Glutathione

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  Subject Areas on Research

  • (1)H MRS detection of glycine residue of reduced glutathione in vivo. 
  • 4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart. 
  • A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. 
  • A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis. 
  • A comparison of glutathione-dependent enzymes in liver, gills and posterior kidney of channel catfish (Ictalurus punctatus). 
  • A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. 
  • A glutathione-dependent control of the indole butyric acid pathway supports Arabidopsis root system adaptation to phosphate deprivation. 
  • A joint analysis of metabolomics and genetics of breast cancer. 
  • A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. 
  • A mathematical model of glutathione metabolism. 
  • A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. 
  • A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. 
  • A spectrophotometric glutathione S-transferase assay displaying alpha-class selectivity utilizing 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide. 
  • Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. 
  • Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • An age-related difference in hyperoxia lethality: role of lung antioxidant defense mechanisms. 
  • An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules 
  • Analysis of myocardial function in orthotopic cardiac allografts after prolonged storage in UW solution. 
  • Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. 
  • Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos. 
  • Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells. 
  • Antioxidant defense mechanisms in cultured pleural mesothelial cells. 
  • Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. 
  • Antioxidant enzyme activities and malondialdehyde, glutathione and methemoglobin concentrations in channel catfish exposed to DEF and n-butyl mercaptan. 
  • Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. 
  • Antioxidant responses and oxidative stress in sheepshead minnow larvae exposed to Corexit 9500^® or its component surfactant, DOSS. 
  • Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis. 
  • Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. 
  • Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. 
  • Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells. 
  • Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Camptothecin analogues with enhanced antitumor activity at acidic pH. 
  • Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone. 
  • Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione. 
  • Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury. 
  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. 
  • Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response. 
  • Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity. 
  • Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines. 
  • Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death. 
  • Changes in Oxidant Defense, Apoptosis, and Cognitive Abilities During Treatment for Childhood Leukemia. 
  • Characterization of the usage of the serine metabolic network in human cancer. 
  • Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. 
  • Cyclophosphamide resistance in medulloblastoma. 
  • Cysteine and glutathione levels in developing rat kidney and liver. 
  • Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats. 
  • Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. 
  • Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione. 
  • Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents. 
  • Degradation of collagen by a human granulocyte collagenolytic system. 
  • Determination of intracellular species at the level of a single erythrocyte via capillary electrophoresis with direct and indirect fluorescence detection. 
  • Development of a model of melphalan-induced gastrointestinal toxicity in mice. 
  • Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver. 
  • Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System. 
  • Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits. 
  • Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants 
  • Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. 
  • Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. 
  • Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex. 
  • Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells. 
  • Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats. 
  • Effect of irrigation fluids on arterial and venous endothelium after ischemia. 
  • Effects of S-nitrosation on oxygen binding by normal and sickle cell hemoglobin. 
  • Effects of buthionine sulfoximine and diethyl maleate on glutathione turnover in the channel catfish. 
  • Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest. 
  • Effects of glutathione or polyamine depletion on in vivo thermosensitization. 
  • Enhanced cardiac preservation with oxygenated University of Wisconsin solution. 
  • Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. 
  • Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion. 
  • Enzymes that counteract nitrosative stress promote fungal virulence. 
  • ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells. 
  • Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. 
  • Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles. 
  • Evaluation of solutions for small intestinal preservation. Biochemical changes as a function of storage time. 
  • Experience with combined hepatic, pancreaticoduodenal, and renal procurement with UW solution. 
  • Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. 
  • Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment. 
  • Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. 
  • Functional coupling of oxygen binding and vasoactivity in S-nitrosohemoglobin. 
  • Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4. 
  • Glutamine as indispensable nutrient in oncology: experimental and clinical evidence. 
  • Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. 
  • Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro. 
  • Glutathione S-transferase-mediated chlorothalonil metabolism in liver and gill subcellular fractions of channel catfish. 
  • Glutathione activates virulence gene expression of an intracellular pathogen. 
  • Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation? 
  • Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues. 
  • Glutathione and zebrafish: Old assays to address a current issue. 
  • Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines. 
  • Glutathione depletion in epithelial lining fluid of lung allograft patients. 
  • Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line. 
  • Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma. 
  • Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. 
  • Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity. 
  • Glutathione reductases from a variety of sources are inhibited by physiological levels of glutathione. 
  • Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes. 
  • Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Glutathione-dependent defense in channel catfish (Ictalurus punctatus) and brown bullhead (Ameriurus nebulosus). 
  • Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver. 
  • Hepatotoxic effects of CCl4 on English sole (Parophrys vetulus): possible indicators of liver dysfunction. 
  • Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain. 
  • Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung. 
  • Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane. 
  • Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney. 
  • Impact of donor factors and preservation on function and survival after liver transplantation. 
  • In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization. 
  • In-transit melanoma: the role of alkylating-agent resistance in regional therapy. 
  • Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. 
  • Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone. 
  • Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin. 
  • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 
  • Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers. 
  • Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes. 
  • Interleukin-1-induced nitric oxide production modulates glutathione synthesis in cultured rat hepatocytes. 
  • Intestinal transplantation: the University of Wisconsin experience. 
  • Investigations into the loss of glutathione from lenses in organ culture. 
  • Involvement of reactive oxygen species in the electrochemical inhibition of barnacle (Amphibalanus amphitrite) settlement 
  • Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. 
  • Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment. 
  • Lack of effect of cimetidine on acetaminophen disposition in humans. 
  • Large Cellular Inclusions Accumulate in Arabidopsis Roots Exposed to Low-Sulfur Conditions. 
  • Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. 
  • Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. 
  • Magnesium deficiency prolongs myocardial stunning in an open-chest swine model. 
  • Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells. 
  • Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells. 
  • Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia. 
  • Mathematical modeling of the effects of glutathione on arsenic methylation. 
  • Mechanism of allyl formate-induced hepatotoxicity in rainbow trout. 
  • Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma. 
  • Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells. 
  • Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma. 
  • Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine. 
  • Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. 
  • Mitochondrial adaptations to obesity-related oxidant stress. 
  • Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. 
  • Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. 
  • Modulation of resistance to regional chemotherapy in the extremity melanoma model. 
  • Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia? 
  • Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas. 
  • Morphologic, biochemical, and cytogenetic studies of bone marrow and circulating blood cells in painters exposed to ethylene glycol ethers. 
  • Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen. 
  • Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells. 
  • NO waiting to exhale in asthma. 
  • Nano-C60 cytotoxicity is due to lipid peroxidation. 
  • Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase. 
  • Nitric oxide decreases oxidant-mediated hepatocyte injury. 
  • Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event. 
  • Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation. 
  • Nitrofurantoin-stimulated proteolysis in human erythrocytes: a novel index of toxic insult by nitroaromatics. 
  • Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase. 
  • Observations on man in an oxygen-helium environment at 380 mm. Hg total pressure. I. Clinical. 
  • Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. 
  • Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. 
  • Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. 
  • Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen. 
  • Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories. 
  • Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. 
  • Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. 
  • PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury. 
  • Pathways of folding of reduced bovine pancreatic ribonuclease. 
  • Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. 
  • Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. 
  • Platelet glutathione transport: characteristics and evidence for regulation by intraplatelet thiol status. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Prevention of chemotherapy and radiation toxicity with glutamine. 
  • Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system. 
  • Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells. 
  • Procurement, preservation, and transport of cadaver kidneys. 
  • Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide. 
  • Pulmonary and hepatic glutathione levels, glutathione shuttle enzymes and lipid peroxidation in rats exposed intratracheally to coal fly ash. 
  • Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line. 
  • Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. 
  • Quitting smoking raises whole blood glutathione. 
  • Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. 
  • Regulation of mitochondrial processes by protein S-nitrosylation. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Role of glutathione in cellular resistance to alkylating agents. 
  • S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets. 
  • S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action. 
  • S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. 
  • Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis. 
  • Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. 
  • Stability of Metal-Glutathione Complexes During Oxidation by Hydrogen Peroxide and Cu(II)-Catalysis 
  • Strong hg(II) complexation in municipal wastewater effluent and surface waters. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene. 
  • Ternary complex formation facilitates a redox mechanism for iron release from a siderophore. 
  • The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model 
  • The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation. 
  • The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine. 
  • The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose. 
  • The use of UW solution in clinical transplantation. A 4-year experience. 
  • Toxicological effects of methylmercury on walleye (Sander vitreus) and perch (Perca flavescens) from lakes of the boreal forest. 
  • Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. 
  • Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
  • Trout liver slices for metabolism and toxicity studies. 
  • Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro. 
  • Update on preservation of liver grafts. 
  • Utilization of pediatric donors for pancreas transplantation. 
  • Visible light photochemical release of nitric oxide from S-nitrosoglutathione: potential photochemotherapeutic applications. 
  • XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells. 
  • cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. 
  • microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. 
  • pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor of Medicine, Pharmacology & Cancer Biology
  • Hsu-Kim, Heileen, Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering