potassium, neuroglia, and oxidative metabolism in central gray matter. 
  • Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. 
  • Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system. 
  • Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL. 
  • Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity. 
  • Prominent expression of bFGF in dorsal root ganglia after axotomy. 
  • Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. 
  • Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. 
  • Regenerative scaffold electrodes for peripheral nerve interfacing. 
  • Regulation of axon guidance and extension by three-dimensional constraints. 
  • Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. 
  • Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. 
  • Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 
  • Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains. 
  • Reversible effects of hypoxia on neurons in mouse dorsal root ganglia in vitro. 
  • Role of fibronectin in topographical guidance of neurite extension on electrospun fibers. 
  • SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. 
  • STING suppresses bone cancer pain via immune and neuronal modulation. 
  • Stimulus-evoked and seizure-related responses of extracellular calcium activity in spinal cord compared to those in cerebral cortex. 
  • Sustained release of nerve growth factor from biodegradable polymer microspheres. 
  • TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation. 
  • TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. 
  • TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms. 
  • TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. 
  • Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. 
  • Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain. 
  • The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. 
  • The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. 
  • The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold. 
  • The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors. 
  • The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. 
  • The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. 
  • The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs. 
  • The uptake of methyl mercury (203Hg) in different tissues related to its neurotoxic effects. 
  • Theoretical analysis of lipid transport in sciatic nerve. 
  • Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. 
  • Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. 
  • Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels. 
  • Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. 
  • Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. 
  • Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 
  • Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. 
  • Treatment of neuroinflammation by soluble tumor necrosis factor receptor Type II fused to a thermally responsive carrier. 
  • Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. 
  • Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. 
  • Unfocused laser illumination kills dye-targeted mouse neurons by selective photothermolysis. 
  • Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. 
  • Urethral flow-responsive afferents in the cat sacral dorsal root ganglia. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter. 
  • Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. 
  • Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus. 
  • aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy. 
  • beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. 
  • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. 
  • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute