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Subject Areas on Research
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A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.
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A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity.
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A physical map of the human Y chromosome.
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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
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AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells.
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Abundant gene conversion between arms of palindromes in human and ape Y chromosomes.
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Alterations of the TP53 gene in human gliomas.
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Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.
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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
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Amplification of HER-2/neu gene in human gastric adenocarcinomas: correlation with primary site.
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Amplification of bacterial 16S ribosomal DNA with polymerase chain reaction.
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Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
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Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.
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An integrated genomic analysis of human glioblastoma multiforme.
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Assessment of c-erbB-2 amplification by immunohistochemistry in paraffin-embedded breast cancer.
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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
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Atypical features of familial hemophagocytic lymphohistiocytosis.
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Bacterial artificial chromosome cloning and mapping of a 630-kb human extrachromosomal structure.
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Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.
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Characterization of a partial cDNA for lysyl hydroxylase from human skin fibroblasts; lysyl hydroxylase mRNAs are regulated differently by minoxidil derivatives and hydralazine.
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Characterization of gains, losses, and regional amplification in testicular germ cell tumor cell lines by comparative genomic hybridization.
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Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.
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Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.
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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.
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Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma.
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Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines.
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Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression.
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Comparative genomic hybridization studies in hydatidiform moles and choriocarcinoma: amplification of 7q21-q31 and loss of 8p12-p21 in choriocarcinoma.
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Comparison of direct and indirect methods of carrier detection in an X-linked disease.
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Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study.
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Cross-species amplification, non-invasive genotyping, and non-Mendelian inheritance of human STRPs in Savannah baboons.
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Cryptococcus neoformans shows a remarkable genotypic diversity in Brazil.
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DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair.
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Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.
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Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.
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Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification.
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Developmental regulation of DNA replication: replication fork barriers and programmed gene amplification in Tetrahymena thermophila.
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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.
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Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells.
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Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.
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Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors.
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Epidermal growth factor receptor gene analysis in renal cell carcinoma.
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Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole.
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Evaluation of an atypical HIV type 1 antibody. Serologic pattern leading to detection of HIV type 2 infection in North America.
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Expression and amplification of the HER-2/neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines.
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Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans.
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Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.
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Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.
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Gene amplification in malignant human gliomas: clinical and histopathologic aspects.
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Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae.
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Genetic selection for enhanced serine metabolism in cancer development.
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Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients.
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Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors.
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Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
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Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.
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Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization.
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Group-I intron family in the nuclear ribosomal RNA small subunit genes of Cenococcum geophilum isolates.
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HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.
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HER2 testing in metastatic colorectal cancer: ready for prime time?
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HIV-1 diversity and compartmentalization in urine, semen, and blood.
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Heat induces gene amplification in cancer cells.
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Hedgehog signaling patterns mesoderm in the sea urchin.
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High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.
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High-fidelity mRNA amplification for gene profiling.
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Human papillomavirus types 16 and 18 are not involved in human prostate carcinogenesis: analysis of archival human prostate cancer specimens by differential polymerase chain reaction.
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Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.
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Identification of a fetal exon in the human fast troponin T gene.
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Identification of an amplified, highly expressed gene in a human glioma.
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Increased erbB-2 gene copies and expression in multiple stages of breast cancer.
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Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.
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Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA.
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Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.
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Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC.
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Localized adenocarcinoma of the lung: oncogene expression of erbB-2 and p53 in 150 patients.
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MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.
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MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.
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Magnification: gene amplification by an inducible system of sister chromatid exchange.
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Maintenance of DNA content and erbB-2 alterations in intraductal and invasive phases of mammary cancer.
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Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH.
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Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis.
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Molecular biology as a tool for taxonomy.
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Molecular pathogenesis of malignant gliomas.
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Molecular phylogeny of naidid worms (Annelida: Clitellata) based on cytochrome oxidase I.
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Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification.
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Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor.
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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
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NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.
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Neuroblastoma in a pediatric patient with a microduplication of 2p involving the MYCN locus.
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Oncogene amplification in pediatric brain tumors.
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Oncogenes and anti-oncogenes in human central nervous system tumors.
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Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling.
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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
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Overexpression and mutation of p53 in endometrial carcinoma.
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Overexpression and mutation of p53 in epithelial ovarian cancer.
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Overexpression of p53 and HER-2/neu proteins as prognostic markers in early stage breast cancer.
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PHGDH amplification and altered glucose metabolism in human melanoma.
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Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study.
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Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.
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Polymerase chain reaction amplification and in situ hybridization for the detection of human B-lymphotropic virus.
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Polymorphic markers of the glycogen debranching enzyme gene allowing linkage analysis in families with glycogen storage disease type III.
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Predictors of differential response to induction therapy in high-risk neuroblastoma: A report from the Children's Oncology Group (COG).
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Probe directed at a segment of Rickettsia rickettsii rRNA amplified with polymerase chain reaction.
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Probing the interaction of the multidrug-resistance phenotype with the polypeptide ionophore gramicidin D via functional channel formation.
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Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial.
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Quantitation of residual white cells in filtered blood components by polymerase chain reaction amplification of HLA DQ-A DNA.
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RUNX1 Amplification Increases the Risk for Thrombosis in Children With B-cell Acute Lymphoblastic Leukemia.
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Rapid mapping of deletion and duplication mutations by the polymerase chain reaction.
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Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure.
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Relationship between gene amplification and chromosomal deviations in malignant human gliomas.
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Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification.
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Ring chromosomes and rDNA magnification in Drosophila.
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Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics.
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Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.
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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.
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Sample type bias in the analysis of cancer genomes.
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Short-term kinetics of tumor antigen expression in response to vaccination.
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Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR.
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Stage III neuroblastoma over 1 year of age at diagnosis: improved survival with intensive multimodality therapy including multiple alkylating agents.
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Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes.
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Structural and functional studies of cyclic GMP phosphodiesterase.
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Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
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TERC is not a major gene in human neural tube defects.
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Targeting MET Amplification with Crizotinib in a Case of Sinonasal Undifferentiated Carcinoma.
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Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer.
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The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.
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The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system.
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The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
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The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks.
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Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.
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Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe.
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Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation.
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Zidovudine administered to women infected with human immunodeficiency virus type 1 and to their neonates reduces pediatric infection independent of an effect on levels of maternal virus.
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lambda RNA internal standards quantify sensitivity and amplification efficiency of mammalian gene expression profiling.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Shinohara, Mari L.,
Associate Professor of Immunology,
Immunology
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Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology