Germ Cells

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  Subject Areas on Research

  • A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A guide for performing germ cell mutagenesis assays using Drosophila melanogaster. 
  • A mitotic recombination system for mouse chromosome 17. 
  • A new method for the cytological analysis of autoantibody specificities using whole-mount, surface-spread meiotic nuclei. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 
  • A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†. 
  • A zebrafish model of germ cell aneuploidy. 
  • ASO Author Reflections: The Pressing Need for Germline Genetic Testing. 
  • Academies' action plan for germline editing. 
  • Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest. 
  • Association between germline variants and somatic mutations in colorectal cancer. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. 
  • Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Cell fate commitment during mammalian sex determination. 
  • Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. 
  • Collective oscillations of coupled cell cycles. 
  • Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers. 
  • Coupled oscillators coordinate collective germline growth. 
  • DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence. 
  • DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. 
  • De novo MECP2 duplication derived from paternal germ line result in dysmorphism and developmental delay. 
  • Development of germ cells in the mouse. 
  • Developmental biology: decisions, decisions! 
  • Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. 
  • Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. 
  • E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. 
  • Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle. 
  • Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. 
  • Engineering musculoskeletal tissues with human embryonic germ cell derivatives. 
  • Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo. 
  • Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. 
  • Exploiting DNA damage without repair: The activity of platinum chemotherapy in BRCA-mutated prostate cancers. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Four-dimensional analysis of vascularization during primary development of an organ, the gonad. 
  • Gastrulation in the sea urchin. 
  • Genetic dissection of late-life fertility in Caenorhabditis elegans. 
  • Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta). 
  • Germ cells are not required to establish the female pathway in mouse fetal gonads. 
  • Germline AGO2 mutations impair RNA interference and human neurological development. 
  • Germline Variants in DNA Damage Repair Genes and HOXB13 Among Black Patients With Early-Onset Prostate Cancer. 
  • Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution. 
  • Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. 
  • Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita. 
  • Germline transcription: a key regulator of accessibility and recombination. 
  • Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia. 
  • HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Identification and characterization of primordial germ cells in a vocal learning Neoaves species, the zebra finch. 
  • Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells. 
  • Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. 
  • Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. 
  • Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. 
  • Loss of LDAH associated with prostate cancer and hearing loss. 
  • Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. 
  • Molecular dosimetry of chemical mutagens. Determination of molecular dose to the germ line. 
  • Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. 
  • Mouse germ cell clusters form by aggregation as well as clonal divisions. 
  • Mouse primordial germ cells. Isolation and in vitro culture. 
  • Mouse primordial germ cells: isolation and in vitro culture. 
  • Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells. 
  • NIEHS/EPA Workshops. Cellular migration. 
  • New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. 
  • Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure 
  • Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. 
  • Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. 
  • Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice. 
  • Pathogenic Germline Variants in 10,389 Adult Cancers. 
  • Phenotypic spectrum and transcriptomic profile associated with germline variants in TRAF7. 
  • Pin1 regulates the timing of mammalian primordial germ cell proliferation. 
  • Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC. 
  • Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold. 
  • Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing . 
  • Recommendations for reducing the risk of viral transmission during fertility treatment with the use of autologous gametes: a committee opinion. 
  • Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. 
  • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. 
  • Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans. 
  • Sex in fungi. 
  • Signaling at the crossroads of gonad development. 
  • Size scaling in collective cell growth. 
  • Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche. 
  • Stem cells and their niches: integrated units that maintain Drosophila tissues. 
  • Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. 
  • Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. 
  • Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates. 
  • The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. 
  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. 
  • The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. 
  • The relation of germ line mosaicism to somatic mosaicism in Drosophila. 
  • To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest. 
  • Vaccination induces HIV broadly neutralizing antibody precursors in humans. 
  • Variable region sequence analysis of anti-DNA antibodies: evidence for a family of closely related germ-line VH genes encoding lupus autoantibodies. 
  • Whole-body magnetic resonance imaging as surveillance for subsequent malignancies in preadolescent, adolescent, and young adult survivors of germline retinoblastoma: An update. 
  • ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. 
  • Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. 
  • ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. 
  • β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila. 
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  Keywords of People

  • Baugh, L. Ryan, Associate Professor of Biology, Biology
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology