Multigene Family

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  Subject Areas on Research

  • A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. 
  • A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases. 
  • A common duplication in the lysyl hydroxylase gene of patients with Ehlers Danlos syndrome type VI results in preferential stimulation of lysyl hydroxylase activity and mRNA by hydralazine. 
  • A comparative analysis of the information content in long and short SAGE libraries. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A critical role for CRM1 in regulating HOXA gene transcription in CALM-AF10 leukemias. 
  • A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. 
  • A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway. 
  • A gene map of the human genome. 
  • A generalized least-squares estimate for the origin of sporophytic self-incompatibility. 
  • A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A multigene family encoding a diverse array of putative pheromone receptors in mammals. 
  • A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. 
  • A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome. 
  • A novel polypeptide secreted by activated human T lymphocytes. 
  • A penalized likelihood approach for bivariate conditional normal models for dynamic co-expression analysis. 
  • A phylotranscriptomic analysis of gene family expansion and evolution in the largest order of pleurocarpous mosses (Hypnales, Bryophyta). 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • A role for LKP2 in the circadian clock of Arabidopsis. 
  • A standardized kinesin nomenclature. 
  • A tenascin knockout with a phenotype. 
  • ATM: genome stability, neuronal development, and cancer cross paths. 
  • Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • An expanded view of inositol signaling. 
  • Annotating nonspecific SAGE tags with microarray data. 
  • Antigen-binding repertoire and Ig H chain gene usage among B cell hybridomas from normal and autoimmune mice. 
  • Axon regeneration pathways identified by systematic genetic screening in C. elegans. 
  • Beta satellite DNA: characterization and localization of two subfamilies from the distal and proximal short arms of the human acrocentric chromosomes. 
  • Beta-adrenergic receptor kinase: primary structure delineates a multigene family. 
  • Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. 
  • Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida. 
  • Bombyxin is a growth factor for wing imaginal disks in Lepidoptera. 
  • Building pathway clusters from Random Forests classification using class votes. 
  • Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. 
  • Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells. 
  • Chaperone-assisted assembly and molecular architecture of adhesive pili. 
  • Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings. 
  • Characterization of murine carcinoembryonic antigen gene family members. 
  • Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. 
  • Chromosomal organization of rRNA operons in Bacillus subtilis. 
  • Chromosome distribution, molecular motors and the claret protein. 
  • Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. 
  • Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. 
  • Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. 
  • Clustering and heritability of insulin resistance in Chinese and Japanese hypertensive families: a Stanford-Asian Pacific Program in Hypertension and Insulin Resistance sibling study. 
  • Clusters of adjacent and similarly expressed genes across normal human tissues complicate comparative transcriptomic discovery. 
  • Combining expression and comparative evolutionary analysis. The COBRA gene family. 
  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 
  • Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. 
  • Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene. 
  • Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. 
  • Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. 
  • Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition. 
  • DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival. 
  • DNA topoisomerases. 
  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses. 
  • Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis. 
  • Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. 
  • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. 
  • Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. 
  • Diversity of ankyrins in the brain. 
  • Downregulation of RNA polymerase III transcription of the hY3 gene in vitro. 
  • Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. 
  • Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles. 
  • Emergence of the keratinocyte growth factor multigene family during the great ape radiation. 
  • Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. 
  • Evolution of alpha satellite. 
  • Evolution of genes and genomes on the Drosophila phylogeny. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. 
  • Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates. 
  • Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication. 
  • Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 
  • Experimental determination of rates of concerted evolution. 
  • Exploring motif composition of eukaryotic promoter regions. 
  • Expression of TGF-beta-related genes during mouse embryo whisker morphogenesis. 
  • Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor. 
  • Expression, purification, crystallization and preliminary X-ray analysis of human argininosuccinic acid lyase. 
  • FMRP targets distinct mRNA sequence elements to regulate protein expression. 
  • Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. 
  • From anemia to cerebellar dysfunction. A review of the ankyrin gene family. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional diversity of notch family genes in fetal lung development. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Genes encoding high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae are part of gene clusters. 
  • Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies. 
  • Genetic approaches to molecular motors. 
  • Genetic control of blood pressure and the angiotensinogen locus. 
  • Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment. 
  • Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria. 
  • Genome organization and three kinds of heritable changes: general description and stochastic factors (a review). 
  • Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. 
  • Genome-wide survey and expression analysis of the OSCA gene family in rice. 
  • Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution. 
  • Gibberellin Signaling Requires Chromatin Remodeler PICKLE to Promote Vegetative Growth and Phase Transitions. 
  • HLA-DR15 haplotype and multiple sclerosis: a HuGE review. 
  • High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. 
  • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. 
  • Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. 
  • Identification of a U5-specific sequence required for efficient polyadenylation within the human immunodeficiency virus long terminal repeat. 
  • Identification of a copper transporter family in Arabidopsis thaliana. 
  • Identification of a new family of protein phosphatase 2A regulatory subunits. 
  • Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. 
  • Identification of additional members of human G-protein-coupled receptor kinase multigene family. 
  • Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets. 
  • Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. 
  • Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases. 
  • Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. 
  • Initial sequencing and comparative analysis of the mouse genome. 
  • Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone. 
  • Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). 
  • Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14. 
  • Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. 
  • Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. 
  • Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin. 
  • Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. 
  • Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. 
  • LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT. 
  • Large-scale profiling of Rab GTPase trafficking networks: the membrome. 
  • Lineage-specific expansions provide genomic complexity among sea urchin GTPases. 
  • Location of the host attachment site for phage HPl within a cluster of Haemophilus influenzae tRNA genes. 
  • Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae. 
  • Lutheran antigens, CD44-related antigens, and Lutheran regulatory genes. 
  • Manipulating large-scale Arabidopsis microarray expression data: identifying dominant expression patterns and biological process enrichment. 
  • Meiotic recombination between dispersed repeated genes is associated with heteroduplex formation. 
  • Meiotic sister chromatid recombination. 
  • Mice with duplications and deletions at the Tme locus have altered MnSOD activity. 
  • Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • Molecular analyses of the Arabidopsis TUBBY-like protein gene family. 
  • Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. 
  • Molecular definition of breakpoints associated with human Xq isochromosomes: implications for mechanisms of formation. 
  • Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. 
  • Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates. 
  • Molecular genetics of neurodegenerative diseases. 
  • Molecular phylogeny of the kinesin family of microtubule motor proteins. 
  • Odorant receptors and desensitization proteins colocalize in mammalian sperm. 
  • Ontogeny and oncogenesis balance the transcriptional profile of renal cell cancer. 
  • Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse. 
  • Organization and molecular evolution of CENP-A--associated satellite DNA families in a basal primate genome. 
  • Organization of carboxysome genes in the thiobacilli. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. 
  • Pairing of VK and VK gene families in self-reactive antibodies. 
  • Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci. 
  • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. 
  • Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. 
  • Phylogenetic implications of the superfast myosin in extraocular muscles. 
  • Physical mapping of mouse histone gene clusters. 
  • Positive selection driving diversification in plant secondary metabolism. 
  • Predicting the clinical status of human breast cancer by using gene expression profiles. 
  • Properties of Mitotic and Meiotic Recombination in the Tandemly-Repeated CUP1 Gene Cluster in the Yeast Saccharomyces cerevisiae. 
  • Pulsed-field map of Xq13 in the region of the human X inactivation center. 
  • Rapid evolution of a pollen-specific oleosin-like gene family from Arabidopsis thaliana and closely related species. 
  • Rat sulfite oxidase antibodies cross-react with two gene family-related proteins: albumin and vitamin D-binding protein. 
  • Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment. 
  • Recombination between repeated genes in microorganisms. 
  • Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. 
  • Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. 
  • Restriction fragment length polymorphism of the apoprotein A-I-C-III gene cluster in control and stroke-prone white and black subjects: racial differences. 
  • Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors. 
  • Role of the ABL oncogene tyrosine kinase activity in human leukaemia. 
  • SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. 
  • Sakacin P non-producing Lactobacillus sakei strains contain homologues of the sakacin P gene cluster. 
  • Secreted placental alkaline phosphatase as a eukaryotic reporter gene. 
  • Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. 
  • Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster. 
  • Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome. 
  • Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice. 
  • Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. 
  • Structural organization of the human MS4A gene cluster on Chromosome 11q12. 
  • Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2. 
  • Symmetry breaking and the establishment of cell polarity in budding yeast. 
  • Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States. 
  • The 185/333 gene family is a rapidly diversifying host-defense gene cluster in the purple sea urchin Strongylocentrotus purpuratus. 
  • The Abl family kinases: mechanisms of regulation and signaling. 
  • The COBRA family of putative GPI-anchored proteins in Arabidopsis. A new fellowship in expansion. 
  • The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. 
  • The DVR gene family in embryonic development. 
  • The DXS423E gene in Xp11.21 escapes X chromosome inactivation. 
  • The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes. 
  • The LOV domain family: photoresponsive signaling modules coupled to diverse output domains. 
  • The TGF-beta-related DVR gene family in mammalian development. 
  • The TOR kinases link nutrient sensing to cell growth. 
  • The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development. 
  • The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster. 
  • The genome of a songbird. 
  • The genomics of long tandem arrays of satellite DNA in the human genome. 
  • The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer. 
  • The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. 
  • The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. 
  • The interleukin 1 receptor. 
  • The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. 
  • The myoD gene family: nodal point during specification of the muscle cell lineage. 
  • The peripheral myelin protein gene PMP-22 is contained within the Charcot-Marie-Tooth disease type 1A duplication. 
  • The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering. 
  • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. 
  • The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. 
  • Thousands of human mobile element fragments undergo strong purifying selection near developmental genes. 
  • Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family. 
  • Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity. 
  • Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Two tRNA gene clusters associated with rRNA operons rrnD and rrnE in Bacillus subtilis. 
  • Unbalanced translocation 46,XY,-15,+der(22)t(15;22)(q13;q11)pat: case report and review of the literature. 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • Unprecedented loss of ammonia assimilation capability in a urease-encoding bacterial mutualist. 
  • Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. 
  • Whole-Genome Identification, Phylogeny, and Evolution of the Cytochrome P450 Family 2 (CYP2) Subfamilies in Birds. 
  • Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases. 
  • miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
  • Mitchell-Olds, Thomas, Newman Ivey White Professor of Biology in Trinity College of Arts and Sciences, Biology
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
  • Steinbach, William J., Professor of Pediatrics, Information Initiative at Duke