Genes, Bacterial

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  Subject Areas on Research

  • 50 million years of genomic stasis in endosymbiotic bacteria. 
  • A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium. 
  • A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation. 
  • A new dominant selectable marker for use in Cryptococcus neoformans. 
  • A novel thermostable branching enzyme from an extremely thermophilic bacterial species, Rhodothermus obamensis. 
  • A single base substitution in the variable pocket of yeast tRNA(Arg) eliminates species-specific aminoacylation. 
  • A strong effect of AT mutational bias on amino acid usage in Buchnera is mitigated at high-expression genes. 
  • Adhesin presentation in bacteria requires molecular chaperones and ushers. 
  • An in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteers. 
  • Analysis of the genotype and virulence of Staphylococcus epidermidis isolates from patients with infective endocarditis. 
  • Application of a moving bed biofilm reactor for tertiary ammonia treatment in high temperature industrial wastewater. 
  • Applications of gene fusions to green fluorescent protein and flow cytometry to the study of bacterial gene expression in host cells. 
  • Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. 
  • Association of molybdopterin guanine dinucleotide with Escherichia coli dimethyl sulfoxide reductase: effect of tungstate and a mob mutation. 
  • Associations between the genotypes of Staphylococcus aureus bloodstream isolates and clinical characteristics and outcomes of bacteremic patients. 
  • Bacterial infection remains a leading cause of death in both Western and developing world. Preface. 
  • Bayesian learning from marginal data in bionetwork models. 
  • Binding of bacteria to mucosal surfaces. 
  • Broad host range vectors for stable genomic library construction. 
  • C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation. 
  • Characterization of Mycobacterium montefiorense sp. nov., a novel pathogenic Mycobacterium from moray eels that is related to Mycobacterium triplex. 
  • Characterization of a major cluster of nif, fix, and associated genes in a sugarcane endophyte, Acetobacter diazotrophicus. 
  • Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion. 
  • Characterization of the flavoprotein moieties of NADPH-sulfite reductase from Salmonella typhimurium and Escherichia coli. Physicochemical and catalytic properties, amino acid sequence deduced from DNA sequence of cysJ, and comparison with NADPH-cytochrome P-450 reductase. 
  • Characterization of the variable-number tandem repeats in vrrA from different Bacillus anthracis isolates. 
  • Choreography of the transcriptome, photophysiology, and cell cycle of a minimal photoautotroph, prochlorococcus. 
  • Chromosomal organization of rRNA operons in Bacillus subtilis. 
  • Cloned Erwinia chrysanthemi out genes enable Escherichia coli to selectively secrete a diverse family of heterologous proteins to its milieu. 
  • Clostridium taeniosporum spore ribbon-like appendage structure, composition and genes. 
  • Comparison of the evolutionary dynamics of symbiotic and housekeeping loci: a case for the genetic coherence of rhizobial lineages. 
  • Complete genomic nucleotide sequence of the temperate bacteriophage Aa Phi 23 of Actinobacillus actinomycetemcomitans. 
  • Conservation of structure and location of Rhizobium meliloti and Klebsiella pneumoniae nifB genes. 
  • Construction of a fluorescent biosensor family. 
  • Contribution of aerobic photoheterotrophic bacteria to the carbon cycle in the ocean. 
  • Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns. 
  • Cytosine deamination in mismatched base pairs. 
  • DNA bending near the replication origin of IncFII plasmid NR1. 
  • DNA nicks inflicted by restriction endonucleases are repaired by a RecA- and RecB-dependent pathway in Escherichia coli. 
  • Decay of mutualistic potential in aphid endosymbionts through silencing of biosynthetic loci: Buchnera of Diuraphis. 
  • Deep divergence and rapid evolutionary rates in gut-associated Acetobacteraceae of ants. 
  • Determinations of restriction fragment length polymorphism in bacteria using ribosomal RNA genes. 
  • Directed evolution of the surface chemistry of the reporter enzyme beta-glucuronidase. 
  • Discrimination of tRNALeu isoacceptors by the insertion mutant of Escherichia coli leucyl-tRNA synthetase. 
  • Dominant selection system for use in Cryptococcus neoformans. 
  • Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. 
  • Ecology drives a global network of gene exchange connecting the human microbiome. 
  • Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli. 
  • Emancipating Chlamydia: Advances in the Genetic Manipulation of a Recalcitrant Intracellular Pathogen. 
  • Engineering multicellular systems by cell-cell communication. 
  • Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. 
  • Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction. 
  • Evaluation of the accuracy and reproducibility of a practical PCR panel assay for rapid detection and differentiation of Mycobacterium avium subspecies. 
  • Evidence for genetic drift in endosymbionts (Buchnera): analyses of protein-coding genes. 
  • Examining relationships between total silver concentration and Sil silver resistance genes in domestic wastewater treatment plants. 
  • Excision and transposition of Tn5 as an SOS activity in Escherichia coli. 
  • Exploitation of macrophages as a replication niche by Legionella pneumophila: response. 
  • Expression of penicillin G acylase from the cloned pac gene of Escherichia coli ATCC11105. Effects of pacR and temperature. 
  • Expression of the Pseudomonas syringae avirulence protein AvrB in plant cells alleviates its dependence on the hypersensitive response and pathogenicity (Hrp) secretion system in eliciting genotype-specific hypersensitive cell death. 
  • Extracellular secretion of pectate lyase by the Erwinia chrysanthemi out pathway is dependent upon Sec-mediated export across the inner membrane. 
  • Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. 
  • FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria. 
  • Fine-scale phylogenetic architecture of a complex bacterial community. 
  • Functional Advantages of Porphyromonas gingivalis Vesicles. 
  • Further evidence that transposition of Tn5 in Escherichia coli is strongly enhanced by constitutively activated RecA proteins. 
  • Genetic structure and DNA sequences at junctions involved in the rearrangements of Bacillus subtilis strains carrying the trpE26 mutation. 
  • Genetic variability of Bacillus anthracis and related species. 
  • Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria. 
  • Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation. 
  • Genomic sequencing-based mutational enrichment analysis identifies motility genes in a genetically intractable gut microbe. 
  • Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease. 
  • Harpin, elicitor of the hypersensitive response produced by the plant pathogen Erwinia amylovora. 
  • High-frequency S-layer protein variation in Campylobacter fetus revealed by sapA mutagenesis. 
  • Hrp-controlled interkingdom protein transport: learning from flagellar assembly? 
  • Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface. 
  • Identification of a homogentisate-1,2-dioxygenase gene in the fungus Exophiala lecanii-corni: analysis and implications. 
  • Identification of novel hrp-regulated genes through functional genomic analysis of the Pseudomonas syringae pv. tomato DC3000 genome. 
  • Identification of two ancillary subunits of Escherichia coli type 1 fimbriae by using antibodies against synthetic oligopeptides of fim gene products. 
  • Impacts of silver nanoparticle coating on the nitrification potential of Nitrosomonas europaea. 
  • Indole-3-acetic acid biosynthesis is deficient in Gluconacetobacter diazotrophicus strains with mutations in cytochrome c biogenesis genes. 
  • Initiation of methyl-directed mismatch repair. 
  • Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. 
  • Involvement of chlA, E, M, and N loci in Escherichia coli molybdopterin biosynthesis. 
  • Involvement of the S-layer proteins Hpi and SlpA in the maintenance of cell envelope integrity in Deinococcus radiodurans R1. 
  • Isolation and characterization of the Escherichia coli mutL gene product. 
  • Location of the host attachment site for phage HPl within a cluster of Haemophilus influenzae tRNA genes. 
  • Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. 
  • Low-frequency infection of F- bacteria by transducing particles of filamentous bacteriophages. 
  • Mapping of rRNA genes with integrable plasmids in Bacillus subtilis. 
  • Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NRII or NtrB): trans-phosphorylation between subunits. 
  • Mechanisms and biological effects of mismatch repair. 
  • Methyl-directed mismatch repair is bidirectional. 
  • Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon. 
  • Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein. 
  • Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth. 
  • Molecular Detection and Typing of Pathogenic Leptospira in Febrile Patients and Phylogenetic Comparison with Leptospira Detected among Animals in Tanzania. 
  • Molecular cloning of dimethyl sulfoxide reductase from Rhodobacter sphaeroides. 
  • Molecular cloning, nucleotide sequence, and marker exchange mutagenesis of the exo-poly-alpha-D-galacturonosidase-encoding pehX gene of Erwinia chrysanthemi EC16. 
  • Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions. 
  • Multilaboratory evaluation of screening methods for detection of high-level aminoglycoside resistance in enterococci. National Committee for Clinical Laboratory Standards Study Group on Enterococci. 
  • Multiple gonococcal opacity proteins are expressed during experimental urethral infection in the male. 
  • MutL traps MutS at a DNA mismatch. 
  • Mutation detection with MutH, MutL, and MutS mismatch repair proteins. 
  • Niche partitioning among Prochlorococcus ecotypes along ocean-scale environmental gradients. 
  • Nonhomogeneous model of sequence evolution indicates independent origins of primary endosymbionts within the enterobacteriales (gamma-Proteobacteria). 
  • Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli. 
  • Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1. 
  • Organization of carboxysome genes in the thiobacilli. 
  • PCR identification of Mycobacterium bovis BCG. 
  • Phage Trojan horses: a conditional expression system for lethal genes. 
  • Phylogeny of Wolbachia pipientis based on gltA, groEL and ftsZ gene sequences: clustering of arthropod and nematode symbionts in the F supergroup, and evidence for further diversity in the Wolbachia tree. 
  • Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition. 
  • Potential associations between severity of infection and the presence of virulence-associated genes in clinical strains of Staphylococcus aureus. 
  • Probing bacterial gene expression within host cells. 
  • Programmed population control by cell-cell communication and regulated killing. 
  • Properties of overlapping genes are conserved across microbial genomes. 
  • Proposed nomenclature for the genes involved in molybdenum metabolism in Escherichia coli and Salmonella typhimurium. 
  • Pseudomonas syringae pv. tomato DC3000 HopPtoM (CEL ORF3) is important for lesion formation but not growth in tomato and is secreted and translocated by the Hrp type III secretion system in a chaperone-dependent manner. 
  • Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties. 
  • Sakacin P non-producing Lactobacillus sakei strains contain homologues of the sakacin P gene cluster. 
  • Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems. 
  • Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays. 
  • Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. 
  • Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem. 
  • Staphylococcus aureus bacteremia at 5 US academic medical centers, 2008-2011: significant geographic variation in community-onset infections. 
  • Statistical analysis of genetic interactions in Tn-Seq data. 
  • Structure and evolution of prokaryotic and eukaryotic RNA polymerases: a model. 
  • Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. 
  • Subspecific differentiation of Mycobacterium avium complex strains by automated sequencing of a region of the gene (hsp65) encoding a 65-kilodalton heat shock protein. 
  • Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement. 
  • The Hrp pilus: learning from flagella. 
  • The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. 
  • The Pseudomonas syringae pv. tomato HrpW protein has domains similar to harpins and pectate lyases and can elicit the plant hypersensitive response and bind to pectate. 
  • The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato. 
  • The genetic determinant of adhesive function in type 1 fimbriae of Escherichia coli is distinct from the gene encoding the fimbrial subunit. 
  • The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions. 
  • The pterin molybdenum cofactors. 
  • The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus. 
  • The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus. 
  • Tn5-mediated bleomycin resistance in Escherichia coli requires the expression of host genes. 
  • Trait-to-gene: a computational method for predicting the function of uncharacterized genes. 
  • Transcriptional pausing in a region important for plasmid NR1 replication control. 
  • Two proteins encoded at the chlA locus constitute the converting factor of Escherichia coli chlA1. 
  • Two tRNA gene clusters associated with rRNA operons rrnD and rrnE in Bacillus subtilis. 
  • Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. 
  • Unprecedented loss of ammonia assimilation capability in a urease-encoding bacterial mutualist. 
  • Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006-2009. 
  • Vertical transmission of biosynthetic plasmids in aphid endosymbionts (Buchnera). 
  • Vibrio metoecus sp. nov., a close relative of Vibrio cholerae isolated from coastal brackish ponds and clinical specimens. 
  • fii, a bacterial locus required for filamentous phage infection and its relation to colicin-tolerant tolA and tolB. 
  • hrp gene-dependent induction of hin1: a plant gene activated rapidly by both harpins and the avrPto gene-mediated signal. 
  • mig-14 is a horizontally acquired, host-induced gene required for salmonella enterica lethal infection in the murine model of typhoid fever. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology