Gastric Inhibitory Polypeptide
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Subject Areas on Research
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Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques.
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Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones.
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Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery.
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Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.
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Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP.
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Contributions of fat and protein to the incretin effect of a mixed meal.
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Developmental expression of the glucose-dependent insulinotropic polypeptide gene in rat intestine.
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Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.
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Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine.
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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems.
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Effect of intracerebroventricular infusion of insulin on glucose-dependent insulinotropic peptide in dogs.
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Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis.
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Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes.
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Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs.
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Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism.
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GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.
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GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue.
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Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1.
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Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.
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Glucagon-like peptide 1 (GLP-1).
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Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland.
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Gut peptides in the treatment of diabetes mellitus.
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Hyperacidity and hypergastrinemia following extensive intestinal resection.
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Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.
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Intracerebroventricular infusion of bombesin modulates GIP secretion in conscious dogs.
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Isolation and characterization of the gene encoding rat glucose-dependent insulinotropic peptide.
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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
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LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial.
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Localization and characterization of secretin binding sites expressed by rat bile duct epithelium.
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Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia.
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Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP).
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Pharmacology, physiology, and mechanisms of incretin hormone action.
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Physiology of weight loss surgery.
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Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
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Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes.
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The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats.
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The enteroinsular axis revisited. A novel role for an incretin.
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The hepatic extraction of gastric inhibitory polypeptide and insulin.
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The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes.
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The role of GIP in α-cells and glucagon secretion.
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Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.
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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
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Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose.
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β Cell tone is defined by proglucagon peptides through cAMP signaling.
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Keywords of People