Glutamates

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  Subject Areas on Research

  • A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Fragile X Syndrome. 
  • A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A multimodal cell census and atlas of the mammalian primary motor cortex. 
  • A phase II study of biweekly pemetrexed and gemcitabine in patients with metastatic breast cancer. 
  • A temperature jump study of aspartate aminotransferase. a reinvestigation. 
  • Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction. 
  • Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. 
  • Alpha-receptor mediated inhibition of A2 noradrenergic neurons. 
  • Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents. 
  • Association of obesity and inflammatory marker levels on treatment outcome: results from a double-blind, randomized study of adjunctive L-methylfolate calcium in patients with MDD who are inadequate responders to SSRIs. 
  • Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area. 
  • Biochemical correlates of transmission mediated by glutamate and aspartate. 
  • Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel. 
  • Biochemical plasticity of short-axon interneurons: increased glutamate decarboxylase activity in the denervated area of rat dentate gyrus following entorhinal lesion. 
  • Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists. 
  • Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity. 
  • CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer. 
  • Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis. 
  • Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome. 
  • Changes in synaptic transmission produced by hydrogen peroxide. 
  • Characteristics of cystine uptake by cultured LLC-PK1 cells. 
  • Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro. 
  • Characterization of putative amino acid transmitter release from slices of rat dentate gyrus. 
  • Chromosomal localization of human glutamate receptor genes. 
  • Cisplatin versus carboplatin-based regimens for the treatment of patients with metastatic lung cancer. An analysis of Veterans Health Administration data. 
  • Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. 
  • Colocalization of excitatory and inhibitory neurotransmitter markers in striatal projection neurons in the rat. 
  • Comparative cellular analysis of motor cortex in human, marmoset and mouse. 
  • Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. 
  • Complex binding of L-[3H]glutamate to hippocampal synaptic membranes in the absence of sodium. 
  • Cost-effectiveness of epidermal growth factor receptor mutation testing and first-line treatment with gefitinib for patients with advanced adenocarcinoma of the lung. 
  • Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells. 
  • Defining best supportive care. 
  • Depression of glutamate-mediated synaptic transmission by benzyl alcohol. 
  • Dual response of lobster muscle fibers to L-glutamate. 
  • Effect of glutamate analogues on brain tumor cell lines. 
  • Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro. 
  • Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal. 
  • Effects of sodium fluoroacetate on the metabolism of N-acetylaspartate and aspartate in mouse brain. 
  • Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1. 
  • Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata. 
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. 
  • Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980. 
  • Excitatory amino acid receptor activation produces a selective and long-lasting modulation of gene expression in hippocampal neurons. 
  • Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. 
  • Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes. 
  • Glutamate as transmitter of hippocampal perforant path. 
  • Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes. 
  • Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system? 
  • Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes. 
  • Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate. 
  • Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication. 
  • Imaging of primary Ewing sarcoma with 13N-L-glutamate. 
  • Imaging of the human heart after administration of L-(N-13)glutamate. 
  • Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. 
  • Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. 
  • Isolation from the mushroom Agaricus bisporus and chemical synthesis of gamma-L-glutaminyl-4-hydroxybenzene. 
  • Isolation of -L-glutaminyl 4-hydroxybenzene and -L-glutaminyl 3,4-benzoquinone: a natural sulfhydryl reagent, from sporulating gill tissue of the mushroom Agaricus bisporus. 
  • Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways. 
  • Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA. 
  • L-[3H]Glutamate binding to hippocampal synaptic membranes: two binding sites discriminated by their differing affinities for quisqualate. 
  • La3+ blockage of glutamate action at the lobster neuromuscular junction. 
  • Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles. 
  • Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. 
  • Metabolism of the aspartyl moiety of N-acetyl-L-aspartic acid in the rat brain. 
  • Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists. 
  • Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism. 
  • N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling. 
  • Pemetrexed Plus Cisplatin Versus Gemcitabine Plus Cisplatin According to Thymidylate Synthase Expression in Nonsquamous Non-Small-Cell Lung Cancer: A Biomarker-Stratified Randomized Phase II Trial. 
  • Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. 
  • Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer. 
  • Pharmacology of recovery after stroke. 
  • Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium. 
  • Phase II trial of pemetrexed-based induction chemotherapy followed by concomitant chemoradiotherapy in previously irradiated patients with squamous cell carcinoma of the head and neck. 
  • Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption. 
  • Purification and some properties of the Glu- and Lys-human plasmin heavy chains. 
  • Quantitative scanning of osteogenic sarcoma with nitrogen-13-labeled L-glutamate. 
  • Quantitative scanning of soft-tissue sarcomas with nitrogen-13-labeled L-glutamate. 
  • Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability. 
  • Randomized phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and Leukemia Group B trial 30407. 
  • Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer. 
  • Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen. 
  • Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells. 
  • Results of a phase II study of pemetrexed as first-line chemotherapy in patients with advanced or metastatic breast cancer. 
  • Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. 
  • Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes. 
  • Scanning with L-(13 N) glutamate: Assessment of the response to chemotherapy of a patient with embryonal rhabdomyosarcoma. 
  • Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling. 
  • Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling. 
  • Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells. 
  • Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas. 
  • Structural mechanisms of QacR induction and multidrug recognition. 
  • Structure of macromolecular aggregates. I. Aggregation-induced conformational changes in polypeptides. 
  • Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus. 
  • The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro. 
  • The effect of divalent cations on the conformation and function of human plasminogen. 
  • The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. 
  • The neural basis of sugar preference. 
  • The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. 
  • Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel. 
  • Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. 
  • gamma-Aminobutyrate, alpha-carboxy-2-nitrobenzyl ester selectively blocks inhibitory synaptic transmission in rat dentate gyrus. 
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  Keywords of People

  • Zafar, Syed Yousuf, Adjunct Professor in the Department of Medicine, Duke Science & Society