Genes

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  Subject Areas on Research

  • 5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. 
  • A 38 base pair insertion in the pro alpha 2(I) collagen gene of a patient with Marfan syndrome. 
  • A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. 
  • A candidate taste receptor gene near a sweet taste locus. 
  • A classification for genetic disorders of interest to orthopaedists. 
  • A cloned calmodulin structural gene probe is complementary to DNA sequences from diverse species. 
  • A human gamma globin gene variant binds SP1. 
  • A hyaline layer protein that becomes localized to the oral ectoderm and foregut of sea urchin embryos. 
  • A large-scale functional approach to uncover human genes and pathways in Drosophila. 
  • A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium. 
  • A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice. 
  • A new phase in the study of human inherited eye diseases. 
  • A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • A three allele TaqI polymorphism at TOP1 gene. 
  • Activation and repression of mammalian gene expression by the c-myc protein. 
  • Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. 
  • Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. 
  • Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. 
  • Alternative splicing: a mechanism for phenotypic rescue of a common inherited defect. 
  • Amanitin-resistant RNA polymerase II mutations are in the enzyme's largest subunit. 
  • An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. 
  • Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. 
  • Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster. 
  • Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. 
  • Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila. 
  • Analysis of the junction between ribosomal RNA genes and single-copy chromosomal sequences in the yeast Saccharomyces cerevisiae. 
  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. 
  • Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences. 
  • Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. 
  • Assessment of gene-by-sex interaction effect on bone mineral density. 
  • Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. 
  • Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. 
  • Bacterial expression vectors for calmodulin. 
  • Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli. 
  • Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. 
  • Biodemographic trajectories of longevity. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • Calmodulin as a mediator of hormone action and cell regulation. 
  • Calmodulin is involved in regulation of cell proliferation. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Can three incongruence tests predict when data should be combined? 
  • Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. 
  • Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus. 
  • Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. 
  • Characterization of a Drosophila U snRNP RNA-binding protein. 
  • Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21. 
  • Characterization of the flavoprotein moieties of NADPH-sulfite reductase from Salmonella typhimurium and Escherichia coli. Physicochemical and catalytic properties, amino acid sequence deduced from DNA sequence of cysJ, and comparison with NADPH-cytochrome P-450 reductase. 
  • Characterization of two types of yeast ribosomal DNA genes. 
  • Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone. 
  • Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content. 
  • Cholecystokinin cells. 
  • Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse. 
  • Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family. 
  • Chromosomal distribution of the major insert in Drosophila melanogaster 28S rRNA genes. 
  • Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. 
  • Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. 
  • Chromosomal rearrangements accompanying yeast mating-type switching: evidence for a gene-conversion model. 
  • Chromosomes with high gene density are preferentially repaired in human cells. 
  • Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes. 
  • Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. 
  • Cloning and expression of full-length cDNA encoding human vitamin D receptor. 
  • Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. 
  • Cloning genes that encode inducible forms of P-450. 
  • Cloning of human androgen receptor complementary DNA and localization to the X chromosome. 
  • Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. 
  • Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. 
  • Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. 
  • Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. 
  • Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3). 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. II. Modification of response to sharing of histocompatibility antigens. 
  • Combinatorial codon scrambling enables scalable gene synthesis and amplification of repetitive proteins. 
  • Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. 
  • Comparative genomics reveals insights into avian genome evolution and adaptation. 
  • Comparisons of predicted genetic modules: identification of co-expressed genes through module gene flow. 
  • Complex structure and regulation of the ABP/SHBG gene. 
  • Conservation of structure and location of Rhizobium meliloti and Klebsiella pneumoniae nifB genes. 
  • Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition. 
  • Cytochrome P1-450 structural gene in mouse, rat, and rabbit: differences in DNA methylation and developmental expression of mRNA. 
  • Cytoskeletal actin gene families of Xenopus borealis and Xenopus laevis. 
  • DNA sequence analysis of X-ray induced Adh null mutations in Drosophila melanogaster. 
  • DNA sequence patents are not in the grave yet. 
  • DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes. 
  • DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2. 
  • Defending information-free genocentrism. 
  • Deletion of carboxy-terminal residues of murine granulocyte-macrophage colony-stimulating factor results in a loss of biologic activity and altered glycosylation. 
  • Development and characterization of an Fv-1-sensitive retrovirus-packaging system: single-hit titration kinetics observed in restrictive cells. 
  • Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11. 
  • Developmental regulation of mouse SPARC (osteonectin) gene expression. 
  • Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. 
  • Dicistronic polioviruses as expression vectors for foreign genes. 
  • Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia. 
  • Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia. 
  • Differential replication of ribosomal gene repeats in polytene nuclei of Drosophila. 
  • Domain II of calmodulin is involved in activation of calcineurin. 
  • Downregulation of RNA polymerase III transcription of the hY3 gene in vitro. 
  • Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins. 
  • Effect of estrogen on gene expression in the chick oviduct. Regulation of the ovomucoid gene. 
  • Effects of cholecystokinin on pancreatic ornithine decarboxylase gene expression. 
  • Engineering soluble major histocompatibility molecules: why and how. 
  • Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth. 
  • Escherichia coli phage T4 topoisomerase. 
  • Eukaryotic gene transcription with purified components. 
  • Evidence for a striking increase in acetylcholinesterase activity in cultured human fibroblasts which are trisomic for chromosome two. 
  • Evidence for locus heterogeneity in the Bethlem myopathy and linkage to 2q37. 
  • Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene. 
  • Evidence that the ribosomal DNA genes of yeast are not on chromosome I. 
  • Evolution of a complex eukaryotic gene. 
  • Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. 
  • Evolutionary mechanisms for eucaryotic genes. 
  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. 
  • Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. 
  • Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae). 
  • Extensive junctional diversity of rearranged human T cell receptor delta genes. 
  • Food for thought: brain, genes, and nutrition. 
  • Formation of a rate-limiting intermediate in 5S RNA gene transcription. 
  • From anemia to cerebellar dysfunction. A review of the ankyrin gene family. 
  • Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. 
  • Further characterization of erythrocyte p80 and the membrane protein defect of In(Lu) Lu(a-b-) erythrocytes. 
  • GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. 
  • Gene A of X174. 1. Isolation and identification of its products. 
  • Gene Ontology annotations and resources. 
  • Gene conversion between repeated genes. 
  • Gene expression phenotypes of atherosclerosis. 
  • Gene expression signatures that predict radiation exposure in mice and humans. 
  • Genes determining blood cell traits. 
  • Genetic and biochemical characterization of mutants at an RNA polymerase II locus in D. melanogaster. 
  • Genetic approaches for the investigation of genes associated with coronary heart disease. 
  • Genetic approaches to molecular motors. 
  • Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene. 
  • Genetic regulation of beta-adrenergic receptors. 
  • GenoWatch: a disease gene mining browser for association study. 
  • Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation. 
  • Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. 
  • Genomic organization of rat rDNA. 
  • Genomic structure and amino acid sequence domains of the human La autoantigen. 
  • Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio). 
  • HLA antigen structural gene mutants selected with an allospecific monoclonal antibody. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. 
  • Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? 
  • Hemoglobin switching in sheep. Cloning and characterization of the beta A and beta-like embryonic globin genes from genomic DNA. 
  • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. 
  • Histone gene clusters of the newt notophthalmus are separated by long tracts of satellite DNA. 
  • Histone genes are located at the sphere loci of newt lampbrush chromosomes. 
  • Human glycogen debranching enzyme gene (AGL): complete structural organization and characterization of the 5' flanking region. 
  • Humoral immune response to the entire human immunodeficiency virus envelope glycoprotein made in insect cells. 
  • Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. 
  • Identification and cell type specificity of the tyrosine hydroxylase gene promoter. 
  • Identification and quantification of a messenger ribonucleic acid induced by polynuclear aromatic hydrocarbons--using a cloned human cytochrome P-450 gene. 
  • Identification of a deletion in the adenosine deaminase gene in a child with severe combined immunodeficiency. 
  • Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene. 
  • Identification of a structural gene for a RNA polymerase II polypeptide in Drosophila melanogaster and mammalian species. 
  • Identification of additional members of human G-protein-coupled receptor kinase multigene family. 
  • Identification of an X-ray induced deletion mutant flanked by direct repeats. 
  • Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men. 
  • Identification of four classes of cell surface antigens appearing at gastrulation in sea urchin embryos. 
  • Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. 
  • Identification of genetic markers to 20 NIDDM candidate genes by radiation hybrid analysis. 
  • Identification of novel mediators of NF-kappaB through genome-wide survey of monocyte adherence-induced genes. 
  • Identification of putative human T cell receptor delta complementary DNA clones. 
  • Identification, molecular cloning, and mutagenesis of Saccharomyces cerevisiae RNA polymerase genes. 
  • Idiotypic determinants used in the analysis of antibody diversification and as regulatory targets. 
  • Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. 
  • Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. 
  • Impact of Gene Patents and Licensing Practices on Access to Genetic Testing for Cystic Fibrosis 
  • Impact of Patents and Licensing Practices on Access to Genetic Testing for Inherited Susceptibility to Cancer: Comparing Breast and Ovarian Cancers to Colon Cancers 
  • Impact of gene patents and licensing practices on access to genetic testing for long QT syndrome. 
  • In vitro synthesis of messenger RNA by a defective interfering particle of vesicular stomatitis virus. 
  • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. 
  • Induction of a human carbonyl reductase gene located on chromosome 21. 
  • Inferring genetic ancestry: opportunities, challenges, and implications. 
  • Instrinsic defect of the polymorphonuclear leucocyte resulting in impaired chemotaxis and phagocytosis. 
  • Interactions between sustained contractile activity and beta-adrenergic receptors in regulation of gene expression in skeletal muscles. 
  • Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. 
  • Interpreting microarray results with gene ontology and MeSH. 
  • Interrupter sequences that are widely distributed in the Drosophila genome. 
  • Intragenic regulation of the synthesis of phi chi 174 gene A proteins. 
  • Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. 
  • Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. 
  • Is there left-handed DNA at the ends of yeast chromosomes? 
  • Isolation and characterization of a human pro alpha 2(I) collagen gene segment. 
  • Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1. 
  • Isolation and characterization of cDNA clones encoding pig gastric mucin. 
  • Isolation and characterization of the Escherichia coli mutL gene product. 
  • Isolation and structural analysis of the chromosomal gene for chicken calmodulin. 
  • Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse. 
  • Isolation of a rat parvalbumin gene and full length cDNA. 
  • Isolation of gram quantities of EcoRI restriction and modification enzymes from an overproducing strain. 
  • Isolation of human sequences that replicate autonomously in human cells. 
  • Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. 
  • Isolation of the structural gene for calmodulin. 
  • Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator. 
  • Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. 
  • Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. 
  • Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. 
  • Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. 
  • Localization of three genes expressed in retina on mouse chromosome 11. 
  • Location of the 5.8S rRNA gene of Saccharomyces cerevisiae. 
  • Location of the gene involving the small eye mutation on mouse chromosome 2 suggests homology with human aniridia 2 (AN2). 
  • Long poly(A) tracts in the human genome are associated with the Alu family of repeated elements. 
  • Lutheran antigens, CD44-related antigens, and Lutheran regulatory genes. 
  • Magnification of the ribosomal genes in female Drosophila melanogaster. 
  • Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttle. 
  • Meiotic mapping of yeast ribosomal deoxyribonucleic acid on chromosome XII. 
  • Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase. 
  • Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product. 
  • Methods for analyzing bovine papilloma virus-based calmodulin expression vectors. 
  • Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations. 
  • Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. 
  • Mixed lymphocyte responses in a four-generation C2 deficiency family. 
  • Model selection in binary trait locus mapping. 
  • Modulation of microfilament protein composition by transfected cytoskeletal actin genes. 
  • Molecular analysis of X-ray-induced alcohol dehydrogenase (ADH) null mutations in Drosophila melanogaster. 
  • Molecular analysis of alcohol dehydrogenase electromorphs in wild type and transformed Drosophila melanogaster. 
  • Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33. 
  • Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr). 
  • Molecular biology of adrenergic receptors. 
  • Molecular biology of hypertension. 
  • Molecular biology of the renin-angiotensin system. 
  • Molecular characterization of ribosomal genes on the Ybb- chromosome of Drosophila melanogaster. 
  • Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA. 
  • Molecular cloning and sequencing of chicken liver fatty acid synthase cDNA. 
  • Molecular cloning of a novel human GTP-binding protein and its potential role in chemoattractant stimulus-response coupling. 
  • Molecular cloning of laminin. 
  • Molecular cloning of ovomucoid gene sequences from partially purified ovomucoid messenger RNA. 
  • Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging. 
  • Molecular cloning of the gene sequences of a major apoprotein in avian very low density lipoproteins. 
  • Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein. 
  • Molecular genetics of yeast. 
  • Molecular structure and flanking nucleotide sequences of the natural chicken ovomucoid gene. 
  • Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics. 
  • Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. 
  • Moving Beyond "Isolated" Gene Patents 
  • Multifactorial/threshold models and their application to cleft lip and cleft palate. 
  • Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. 
  • Mutations in the maize mitochondrial T-urf13 gene eliminate sensitivity to a fungal pathotoxin. 
  • Myosin light chain kinase structure function analysis using bacterial expression. 
  • Nature of the 3'-terminal sequences of the plus and minus strands of the S1 gene of reovirus serotypes 1, 2 and 3. 
  • Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes. 
  • Neurobiological pathways that link gene and environment: early life stress disorder. 
  • Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains. 
  • Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase. 
  • Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli. 
  • Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences. 
  • On ribosomal gene compensation in Drosophila. 
  • On the association between genes and complex traits. 
  • On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation. 
  • Ovalbumin gene: purification of the coding strand. 
  • Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster. 
  • Ovomucoid intervening sequences specify functional domains and generate protein polymorphism. 
  • Partial NH2- and cooh-terminal sequence analyses of Eco RI DNA restriction and modification enzymes. 
  • Performance assessment of promoter predictions on ENCODE regions in the EGASP experiment. 
  • Peripheral Neuropathy and the Ceruloplasmin Gene. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Pleiotropic plasma membrane ATPase mutations of Saccharomyces cerevisiae. 
  • Polycistronic vesicular stomatitis virus RNA transcripts. 
  • Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemic cells, and breast cancer. 
  • Polymorphism of DNA sequence in the human pro alpha 2(I) collagen gene. 
  • Polytenization of the ribosomal genes on the X and Y chromosomes of Drosophila melanogaster. 
  • Positive-selection cloning vehicle useful for overproduction of hybrid proteins. 
  • Practice and public policy in the era of gene-environment interactions. 
  • Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus. 
  • Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. 
  • Probable exclusion of GLC1A as a candidate glaucoma gene in a family with middle-age-onset primary open-angle glaucoma. 
  • Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor. 
  • RNA-seq: impact of RNA degradation on transcript quantification. 
  • Rapid dissection of a complex phenotype through genomic-scale mapping of fitness altering genes. 
  • Recombination between genes located on nonhomologous chromosomes in Saccharomyces cerevisiae. 
  • Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes. 
  • Regulated expression of p18, a major phosphoprotein of leukemic cells. 
  • Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase. 
  • Regulation of the human c-myc gene: 5' noncoding sequences do not affect translation. 
  • Regulation of tissue renin and angiotensin gene expressions. 
  • Regulatory genes linked to the albino locus in the mouse confer competence for inducible expression on the structural gene encoding serine dehydratase. 
  • Remarkable conservation of structure among intermediate filament genes. 
  • Repeat polymorphisms within gene regions: phenotypic and evolutionary implications. 
  • Replicating circular DNA molecules in yeast. 
  • Report of the committee on the genetic constitution of chromosome 19. 
  • Report of the committee on the genetic constitution of chromosomes 18 and 19. 
  • Rh-related antigen CD47 is the signal-transducer integrin-associated protein. 
  • Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. 
  • Roles of wingless in patterning the larval epidermis of Drosophila. 
  • SGP-1: prediction and validation of homologous genes based on sequence alignments. 
  • Salmonella typhimurium SA host specificity system is based on deoxyribonucleic acid-adenine methylation. 
  • Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. 
  • Segregation and linkage analysis of alpha-N-acetyl-D-glucosaminidase (NAG) levels in a black family. 
  • Selection and validation of endogenous reference genes using a high throughput approach. 
  • Selection of optimal reference genes for normalization in quantitative RT-PCR. 
  • Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. 
  • Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor. 
  • Sequences within the spacer region of yeast rRNA cistrons that stimulate 35S rRNA synthesis in vivo mediate RNA polymerase I-dependent promoter and terminator activities. 
  • Simple Mendelian inheritance of the repeating yeast ribosomal DNA genes. 
  • Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase. 
  • Sites of P element insertion and structures of P element deletions in the 5' region of Drosophila melanogaster RpII215. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Steroid and high-temperature induction of the small heat-shock protein genes in Drosophila. 
  • Stimulation of cytoplasmic actin gene transcription and translation in cultured Drosophila cells by ecdysterone. 
  • Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. 
  • Structural organization and chromosomal assignment of the parvalbumin gene. 
  • Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes. 
  • Structure and evolution of prokaryotic and eukaryotic RNA polymerases: a model. 
  • Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. 
  • Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II. 
  • Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1). 
  • Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. 
  • Studies of viral antibody responses among Amish families. 
  • Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct. 
  • Synthesis of DNA coding for human proinsulin. 
  • T-cell receptors of human suppressor cells. 
  • T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes. 
  • Technology advancement for studying gene expression and gene function: a workshop report. Sponsored by National Institute of Child Health and Human Development, National Institute of General Medical Sciences, National Center for Human Genome Research, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland 20892, USA. 
  • The Disease and Gene Annotations (DGA): an annotation resource for human disease. 
  • The Gene Ontology (GO) database and informatics resource. 
  • The Gene Ontology (GO) project in 2006. 
  • The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2. 
  • The cardiofaciocutaneous syndrome. 
  • The chick ovomucoid gene contains at least six intervening sequences. 
  • The gamma delta T cell receptor. 
  • The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. 
  • The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. 
  • The genetic and molecular dissection of a prototypic circadian system. 
  • The genome of the sea urchin Stongylocentrotus purpuratus 
  • The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20. 
  • The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene. 
  • The immune response to staphylococcal nuclease: a probe of cellular and humoral antigen-specific receptors. 
  • The immunogenetics of the major histocompatibility chromosomal region in man. 
  • The isolation of ecdysterone inducible genes by hybridization subtraction chromatography. 
  • The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. 
  • The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. 
  • The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16. 
  • The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. 
  • The nontranscribed chicken calmodulin pseudogene cross-hybridizes with mRNA from the slow-muscle troponin C gene. 
  • The ovalbumin gene. Partial purification of the coding strand. 
  • The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2. 
  • The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14. 
  • The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila. 
  • Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. 
  • Tissue specificity of renin promoter activity and regulation in mice. 
  • Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences. 
  • Tissue-specific expression of kallikrein-related genes in the rat. 
  • Tissue-specific expression of the mammalian bombesin gene. 
  • Tissue-specific gene expression in mouse F9 embryonal carcinoma cells: type IV collagen. 
  • Transcript length heterogeneity at the small heat shock protein genes of Drosophila. 
  • Transcription of H-2 and Qa genes in embryonic and adult mice. 
  • Transcription of class III genes: formation of preinitiation complexes. 
  • Transcription of spacer sequences flanking the rat 45S ribosomal DNA gene. 
  • Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. 
  • Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. 
  • Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. 
  • Two mouse early embryonic beta-globin gene sequences. Evolution of the nonadult beta-globins. 
  • Two proteins of gene A of psiX174. 
  • Unequal meiotic recombination within tandem arrays of yeast ribosomal DNA genes. 
  • Use of a CEPH meiotic breakpoint panel to refine the locus of limb-girdle muscular dystrophy type 1A (LGMD1A) to a 2-Mb interval on 5q31. 
  • Use of eukaryotic expression technology in the functional analysis of cloned genes. 
  • Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. 
  • Visual pigments, blue cone monochromasy, and retinitis pigmentosa. 
  • When is homology not homology? 
  • Who owns the genome? 
  • Whole-genome analyses resolve early branches in the tree of life of modern birds. 
  • Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. 
  • Yeast ribosomal DNA genes are located on chromosome XII. 
  • apex: phylogenetics with multiple genes. 
  • cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. 
  • rqt: an R package for gene-level meta-analysis. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Dodge, Kenneth A., William McDougall Distinguished Professor of Public Policy Studies, Duke Science & Society
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Schmid, Amy K., Associate Professor of Biology, Duke Science & Society
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology