Genes, Viral

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  Subject Areas on Research

  • A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers. 
  • A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis. 
  • A highly conserved RNA folding region coincident with the Rev response element of primate immunodeficiency viruses. 
  • A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice. 
  • A system of transposon mutagenesis for bacteriophage T4. 
  • Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. 
  • Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. 
  • Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication. 
  • Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. 
  • Ancient co-speciation of simian foamy viruses and primates. 
  • Appropriate expression of filamentous phage f1 DNA replication genes II and X requires RNase E-dependent processing and separate mRNAs. 
  • Association of 3' terminal RNA sequences with avian leukosis viruses causing a high incidence of osteopetrosis. 
  • B-MuX: a unique murine C-type virus containing the "env" gene of xenotropic viruses and the "gag" gene of the ecotropic virus. 
  • Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli. 
  • Base mutations in the terminal noncoding regions of the genome of vesicular stomatitis virus isolated from persistent infections of L cells. 
  • Biochemistry and Molecular Biology of Flaviviruses. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • Cassettes of the f1 intergenic region. 
  • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. 
  • Characterization of the transcriptional trans activator of human foamy retrovirus. 
  • Chimeric alphavirus vaccine candidates for chikungunya. 
  • Clonal isolate of the simian sarcoma virus codes for a Gag-related 65,000-dalton protein. 
  • Cloning of the terminal loop of vaccinia virus DNA. 
  • Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine. 
  • Complete genomic nucleotide sequence of the temperate bacteriophage Aa Phi 23 of Actinobacillus actinomycetemcomitans. 
  • Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes. 
  • Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus. 
  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant: further clarifications. 
  • Convergent evolution of escape from hepaciviral antagonism in primates. 
  • Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex. 
  • Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV-I, -II, -III). 
  • Deletion of the essential gene 24 from the bacteriophage T4 genome. 
  • Development of a vaccine for the prevention of AIDS, a critical appraisal. 
  • Development of an env gp41-based heteroduplex mobility assay for rapid human immunodeficiency virus type 1 subtyping. 
  • Dicistronic polioviruses as expression vectors for foreign genes. 
  • Distinct DNA targets for trans-activation by HTLV-1 tax and adenovirus E1A. 
  • Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape. 
  • Effects of the src gene product on microfilament and microtubule organization in avian and mammalian cells infected with the same temperature-sensitive mutant of Rous sarcoma virus. 
  • Effects of tumor growth on host defenses. 
  • Endogenous avian retroviruses contain deficient promoter and leader sequences. 
  • Expression and function of the uvsW gene of bacteriophage T4. 
  • Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase. 
  • From the Institute of Medicine. 
  • Functional analysis of the transcription control region located within the avian retroviral long terminal repeat. 
  • Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2. 
  • Genetic recombination of poliovirus in a cell-free system. 
  • Genome structure and expression of a defective interfering mutant of the killer virus of yeast. 
  • Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. 
  • Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice. 
  • HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. 
  • HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. 
  • HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. 
  • Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. 
  • Human immunodeficiency virus as a prototypic complex retrovirus. 
  • Humoral immune response to the entire human immunodeficiency virus envelope glycoprotein made in insect cells. 
  • ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. 
  • Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein. 
  • Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter. 
  • Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences. 
  • Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. 
  • Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus. 
  • Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. 
  • Intervening sequence between the leader region and the nucleopcapsid gene of vesicular stomatitis virus RNA. 
  • Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. 
  • Light-inducible gene regulation with engineered zinc finger proteins. 
  • Localization and characterization of the src-gene product of Rous sarcoma virus. 
  • Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1. 
  • Lysis and lysis inhibition in bacteriophage T4: rV mutations reside in the holin t gene. 
  • Mechanism of action of regulatory proteins encoded by complex retroviruses. 
  • Messenger RNAs of a strongly-expressed late gene of cowpox virus contain 5'-terminal poly(A) sequences. 
  • Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith Strain). 
  • Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66. 
  • Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component. 
  • Murine cytomegalovirus gene amplification and culture after submaxillary salivary gland biopsy. 
  • Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA. 
  • Mutational analysis of an inherently defective translation initiation site. 
  • Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat. 
  • Nature of the 3'-terminal sequences of the plus and minus strands of the S1 gene of reovirus serotypes 1, 2 and 3. 
  • Necrotizing lymphoid vasculitis in X-linked lymphoproliferative syndrome. 
  • Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. 
  • Novel circular DNA viruses in stool samples of wild-living chimpanzees. 
  • Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. 
  • Nucleotide sequence and host La protein interactions of rabies virus leader RNA. 
  • Nucleotide sequence of the envelope protein genes of a highly virulent, neurotropic strain of Newcastle disease virus. 
  • Parallel molecular evolution of deletions and nonsense mutations in bacteriophage T7. 
  • Patterns of regulation from mRNA and protein time series. 
  • Phage T3 DNA contains an exact copy of the 23 base-pair phage T7 RNA polymerase promoter sequence. 
  • Photosynthesis genes in marine viruses yield proteins during host infection. 
  • Phylogenetic analysis of protease and transmembrane region of HIV type 1 group O. 
  • Plasmid models for bacteriophage T4 DNA replication: requirements for fork proteins. 
  • Plasmids for recombination-based screening. 
  • Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction. 
  • Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction. 
  • Polycistronic vesicular stomatitis virus RNA transcripts. 
  • Positive-selection cloning vehicle useful for overproduction of hybrid proteins. 
  • Prevalence of human papillomavirus types 16 and 18 in squamous-cell carcinoma of the penis: a retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction. 
  • Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. 
  • Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted. 
  • Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys. 
  • Purified MotA protein binds the -30 region of a bacteriophage T4 middle-mode promoter and activates transcription in vitro. 
  • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. 
  • RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus. 
  • RNA sequence and transcriptional properties of the 3' end of the Newcastle disease virus genome. 
  • Recognition and cleavage signals for mRNA processing lie within local domains of the phage f1 RNA precursors. 
  • Recombinant DNA Advisory Committee. Department of Health and Human Services. National Institutes of Health. Minutes of meeting. December 15-16, 1997. 
  • Recombination hotspots in bacteriophage T4 are dependent on replication origins. 
  • Regulatory pathways governing HIV-1 replication. 
  • Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. 
  • Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. 
  • Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus. 
  • Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products. 
  • Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. 
  • Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40. 
  • Sequence at both termini of the 10 genes of reovirus serotype 3 (strain Dearing). 
  • Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene. 
  • Sequential synthesis of small capped RNA transcripts in vitro by vesicular stomatitis virus. 
  • Site on the vesicular stomatitis virus genome specifying polyadenylation and the end of the L gene mRNA. 
  • Site-specific integration of the Haemophilus influenzae bacteriophage HP1. Identification of the points of recombinational strand exchange and the limits of the host attachment site. 
  • Site-specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants. 
  • Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase. 
  • Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Spontaneous deletions and duplications of sequences in the genome of cowpox virus. 
  • Structure and morphogenesis of type-C retroviruses. 
  • Substitution model of sequence evolution for the human immunodeficiency virus type 1 subtype B gp120 gene over the C2-V5 region. 
  • Superimmunity: characterization of a new gene in the immunity region of P1. 
  • T7-induced DNA polymerase. Characterization of associated exonuclease activities and resolution into biologically active subunits. 
  • Tandemly repeated sequences are present at the ends of the DNA of raccoonpox virus. 
  • The HIV cytopathic effect: potential target for therapy? 
  • The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters. 
  • The complete sequence of a unique RNA species synthesized by a DI particle of VSV. 
  • The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. 
  • The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice. 
  • The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene. 
  • The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. 
  • The origins of defective interfering particles of the negative-strand RNA viruses. 
  • The plus strand of reovirus gene S2 is identical with its in vitro transcript. 
  • The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation. 
  • The products of gene I and the overlapping in-frame gene XI are required for filamentous phage assembly. 
  • The role of avian retroviral LTRs in the regulation of gene expression and viral replication. 
  • The roles of the bacteriophage T4 r genes in lysis inhibition and fine-structure genetics: a new perspective. 
  • The second-largest subunit of the poxvirus RNA polymerase is similar to the corresponding subunits of procaryotic and eucaryotic RNA polymerases. 
  • The self-cleaving domain from the genomic RNA of hepatitis delta virus: sequence requirements and the effects of denaturant. 
  • The sequence at the termini of four genes of the three reovirus serotypes. 
  • The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively. 
  • Toward a vaccine against AIDS: rationale and current progress. 
  • Transcription of a poxvirus early gene is regulated both by a short promoter element and by a transcriptional termination signal controlling transcriptional interference. 
  • Transcription of orthopoxvirus telomeres at late times during infection. 
  • Translation at higher than an optimal level interferes with coupling at an intercistronic junction. 
  • Translation limits synthesis of an assembly-initiating coat protein of filamentous phage IKe. 
  • Translation of phage f1 gene VII occurs from an inherently defective initiation site made functional by coupling. 
  • Translational control of phage f1 gene expression by differential activities of the gene V, VII, IX and VIII initiation sites. 
  • Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. 
  • UvsW protein regulates bacteriophage T4 origin-dependent replication by unwinding R-loops. 
  • Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. 
  • Vaccinia virus directs the synthesis of early mRNAs containing 5' poly(A) sequences. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Viral sequences determining the oncogenicity of avian leukosis viruses. 
  • Visna virus encodes a post-transcriptional regulator of viral structural gene expression. 
  • [Molecular epidemiology of measles virus]. 
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  Keywords of People

  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Yang, Yiping, Professor of Medicine, Immunology