Genes, Viral

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  Subject Areas on Research

  • A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers. 
  • A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis. 
  • A highly conserved RNA folding region coincident with the Rev response element of primate immunodeficiency viruses. 
  • A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice. 
  • A research for the relationship between human papillomavirus and human uterine cervical carcinoma. I. The identification of viral genome and subgenomic sequences in biopsies of Chinese patients. 
  • A research for the relationship between human papillomavirus and human uterine cervical carcinoma. II. Molecular genetic and ultrastructural study on the transforming activity of recombinant retrovirus containing human papillomavirus type 16 subgenomic sequences. 
  • A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. 
  • A system of transposon mutagenesis for bacteriophage T4. 
  • Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. 
  • Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. 
  • Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product. 
  • Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication. 
  • Adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells. 
  • An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. 
  • Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. 
  • Ancient co-speciation of simian foamy viruses and primates. 
  • Antigenic and molecular characterization of avian influenza A(H9N2) viruses, Bangladesh. 
  • Appropriate expression of filamentous phage f1 DNA replication genes II and X requires RNase E-dependent processing and separate mRNAs. 
  • Association of 3' terminal RNA sequences with avian leukosis viruses causing a high incidence of osteopetrosis. 
  • B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus. 
  • Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli. 
  • Base mutations in the terminal noncoding regions of the genome of vesicular stomatitis virus isolated from persistent infections of L cells. 
  • Bioaerosol Sampling for Respiratory Viruses in Singapore's Mass Rapid Transit Network. 
  • Biochemistry and Molecular Biology of Flaviviruses. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • Cassettes of the f1 intergenic region. 
  • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. 
  • Characterization of the transcriptional trans activator of human foamy retrovirus. 
  • Chimeric alphavirus vaccine candidates for chikungunya. 
  • Clonal isolate of the simian sarcoma virus codes for a Gag-related 65,000-dalton protein. 
  • Cloning of the terminal loop of vaccinia virus DNA. 
  • Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine. 
  • Complete genomic nucleotide sequence of the temperate bacteriophage Aa Phi 23 of Actinobacillus actinomycetemcomitans. 
  • Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes. 
  • Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus. 
  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant: further clarifications. 
  • Convergent evolution of escape from hepaciviral antagonism in primates. 
  • Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex. 
  • Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV-I, -II, -III). 
  • Deletion of the essential gene 24 from the bacteriophage T4 genome. 
  • Development of a vaccine for the prevention of AIDS, a critical appraisal. 
  • Development of an env gp41-based heteroduplex mobility assay for rapid human immunodeficiency virus type 1 subtyping. 
  • Dicistronic polioviruses as expression vectors for foreign genes. 
  • Distinct DNA targets for trans-activation by HTLV-1 tax and adenovirus E1A. 
  • Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. 
  • Effects of the src gene product on microfilament and microtubule organization in avian and mammalian cells infected with the same temperature-sensitive mutant of Rous sarcoma virus. 
  • Effects of tumor growth on host defenses. 
  • Endogenous avian retroviruses contain deficient promoter and leader sequences. 
  • Epstein-Barr virus and chronic lymphadenomegaly in male homosexuals with acquired immunodeficiency syndrome (AIDS). 
  • Establishment of influenza A virus (H6N1) in minor poultry species in southern China. 
  • Evolutionary implications of primate endogenous retroviruses. 
  • Expression and function of the uvsW gene of bacteriophage T4. 
  • Extended ORF8 Gene Region Is Valuable in the Epidemiological Investigation of Severe Acute Respiratory Syndrome-Similar Coronavirus. 
  • Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase. 
  • From the Institute of Medicine. 
  • Functional analysis of the transcription control region located within the avian retroviral long terminal repeat. 
  • Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2. 
  • Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. 
  • Genetic recombination of poliovirus in a cell-free system. 
  • Genetic relatedness and colinearity of genomes of equine herpesvirus types 1 and 3. 
  • Genome structure and expression of a defective interfering mutant of the killer virus of yeast. 
  • Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. 
  • Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice. 
  • HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. 
  • HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. 
  • HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. 
  • HIV-associated nephropathy. 
  • Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. 
  • Human immunodeficiency virus as a prototypic complex retrovirus. 
  • Humoral immune response to the entire human immunodeficiency virus envelope glycoprotein made in insect cells. 
  • ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. 
  • Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein. 
  • Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter. 
  • Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences. 
  • Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. 
  • Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing. 
  • Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus. 
  • Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. 
  • Intervening sequence between the leader region and the nucleopcapsid gene of vesicular stomatitis virus RNA. 
  • Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. 
  • Light-inducible gene regulation with engineered zinc finger proteins. 
  • Localization and characterization of the src-gene product of Rous sarcoma virus. 
  • Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1. 
  • Lysis and lysis inhibition in bacteriophage T4: rV mutations reside in the holin t gene. 
  • Mechanism of action of regulatory proteins encoded by complex retroviruses. 
  • Messenger RNAs of a strongly-expressed late gene of cowpox virus contain 5'-terminal poly(A) sequences. 
  • Molecular analysis of avian H7 influenza viruses circulating in Eurasia in 1999-2005: detection of multiple reassortant virus genotypes. 
  • Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith Strain). 
  • Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66. 
  • Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component. 
  • Murine cytomegalovirus gene amplification and culture after submaxillary salivary gland biopsy. 
  • Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA. 
  • Mutational analysis of an inherently defective translation initiation site. 
  • Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat. 
  • Nature of the 3'-terminal sequences of the plus and minus strands of the S1 gene of reovirus serotypes 1, 2 and 3. 
  • Necrotizing lymphoid vasculitis in X-linked lymphoproliferative syndrome. 
  • Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. 
  • Novel circular DNA viruses in stool samples of wild-living chimpanzees. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Nucleotide sequence and host La protein interactions of rabies virus leader RNA. 
  • Nucleotide sequence of the envelope protein genes of a highly virulent, neurotropic strain of Newcastle disease virus. 
  • Parallel molecular evolution of deletions and nonsense mutations in bacteriophage T7. 
  • Patterns of regulation from mRNA and protein time series. 
  • Phage T3 DNA contains an exact copy of the 23 base-pair phage T7 RNA polymerase promoter sequence. 
  • Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system. 
  • Photosynthesis genes in marine viruses yield proteins during host infection. 
  • Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O. 
  • Plasmid models for bacteriophage T4 DNA replication: requirements for fork proteins. 
  • Plasmids for recombination-based screening. 
  • Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction. 
  • Polycistronic vesicular stomatitis virus RNA transcripts. 
  • Positive-selection cloning vehicle useful for overproduction of hybrid proteins. 
  • Prevalence of human papillomavirus types 16 and 18 in squamous-cell carcinoma of the penis: a retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction. 
  • Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. 
  • Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted. 
  • Properties of the genome of equine herpesvirus type 3. 
  • Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys. 
  • Purified MotA protein binds the -30 region of a bacteriophage T4 middle-mode promoter and activates transcription in vitro. 
  • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. 
  • RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus. 
  • RNA sequence and transcriptional properties of the 3' end of the Newcastle disease virus genome. 
  • Reassortment of pandemic H1N1/2009 influenza A virus in swine. 
  • Recognition and cleavage signals for mRNA processing lie within local domains of the phage f1 RNA precursors. 
  • Recombinant DNA Advisory Committee. Department of Health and Human Services. National Institutes of Health. Minutes of meeting. December 15-16, 1997. 
  • Recombination hotspots in bacteriophage T4 are dependent on replication origins. 
  • Regulatory pathways governing HIV-1 replication. 
  • Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. 
  • Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. 
  • Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus. 
  • Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products. 
  • Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. 
  • Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40. 
  • Sequence at both termini of the 10 genes of reovirus serotype 3 (strain Dearing). 
  • Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene. 
  • Sequential synthesis of small capped RNA transcripts in vitro by vesicular stomatitis virus. 
  • Site on the vesicular stomatitis virus genome specifying polyadenylation and the end of the L gene mRNA. 
  • Site-specific integration of the Haemophilus influenzae bacteriophage HP1. Identification of the points of recombinational strand exchange and the limits of the host attachment site. 
  • Site-specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants. 
  • Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase. 
  • Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Spontaneous deletions and duplications of sequences in the genome of cowpox virus. 
  • Structure and morphogenesis of type-C retroviruses. 
  • Substitution model of sequence evolution for the human immunodeficiency virus type 1 subtype B gp120 gene over the C2-V5 region. 
  • Superimmunity: characterization of a new gene in the immunity region of P1. 
  • T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. 
  • Tandemly repeated sequences are present at the ends of the DNA of raccoonpox virus. 
  • The HIV cytopathic effect: potential target for therapy? 
  • The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation. 
  • The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters. 
  • The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation. 
  • The complete sequence of a unique RNA species synthesized by a DI particle of VSV. 
  • The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. 
  • The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease. A study of 50 patients. 
  • The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice. 
  • The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005. 
  • The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene. 
  • The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. 
  • The origins of defective interfering particles of the negative-strand RNA viruses. 
  • The plus strand of reovirus gene S2 is identical with its in vitro transcript. 
  • The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation. 
  • The products of gene I and the overlapping in-frame gene XI are required for filamentous phage assembly. 
  • The role of avian retroviral LTRs in the regulation of gene expression and viral replication. 
  • The roles of the bacteriophage T4 r genes in lysis inhibition and fine-structure genetics: a new perspective. 
  • The second-largest subunit of the poxvirus RNA polymerase is similar to the corresponding subunits of procaryotic and eucaryotic RNA polymerases. 
  • The self-cleaving domain from the genomic RNA of hepatitis delta virus: sequence requirements and the effects of denaturant. 
  • The sequence at the termini of four genes of the three reovirus serotypes. 
  • The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively. 
  • Toward a vaccine against AIDS: rationale and current progress. 
  • Transactivation by the adenovirus E1A gene. 
  • Transcription of a poxvirus early gene is regulated both by a short promoter element and by a transcriptional termination signal controlling transcriptional interference. 
  • Transcription of orthopoxvirus telomeres at late times during infection. 
  • Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage. 
  • Translation at higher than an optimal level interferes with coupling at an intercistronic junction. 
  • Translation limits synthesis of an assembly-initiating coat protein of filamentous phage IKe. 
  • Translation of phage f1 gene VII occurs from an inherently defective initiation site made functional by coupling. 
  • Translational control of phage f1 gene expression by differential activities of the gene V, VII, IX and VIII initiation sites. 
  • Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. 
  • Utilization of cellular transcription factors for adenovirus-induced transcription. 
  • UvsW protein regulates bacteriophage T4 origin-dependent replication by unwinding R-loops. 
  • Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. 
  • Vaccinia virus directs the synthesis of early mRNAs containing 5' poly(A) sequences. 
  • Variation in the loss of O6-methylguanine-DNA methyltransferase during immortalization of human fibroblasts. 
  • Vesicular stomatitis virus defective interfering particle containing a muted internal leader RNA gene. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Viral sequences determining the oncogenicity of avian leukosis viruses. 
  • Visna virus encodes a post-transcriptional regulator of viral structural gene expression. 
  • [Cloning and sequence analysis of a partial gene of Trichomonas vaginalis dsRNA virus]. 
  • [Molecular epidemiology of measles virus]. 
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  Keywords of People

  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology