Genetic Complementation Test
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Subject Areas on Research
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A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
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A critical role of STAYGREEN/Mendel's I locus in controlling disease symptom development during Pseudomonas syringae pv tomato infection of Arabidopsis.
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A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants.
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A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation.
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A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice.
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A new dominant selectable marker for use in Cryptococcus neoformans.
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A new face of the Rhesus antigen.
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A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
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A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells.
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A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.
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A yeast expression system for human galactose-1-phosphate uridylyltransferase.
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Adenine auxotrophic mutants of Aspergillus oryzae: development of a novel transformation system with triple auxotrophic hosts.
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Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase.
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An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production.
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Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster.
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Analysis of SCARECROW expression using a rapid system for assessing transgene expression in Arabidopsis roots.
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Analysis of meiotic recombination events near a recombination hotspot in the yeast Saccharomyces cerevisiae.
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Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis.
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Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest.
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Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes.
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Bcl-2 accelerates multistep prostate carcinogenesis in vivo.
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CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.
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CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
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CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.
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Calcineurin governs thermotolerance and virulence of Cryptococcus gattii.
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Calcium binding is required for calmodulin function in Aspergillus nidulans.
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Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.
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Characterization of cis-regulatory regions responsible for developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana.
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Characterization of the Vibrio cholerae VolA surface-exposed lipoprotein lysophospholipase.
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Characterization of vps33+, a gene required for vacuolar biogenesis and protein sorting in Schizosaccharomyces pombe.
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Chemico-genetic discovery of astrocytic control of inhibition in vivo.
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Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes.
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Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways.
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Cloned Erwinia chrysanthemi out genes enable Escherichia coli to selectively secrete a diverse family of heterologous proteins to its milieu.
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Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate.
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Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae.
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Complementation of npf mutations in diploid amoebae of Physarum polycephalum: the basis for a general method of complementation analysis at the amoebal stage.
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Conservation and diversification of SCARECROW in maize.
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Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae.
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Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo.
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Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host.
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Derivation of a biologically contained replication system for human immunodeficiency virus type 1.
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Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack.
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Dominant selection system for use in Cryptococcus neoformans.
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Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia.
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Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.
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Expression and function of the uvsW gene of bacteriophage T4.
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Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells.
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Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans.
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Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi.
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FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria.
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Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase.
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Fragments of ATM which have dominant-negative or complementing activity.
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FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli.
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Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. II. In vivo studies.
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Functional analysis of the transcription control region located within the avian retroviral long terminal repeat.
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Functional complementation between FADD and RIP1 in embryos and lymphocytes.
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Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p.
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Functional equivalence of an evolutionarily conserved RNA binding module.
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Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae.
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Functional studies of the carboxy-terminal repeat domain of Drosophila RNA polymerase II in vivo.
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Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA.
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Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.
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Genetic and biochemical characterization of mutants at an RNA polymerase II locus in D. melanogaster.
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Genetic changes associated with floral adaptation restrict future evolutionary potential.
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Genetic changes contributing to the parallel evolution of red floral pigmentation among Ipomoea species.
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Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11.
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Human immunodeficiency virus type 1 rev protein as a negative trans-regulator.
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Identification and characterization of rns4/vps32 mutation in the RNase T1 expression-sensitive strain of Saccharomyces cerevisiae: Evidence for altered ambient response resulting in transportation of the secretory protein to vacuoles.
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Identification of a negative regulatory function for steroid receptors.
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Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions.
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Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase.
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Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi.
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In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase.
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In vivo characterization of Escherichia coli ftsZ mutants: effects on Z-ring structure and function.
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Indole-3-acetic acid biosynthesis is deficient in Gluconacetobacter diazotrophicus strains with mutations in cytochrome c biogenesis genes.
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Inositol diphosphate signaling regulates telomere length.
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Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69.
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Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence.
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Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals.
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Involvement of chlA, E, M, and N loci in Escherichia coli molybdopterin biosynthesis.
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Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae.
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Isolation and characterization of effector-loop mutants of CDC42 in yeast.
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Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.
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Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae.
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Life with too much polyprenol: polyprenol reductase deficiency.
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Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans.
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Major-gene resistance to the rust pathogen Coleosporium ipomoeae is common in natural populations of Ipomoea purpurea.
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Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.
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Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency.
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Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans.
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Methyl-directed repair of DNA base-pair mismatches in vitro.
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Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function.
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Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs.
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Partial reconstitution of the RNAi response in human cells using Drosophila gene products.
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Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.
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Requirement for the vasa RNA helicase in gurken mRNA localization.
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Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
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Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans.
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SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.
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Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis.
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Site-specific mutations of FtsZ--effects on GTPase and in vitro assembly.
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Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability.
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Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling.
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Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.
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Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
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The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis.
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The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats.
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The GA2 locus of Arabidopsis thaliana encodes ent-kaurene synthase of gibberellin biosynthesis.
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The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
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The Pseudomonas syringae Type III Effector HopG1 Induces Actin Remodeling to Promote Symptom Development and Susceptibility during Infection.
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The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.
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The beta sliding clamp binds to multiple sites within MutL and MutS.
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The epsilon subunit of DNA polymerase III Is involved in the nalidixic acid-induced SOS response in Escherichia coli.
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The genetic basis of a flower color polymorphism in the common morning glory (Ipomoea purpurea).
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The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells.
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The molecular basis of class II MHC allelic control of T cell responses.
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The products of gene I and the overlapping in-frame gene XI are required for filamentous phage assembly.
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The regulation of DNA topoisomerase II by casein kinase II.
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The role of the supernumerary subunit of Rhodobacter sphaeroides cytochrome bc1 complex.
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Two new loci, PLEIADE and HYADE, implicate organ-specific regulation of cytokinesis in Arabidopsis.
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Two proteins encoded at the chlA locus constitute the converting factor of Escherichia coli chlA1.
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Using viral species specificity to define a critical protein/RNA interaction surface.
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Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin.
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crl mutants of Saccharomyces cerevisiae resemble both mutants affecting general control of amino acid biosynthesis and omnipotent translational suppressor mutants.
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