Gene Expression Regulation

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  Subject Areas on Research

  • 5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. 
  • 5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. 
  • 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. 
  • A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis. 
  • A CRISPR/Cas9-based system for reprogramming cell lineage specification. 
  • A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. 
  • A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. 
  • A Potential Contributory Role for Ciliary Dysfunction in the 16p11.2 600 kb BP4-BP5 Pathology. 
  • A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. 
  • A bistable Rb-E2F switch underlies the restriction point. 
  • A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. 
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. 
  • A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 
  • A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues. 
  • A compensatory base change in U1 snRNA suppresses a 5' splice site mutation. 
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. 
  • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. 
  • A conserved sorting-associated protein is mutant in chorea-acanthocytosis. 
  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. 
  • A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. 
  • A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression. 
  • A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. 
  • A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice. 
  • A futile metabolic cycle activated in adipocytes by antidiabetic agents. 
  • A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. 
  • A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function. 
  • A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. 
  • A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. 
  • A large network of interconnected signaling pathways in human ovarian follicles is supported by the gene expression activity of the granulosa cells. 
  • A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. 
  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
  • A meta-analysis of gene expression signatures of blood pressure and hypertension. 
  • A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium. 
  • A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. 
  • A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. 
  • A naturally occurring gamma globin gene mutation enhances SP1 binding activity. 
  • A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation. 
  • A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS. 
  • A novel model for IFN-γ-mediated autoinflammatory syndromes. 
  • A novel polypeptide secreted by activated human T lymphocytes. 
  • A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. 
  • A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • A positive addition to a negative tail's tale. 
  • A potential role for Elf-1 in CD4 promoter function. 
  • A poxvirus-derived vector that directs high levels of expression of cloned genes in mammalian cells. 
  • A rapid and simple procedure for the preparation of homogeneously labeled DNA probes. 
  • A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. 
  • A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • A role for the putative tumor suppressor Bin1 in muscle cell differentiation. 
  • A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia. 
  • A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements. 
  • A threshold for central T cell tolerance to an inducible serum protein. 
  • A transcription factor affinity-based code for mammalian transcription initiation. 
  • A transforming growth factor beta type I receptor that signals to activate gene expression. 
  • A unique role of the DNA fragmentation factor in maintaining genomic stability. 
  • A viral microRNA functions as an orthologue of cellular miR-155. 
  • A whole-genome analysis of premature termination codons. 
  • A yeast TATA-binding protein mutant that selectively enhances gene expression from weak RNA polymerase II promoters. 
  • A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1β and Inhibition of PGE2. 
  • ADAM10 is essential for proteolytic activation of Notch during thymocyte development. 
  • ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression. 
  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. 
  • ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. 
  • Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. 
  • Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. 
  • Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. 
  • Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. 
  • Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease. 
  • Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. 
  • Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine. 
  • Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: implications for a role of disturbances of endoplasmic reticulum calcium homeostasis. 
  • Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells. 
  • Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Activation signals regulate heat shock transcription factor 1 in human B lymphocytes. 
  • Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. 
  • Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. 
  • Acute brain death alters left ventricular myocardial gene expression. 
  • Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses. 
  • Acute oxygen-sensing mechanisms. 
  • Adaptation of skeletal muscle to increased contractile activity. Expression nuclear genes encoding mitochondrial proteins. 
  • Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism. 
  • Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease. 
  • Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus. 
  • Advances to Bayesian network inference for generating causal networks from observational biological data. 
  • Allele-specific distribution of RNA polymerase II on female X chromosomes. 
  • Allele-specific gene expression in a wild nonhuman primate population. 
  • Allelic exclusion of the T cell receptor alpha-chain: developmental regulation of a post-translational event. 
  • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. 
  • Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel. 
  • Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. 
  • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. 
  • Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblasts. 
  • Alterations in levels of mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of hens treated with diisopropyl phosphorofluoridate (DFP). 
  • Alterations in microRNA expression in stress-induced cellular senescence. 
  • Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. 
  • Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia. 
  • Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts. 
  • Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. 
  • Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. 
  • Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. 
  • Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. 
  • Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium. 
  • Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev. 
  • An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. 
  • An analysis of alternatively spliced CD45 mRNA transcripts during T cell maturation in humans. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity. 
  • An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau. 
  • Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation. 
  • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. 
  • Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. 
  • Ancient and recent positive selection transformed opioid cis-regulation in humans. 
  • Angiopoietin-1 enhances skeletal muscle regeneration in mice. 
  • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease. 
  • Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. 
  • Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay. 
  • Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. 
  • Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury. 
  • ApolipoproteinE mimetic peptides improve outcome after focal ischemia. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. 
  • Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. 
  • Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. 
  • Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Associative learning and stimulus novelty influence the song-induced expression of an immediate early gene in the canary forebrain. 
  • Atherosclerosis and cancer: common molecular pathways of disease development and progression. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. 
  • Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. 
  • B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells. 
  • Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. 
  • Bayesian joint analysis of heterogeneous genomics data. 
  • Behaviourally driven gene expression reveals song nuclei in hummingbird brain. 
  • Benchmarking of dynamic Bayesian networks inferred from stochastic time-series data. 
  • Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation. 
  • Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. 
  • Beta-arrestin goes nuclear. 
  • Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. 
  • Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. 
  • Biochemistry. A glucose-to-gene link. 
  • Biological clocks and the coordination theory of RNA operons and regulons. 
  • Biphasic induction of immediate early gene expression accompanies activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle. 
  • Bleomycin induces the hsp 70 heat shock promoter in cultured cells. 
  • Blurring the edges in vertebrate sex determination. 
  • Body size determination in insects: a review and synthesis of size- and brain-dependent and independent mechanisms. 
  • Bone morphogenetic proteins are expressed by both bone-forming and non-bone-forming lesions. 
  • Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. 
  • Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress. 
  • Brain gene regulation by territorial singing behavior in freely ranging songbirds. 
  • Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling. 
  • CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. 
  • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. 
  • CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. 
  • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. 
  • CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. 
  • CD3 delta and epsilon gene expression in CD3-CD16+ natural killer cell clones derived from thymic precursors. 
  • CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. 
  • CD40 mediated activation of gingival and periodontal ligament fibroblasts. 
  • CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis. 
  • COMT gene locus: new functional variants. 
  • COPD: balancing oxidants and antioxidants. 
  • CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. 
  • CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues. 
  • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 
  • Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. 
  • Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. 
  • Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. 
  • Calcineurin signaling and muscle remodeling. 
  • Calcineurin. Structure, function, and inhibition. 
  • Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. 
  • Calcium regulation of neuronal gene expression. 
  • Calcium, calmodulin and cell proliferation. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. 
  • Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. 
  • Calmodulin as a regulator of cell growth and gene expression. 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. 
  • Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. 
  • Cell cycle regulation of human pancreatic cancer by tamoxifen. 
  • Cell cycle-dependent regulation of smooth muscle cell activation. 
  • Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter. 
  • Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. 
  • Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. 
  • Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition. 
  • Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts. 
  • Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. 
  • Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging. 
  • Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. 
  • Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. 
  • Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. 
  • Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings. 
  • Characterization of human prorenin expressed in mammalian cells from cloned cDNA. 
  • Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb. 
  • Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium. 
  • Chemoattractant-induced activation of c-fos gene expression in human monocytes. 
  • Cholinergic receptor subtypes in the olfactory bulbectomy model of depression. 
  • Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. 
  • Chromatin signatures of the Drosophila replication program. 
  • Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression. 
  • Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion. 
  • Circadian oscillation of gene expression in murine calvarial bone. 
  • Cloning of DNA corresponding to rare transcripts of rat brain: evidence of transcriptional and post-transcriptional control and of the existence of nonpolyadenylated transcripts. 
  • Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. 
  • Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. 
  • Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. 
  • Cocaine self-administration in dopamine-transporter knockout mice. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Collagen subtypes III and IV expression in human vein graft atherosclerosis. 
  • Combination antiretroviral therapy results in a rapid increase in T cell receptor variable region beta repertoire diversity within CD45RA CD8 T cells in human immunodeficiency virus-infected children. 
  • Combinatorial and synergistic properties of CaMV 35S enhancer subdomains. 
  • Combined immunodeficiency due to the selective absence of CD4 inducer T lymphocytes. 
  • Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression. 
  • Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. 
  • Comparative genomics of mammalian hibernators using gene networks. 
  • Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. 
  • Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. 
  • Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. 
  • Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells. 
  • Complex relationships of nicotinic receptor actions and cognitive functions. 
  • Complex structure and regulation of the ABP/SHBG gene. 
  • Complex systems analysis: a tool for shock research. 
  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Conditions associated with ER dysfunction activate homer 1a expression. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Conservation of Endo16 expression in sea urchins despite evolutionary divergence in both cis and trans-acting components of transcriptional regulation. 
  • Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms. 
  • Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression. 
  • Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features. 
  • Consumption of a high-fat diet induces central insulin resistance independent of adiposity. 
  • Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. 
  • Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. 
  • Control of electrolyte balance through ubiquitination. 
  • Control of fibroblast senescence and activation of programmed cell death. 
  • Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions. 
  • Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. 
  • Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. 
  • Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. 
  • Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners. 
  • Convergent differential regulation of parvalbumin in the brains of vocal learners. 
  • Convergent transcriptional specializations in the brains of humans and song-learning birds. 
  • Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo. 
  • Coordinate reduction of rat pancreatic islet glucokinase and proinsulin mRNA by exercise training. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Coordinate regulation of mRNAs from multiple calmodulin genes during myoblast differentiation in vitro. 
  • Coordinated activation of corneal wound response genes in vivo as observed by in situ hybridization. 
  • Coordinated posttranscriptional mRNA population dynamics during T-cell activation. 
  • Copper: an essential metal in biology. 
  • Core and region-enriched networks of behaviorally regulated genes and the singing genome. 
  • Correction of aberrant splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by antisense oligonucleotides. 
  • Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. 
  • Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. 
  • Cowpox virus induces interleukin-10 both in vitro and in vivo. 
  • Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. 
  • Critical role of TNF-α in cerebral aneurysm formation and progression to rupture. 
  • Cross-platform prediction of gene expression signatures. 
  • Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. 
  • Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. 
  • Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. 
  • DIO2 modifies inflammatory responses in chondrocytes. 
  • DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. 
  • DNase I sensitivity QTLs are a major determinant of human expression variation. 
  • Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. 
  • Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. 
  • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 
  • Defective pericyte recruitment of villous stromal vessels as the possible etiologic cause of hydropic change in complete hydatidiform mole. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation. 
  • Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Dengue virus-induced autophagy regulates lipid metabolism. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data. 
  • Detailed analysis of gene expression during development of T cell lineages in the thymus. 
  • Detection of inducible clindamycin resistance in staphylococci by broth microdilution using erythromycin-clindamycin combination wells. 
  • Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated. 
  • Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. 
  • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. 
  • Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. 
  • Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. 
  • Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation. 
  • Developmental regulation of mouse SPARC (osteonectin) gene expression. 
  • Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. 
  • Dietary CdSe/ZnS quantum dot exposure in estuarine fish: bioavailability, oxidative stress responses, reproduction, and maternal transfer. 
  • Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine. 
  • Dietary regulation of rat intestinal cholecystokinin gene expression. 
  • Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. 
  • Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression. 
  • Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis? 
  • Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. 
  • Differential effects of static and dynamic compression on meniscal cell gene expression. 
  • Differential expression of S1 and elongation factor-1 alpha during rat development. 
  • Differential expression of galectin-1 and its interactions with cells and laminins in the intervertebral disc. 
  • Differential expression of gamma-aminobutyric acidA receptor subunits. 
  • Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation. 
  • Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential gene expression and genomic patient stratification following left ventricular assist device support. 
  • Differential gene expression in dentate granule cells in mesial temporal lobe epilepsy with and without hippocampal sclerosis. 
  • Differential gene expression in mouse sclera during ocular development. 
  • Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia. 
  • Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. 
  • Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. 
  • Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation. 
  • Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. 
  • Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. 
  • Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction. 
  • Dissection of genetic pathways in C. elegans. 
  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. 
  • Distinct gene expression phenotypes of cells lacking Rb and Rb family members. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Distinctions in the specificity of E2F function revealed by gene expression signatures. 
  • Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. 
  • Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. 
  • Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation. 
  • Donor-specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Dopamine receptors: from structure to function. 
  • Dopamine: from pharmacology to molecular biology and back. 
  • Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Downregulation of RNA polymerase III transcription of the hY3 gene in vitro. 
  • Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • Early differential induction of C-jun in the central nervous system of hens treated with diisopropylphosphorofluoridate (DFP). 
  • Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. 
  • Editing the epigenome: technologies for programmable transcription and epigenetic modulation. 
  • Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. 
  • Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA. 
  • Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion. 
  • Effect of herpes simplex virus types 1 and 2 on surface expression of class I major histocompatibility complex antigens on infected cells. 
  • Effect of influenza virus vaccine on the expression of human immunodeficiency virus co-receptor CCR5. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. 
  • Effects of inhibition of mitochondrial protein synthesis in skeletal muscle. 
  • Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. 
  • Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. 
  • Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. 
  • Elevated serum L-selectin levels and abnormal regulation of L-selectin expression on leukocytes in atopic dermatitis: soluble L-selectin levels indicate disease severity. 
  • Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. 
  • Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus). 
  • Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Emerging clinical applications of RNA. 
  • Endogenous avian retroviruses contain deficient promoter and leader sequences. 
  • Endogenous lung stem cells and contribution to disease. 
  • Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. 
  • Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells. 
  • Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. 
  • Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia. 
  • Engineering musculoskeletal tissues with human embryonic germ cell derivatives. 
  • Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression. 
  • Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. 
  • Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. 
  • Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. 
  • Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. 
  • Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. 
  • Environmental factors in relation to breast cancer characterized by p53 protein expression. 
  • Eosinophils alter colonic epithelial barrier function: role for major basic protein. 
  • Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions. 
  • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. 
  • Epithelial-mesenchymal interactions in the alteration of gene expression and morphology following lung injury. 
  • Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. 
  • Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. 
  • Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. 
  • Estrogen receptor interconversion, factors regulating conformation and functions. 
  • Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity. 
  • Eukaryotic mRNPs may represent posttranscriptional operons. 
  • Evaluating functional network inference using simulations of complex biological systems. 
  • Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected]. 
  • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. 
  • Evolution of a malaria resistance gene in wild primates. 
  • Evolution. CNCing is believing. 
  • Evolution. Chaperones as buffering agents? 
  • Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. 
  • Excitatory amino acid receptor activation produces a selective and long-lasting modulation of gene expression in hippocampal neurons. 
  • Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome. 
  • Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus. 
  • Exploiting expression patterns across multiple tissues to map expression quantitative trait loci. 
  • Exposure to azide markedly decreases the abundance of mRNAs encoding cholesterol synthetic enzymes and inhibits cholesterol synthesis. 
  • Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. 
  • Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway. 
  • Expression and modulation of RPE cell membrane complement regulatory proteins. 
  • Expression and regulation of alpha 1-adrenergic receptors in human tissues. 
  • Expression in aneuploid Drosophila S2 cells. 
  • Expression of HSP70 in peripheral lymphocytes of the patients with allergic rhinitis. 
  • Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. 
  • Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells. 
  • Expression of TGF-beta-related genes during mouse embryo whisker morphogenesis. 
  • Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization. 
  • Expression of a cloned human interleukin-2 cDNA is enhanced by the substitution of a heterologous mRNA leader region. 
  • Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis. 
  • Expression of differentiation antigens by hybrids of human lymphoblastoid cells. 
  • Expression of growth factor and growth factor receptor RNA in rat pleural mesothelial cells in culture. 
  • Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. 
  • Expression of major histocompatibility complex class I antigens in normal and transformed rat thyroid epithelial cell lines. 
  • Expression of photosynthesis genes in relation to nitrogen fixation in the diazotrophic filamentous nonheterocystous cyanobacterium Trichodesmium sp. IMS 101. 
  • Expression of the homeobox gene, Hox 2.1, during mouse embryogenesis. 
  • Expression of the homeobox genes Hox 2.1 and 2.6 during mouse development. 
  • Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta. 
  • Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells. 
  • Expression of transfected DNA in avian cells can be enhanced in trans by retroviral infection. 
  • Expression quantitative trait locus analysis identifies novel genes for statin myopathy. 
  • Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells. 
  • Extensive changes in the expression of the opioid genes between humans and chimpanzees. 
  • Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. 
  • Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source. 
  • FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. 
  • FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. 
  • Factors regulating islet regeneration in the post-insulinoma NEDH rat. 
  • Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. 
  • Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. 
  • Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. 
  • Fatty Acid binding protein 4 is associated with carotid atherosclerosis and outcome in patients with acute ischemic stroke. 
  • Fenoldopam improves corticomedullary oxygen delivery and attenuates angiogenesis gene expression in acute ischemic renal injury. 
  • Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. 
  • Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. 
  • Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. 
  • Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. 
  • Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. 
  • Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder. 
  • Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences. 
  • For whom the bird sings: context-dependent gene expression. 
  • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy. 
  • Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. 
  • Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region. 
  • Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function. 
  • Functional expression of Mammalian odorant receptors. 
  • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. 
  • Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. 
  • Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein. 
  • Further characterization of erythrocyte p80 and the membrane protein defect of In(Lu) Lu(a-b-) erythrocytes. 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • GATA4 and the two sides of gene expression reprogramming. 
  • GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. 
  • GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS. 
  • Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary. 
  • Galectin-3 expression in cardiac remodeling after myocardial infarction. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease. 
  • Gastrin-releasing peptide gene expression in developing, hyperplastic, and neoplastic human thyroid C-cells. 
  • Gene Expression Profiling in the Hibernating Primate, Cheirogaleus Medius. 
  • Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma. 
  • Gene duplication in Mimulus underlies parallel floral evolution via independent trans-regulatory changes. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression. 
  • Gene expression clustering using self-organizing maps: analysis of the macrophage response to particulate biomaterials. 
  • Gene expression elucidates functional impact of polygenic risk for schizophrenia. 
  • Gene expression in the rectus abdominus muscle of patients with and without pelvic organ prolapse. 
  • Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease. 
  • Gene expression phenotypes of atherosclerosis. 
  • Gene expression phenotypes of oncogenic signaling pathways. 
  • Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma. 
  • Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure. 
  • Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen. 
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 
  • Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins. 
  • Gene segment selection in V(D)J recombination: accessibility and beyond. 
  • Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers. 
  • Gene targeting of a CFTR allele in HT29 human epithelial cells. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications. 
  • Gene-expression patterns predict phenotypes of immune-mediated thrombosis. 
  • Generation of silent synapses by acute in vivo expression of CaMKIV and CREB. 
  • Genes associated with pro-apoptotic and protective mechanisms are affected differently on exposure of neuronal cell cultures to arsenite. No indication for endoplasmic reticulum stress despite activation of grp78 and gadd153 expression. 
  • Genes on the wing. 
  • Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. 
  • Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. 
  • Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. 
  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. 
  • Genetic counseling for fragile x syndrome: updated recommendations of the national society of genetic counselors. 
  • Genetic mechanisms that determine oxidative capacity of striated muscles. Control of gene transcription. 
  • Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues. 
  • Genetic regulation of pristane-induced oil granuloma responses. 
  • Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14. 
  • Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. 
  • Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. 
  • Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. 
  • Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. 
  • Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel disease. 
  • Genomic approaches for understanding the genetics of complex disease. 
  • Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation. 
  • Genomics of varicose veins and chronic venous insufficiency. 
  • Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. 
  • Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis. 
  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage. 
  • Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis. 
  • Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. 
  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. 
  • Glutamate receptor activation regulates mRNA at both transcriptional and posttranscriptional levels. 
  • Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. 
  • Glutamine and heat shock protein expression. 
  • Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. 
  • Glutamine's protection against cellular injury is dependent on heat shock factor-1. 
  • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Glutamine: the first clinically relevant pharmacological regulator of heat shock protein expression? 
  • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. 
  • Glycosylation of KEAP1 links nutrient sensing to redox stress signaling. 
  • Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart. 
  • Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. 
  • Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells. 
  • Growth and patterning are evolutionarily dissociated in the vestigial wing discs of workers of the red imported fire ant, Solenopsis invicta. 
  • Growth factor modulation of p53-mediated growth arrest versus apoptosis. 
  • Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Gustatory effects of capsaicin that are independent of TRPV1 receptors. 
  • H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury. 
  • HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. 
  • HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. 
  • HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. 
  • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. 
  • HNF-3 beta as a regulator of floor plate development. 
  • Heart regeneration in zebrafish. 
  • Heat shock and genetic activation of HSF-1 enhance immunity to bacteria. 
  • Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. 
  • Hedgehog controls hepatic stellate cell fate by regulating metabolism. 
  • Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. 
  • Hedgehog signaling patterns mesoderm in the sea urchin. 
  • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. 
  • Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. 
  • Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. 
  • Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. 
  • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. 
  • Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector. 
  • Heritable individual-specific and allele-specific chromatin signatures in humans. 
  • Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution. 
  • Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells. 
  • Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. 
  • Highly coordinated gene regulation in mouse skeletal muscle regeneration. 
  • Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations. 
  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. 
  • Histone modifications at human enhancers reflect global cell-type-specific gene expression. 
  • Homer: a protein that selectively binds metabotropic glutamate receptors. 
  • Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures. 
  • Hormonal regulation of a chicken oviduct messenger ribonucleic acid that shares a common domain with gizzard myosin light chain kinase. 
  • Host gene expression classifiers diagnose acute respiratory illness etiology. 
  • Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity. 
  • Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. 
  • Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine. 
  • Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. 
  • Human erythrocyte antigens. Regulation of expression of a novel erythrocyte surface antigen by the inhibitor Lutheran In(Lu) gene. 
  • Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. 
  • Human lung innate immune response to Bacillus anthracis spore infection. 
  • Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. 
  • Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. 
  • Hyperadhesive mutant of type 1-fimbriated Escherichia coli associated with formation of FimH organelles (fimbriosomes). 
  • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. 
  • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. 
  • Hypoxia in the thymus: role of oxygen tension in thymocyte survival. 
  • Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. 
  • Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. 
  • Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury. 
  • IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver. 
  • IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance. 
  • IL-10 stimulatory effects on human NK cells explored by gene profile analysis. 
  • IL-1beta decreases the elastic modulus of human tenocytes. 
  • IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. 
  • Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics. 
  • Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes. 
  • Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. 
  • Identification of a third autonomous activation domain within the human estrogen receptor. 
  • Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique. 
  • Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. 
  • Identification of negative and positive regulatory elements in the human renin gene. 
  • Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. 
  • Identification of potential regulatory regions in the renin gene. 
  • Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 
  • Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. 
  • Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. 
  • Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. 
  • Idiotypic determinants used in the analysis of antibody diversification and as regulatory targets. 
  • Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. 
  • Imaging genetics of brain longevity and mental wellness: the next frontier? 
  • Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. 
  • Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. 
  • Impact on genetic networks in human macrophages by a CCR5 strain of human immunodeficiency virus type 1. 
  • Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. 
  • Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. 
  • Implications of hypoxia on mucosal barrier function. 
  • Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector. 
  • In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia. 
  • In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models. 
  • In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. 
  • In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. 
  • In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. 
  • Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. 
  • Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma. 
  • Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Increased expression of p130 in Alzheimer disease. 
  • Increased expression of the glucose-regulated gene encoding the Mr 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells. 
  • Increases in ribosomal RNA within the denervated neuropil of the dentate gyrus during reinnervation: evaluation by in situ hybridization using DNA probes complementary to ribosomal RNA. 
  • Increasing amyloid peptide precursor production and its impact on Alzheimer's disease. 
  • Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. 
  • Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. 
  • Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation. 
  • Inducible regulation of Runx2-stimulated osteogenesis. 
  • Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. 
  • Induction of IL-6 expression by mechanical stress in the trabecular meshwork. 
  • Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. 
  • Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity. 
  • Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep. 
  • Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes. 
  • Induction of lef1 during zebrafish fin regeneration. 
  • Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. 
  • Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK. 
  • Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis. 
  • Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. 
  • Inefficient dystrophin expression after cord blood transplantation in Duchenne muscular dystrophy. 
  • Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response. 
  • Infection-Induced Vascular Permeability Aids Mycobacterial Growth. 
  • Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. 
  • Inflammation influences vascular remodeling through AT2 receptor expression and signaling. 
  • Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. 
  • Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures. 
  • Inflammatory biomarkers in osteoarthritis. 
  • Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. 
  • Inflammatory hypoxia: role of hypoxia-inducible factor. 
  • Influence of androgen on translatable renin mRNA in the mouse submandibular gland. 
  • Influence of network topology and data collection on network inference. 
  • Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis. 
  • Initial sequencing and comparative analysis of the mouse genome. 
  • Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. 
  • Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Inositol phosphate synthesis and the nuclear processes they affect. 
  • Insights from a chimpanzee adipose stromal cell population: opportunities for adult stem cells to expand primate functional genomics. 
  • Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. 
  • Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. 
  • Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression. 
  • Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. 
  • Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. 
  • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. 
  • Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. 
  • Interaction between transcriptional activator protein LAC9 and negative regulatory protein GAL80. 
  • Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells. 
  • Interactions between sustained contractile activity and beta-adrenergic receptors in regulation of gene expression in skeletal muscles. 
  • Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. 
  • Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation. 
  • Interferon regulatory factors are transcriptional regulators of adipogenesis. 
  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. 
  • Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. 
  • Interleukin-1-induced nitric oxide production modulates glutathione synthesis in cultured rat hepatocytes. 
  • Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma. 
  • Interleukin-15 increases hepatic regenerative activity. 
  • Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. 
  • Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. 
  • Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. 
  • Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. 
  • Intracellular innate immune cascades and interferon defenses that control hepatitis C virus. 
  • Introduction: Regulatory B Cell Special Issue-making all the pieces fit. 
  • Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. 
  • Ion channels under the sun. 
  • Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation. 
  • Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. 
  • Iron increases expression of iron-export protein MTP1 in lung cells. 
  • Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1. 
  • Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin. 
  • Isolation of genes negatively or positively co-expressed with human recombination activating gene 1 (RAG1) by differential display PCR (DD RT-PCR). 
  • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. 
  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 
  • K+ regulates DNA binding of transcription factors to control gene expression related to neuronal apoptosis. 
  • Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. 
  • L-Threonine induces heat shock protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LMP2 expression and proteasome activity in NOD mice. 
  • Lactobacillus rhamnosus GG improves outcome in experimental pseudomonas aeruginosa pneumonia: potential role of regulatory T cells. 
  • Learning protein-DNA interaction landscapes by integrating experimental data through computational models. 
  • Leptin regulates proinflammatory immune responses. 
  • Leptin therapy in insulin-deficient type I diabetes. 
  • Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. 
  • Life without myoglobin. 
  • Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. 
  • Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. 
  • Linkage disequilibrium and signatures of positive selection around LINE-1 retrotransposons in the human genome. 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Liver X receptors alpha and beta regulate renin expression in vivo. 
  • Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. 
  • Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals. 
  • Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 
  • Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer. 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients. 
  • Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice. 
  • Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function. 
  • Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. 
  • Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss. 
  • Low level exposure to the flame retardant BDE-209 reduces thyroid hormone levels and disrupts thyroid signaling in fathead minnows. 
  • Lutheran antigens, CD44-related antigens, and Lutheran regulatory genes. 
  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. 
  • Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. 
  • M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice. 
  • MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIb. 
  • MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans. 
  • Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators. 
  • Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes. 
  • Mapping of antibody specificities to VH gene families. 
  • Mapping phenotypic landscapes using DNA micro-arrays. 
  • Mapping regulatory elements by DNaseI hypersensitivity chip (DNase-Chip). 
  • Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. 
  • MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. 
  • MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5. 
  • Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. 
  • Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. 
  • Mechanism of shortened bones in mucopolysaccharidosis VII. 
  • Mechanisms coordinating ELAV/Hu mRNA regulons. 
  • Mechanisms of cellular protrusions branch out. 
  • Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. 
  • Mechanisms of specificity in neuronal activity-regulated gene transcription. 
  • Mechanisms of the proteinuria induced by Rho GTPases. 
  • Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. 
  • Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization. 
  • Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors. 
  • Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells. 
  • Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. 
  • Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. 
  • Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid. 
  • Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. 
  • Metabolism and vascular fatty acid transport. 
  • Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. 
  • Metaphors and the role of genes in development. 
  • MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex. 
  • Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. 
  • MicroRNA expression differentiates squamous epithelium from Barrett's esophagus and esophageal cancer. 
  • MicroRNA regulation and interspecific variation of gene expression. 
  • MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN. 
  • MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. 
  • MicroRNAs and Cardiac Regeneration. 
  • MicroRNAs as mediators of viral evasion of the immune system. 
  • MicroRNAs preferentially target the genes with high transcriptional regulation complexity. 
  • MicroRNAs relate to early worsening of renal function in patients with acute heart failure. 
  • Microarray analysis of gene expression in adult retinal ganglion cells. 
  • Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages. 
  • Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. 
  • Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. 
  • Microtubule binding to Smads may regulate TGF beta activity. 
  • Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. 
  • Mitochondrial gene expression in mammalian striated muscle. Evidence that variation in gene dosage is the major regulatory event. 
  • Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. 
  • Modeling the evolution of regulatory elements by simultaneous detection and alignment with phylogenetic pair HMMs. 
  • Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. 
  • Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular and biochemical characterization of folate transport proteins in retinal Müller cells. 
  • Molecular and physiological alterations in murine ventricular dysfunction. 
  • Molecular biology in cardiology: recent developments and opportunities for clinical applications. 
  • Molecular biology. Versatility of self-cleaving ribozymes. 
  • Molecular cloning and characterization of Aspergillus nidulans cyclophilin B. 
  • Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. 
  • Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. 
  • Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney. 
  • Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. 
  • Molecular mapping of brain areas involved in parrot vocal communication. 
  • Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells. 
  • Molecular sequelae of topographically guided peripheral nerve repair. 
  • Molecular studies of human renin synthesis and gene expression. 
  • Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice. 
  • Motor-driven gene expression. 
  • Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia. 
  • MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. 
  • Mucosal candidiasis elicits NF-κB activation, proinflammatory gene expression and localized neutrophilia in zebrafish. 
  • Multilayered electrospun scaffolds for tendon tissue engineering. 
  • Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. 
  • Multiple potential regulatory elements in the 5' flanking region of the human alpha 1a-adrenergic receptor. 
  • Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. 
  • Murine V kappa gene expression does not follow the VH paradigm. 
  • Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models. 
  • Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction. 
  • Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. 
  • Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes. 
  • Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes. 
  • Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein. 
  • Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat. 
  • Mutations in SCO2 are associated with autosomal-dominant high-grade myopia. 
  • Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. 
  • Mutual information in random Boolean models of regulatory networks. 
  • Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma. 
  • Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries. 
  • Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. 
  • NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. 
  • NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. 
  • NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells. 
  • NF-kappaB p65 involves in reperfusion injury and iNOS gene regulation in skeletal muscle. 
  • NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine. 
  • Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes. 
  • Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. 
  • Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation. 
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. 
  • Netrin-1 and peripheral nerve regeneration in the adult rat. 
  • Network growth models and genetic regulatory networks. 
  • Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system. 
  • Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation. 
  • Neuronal activity-regulated gene transcription in synapse development and cognitive function. 
  • Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology. 
  • Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain. 
  • Neurotrophins: transcription and translation. 
  • Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. 
  • Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. 
  • Neutrophil elastase induces mucus cell metaplasia in mouse lung. 
  • Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1. 
  • Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 
  • New insights into E-protein function in lymphocyte development. 
  • New insights into gestational glucose metabolism: lessons learned from 21st century approaches. 
  • New regulators of vertebrate appendage regeneration. 
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. 
  • Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. 
  • Nitrosation and oxidation in the regulation of gene expression. 
  • Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. 
  • Normal and shear stresses influence the spatial distribution of intracellular adhesion molecule-1 expression in human umbilical vein endothelial cells exposed to sudden expansion flow. 
  • Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. 
  • Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. 
  • Nrf2, a multi-organ protector? 
  • Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells. 
  • Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. 
  • Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. 
  • Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase. 
  • Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences. 
  • Nutritional regulation of insulin-like growth factor-binding protein gene expression in the ovine fetus and pregnant ewe. 
  • Omental gene expression of adiponectin correlates with degree of insulin sensitivity before and after gastric bypass surgery. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. 
  • Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. 
  • Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice. 
  • Origin of fetal troponin T: developmentally regulated splicing of a new exon in the fast troponin T gene. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR. 
  • Osteoclast differentiation and function in aquaglyceroporin AQP9-null mice. 
  • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. 
  • Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. 
  • Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. 
  • Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. 
  • Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. 
  • P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. 
  • P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. 
  • P53, cell cycle control and apoptosis: implications for cancer. 
  • PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI. 
  • PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. 
  • PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration. 
  • PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. 
  • Pancreatic digestive enzyme gene expression: effects of CCK and soybean trypsin inhibitor. 
  • Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. 
  • Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. 
  • Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. 
  • Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification. 
  • Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. 
  • Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. 
  • Performance of polymerase chain reaction techniques detecting perforin in the diagnosis of acute renal rejection: a meta-analysis. 
  • Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. 
  • Peripheral blood signatures of lead exposure. 
  • Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. 
  • Peroxidative stress selectively down-regulates the neuronal stress response activated under conditions of endoplasmic reticulum dysfunction. 
  • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. 
  • Pervasive Effects of Aging on Gene Expression in Wild Wolves. 
  • Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. 
  • Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. 
  • Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. 
  • Phosphorylation of the rev gene product of human immunodeficiency virus type 1. 
  • Photoreceptor synapses degenerate early in experimental choroidal neovascularization. 
  • Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness. 
  • Physiological impact of increased expression of the AT1 angiotensin receptor. 
  • Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. 
  • Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. 
  • Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. 
  • Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. 
  • Polarized monocyte response to cytokine stimulation. 
  • Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals. 
  • Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis. 
  • Positive and negative elements regulate human interleukin 3 expression. 
  • Positive selection on MMP3 regulation has shaped heart disease risk. 
  • Positive selection on a human-specific transcription factor binding site regulating IL4 expression. 
  • Post-transcriptional operons and regulons co-ordinating gene expression. 
  • Post-translational modifications regulate the ticking of the circadian clock. 
  • Post-translational regulation enables robust p53 regulation. 
  • Postmortem delay has minimal effect on brain RNA integrity. 
  • Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex. 
  • Posttranscriptional generation of macromolecular complexes. 
  • Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. 
  • Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. 
  • Precise regulation of porcupine activity is required for physiological Wnt signaling. 
  • Predicting cell-type-specific gene expression from regions of open chromatin. 
  • Predicting longevity in C. elegans: fertility, mobility and gene expression. 
  • Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. 
  • Pretranslational regulation of myoglobin gene expression. 
  • Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. 
  • Principles of microRNA regulation of a human cellular signaling network. 
  • Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2. 
  • Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2. 
  • Prolonged dark adaptation changes connexin expression in the mouse retina. 
  • Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. 
  • Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. 
  • Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux. 
  • Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition. 
  • Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions. 
  • Quantitative expression profile of androgen-regulated genes in prostate cancer cells and identification of prostate-specific genes. 
  • Quantitative genetic variation in CD19 expression correlates with autoimmunity. 
  • RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. 
  • RNA regulons: coordination of post-transcriptional events. 
  • RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells. 
  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil. 
  • Rapid dendritic transport of TGN38, a putative cargo receptor. 
  • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Rat amylin: cloning and tissue-specific expression in pancreatic islets. 
  • Rat thecal/interstitial cells express transforming growth factor-beta type 1 and 2, but only type 2 is regulated by gonadotropin in vitro. 
  • Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor. 
  • Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector. 
  • Reconstructing regulatory network transitions. 
  • Recovery and expression of messenger RNA from postmortem human brain tissue. 
  • Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. 
  • Redox regulation of mitochondrial biogenesis. 
  • Redox signaling: nitrosylation and related target interactions of nitric oxide. 
  • Redox-based regulation of signal transduction: principles, pitfalls, and promises. 
  • Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. 
  • Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor. 
  • Regulated heat shock protein 27 expression in human retinal pigment epithelium. 
  • Regulating the regulator: NF-kappaB signaling in heart. 
  • Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor. 
  • Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage. 
  • Regulation of E2A gene expression in B-lymphocyte development. 
  • Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: potential role of immediate-early genes. 
  • Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. 
  • Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. 
  • Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. 
  • Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. 
  • Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene. 
  • Regulation of alpha-synuclein expression: implications for Parkinson's disease. 
  • Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. 
  • Regulation of beta-cell glucose transporter gene expression. 
  • Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells. 
  • Regulation of cholecystokinin gene expression in rat intestine. 
  • Regulation of cholecystokinin synthesis and secretion in rat intestine. 
  • Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation. 
  • Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. 
  • Regulation of gene expression in the lung. 
  • Regulation of gene expression is preserved in aging Drosophila melanogaster. 
  • Regulation of insulin secretion from novel engineered insulinoma cell lines. 
  • Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells. 
  • Regulation of lipoprotein lipase activity and mRNA in the mammary gland of the lactating mouse. 
  • Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1. 
  • Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. 
  • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. 
  • Regulation of proliferation and platelet-derived growth factor expression in palmar fibromatosis (Dupuytren contracture) by mechanical strain. 
  • Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. 
  • Regulation of the Na/H exchanger regulatory factor in OK cells. 
  • Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors. 
  • Regulation of the beta 2-adrenergic receptor and its mRNA in the rat ventral prostate by testosterone. 
  • Regulation of the human interleukin-3 gene. 
  • Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb. 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Regulation of tissue renin and angiotensin gene expressions. 
  • Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c. 
  • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. 
  • Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes. 
  • Regulatory B10 cell development and function. 
  • Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. 
  • Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. 
  • Regulatory elements governing transcription in specialized myofiber subtypes. 
  • Regulatory pathways governing HIV-1 replication. 
  • Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. 
  • Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers. 
  • Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice. 
  • Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression. 
  • Remaining flexible in old alliances: functional plasticity in constrained mutualisms. 
  • Renal systems biology of patients with systemic inflammatory response syndrome. 
  • Renin gene expression, biosynthesis, and cellular pathways of secretion. 
  • Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism. 
  • Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord. 
  • Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells. 
  • Repression of interleukin-2 mRNA translation in primary human breast carcinoma tumor-infiltrating lymphocytes. 
  • Reproductive factors in relation to breast cancer characterized by p53 protein expression (United States). 
  • Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. 
  • Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300. 
  • Reverse engineering gene regulatory networks. 
  • Reversing adipocyte differentiation: implications for treatment of obesity. 
  • Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome. 
  • Riboswitches--to kill or save the messenger. 
  • Right ventricular hypertrophy with early dysfunction: A proteomics study in a neonatal model. 
  • Role of AP-1 complex in angiotensin II-mediated transforming growth factor-beta expression and growth of smooth muscle cells: using decoy approach against AP-1 binding site. 
  • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. 
  • Role of interleukin-1beta in postoperative cognitive dysfunction. 
  • Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells. 
  • Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress. 
  • Role of microRNAs in the trabecular meshwork. 
  • Role of natural product diversity in chemical biology. 
  • Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. 
  • Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection. 
  • S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. 
  • S-nitrosylation in the regulation of gene transcription. 
  • S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. 
  • S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. 
  • SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. 
  • SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane. 
  • SR proteins control a complex network of RNA-processing events. 
  • SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation. 
  • Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4. 
  • Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. 
  • Screening of the Seed Region of MIR184 in Keratoconus Patients from Saudi Arabia. 
  • Screening the human exome: a comparison of whole genome and whole transcriptome sequencing. 
  • Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells. 
  • Searching for transcriptional regulators of Ang II-induced vascular pathology. 
  • Secretion and movement of wingless protein in the epidermis of the Drosophila embryo. 
  • Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway. 
  • Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. 
  • Selection and validation of endogenous reference genes using a high throughput approach. 
  • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. 
  • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. 
  • Sensing and integration of Erk and PI3K signals by Myc. 
  • Sensitization of tumor cells to fas killing through overexpression of heat-shock transcription factor 1. 
  • Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. 
  • Sequences within the coding regions of clotting factor VIII and CFTR block transcriptional elongation. 
  • Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. 
  • Serotonin depletion exacerbates changes in striatal gene expression following quinolinic acid injection. 
  • Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. 
  • Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. 
  • Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. 
  • Shigella dysenteriae modulates BMP pathway to induce mucin gene expression in vivo and in vitro. 
  • Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes. 
  • Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells. 
  • Site-specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants. 
  • Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. 
  • Small changes in expression affect predisposition to tumorigenesis. 
  • Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation. 
  • Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. 
  • Social status alters immune regulation and response to infection in macaques. 
  • Somatostatin regulates duodenal cholecystokinin and somatostatin messenger RNA. 
  • Some nuts are tougher to crack than others. 
  • Some things I thought I knew about tissue factor that turn out to be wrong. 
  • Spatial preferences of microRNA targets in 3' untranslated regions. 
  • Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis. 
  • Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds. 
  • Spermatogonial depletion in adult Pin1-deficient mice. 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. 
  • Spinal cord trauma activates processing of xbp1 mRNA indicative of endoplasmic reticulum dysfunction. 
  • Spontaneous delta- to beta-globin switching in K562 human leukemia cells. 
  • Spreading depression activates unfolded protein response. 
  • Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. 
  • Stage-specific expression of B cell translocation gene 1 in rat testis. 
  • Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost. 
  • Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice. 
  • Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. 
  • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 
  • Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. 
  • Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation. 
  • Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. 
  • Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations. 
  • Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. 
  • Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. 
  • Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia. 
  • Structural basis for the differential regulation of DNA by the methionine repressor MetJ. 
  • Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing. 
  • Structure and regulation of the murine Clara cell secretory protein gene. 
  • Studies of the lethargic (lh/lh) mouse model of absence seizures: regulatory mechanisms and identification of the lh gene. 
  • Subcellular localization of the human immunodeficiency virus trans-acting art gene product. 
  • Superimmunity: characterization of a new gene in the immunity region of P1. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. 
  • Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4. 
  • Suppression of the NF-κB pathway by diesel exhaust particles impairs human antimycobacterial immunity. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Surface projections of titanium substrates increase antithrombotic endothelial function in response to shear stress. 
  • Surfactant protein A modulates induction of regulatory T cells via TGF-β. 
  • Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs. 
  • Survey of variation in human transcription factors reveals prevalent DNA binding changes. 
  • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. 
  • Sustained in vivo gene delivery from agarose hydrogel prolongs nonviral gene expression in skin. 
  • Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits. 
  • Synergism of accessory factors in functional expression of mammalian odorant receptors. 
  • Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes. 
  • Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. 
  • Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. 
  • Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition. 
  • Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies. 
  • Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators. 
  • Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. 
  • Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer. 
  • T cell CD7 mRNA expression is regulated by both transcriptional and post-transcriptional mechanisms. 
  • T cell development: better living through chromatin. 
  • T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • T-cell-directed cancer vaccines: the melanoma model. 
  • TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations. 
  • TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. 
  • TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology. 
  • TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. 
  • TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. 
  • TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. 
  • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. 
  • Targeted inhibition of V(D)J recombination by a histone methyltransferase. 
  • Targeted resequencing identifies PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network. 
  • Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. 
  • Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. 
  • Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation. 
  • Temporal and tissue-specific expression of distinct retrovirus-like (VL30) elements during mouse development. 
  • Temporal specific patterns of semaphorin gene expression in rat brain after kainic acid-induced status epilepticus. 
  • Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. 
  • Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • The 5'-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation. 
  • The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. 
  • The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex. 
  • The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance. 
  • The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. 
  • The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. 
  • The DVR gene family in embryonic development. 
  • The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The Local Edge Machine: inference of dynamic models of gene regulation. 
  • The Lutheran glycoprotein: a multifunctional adhesion receptor. 
  • The PICALM protein plays a key role in iron homeostasis and cell proliferation. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. 
  • The TOR kinases link nutrient sensing to cell growth. 
  • The acute promyelocytic leukaemia-associated PML gene is induced by interferon. 
  • The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. 
  • The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. 
  • The avian cardiac alpha-actin promoter is regulated through a pair of complex elements composed of E boxes and serum response elements that bind both positive- and negative-acting factors. 
  • The balance of benefit and safety of rosiglitazone: important lessons for our system of drug development and postmarketing assessment. 
  • The biological significance of substrate inhibition: a mechanism with diverse functions. 
  • The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The coactivator SRC-1 is an essential coordinator of hepatic glucose production. 
  • The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. 
  • The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity. 
  • The differential expression of IL-4 and IL-13 and its impact on type-2 immunity. 
  • The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. 
  • The dishevelled protein is modified by wingless signaling in Drosophila. 
  • The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons. 
  • The effects of BMP6 overexpression on adipose stem cell chondrogenesis: Interactions with dexamethasone and exogenous growth factors. 
  • The evolution of transcriptional regulation in eukaryotes. 
  • The evolutionary significance of cis-regulatory mutations. 
  • The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure. 
  • The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. 
  • The g-value paradox. 
  • The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. 
  • The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. 
  • The helix-loop-helix gene E2A is required for B cell formation. 
  • The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. 
  • The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The human olfactory transcriptome. 
  • The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy. 
  • The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy. 
  • The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. 
  • The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. 
  • The mitochondrial cyanide-resistant oxidase: structural conservation amid regulatory diversity. 
  • The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor. 
  • The new age of medical genomics. 
  • The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells. 
  • The p53-dependent gamma-ray response of GADD45. 
  • The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. 
  • The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation. 
  • The relations of major platelet receptor expression during myocardial infarction. Monitoring efficacy of GPIIb/IIIa inhibitors by measuring P-selectin? 
  • The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines. 
  • The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. 
  • The ribonome: a dominant force in co-ordinating gene expression. 
  • The role of Bcl-xL in mouse RPE cell survival. 
  • The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy. 
  • The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases. 
  • The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. 
  • The role of avian retroviral LTRs in the regulation of gene expression and viral replication. 
  • The role of cytokines in posttraumatic arthritis. 
  • The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo. 
  • The role of modulatory calcineurin-interacting proteins in calcineurin signaling. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death. 
  • The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease. 
  • The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. 
  • The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. 
  • The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans. 
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. 
  • The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia. 
  • Thrombogenesis in atrial fibrillation contributing mechanisms and natural history. 
  • Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. 
  • Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. 
  • Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. 
  • Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences. 
  • Tissue-specific expression of the mammalian bombesin gene. 
  • Topology and control of the cell-cycle-regulated transcriptional circuitry. 
  • Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events. 
  • Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. 
  • Transcription and processing of human microRNA precursors. 
  • Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. 
  • Transcription interruption may be a common mechanism of c-myc regulation during HL-60 differentiation. 
  • Transcription of class III genes: formation of preinitiation complexes. 
  • Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells. 
  • Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity. 
  • Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition. 
  • Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. 
  • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. 
  • Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. 
  • Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis. 
  • Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. 
  • Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. 
  • Transcriptional regulation of the human T cell receptor delta gene. 
  • Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region. 
  • Transcriptional regulation of the mouse presenilin-1 gene. 
  • Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. 
  • Transcriptional responses of rat skeletal muscle following hypoxia-reoxygenation and near ischaemia-reperfusion. 
  • Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. 
  • Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans. 
  • Transgenic animals. New approaches to hypertension research. 
  • Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. 
  • Transient regulation of c-fos, alpha B-crystallin, and hsp70 in muscle during recovery from contractile activity. 
  • Translational control of phage f1 gene expression by differential activities of the gene V, VII, IX and VIII initiation sites. 
  • Transposed LEU2 gene of Saccharomyces cerevisiae is regulated normally. 
  • Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor. 
  • TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease. 
  • Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice. 
  • Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. 
  • Tumor necrosis factor alpha gene expression in human peritoneal macrophages is suppressed by extra-abdominal trauma. 
  • Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages. 
  • Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. 
  • Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. 
  • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. 
  • Umbilical Cord Blood-Derived Mononuclear Cells Exhibit Pericyte-Like Phenotype and Support Network Formation of Endothelial Progenitor Cells In Vitro. 
  • Unmasking a role for sex chromosomes in gene silencing. 
  • Unveiling the secrets to her heart. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. 
  • Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. 
  • Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. 
  • Use of cartilage derived from murine induced pluripotent stem cells for osteoarthritis drug screening. 
  • Use of viral systems to study miRNA-mediated regulation of gene expression in human cells. 
  • Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. 
  • Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture. 
  • Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. 
  • Variables affecting the T cell receptor V beta repertoire heterogeneity of T cells infiltrating human renal allografts. 
  • Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. 
  • Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. 
  • Vibratory loading decreases extracellular matrix and matrix metalloproteinase gene expression in rabbit annulus cells. 
  • Viral RNAs: lessons from the enemy. 
  • Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC. 
  • Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. 
  • Viruses, microRNAs, and host interactions. 
  • Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. 
  • What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? 
  • Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration? 
  • Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. 
  • Zebrafish assays of ciliopathies. 
  • [Induction of synthesis specific for females of variants growth hormone receptor mRNA in liver of male rats] 
  • [LMP-420, a new therapeutic approach for cerebral malaria?]. 
  • beta Adrenergic control of c-fos protooncogene expression in developing rat brain regions. 
  • beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. 
  • beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. 
  • beta-Arrestin: a protein that regulates beta-adrenergic receptor function. 
  • beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. 
  • cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8). 
  • eNOS, a pressure-dependent regulator of intraocular pressure. 
  • mNos2 deletion and human NOS2 replacement in Alzheimer disease models. 
  • miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. 
  • miR-181a is an intrinsic modulator of T cell sensitivity and selection. 
  • microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. 
  • p53 regulates the expression of the tumor suppressor gene maspin. 
  • ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. 
  • β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. 
• 

  Keywords of People

  • Aballay, Alejandro, Adjunct Professor in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • Alberts, Susan C., Robert F. Durden Professor of Biology, Marine Science and Conservation
  • Barfield, Raymond Carlton, Associate Professor of Pediatrics, Duke Science & Society
  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Cianciolo, George James, Associate Professor Emeritus in Pathology, Pathology
  • Ciofani, Maria, Assistant Professor of Immunology, Immunology
  • Davis, Erica Ellen, Associate Professor of Pediatrics, Cell Biology
  • Erickson, Harold Paul, James B. Duke Professor of Medicine, Cell Biology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Computer Science
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hirschey, Matthew, Associate Professor in Medicine, Pharmacology & Cancer Biology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia
  • Karhausen, Jorn, Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Laskowitz, Daniel Todd, Professor of Neurology, Neurobiology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Olson, Steven Arthur, Professor of Orthopaedic Surgery, Orthopaedics
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Reddy, Timothy E, Assistant Professor of Biostatistics & Bioinformatics, Biomedical Engineering
  • Sanchez-Perez, Luis Ariel, Assistant Professor of Neurosurgery, Neurosurgery
  • Setton, Lori A., Adjunct Professor of Biomedical Engineering, Biomedical Engineering
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Soderling, Scott Haydn, Associate Professor in Cell Biology, Cell Biology
  • Sullivan, Beth Ann, Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Swartzwelder, Harry Scott, Professor in Psychiatry and Behavioral Sciences, Duke Science & Society
  • Terrando, Niccolò, Assistant Professor in Anesthesiology, Anesthesiology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Tung, Jenny, Associate Professor of Evolutionary Anthropology, Duke Science & Society
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology
  • Yildirim, Eda, Assistant Professor of Cell Biology, Cell Biology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology