Genes, Immunoglobulin
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Subject Areas on Research
- A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries.
- A defect in the humoral immune response to protein antigens and haptens in immunoglobulin mu heavy-chain transgenic mice.
- A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.
- A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries.
- Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling.
- Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
- Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline.
- Antigen-binding repertoire and Ig H chain gene usage among B cell hybridomas from normal and autoimmune mice.
- Autoantibodies and their idiotypes.
- B cells in epithelial and perivascular compartments of human adult thymus.
- CD28 is required for germinal center formation.
- CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells.
- Changes in hairy cells after alpha-interferon treatment as measured by flow cytometry.
- Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.
- Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling.
- Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice.
- Developmental regulation of V(D)J recombination at the TCR alpha/delta locus.
- Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis.
- Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain.
- Diversification of Ig superfamily genes in an invertebrate.
- Enhanced evolvability in immunoglobulin V genes under somatic hypermutation.
- Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.
- Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay.
- Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.
- Gene segment selection in V(D)J recombination: accessibility and beyond.
- Germline transcription: a key regulator of accessibility and recombination.
- High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies.
- Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy.
- Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase.
- Immunoglobulin gene rearrangement in multiple myeloma: limitations of Southern blot analysis.
- In situ studies of the antigen-driven somatic hypermutation of immunoglobulin genes.
- In situ studies of the germinal center reaction.
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.
- In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains.
- In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.
- Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences.
- Inter-VH-gene-family shared idiotype on acquired immunodeficiency syndrome-associated lymphomas.
- Interdependence of N nucleotide addition and recombination site choice in V(D)J rearrangement.
- Intraclonal generation of antibody mutants in germinal centres.
- Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.
- Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.
- Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.
- Locus-specific somatic hypermutation in germinal centre T cells.
- Lymphocyte development and selection in germinal centers.
- Mapping of antibody specificities to VH gene families.
- Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse.
- Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.
- Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA.
- Multiple genetic lesions in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma.
- Murine V kappa gene expression does not follow the VH paradigm.
- Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool.
- Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
- Pairing of VH gene families with the lambda 1 light chain: evidence for a non-stochastic association.
- Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.
- Prominent Dutcher body formation in a case of follicular lymphoma with BCL6 gene rearrangement and intact BCL2 gene.
- Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.
- Regulation of E2A gene expression in B-lymphocyte development.
- Regulation of V(D)J recombination by E-protein transcription factors.
- Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.
- Regulation of early lymphocyte development by E2A family proteins.
- Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls.
- Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis.
- Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice.
- SoDA2: a Hidden Markov Model approach for identification of immunoglobulin rearrangements.
- Somatic diversification of antibody responses.
- Some nuts are tougher to crack than others.
- Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand.
- Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.
- Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.
- Targeting AID to the Ig genes.
- The interleukin 1 receptor.
- The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.
- The nude mutation results in impaired primary antibody repertoire.
- Transformation of hairy cell leukemia to EBV genome-containing aggressive B cell lymphoma.
- Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII.
- V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.
- V(D)J hypermutation and DNA mismatch repair: vexed by fixation.
- V(D)J hypermutation and receptor revision: coloring outside the lines.
- V(D)J recombinase activity in a subset of germinal center B lymphocytes.
- VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies.
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Keywords of People
- Halabi, Susan, Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
- Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
- Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
- Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
- Zhong, Xiaoping, Professor of Pediatrics, Immunology