Gastroesophageal Reflux

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  Subject Areas on Research

  • A canine model of gastroesophageal reflux disease (GERD). 
  • A cost analysis of outpatient care for patients with Barrett's esophagus in a managed care setting. 
  • A novel endoscopic transgastric fundoplication procedure for gastroesophageal reflux: an initial animal evaluation. 
  • A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms. 
  • Acid Suppression Therapy and Symptom Improvement (or Lack Thereof) in Children. 
  • Acid-based parameters on pH-impedance testing predict symptom improvement with medical management better than impedance parameters. 
  • Acute histologic effects of extraesophageal reflux on vocal fold healing. 
  • Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis. 
  • Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis. 
  • Ambulatory pH monitoring in the management of reflux. 
  • Ambulatory reflux monitoring for diagnosis of gastro-esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group. 
  • Amelioration of gastroesophageal reflux symptoms following Roux-en-Y gastric bypass for clinically significant obesity. 
  • An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. 
  • Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials. 
  • Antireflux surgery in the setting of lung transplantation: strategies for treating gastroesophageal reflux disease in a high-risk population. 
  • Aspiration of gastric fluid in pulmonary allografts: effect of pH. 
  • Barrett's esophagus and β-carotene therapy: symptomatic improvement in GERD and enhanced HSP70 expression in esophageal mucosa. 
  • Behavior modification in the treatment of rumination. 
  • Bile acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation. 
  • Biologic mechanisms of environmental tobacco smoke in children with poorly controlled asthma: results from a multicenter clinical trial. 
  • Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. 
  • Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease. 
  • Characterization of the innate immune response to chronic aspiration in a novel rodent model. 
  • Chest Pain: If It Is Not the Heart, What Is It? 
  • Childhood gastroesophageal reflux symptoms in adult patients. 
  • Cholelithiasis in a 2-year-old child with reflux esophagitis and hiatus hernia. 
  • Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma. 
  • Cimetidine 800 mg twice daily for healing erosions and ulcers in gastroesophageal reflux disease. 
  • Classification of esophageal motor findings in gastro-esophageal reflux disease: Conclusions from an international consensus group. 
  • Clinical and demographic predictors of Barrett's esophagus among patients with gastroesophageal reflux disease: a multivariable analysis in veterans. 
  • Coexisting endogenous and exogenous lipoid pneumonia and pulmonary alveolar proteinosis in a patient with neurodevelopmental disease. 
  • Coexisting endogenous lipoid pneumonia, cholesterol granulomas, and pulmonary alveolar proteinosis in a pediatric population: a clinical, radiographic, and pathologic correlation. 
  • Descriptive epidemiology and risk factors for head and neck cancer. 
  • Diagnosing night sweats. 
  • Dilated intercellular spaces as a marker of GERD. 
  • Distal mean nocturnal baseline impedance on pH-impedance monitoring predicts reflux burden and symptomatic outcome in gastro-oesophageal reflux disease. 
  • Does acid suppressive therapy reduce the risk of laryngeal cancer recurrence? 
  • Economic considerations in the treatment of gastroesophageal reflux disease: a review. 
  • Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects. 
  • Effects of obstructive sleep apnea and gastroesophageal reflux disease on asthma control in obesity. 
  • Efficacy of esomeprazole for treatment of poorly controlled asthma. 
  • Endoluminal GERD treatments: critical appraisal of current literature with evidence-based medicine instruments. 
  • Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease: A randomized, sham-controlled trial. 
  • Endoscopic mucosal tissue sampling. 
  • Endoscopic treatment modalities for gastroesophageal reflux disease. 
  • Eosinophilic esophagitis -- a mimic of GERD. 
  • Esophageal Dysmotility, Gastro-esophageal Reflux Disease, and Lung Transplantation: What Is the Evidence? 
  • Esophageal High-Resolution Manometry in Gastroesophageal Reflux Disease. 
  • Esophageal acid-clearance physiology is altered after Nissen-Collis gastroplasty. 
  • Esophagogastric junction contractile integral (EGJ-CI) quantifies changes in EGJ barrier function with surgical intervention. 
  • Evaluation of Nissen fundoplication in neurologically impaired children. 
  • Five-Year Outcomes After Vertical Sleeve Gastrectomy for Severe Obesity: A Prospective Cohort Study. 
  • Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux. 
  • GERD phenotypes from pH-impedance monitoring predict symptomatic outcomes on prospective evaluation. 
  • Gastric infarction secondary to small bowel obstruction: a preventable complication after Nissen fundoplication. 
  • Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution? 
  • Gastroesophageal Reflux Monitoring. 
  • Gastroesophageal reflux and altered motility in lung transplant rejection. 
  • Gastroesophageal reflux and atrial fibrillation: is there any correlation? 
  • Gastroesophageal reflux and esophagitis in infants and children. 
  • Gastroesophageal reflux and severe combined immunodeficiency. 
  • Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. 
  • Gastroesophageal reflux disease in lung transplant recipients. 
  • Gastroesophageal reflux disease-induced aspiration injury following lung transplantation. 
  • Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates. 
  • Gastroesophageal reflux-associated aspiration alters the immune response in asthma. 
  • Genetic risk factors for perception of symptoms in GERD: an observational cohort study. 
  • Health-related quality of life and severity of symptoms in patients with Barrett's esophagus and gastroesophageal reflux disease patients without Barrett's esophagus. 
  • Heller myotomy versus Heller myotomy with Dor fundoplication for achalasia: a prospective randomized double-blind clinical trial. 
  • Heller myotomy vs Heller myotomy plus Dor fundoplication: cost-utility analysis of a randomized trial. 
  • High economic burden of caring for patients with suspected extraesophageal reflux. 
  • Hoarseness: is it really laryngopharyngeal reflux? 
  • How to Optimally Apply Impedance in the Evaluation of Esophageal Dysmotility. 
  • Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients. 
  • Image of the month-quiz case. Heterotopic pancreas. 
  • Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. 
  • Improvement of gastroesophageal reflux disease after initiation of a low-carbohydrate diet: five brief case reports. 
  • Ineffective esophageal motility phenotypes following fundoplication in gastroesophageal reflux disease. 
  • Influence of ethnicity on the efficacy and utilization of bariatric surgery in the USA. 
  • Intestinal malrotation in neonates with nonbilious emesis. 
  • Invited commentary. 
  • Is esophagoscopy alone sufficient for patients with reflux symptoms? 
  • J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. 
  • Lansoprazole Is Associated with Worsening Asthma Control in Children with the CYP2C19 Poor Metabolizer Phenotype. 
  • Laparoscopic Nissen fundoplication for treating reflux in lung transplant recipients. 
  • Laparoscopic Nissen fundoplication: operative results and short-term follow-up. 
  • Laparoscopic anti-reflux surgery for idiopathic pulmonary fibrosis at a single centre. 
  • Laparoscopic anti-reflux surgery for the treatment of idiopathic pulmonary fibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2 trial. 
  • Laparoscopic antireflux surgery in infants with single ventricle physiology: a review. 
  • Laparoscopic antireflux surgery in the lung transplant population. 
  • Laparoscopic approaches to symptomatic gastroesophageal reflux. 
  • Laparoscopic fundoplication: 5-year follow-up. 
  • Laparoscopic fundoplication: an alternate approach in the surgical treatment of esophageal reflux (continuing education credit). 
  • Laparoscopic nephron-sparing surgery in a Jehovah's Witness patient. 
  • Large mesenteric lymphangioma in an adult patient: an unusual presentation of a rare disease. 
  • Left Transthoracic Approach for Magnetic Sphincter Augmentation Device LINX Implantation. 
  • Long-term evaluation of patient satisfaction and reflux symptoms after laparoscopic fundoplication with Collis gastroplasty. 
  • Long-term follow-up study of the Stretta procedure for the treatment of gastroesophageal reflux disease. 
  • Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants. 
  • Lung disease severity in idiopathic pulmonary fibrosis is more strongly associated with impedance measures of bolus reflux than pH parameters of acid reflux alone. 
  • Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients. 
  • Lung transplantation exacerbates gastroesophageal reflux disease. 
  • Maintenance treatment of gastroesophageal reflux disease: an evaluation of continuous and on-demand therapy with rabeprazole 20 mg. 
  • Management of gastrointestinal dysfunction after gastric surgery. 
  • Medication discontinuation after curative surgery for sporadic primary hyperparathyroidism. 
  • Metoclopramide, H2 blockers, and proton pump inhibitors: pharmacotherapy for gastroesophageal reflux in neonates. 
  • Misconceptions concerning gastroesophageal reflux in children. 
  • Modulation of salivation and heartburn in response to the site of acid infusion in the human oesophagus. 
  • Nutrition and gastrointestinal tract assessment and management of children with dysphagia. 
  • Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. 
  • Otolaryngological perspective on patients with throat symptoms and laryngeal irritation. 
  • Outcomes of bariatric surgery in patients > or =65 years. 
  • Overuse of Repeat Upper Endoscopy in the Veterans Health Administration: A Retrospective Analysis. 
  • Paradigm shift in the management of gastroesophageal reflux disease. 
  • Parameters on esophageal pH-impedance monitoring that predict outcomes of patients with gastroesophageal reflux disease. 
  • Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. 
  • Pediatric imaging perspective: the vomiting infant. 
  • Prevalence and causes of dysphonia in a large treatment-seeking population. 
  • Prevalence of contraindications and prescription of pharmacologic therapies for gout. 
  • Prevalence, characteristics, and treatment outcomes of reflux hypersensitivity detected on pH-impedance monitoring. 
  • Prevalence, severity and associated features of gastro-oesophageal reflux and dyspepsia: a population-based study. 
  • Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity. 
  • Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. 
  • Reflux and allograft dysfunction: is there a connection? 
  • Reply: worsening asthma control in children taking lansoprazole: possible mechanisms. 
  • Reproducibility of 24-hour intraesophageal pH monitoring. 
  • Reproducibility patterns of multiple rapid swallows during high resolution esophageal manometry provide insights into esophageal pathophysiology. 
  • Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. 
  • Robotic benign esophageal procedures. 
  • Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. 
  • Screening strategies in gastroesophageal reflux disease: early identification of esophageal carcinoma. 
  • Single site fundoplication and foregut procedures. 
  • Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study. 
  • Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series. 
  • The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD). 
  • The association of gastric leptin with oesophageal inflammation and metaplasia. 
  • The cricoid yoke--a device for providing consistent and reproducible cricoid pressure. 
  • The emerging phenotype of long-term survivors with infantile Pompe disease. 
  • The endoscopic radiofrequency approach to management of GERD. 
  • The epidemiology of gastroesophageal reflux disease. 
  • The laparoscopic management of gastroesophageal reflux disease. 
  • The pathogenesis of the low pleural fluid pH in esophageal rupture. 
  • Three year's experience with the Stretta procedure: did it really make a difference? 
  • Transpyloric tube feeding in very low birthweight infants with suspected gastroesophageal reflux: impact on apnea and bradycardia. 
  • Treatment of gastroesophageal reflux: is nothing sacred? 
  • Upper gastrointestinal endoscopy in infants: diagnostic usefulness and safety. 
  • Use and Safety of Erythromycin and Metoclopramide in Hospitalized Infants. 
  • Use of Reflux Medications in Premature Infants After Hospital Discharge. 
  • Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology
  • Case, Laura Elizabeth, Associate Professor in Orthopaedic Surgery, Orthopaedics, Physical Therapy
  • Patel, Amit, Assistant Professor of Medicine, Medicine, Gastroenterology
  • Yancy Jr., William Samuel, Associate Professor of Medicine, Medicine, General Internal Medicine