Glutarates
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Subject Areas on Research
- 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.
- Analysis of volatile free fatty acids in human urine by capillary column gas chromatography/mass spectrometry.
- Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.
- Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
- Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
- Characterization of new diagnostic acylcarnitines in patients with beta-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry.
- Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE.
- Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.
- Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
- Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.
- Glutaric acidemia type 1 in patients of Lumbee heritage from North Carolina.
- Glutaric acidemia, type I, missed by newborn screening in an infant with dystonia following promethazine administration.
- Glutaric aciduria type I: unusual biochemical presentation.
- Identification of 3-methylglutarylcarnitine. A new diagnostic metabolite of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency.
- Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.
- Isocitrate dehydrogenase mutations in gliomas.
- L-Carnitine insufficiency in disorders of organic acid metabolism: response to L-carnitine by patients with methylmalonic aciduria and 3-hydroxy-3-methylglutaric aciduria.
- Mutant IDH is sufficient to initiate enchondromatosis in mice.
- Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
- Significance of bound glutarate in the diagnosis of glutaric aciduria type I.
- Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies.
- Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
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Keywords of People
- McLendon, Roger Edwin, Professor of Pathology, Pathology