Genes, Lethal

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  Subject Areas on Research

  • Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival. 
  • Are Lethal Alleles Too Abundant in Humans? 
  • Cycloheximide-resistant temperature-sensitive lethal mutations of Saccharomyces cerevisiae. 
  • Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. 
  • DNA topoisomerase I is essential in Drosophila melanogaster. 
  • Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t). 
  • Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. 
  • Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development. 
  • Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis. 
  • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. 
  • Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. 
  • Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. 
  • Evolutionary biology: Genes to make new species. 
  • Genetic and biochemical characterization of mutants at an RNA polymerase II locus in D. melanogaster. 
  • Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase. 
  • Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. 
  • In vitro development of inner cell masses isolated from t0/t0 and tW5/tW5 mouse embryos. 
  • Isolation and characterization of a Drosophila gene essential for early embryonic development and formation of cortical cleavage furrows. 
  • Isoprenylcysteine carboxyl methyltransferase deficiency in mice. 
  • Lambda transducing phages for the nalA gene of Escherichia coli and conditional lethal nalA mutations. 
  • Mekk3 is essential for early embryonic cardiovascular development. 
  • Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. 
  • Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging. 
  • Most of the yeast genomic sequences are not essential for cell growth and division. 
  • Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. 
  • Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. 
  • Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly. 
  • Of mice and men: the mice were right. 
  • One-step and stepwise magnification of a bobbed lethal chromosome in Drosophila melanogaster. 
  • Phage Trojan horses: a conditional expression system for lethal genes. 
  • Phenylalanine hydroxylase in dilute lethal mice 
  • Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. 
  • Selective loss of a DNase I hypersensitive site upstream of the tyrosine aminotransferase gene in mice homozygous for lethal albino deletions. 
  • Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. 
  • Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. 
  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The helix-loop-helix gene E2A is required for B cell formation. 
  • The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. 
  • The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. 
  • The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • Tissue-specific inactivation of murine M6P/IGF2R. 
  • Xist RNA is a potent suppressor of hematologic cancer in mice. 
  • Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. 
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  Keywords of People

  • Baugh, L. Ryan, Associate Professor of Biology, Biology
  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology