Genes, Lethal
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Subject Areas on Research
- A guide for performing germ cell mutagenesis assays using Drosophila melanogaster.
- Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival.
- Are Lethal Alleles Too Abundant in Humans?
- Chromosome breakage in Drosophila melanogaster induced by a monofunctional alkylating agent (EMS).
- Comparison of a chemical assay with a tissue-mediated bio-assay for chemical mutagens.
- Cycloheximide-resistant temperature-sensitive lethal mutations of Saccharomyces cerevisiae.
- Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.
- Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).
- Dosage-response relationships for methyl methanesulfonate in Drosophila melanogaster spermatozoa: DNA methylation per nucleotide vs. sex-linked recessive lethal frequency.
- Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.
- Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis.
- Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
- Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.
- Evolutionary biology: Genes to make new species.
- Genetic and biochemical characterization of mutants at an RNA polymerase II locus in D. melanogaster.
- Genetic and enzymatic characterization of a conditional lethal mutant of Escherichia coli K12 with a temperature-sensitive DNA ligase.
- In vitro development of inner cell masses isolated from t0/t0 and tW5/tW5 mouse embryos.
- Isoprenylcysteine carboxyl methyltransferase deficiency in mice.
- Lambda transducing phages for the nalA gene of Escherichia coli and conditional lethal nalA mutations.
- Mekk3 is essential for early embryonic cardiovascular development.
- Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle.
- Molecular cloning of sequences from a Drosophila RNA polymerase II locus by P element transposon tagging.
- Molecular dosimetry of the mutagen ethyl methanesulfonate in Drosophila melanogaster spermatozoa: linear relation of DNA alkylation per sperm cell (dose) to sex-linked recessive lethals.
- Most of the yeast genomic sequences are not essential for cell growth and division.
- Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
- Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.
- Mutations produced by transmutation of phosphorus-32 to sulfur-32 within Drosophila DNA.
- Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly.
- Of mice and men: the mice were right.
- One-step and stepwise magnification of a bobbed lethal chromosome in Drosophila melanogaster.
- Phage Trojan horses: a conditional expression system for lethal genes.
- Phenylalanine hydroxylase in dilute lethal mice.
- Relative biological effectiveness of tritiated water to gamma radiation for germ line mutations.
- Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
- Selective loss of a DNase I hypersensitive site upstream of the tyrosine aminotransferase gene in mice homozygous for lethal albino deletions.
- Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.
- Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse.
- Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions.
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.
- The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana.
- The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
- The helix-loop-helix gene E2A is required for B cell formation.
- The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.
- The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.
- The sex-linked recessive lethal test for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
- The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth.
- The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo.
- Tissue-specific inactivation of murine M6P/IGF2R.
- Transmutation of carbon-14 within DNA of Drosophila melanogaster spermatozoa.
- Xist RNA is a potent suppressor of hematologic cancer in mice.
- Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
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Keywords of People
- Baugh, L. Ryan, Associate Professor of Biology, Biology
- Bejsovec, Amy, Associate Professor of Biology, Biology
- Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology