Genes, Switch

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  Subject Areas on Research

  • A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation. 
  • Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. 
  • High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. 
  • Out-foxing fate; molecular switches create neuronal diversity in the retina. 
  • Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. 
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  Keywords of People

  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology