Gliosis

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  Subject Areas on Research

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction. 
  • Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH. 
  • Assessing activation states in microglia. 
  • Association between cell-mediated demyelination and astrocyte stimulation. 
  • Astrocytic activation as evidence for brain damage. 
  • COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. 
  • CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. 
  • Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy. 
  • Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis. 
  • Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes. 
  • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. 
  • Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. 
  • Dorsal root ganglia neurite extension is inhibited by mechanical and chondroitin sulfate-rich interfaces. 
  • Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. 
  • Fast spin-echo MR in hippocampal sclerosis: correlation with pathology and surgery. 
  • Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. 
  • Idiopathic intracranial hypertension: a case report with optic nerve histopathology. 
  • Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion 
  • Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. 
  • Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery. 
  • Losing neurons: selective vulnerability and mesial temporal sclerosis. 
  • MR imaging in patients with temporal lobe seizures: correlation of results with pathologic findings. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Nanoscale laminin coating modulates cortical scarring response around implanted silicon microelectrode arrays. 
  • Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. 
  • Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. 
  • Potassium clearance and reactive gliosis in the alumina gel lesion. 
  • Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain. 
  • Radial optic neurotomy in the porcine eye without retinal vein occlusion. 
  • Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice. 
  • Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. 
  • Simian virus 40-induced retinopathy in the rat. 
  • So-called massive retinal gliosis: A critical review and reappraisal. 
  • Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires. 
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. 
  • The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features. 
  • The association of retinitis pigmentosa with preretinal macular gliosis. 
  • The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury. 
  • Toward a self-deploying shape memory polymer neuronal electrode. 
  • Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. 
  • Value of sonography in the diagnosis of intracranial hemorrhage and periventricular leukomalacia: a postmortem study of 35 cases. 
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  Keywords of People

  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society