Genes, Regulator

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  Subject Areas on Research

  • A classification for genetic disorders of interest to orthopaedists. 
  • A genomic regulatory network for development. 
  • A highly complex organization of the regulatory region of the human CYP19 (aromatase) gene revealed by the Human Genome Project. 
  • A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. 
  • A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo. 
  • A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster. 
  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo. 
  • Antisense oligonucleotides directed at cell cycle regulatory genes as strategy for restenosis therapy. 
  • Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. 
  • Conservation of structure and location of Rhizobium meliloti and Klebsiella pneumoniae nifB genes. 
  • Control of CD4 gene expression: connecting signals to outcomes in T cell development. 
  • Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. 
  • Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system. 
  • Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer. 
  • Developmental regulation of mouse SPARC (osteonectin) gene expression. 
  • Developmental regulatory genes and echinoderm evolution. 
  • Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. 
  • Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene. 
  • Evolutionary dissociations between homologous genes and homologous structures. 
  • Expression of penicillin G acylase from the cloned pac gene of Escherichia coli ATCC11105. Effects of pacR and temperature. 
  • Focus on butterfly eyespot development. 
  • Functional analysis of the transcription control region located within the avian retroviral long terminal repeat. 
  • Gene expression during echinoderm metamorphosis. 
  • Genetic analysis of regulatory mutants of alkaline phosphatase of E. coli. 
  • Homoeo boxes and strings for the packaging of genes? 
  • Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine. 
  • Human erythrocyte antigens: II. The In(Lu) gene regulates expression of an antigen on an 80-kilodalton protein of human erythrocytes. 
  • Human medullary thymocyte p80 antigen and In(Lu)-related p80 antigen reside on the same protein. 
  • Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene. 
  • Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting. 
  • Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene. 
  • Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences. 
  • Identification of potential regulatory regions in the renin gene. 
  • Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. 
  • Isolation and initial characterization of the 5' flanking region of the human and murine cyclic guanosine monophosphate-phosphodiesterase beta-subunit genes. 
  • Lutheran antigens, CD44-related antigens, and Lutheran regulatory genes. 
  • Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NRII or NtrB): trans-phosphorylation between subunits. 
  • Molecular biology of the renin-angiotensin system. 
  • Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. 
  • Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea. 
  • Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. 
  • Nucleotide pool in pho regulon mutants and alkaline phosphatase synthesis in Escherichia coli. 
  • Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains. 
  • Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression. 
  • Predictors of agr dysfunction in methicillin-resistant Staphylococcus aureus (MRSA) isolates among patients with MRSA bloodstream infections. 
  • RCC1, a regulator of mitosis, is essential for DNA replication. 
  • Radical alterations in the roles of homeobox genes during echinoderm evolution. 
  • Reconstructing regulatory network transitions. 
  • Regulation of the human c-myc gene: 5' noncoding sequences do not affect translation. 
  • Regulation of the human interleukin-3 gene. 
  • Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein. 
  • Regulatory and structural motifs of chicken gizzard myosin light chain kinase. 
  • Regulatory genes linked to the albino locus in the mouse confer competence for inducible expression on the structural gene encoding serine dehydratase. 
  • Relaxed selection among duplicate floral regulatory genes in Lamiales. 
  • Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis. 
  • SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation. 
  • Skeletal dysplasias and the growth plate. 
  • Structural basis of DNA-protein recognition. 
  • Suppression of leukaemia virus pathogenicity by polyoma virus enhancers. 
  • Synthesis of DNA coding for human proinsulin. 
  • TGF-beta related genes in development. 
  • The HIV cytopathic effect: potential target for therapy? 
  • The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. 
  • The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root. 
  • The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. 
  • The myoD gene family: nodal point during specification of the muscle cell lineage. 
  • Thousands of human mobile element fragments undergo strong purifying selection near developmental genes. 
  • Transcription of a poxvirus early gene is regulated both by a short promoter element and by a transcriptional termination signal controlling transcriptional interference. 
  • Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity. 
  • Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region. 
  • Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. 
  • Transposed LEU2 gene of Saccharomyces cerevisiae is regulated normally. 
  • Waiting for two mutations: with applications to regulatory sequence evolution and the limits of Darwinian evolution. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology