Gastroesophageal Reflux

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  Subject Areas on Research

  • A canine model of gastroesophageal reflux disease (GERD). 
  • A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms. 
  • ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing. 
  • Acid Suppression Therapy and Symptom Improvement (or Lack Thereof) in Children. 
  • Acid-based parameters on pH-impedance testing predict symptom improvement with medical management better than impedance parameters. 
  • Acute histologic effects of extraesophageal reflux on vocal fold healing. 
  • Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis. 
  • Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis. 
  • Amelioration of gastroesophageal reflux symptoms following Roux-en-Y gastric bypass for clinically significant obesity. 
  • An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. 
  • Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials. 
  • Antireflux surgery in the setting of lung transplantation: strategies for treating gastroesophageal reflux disease in a high-risk population. 
  • Artificial intelligence automates and augments baseline impedance measurements from pH-impedance studies in gastroesophageal reflux disease. 
  • Assessment and management of gastroesophageal reflux disease following bariatric surgery. 
  • Assessment of interstitial lung disease among black rheumatoid arthritis patients. 
  • Barrett's esophagus and β-carotene therapy: symptomatic improvement in GERD and enhanced HSP70 expression in esophageal mucosa. 
  • Behavior modification in the treatment of rumination. 
  • Bile acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation. 
  • Biologic mechanisms of environmental tobacco smoke in children with poorly controlled asthma: results from a multicenter clinical trial. 
  • Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration. 
  • Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease. 
  • Characterization of the innate immune response to chronic aspiration in a novel rodent model. 
  • Chest Pain: If It Is Not the Heart, What Is It? 
  • Childhood gastroesophageal reflux symptoms in adult patients. 
  • Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma. 
  • Cimetidine 800 mg twice daily for healing erosions and ulcers in gastroesophageal reflux disease. 
  • Coexisting endogenous and exogenous lipoid pneumonia and pulmonary alveolar proteinosis in a patient with neurodevelopmental disease. 
  • Coexisting endogenous lipoid pneumonia, cholesterol granulomas, and pulmonary alveolar proteinosis in a pediatric population: a clinical, radiographic, and pathologic correlation. 
  • Commentary: The burning questions of reflux management in lung transplantation. 
  • Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms. 
  • Current guidelines for dyspepsia management. 
  • Descriptive epidemiology and risk factors for head and neck cancer. 
  • Development of quality indicators for the diagnosis and management of achalasia. 
  • Diagnosing night sweats. 
  • Dilated intercellular spaces as a marker of GERD. 
  • Distal mean nocturnal baseline impedance on pH-impedance monitoring predicts reflux burden and symptomatic outcome in gastro-oesophageal reflux disease. 
  • Does acid suppressive therapy reduce the risk of laryngeal cancer recurrence? 
  • Dyspepsia. 
  • Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects. 
  • Effects of obstructive sleep apnea and gastroesophageal reflux disease on asthma control in obesity. 
  • Efficacy of esomeprazole for treatment of poorly controlled asthma. 
  • Endoluminal GERD treatments: critical appraisal of current literature with evidence-based medicine instruments. 
  • Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease: A randomized, sham-controlled trial. 
  • Endoscopic treatment modalities for gastroesophageal reflux disease. 
  • Eosinophilic esophagitis -- a mimic of GERD. 
  • Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study. 
  • Esophageal Dysmotility, Gastro-esophageal Reflux Disease, and Lung Transplantation: What Is the Evidence? 
  • Esophageal High-Resolution Manometry in Gastroesophageal Reflux Disease. 
  • Esophageal acid-clearance physiology is altered after Nissen-Collis gastroplasty. 
  • Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation. 
  • Esophageal granular cell tumor and eosinophils: a multicenter experience. 
  • Esophagogastric junction contractile integral (EGJ-CI) quantifies changes in EGJ barrier function with surgical intervention. 
  • Establishing magnetic resonance imaging as an accurate and reliable tool to diagnose and monitor esophageal cancer in a rat model. 
  • Evaluation of Nissen fundoplication in neurologically impaired children. 
  • Five-Year Outcomes After Vertical Sleeve Gastrectomy for Severe Obesity: A Prospective Cohort Study. 
  • Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux. 
  • GERD phenotypes from pH-impedance monitoring predict symptomatic outcomes on prospective evaluation. 
  • GERD: Is laparoscopic surgery cost-effective? 
  • Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution? 
  • Gastro-oesophageal reflux is more prevalent in Western dyspeptics: a prospective comparison of British and South-East Asian patients with dyspepsia. 
  • Gastroesophageal Reflux Monitoring. 
  • Gastroesophageal Reflux Predicts Utilization of Dehydration Treatments After Bariatric Surgery. 
  • Gastroesophageal reflux and altered motility in lung transplant rejection. 
  • Gastroesophageal reflux and atrial fibrillation: is there any correlation? 
  • Gastroesophageal reflux and esophagitis in infants and children. 
  • Gastroesophageal reflux and severe combined immunodeficiency. 
  • Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. 
  • Gastroesophageal reflux disease in lung transplant recipients. 
  • Gastroesophageal reflux disease-induced aspiration injury following lung transplantation. 
  • Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates. 
  • Gastroesophageal reflux-associated aspiration alters the immune response in asthma. 
  • Genetic risk factors for perception of symptoms in GERD: an observational cohort study. 
  • Global prevalence of Barrett's oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis. 
  • Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. 
  • Heller myotomy versus Heller myotomy with Dor fundoplication for achalasia: a prospective randomized double-blind clinical trial. 
  • Heller myotomy vs Heller myotomy plus Dor fundoplication: cost-utility analysis of a randomized trial. 
  • High economic burden of caring for patients with suspected extraesophageal reflux. 
  • High yield reproducible rat model recapitulating human Barrett's carcinogenesis. 
  • Higher Esophageal Symptom Burden in Obese Subjects Results From Increased Esophageal Acid Exposure and Not From Dysmotility. 
  • Hoarseness: is it really laryngopharyngeal reflux? 
  • How to Optimally Apply Impedance in the Evaluation of Esophageal Dysmotility. 
  • Imipramine for Treatment of Esophageal Hypersensitivity and Functional Heartburn. 
  • Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. 
  • Improvement of gastroesophageal reflux disease after initiation of a low-carbohydrate diet: five brief case reports. 
  • Ineffective esophageal motility phenotypes following fundoplication in gastroesophageal reflux disease. 
  • Influence of ethnicity on the efficacy and utilization of bariatric surgery in the USA. 
  • Intestinal malrotation in neonates with nonbilious emesis. 
  • J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. 
  • Lansoprazole Is Associated with Worsening Asthma Control in Children with the CYP2C19 Poor Metabolizer Phenotype. 
  • Laparoscopic Nissen fundoplication for treating reflux in lung transplant recipients. 
  • Laparoscopic Nissen fundoplication: operative results and short-term follow-up. 
  • Laparoscopic anti-reflux surgery for idiopathic pulmonary fibrosis at a single centre. 
  • Laparoscopic anti-reflux surgery for the treatment of idiopathic pulmonary fibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2 trial. 
  • Laparoscopic antireflux surgery in infants with single ventricle physiology: a review. 
  • Laparoscopic antireflux surgery in the lung transplant population. 
  • Laparoscopic approaches to symptomatic gastroesophageal reflux. 
  • Laparoscopic fundoplication: 5-year follow-up. 
  • Laparoscopic fundoplication: an alternate approach in the surgical treatment of esophageal reflux (continuing education credit). 
  • Laparoscopic nephron-sparing surgery in a Jehovah's Witness patient. 
  • Large mesenteric lymphangioma in an adult patient: an unusual presentation of a rare disease. 
  • Left Transthoracic Approach for Magnetic Sphincter Augmentation Device LINX Implantation. 
  • Letter: the effects of overlapping symptoms on the response to PPI therapy in GERD. 
  • Long-term evaluation of patient satisfaction and reflux symptoms after laparoscopic fundoplication with Collis gastroplasty. 
  • Long-term follow-up study of the Stretta procedure for the treatment of gastroesophageal reflux disease. 
  • Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants. 
  • Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients. 
  • Lung transplantation exacerbates gastroesophageal reflux disease. 
  • Mean Nocturnal Baseline Impedance Correlates With Symptom Outcome When Acid Exposure Time Is Inconclusive on Esophageal Reflux Monitoring. 
  • Medication discontinuation after curative surgery for sporadic primary hyperparathyroidism. 
  • Meta-analysis: the epidemiology of noncardiac chest pain in the community. 
  • Metoclopramide, H2 blockers, and proton pump inhibitors: pharmacotherapy for gastroesophageal reflux in neonates. 
  • Minimal differences in prevalence and spectrum of organic disease at upper gastrointestinal endoscopy between selected secondary care patients with symptoms of gastro-oesophageal reflux or dyspepsia. 
  • Misconceptions concerning gastroesophageal reflux in children. 
  • Modulation of salivation and heartburn in response to the site of acid infusion in the human oesophagus. 
  • Non-acid Reflux: What to Do When You Don't Feel the Burn. 
  • Nutrition and gastrointestinal tract assessment and management of children with dysphagia. 
  • Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. 
  • Optimization of impedance-measured reflux events in GORD utilizing acid exposure time. 
  • Otolaryngological perspective on patients with throat symptoms and laryngeal irritation. 
  • Outcomes of bariatric surgery in patients > or =65 years. 
  • Paradigm shift in the management of gastroesophageal reflux disease. 
  • Parameters on esophageal pH-impedance monitoring that predict outcomes of patients with gastroesophageal reflux disease. 
  • Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. 
  • Pediatric imaging perspective: the vomiting infant. 
  • Per-Oral Pyloromyotomy (POP) for Medically Refractory Post-Surgical Gastroparesis. 
  • Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. 
  • Prevalence and causes of dysphonia in a large treatment-seeking population. 
  • Prevalence of Dyspepsia in Individuals With Gastroesophageal Reflux-Type Symptoms in the Community: A Systematic Review and Meta-analysis. 
  • Prevalence of gastro-esophageal reflux-type symptoms in individuals with irritable bowel syndrome in the community: a meta-analysis. 
  • Prevalence, characteristics, and treatment outcomes of reflux hypersensitivity detected on pH-impedance monitoring. 
  • Prevalence, severity and associated features of gastro-oesophageal reflux and dyspepsia: a population-based study. 
  • Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease. 
  • Proton pump inhibitors and oesophageal cancer: Flawed methodology and false alarms. 
  • Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity. 
  • Reflux and allograft dysfunction: is there a connection? 
  • Reply: worsening asthma control in children taking lansoprazole: possible mechanisms. 
  • Reproducibility patterns of multiple rapid swallows during high resolution esophageal manometry provide insights into esophageal pathophysiology. 
  • Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. 
  • Robotic benign esophageal procedures. 
  • Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. 
  • Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development. 
  • Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy. 
  • Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma. 
  • Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study. 
  • Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series. 
  • Surgical management of gastroesophageal reflux disease in patients with systemic sclerosis. 
  • Swallowing Dysfunction and Quality of Life in Adults With Surgically Corrected Esophageal Atresia/Tracheoesophageal Fistula as Infants: Forty Years of Follow-up. 
  • Systematic review with meta-analysis: association of Helicobacter pylori infection with gastro-oesophageal reflux and its complications. 
  • Systematic review with meta-analysis: risk factors for Barrett's oesophagus in individuals with gastro-oesophageal reflux symptoms. 
  • The Short-Form Leeds Dyspepsia Questionnaire validation study. 
  • The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD). 
  • The association of gastric leptin with oesophageal inflammation and metaplasia. 
  • The emerging phenotype of long-term survivors with infantile Pompe disease. 
  • The endoscopic radiofrequency approach to management of GERD. 
  • The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. 
  • The laparoscopic management of gastroesophageal reflux disease. 
  • The natural history of gastro-oesophageal reflux symptoms in the community and its effects on survival: a longitudinal 10-year follow-up study. 
  • The pathogenesis of the low pleural fluid pH in esophageal rupture. 
  • Three year's experience with the Stretta procedure: did it really make a difference? 
  • Transpyloric tube feeding in very low birthweight infants with suspected gastroesophageal reflux: impact on apnea and bradycardia. 
  • Treatment of chronic gastro-oesophageal reflux disease. 
  • Treatment of gastroesophageal reflux: is nothing sacred? 
  • Upper gastrointestinal endoscopy in infants: diagnostic usefulness and safety. 
  • Use and Safety of Erythromycin and Metoclopramide in Hospitalized Infants. 
  • Use of Reflux Medications in Premature Infants After Hospital Discharge. 
  • Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. 
  • Variability in endoscopic assessment of Nissen fundoplication wrap integrity and hiatus herniation. 
  • Whom should we "test and treat" for Helicobacter pylori? 
  • World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Case, Laura Elizabeth, Associate Professor in Orthopaedic Surgery, Pediatrics, Medical Genetics
  • Patel, Amit, Associate Professor of Medicine, Medicine, Gastroenterology
  • Yancy Jr., William Samuel, Professor of Medicine, Medicine, General Internal Medicine