Globins

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  Subject Areas on Research

  • A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood. 
  • A compensatory base change in human U2 snRNA can suppress a branch site mutation. 
  • A human gamma globin gene variant binds SP1. 
  • A naturally occurring gamma globin gene mutation enhances SP1 binding activity. 
  • A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype. 
  • A potential biomarker in the cord blood of preterm infants who develop retinopathy of prematurity. 
  • Altered ligand rebinding kinetics due to distal-side effects in hemoglobin chico (Lysbeta66(E10) --> thr). 
  • Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. 
  • Beta-thalassemia resulting from a single nucleotide substitution in an acceptor splice site. 
  • Binding of HMG-I(Y) elicits structural changes in a silencer of the human beta-globin gene. 
  • Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. 
  • Correction of sickle cell disease in transgenic mouse models by gene therapy. 
  • Differentiation domains of the erythropoietin receptor. 
  • Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. 
  • Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes. 
  • Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA. 
  • Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. 
  • Erythroid transcription factor NF-E2 coordinates hemoglobin synthesis. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells. 
  • Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. 
  • Evidence that structural variants within the human delta-globin protein may reflect genetic interactions between the delta- and beta-globin genes. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes. 
  • HNF-3 beta as a regulator of floor plate development. 
  • Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? 
  • Hemoglobin induction in mouse macrophages. 
  • Hemoglobin sickle-Lepore: report of two siblings and review of the literature. 
  • High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. 
  • Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. 
  • Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. 
  • Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc. 
  • Identification of five hemoglobins in B6C3F1 mice by mass spectrometry and sequence analysis. 
  • In vitro coupled transcription splicing. 
  • In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction. 
  • In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Integration of foreign genes into the mammalian germ line: genetic engineering enters a new era. 
  • Kaposi's-sarcoma-associated herpesvirus is detected in peripheral blood mononuclear cells of HIV-infected homosexuals more often than in heterosexuals. 
  • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 
  • Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region. 
  • Modeling and superposition of multiple protein structures using affine transformations: analysis of the globins. 
  • Molecular biology. Enhancers, chromosome position effects, and transgenic mice. 
  • Molecular cloning and sequence analysis of a cDNA coding for the mouse alpha-like embryonic globin chain x. 
  • Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. 
  • Nonblack patients with sickle cell disease have African beta S gene cluster haplotypes. 
  • Overproduction of alpha chains provides a proton-insensitive component to the bluefish hemoglobin system. 
  • Processing of nuclear heterogeneous RNA: recent developments. 
  • Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. 
  • Regression analysis of multiple protein structures. 
  • Relationship of clinical severity to packed cell rheology in sickle cell anemia. 
  • Retargeting mobile group II introns to repair mutant genes. 
  • Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors. 
  • Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. 
  • Simultaneous Bayesian estimation of alignment and phylogeny under a joint model of protein sequence and structure. 
  • Spliceosome-mediated RNA trans-splicing as a tool for gene therapy. 
  • Spontaneous delta- to beta-globin switching in K562 human leukemia cells. 
  • Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. 
  • Tarsius delta- and beta-globin genes: conversions, evolution, and systematic implications. 
  • The NF-E2 transcription factor. 
  • The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. 
  • The conserved dinucleotide AG of the 3' splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors. 
  • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. 
  • Two mouse early embryonic beta-globin gene sequences. Evolution of the nonadult beta-globins. 
  • UACUAAC is the preferred branch site for mammalian mRNA splicing 
  • Using 5'-PTMs to repair mutant beta-globin transcripts. 
  • Variations in globin synthesis in delta-beta-thalassaemia. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology