Germ Cells

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  Subject Areas on Research

  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A mitotic recombination system for mouse chromosome 17. 
  • A new Drosophila gene wh (wuho) with WD40 repeats is essential for spermatogenesis and has maximal expression in hub cells. 
  • A new method for the cytological analysis of autoantibody specificities using whole-mount, surface-spread meiotic nuclei. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 
  • A zebrafish model of germ cell aneuploidy. 
  • Academies' action plan for germline editing. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Cell fate commitment during mammalian sex determination. 
  • Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. 
  • Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. 
  • DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. 
  • De novo MECP2 duplication derived from paternal germ line result in dysmorphism and developmental delay. 
  • Degree of methylation of transgenes is dependent on gamete of origin. 
  • Development of germ cells in the mouse. 
  • Developmental biology: decisions, decisions! 
  • Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. 
  • Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. 
  • E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. 
  • Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. 
  • Engineering musculoskeletal tissues with human embryonic germ cell derivatives. 
  • Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. 
  • Exploiting DNA damage without repair: The activity of platinum chemotherapy in BRCA-mutated prostate cancers. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • Fetal gene transfer by transuterine injection of cationic liposome-DNA complexes. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Four-dimensional analysis of vascularization during primary development of an organ, the gonad. 
  • Genetic dissection of late-life fertility in Caenorhabditis elegans. 
  • Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta). 
  • Germ cells are not required to establish the female pathway in mouse fetal gonads. 
  • Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution. 
  • Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. 
  • Germline transcription: a key regulator of accessibility and recombination. 
  • HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. 
  • Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. 
  • Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. 
  • Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. 
  • Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. 
  • Loss of LDAH associated with prostate cancer and hearing loss. 
  • Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. 
  • Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. 
  • Mouse germ cell clusters form by aggregation as well as clonal divisions. 
  • Mouse primordial germ cells. Isolation and in vitro culture. 
  • Mouse primordial germ cells: isolation and in vitro culture. 
  • Musculoskeletal differentiation of cells derived from human embryonic germ cells. 
  • NIEHS/EPA Workshops. Cellular migration. 
  • Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. 
  • Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. 
  • Optogenetic dissection of mitotic spindle positioning in vivo. 
  • Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice. 
  • Pathogenic Germline Variants in 10,389 Adult Cancers. 
  • Pin1 regulates the timing of mammalian primordial germ cell proliferation. 
  • Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing. 
  • Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold. 
  • Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. 
  • Remodelling germ cells by intercellular cannibalism. 
  • Sex in fungi. 
  • Signaling at the crossroads of gonad development. 
  • Stem cells and their niches: integrated units that maintain Drosophila tissues. 
  • Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. 
  • Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. 
  • Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. 
  • The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. 
  • To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest. 
  • Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. 
  • Variable region sequence analysis of anti-DNA antibodies: evidence for a family of closely related germ-line VH genes encoding lupus autoantibodies. 
  • Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. 
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  Keywords of People

  • Baugh, L. Ryan, Associate Professor of Biology, Biology
  • Katz, David F., Nello L. Teer, Jr. Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology