Gastric Inhibitory Polypeptide

• 

  Subject Areas on Research

  • Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. 
  • Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. 
  • Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery. 
  • Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. 
  • Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP. 
  • Contributions of fat and protein to the incretin effect of a mixed meal. 
  • Developmental expression of the glucose-dependent insulinotropic polypeptide gene in rat intestine. 
  • Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. 
  • Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine. 
  • Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems. 
  • Effect of intracerebroventricular infusion of insulin on glucose-dependent insulinotropic peptide in dogs. 
  • Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis. 
  • Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes. 
  • Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs. 
  • Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism. 
  • GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells. 
  • GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue. 
  • Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1. 
  • Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice. 
  • Glucagon-like peptide 1 (GLP-1). 
  • Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland. 
  • Gut peptides in the treatment of diabetes mellitus. 
  • Hyperacidity and hypergastrinemia following extensive intestinal resection. 
  • Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction. 
  • Intracerebroventricular infusion of bombesin modulates GIP secretion in conscious dogs. 
  • Isolation and characterization of the gene encoding rat glucose-dependent insulinotropic peptide. 
  • LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept. 
  • LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial. 
  • Localization and characterization of secretin binding sites expressed by rat bile duct epithelium. 
  • Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia. 
  • Molecular cloning of rat glucose-dependent insulinotropic peptide (GIP). 
  • Pharmacology, physiology, and mechanisms of incretin hormone action. 
  • Physiology of weight loss surgery. 
  • Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms. 
  • Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes. 
  • The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats. 
  • The enteroinsular axis revisited. A novel role for an incretin. 
  • The hepatic extraction of gastric inhibitory polypeptide and insulin. 
  • The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes. 
  • The role of GIP in α-cells and glucagon secretion. 
  • Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue. 
  • Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. 
  • Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. 
  • β Cell tone is defined by proglucagon peptides through cAMP signaling. 
• 

  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics