Glucose Tolerance Test

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  Subject Areas on Research

  • 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial. 
  • A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the Diagnosis of Diabetes Using Glycated Hemoglobin Levels. 
  • A controlled high-fat diet induces an obese syndrome in rats. 
  • A model of glucose-insulin homeostasis in man that incorporates the heterogeneous fast pool theory of pancreatic insulin release. 
  • A new look at screening and diagnosing diabetes mellitus. 
  • A novel risk classification paradigm for patients with impaired glucose tolerance and high cardiovascular risk. 
  • Abnormal Fasting Glucose Increases Risk of Unrecognized Myocardial Infarctions in an Elderly Cohort. 
  • Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion. 
  • Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. 
  • Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. 
  • Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis. 
  • Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease. 
  • Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. 
  • Association of high pulse pressure with proteinuria in subjects with diabetes, prediabetes, or normal glucose tolerance in a large Japanese general population sample. 
  • Associations of gestational cardiovascular health with pregnancy outcomes: the Hyperglycemia and Adverse Pregnancy Outcome study. 
  • Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults. 
  • Branched-Chain Amino Acids and Insulin Metabolism: The Insulin Resistance Atherosclerosis Study (IRAS). 
  • Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents. 
  • Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. 
  • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. 
  • Carnitine revisited: potential use as adjunctive treatment in diabetes. 
  • Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. 
  • Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. 
  • Change in levels of physical activity after diagnosis of type 2 diabetes: an observational analysis from the NAVIGATOR study. 
  • Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study. 
  • Comparison of diabetes mellitus and insulin resistance screening methods for women with polycystic ovary syndrome. 
  • Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries. 
  • Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. 
  • Diagnostic criteria for the diagnosis of type 2 diabetes: Discordance of multiple measures. 
  • Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation. 
  • Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test. 
  • Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. 
  • Effects of Roux-en-Y gastric bypass or diabetes support and education on insulin sensitivity and insulin secretion in morbidly obese patients with type 2 diabetes. 
  • Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. 
  • Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study. 
  • Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331,288 participants. 
  • Effects of exercise and weight loss on cardiac risk factors associated with syndrome X. 
  • Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial. 
  • Effects of exercise training intensity on pancreatic beta-cell function. 
  • Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial. 
  • Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects. 
  • Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. 
  • Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons. 
  • Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis. 
  • Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. 
  • Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I. 
  • Ethnic differences translate to inadequacy of high-risk screening for gestational diabetes mellitus in an Asian population: a cohort study. 
  • Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. 
  • Failure of genetically selected miniature swine to model NIDDM. 
  • Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. 
  • Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. 
  • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. 
  • GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. 
  • Gastric emptying, glucose tolerance, and insulin response after duodenojejunostomy. 
  • Genetic variation in aldosterone synthase predicts plasma glucose levels. 
  • Gestational retinal microvasculature and the risk of 5 year postpartum abnormal glucose metabolism. 
  • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. 
  • Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. 
  • Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. 
  • Glucose challenge test screening for prediabetes and undiagnosed diabetes. 
  • Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes. 
  • Glycemic response to stress is altered in euglycemic Pima Indians. 
  • HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use. 
  • Hemoglobin A1c and postpartum abnormal glucose tolerance among women with gestational diabetes mellitus. 
  • Hepatic HKDC1 Expression Contributes to Liver Metabolism. 
  • Higher high-density lipoprotein cholesterol in African-American women with polycystic ovary syndrome compared with Caucasian counterparts. 
  • Hostility and fasting glucose in African American women. 
  • Hostility and minimal model of glucose kinetics in African American women. 
  • Hypothalamic CaMKK2 contributes to the regulation of energy balance. 
  • Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. 
  • Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. 
  • Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. 
  • Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging. 
  • Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes. 
  • Improved insulin sensitivity after gastric bypass correlates with decreased total body fat, but not with changes in free fatty acids. 
  • Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. 
  • Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. 
  • Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents. 
  • Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. 
  • Is peripheral neuropathy associated with retinopathy and albuminuria in individuals with impaired glucose metabolism? The 1999-2000 AusDiab. 
  • Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. 
  • Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance. 
  • Longitudinal association of glucose metabolism with retinopathy: results from the Australian Diabetes Obesity and Lifestyle (AusDiab) study. 
  • Maternal BMI and Glycemia Impact the Fetal Metabolome. 
  • Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries. 
  • Mechanism of postgastrectomy hypoglycemia. 
  • Medrogestone: a prospective study in the pharmaceutical management of benign prostatic hyperplasia. 
  • Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth. 
  • Metabolomic and genetic associations with insulin resistance in pregnancy. 
  • Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. 
  • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. 
  • Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens. 
  • Mouse handling limits the impact of stress on metabolic endpoints. 
  • Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 
  • Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion. 
  • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. 
  • Obesity alters the collagen organization and mechanical properties of murine cartilage. 
  • Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice. 
  • Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. 
  • Physical activity as a determinant of fasting and 2-h post-challenge glucose: a prospective cohort analysis of the NAVIGATOR trial. 
  • Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. 
  • Plasma epinephrine predicts fasting glucose in centrally obese African-American women. 
  • Postpartum diabetes screening in women with a history of gestational diabetes. 
  • Predicting gestational diabetes: choosing the optimal early serum marker. 
  • Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. 
  • Prevalence of diabetes and impaired fasting glucose in Poland--the NATPOL 2011 Study. 
  • Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose. 
  • Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. 
  • Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. 
  • Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia. 
  • Relations of insulin sensitivity to longitudinal blood pressure tracking: variations with baseline age, body mass index, and blood pressure. 
  • Relationships of plasma C-peptide and gender to the urinary excretion of inositols in older people. 
  • Relaxation training for NIDDM. Predicting who may benefit. 
  • Relaxation-induced improvement in glucose tolerance is associated with decreased plasma cortisol. 
  • Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1. 
  • Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab). 
  • Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study. 
  • Screening adults for pre-diabetes and diabetes may be cost-saving. 
  • Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet. 
  • Sleeve gastrectomy rapidly enhances islet function independently of body weight. 
  • Strict glycemic targets need not be so strict: a more permissive glycemic range for critically ill children. 
  • TCF1 links GIPR signaling to the control of beta cell function and survival. 
  • Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups. 
  • Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. 
  • Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance. 
  • Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control. 
  • The Enigma of Glucose and Lipid Metabolism. 
  • The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. 
  • The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. 
  • The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes. 
  • The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats. 
  • The effect of the PREMIER interventions on insulin sensitivity. 
  • The effects of aerobic, resistance, and combination training on insulin sensitivity and secretion in overweight adults from STRRIDE AT/RT: a randomized trial. 
  • The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. 
  • The effects of relaxations on glucose tolerance in non-insulin-dependent diabetes. 
  • The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact? 
  • The role of the transcription factor ETV5 in insulin exocytosis. 
  • Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice. 
  • Triglyceride Induced Metabolic Inflammation: Potential Connection of Insulin Resistance and Recurrent Pregnancy Loss. 
  • Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. 
  • Updated risk factors should be used to predict development of diabetes. 
  • Variation in Postpartum Glycemic Screening in Women With a History of Gestational Diabetes Mellitus. 
  • Visceral fat and adiponectin: associations with insulin resistance are tissue-specific in women. 
  • Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. 
  • β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes. 
  • β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation. 
  • β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus. 
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  Keywords of People

  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Georgiades, Anastasia, Research Scientist, Psychology & Neuroscience
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics