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Subject Areas on Research
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(1)H MRS detection of glycine residue of reduced glutathione in vivo.
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4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart.
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A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.
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A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.
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A comparison of glutathione-dependent enzymes in liver, gills and posterior kidney of channel catfish (Ictalurus punctatus).
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A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma.
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A glutathione-dependent control of the indole butyric acid pathway supports Arabidopsis root system adaptation to phosphate deprivation.
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A joint analysis of metabolomics and genetics of breast cancer.
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A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism.
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A mathematical model of glutathione metabolism.
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A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.
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A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans.
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A spectrophotometric glutathione S-transferase assay displaying alpha-class selectivity utilizing 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide.
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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
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Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli.
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Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.
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An age-related difference in hyperoxia lethality: role of lung antioxidant defense mechanisms.
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An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules
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Analysis of myocardial function in orthotopic cardiac allografts after prolonged storage in UW solution.
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Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation.
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Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos.
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Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells.
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Antioxidant defense mechanisms in cultured pleural mesothelial cells.
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Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses.
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Antioxidant enzyme activities and malondialdehyde, glutathione and methemoglobin concentrations in channel catfish exposed to DEF and n-butyl mercaptan.
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Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish.
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Antioxidant responses and oxidative stress in sheepshead minnow larvae exposed to Corexit 9500®
or its component surfactant, DOSS.
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Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis.
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Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress.
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Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.
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Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.
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Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance.
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Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells.
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Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.
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Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
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Camptothecin analogues with enhanced antitumor activity at acidic pH.
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Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone.
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Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione.
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Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.
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Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.
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Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response.
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Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity.
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Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines.
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Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death.
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Changes in Oxidant Defense, Apoptosis, and Cognitive Abilities During Treatment for Childhood Leukemia.
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Characterization of the usage of the serine metabolic network in human cancer.
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Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.
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Cyclophosphamide resistance in medulloblastoma.
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Cysteine and glutathione levels in developing rat kidney and liver.
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Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats.
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Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
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Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione.
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Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.
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Degradation of collagen by a human granulocyte collagenolytic system.
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Detection and characterization of a glutathione conjugate of ochratoxin A.
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Determination of intracellular species at the level of a single erythrocyte via capillary electrophoresis with direct and indirect fluorescence detection.
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Development of a model of melphalan-induced gastrointestinal toxicity in mice.
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Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver.
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Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System.
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Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits.
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Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants
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Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J.
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Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
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Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex.
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Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans.
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Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.
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Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells.
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Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats.
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Effect of irrigation fluids on arterial and venous endothelium after ischemia.
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Effects of S-nitrosation on oxygen binding by normal and sickle cell hemoglobin.
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Effects of buthionine sulfoximine and diethyl maleate on glutathione turnover in the channel catfish.
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Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest.
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Effects of glutathione or polyamine depletion on in vivo thermosensitization.
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Effects of leukocyte depleted blood on renal reperfusion injury in a porcine model.
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Enhanced cardiac preservation with oxygenated University of Wisconsin solution.
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Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.
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Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion.
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Enzymes that counteract nitrosative stress promote fungal virulence.
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ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells.
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Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.
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Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles.
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Evaluation of solutions for small intestinal preservation. Biochemical changes as a function of storage time.
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Experience with combined hepatic, pancreaticoduodenal, and renal procurement with UW solution.
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Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.
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Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment.
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Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.
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Functional coupling of oxygen binding and vasoactivity in S-nitrosohemoglobin.
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Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4.
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Glutamine as indispensable nutrient in oncology: experimental and clinical evidence.
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Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression.
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Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.
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Glutathione S-transferase-mediated chlorothalonil metabolism in liver and gill subcellular fractions of channel catfish.
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Glutathione activates virulence gene expression of an intracellular pathogen.
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Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation?
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Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues.
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Glutathione and zebrafish: Old assays to address a current issue.
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Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines.
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Glutathione depletion in epithelial lining fluid of lung allograft patients.
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Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line.
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Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma.
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Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.
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Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity.
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Glutathione reductases from a variety of sources are inhibited by physiological levels of glutathione.
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Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes.
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Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma.
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Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.
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Glutathione-dependent defense in channel catfish (Ictalurus punctatus) and brown bullhead (Ameriurus nebulosus).
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Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver.
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Hepatotoxic effects of CCl4 on English sole (Parophrys vetulus): possible indicators of liver dysfunction.
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Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain.
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Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung.
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Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
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Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney.
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Impact of donor factors and preservation on function and survival after liver transplantation.
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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.
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In-transit melanoma: the role of alkylating-agent resistance in regional therapy.
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Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.
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Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone.
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Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin.
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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
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Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
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Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes.
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Interleukin-1-induced nitric oxide production modulates glutathione synthesis in cultured rat hepatocytes.
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Intestinal transplantation: the University of Wisconsin experience.
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Investigations into the loss of glutathione from lenses in organ culture.
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Involvement of reactive oxygen species in the electrochemical inhibition of barnacle (Amphibalanus amphitrite) settlement
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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
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Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment.
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Lack of effect of cimetidine on acetaminophen disposition in humans.
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Large Cellular Inclusions Accumulate in Arabidopsis Roots Exposed to Low-Sulfur Conditions.
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Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes.
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Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
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Magnesium deficiency prolongs myocardial stunning in an open-chest swine model.
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Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.
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Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells.
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Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.
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Mathematical modeling of the effects of glutathione on arsenic methylation.
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Mechanism of allyl formate-induced hepatotoxicity in rainbow trout.
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Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.
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Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.
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Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma.
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Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine.
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Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts.
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Mitochondrial adaptations to obesity-related oxidant stress.
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Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain.
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Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
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Modulation of cytotoxicity of menadione sodium bisulfite versus leukemia L1210 by the acid-soluble thiol pool.
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Modulation of resistance to regional chemotherapy in the extremity melanoma model.
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Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia?
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Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.
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Morphologic, biochemical, and cytogenetic studies of bone marrow and circulating blood cells in painters exposed to ethylene glycol ethers.
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Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen.
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Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells.
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NO waiting to exhale in asthma.
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Nano-C60 cytotoxicity is due to lipid peroxidation.
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Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.
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Nitric oxide decreases oxidant-mediated hepatocyte injury.
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Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event.
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Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
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Nitrofurantoin-stimulated proteolysis in human erythrocytes: a novel index of toxic insult by nitroaromatics.
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Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase.
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Observations on man in an oxygen-helium environment at 380 mm. Hg total pressure. I. Clinical.
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Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study.
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Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash.
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Oxidative stress and adenine nucleotide control of mitochondrial permeability transition.
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Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen.
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Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories.
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Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.
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Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.
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PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury.
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Pathways of folding of reduced bovine pancreatic ribonuclease.
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Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.
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Phase I study of mitomycin C and menadione in advanced solid tumors.
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Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.
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Platelet glutathione transport: characteristics and evidence for regulation by intraplatelet thiol status.
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Postlipopolysaccharide oxidative damage of mitochondrial DNA.
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Prevention of chemotherapy and radiation toxicity with glutamine.
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Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system.
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Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells.
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Procurement, preservation, and transport of cadaver kidneys.
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Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide.
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Pulmonary and hepatic glutathione levels, glutathione shuttle enzymes and lipid peroxidation in rats exposed intratracheally to coal fly ash.
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Purification and biochemical characterization of gamma-glutamylcysteine synthetase from a human malignant astrocytoma cell line.
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Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.
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Quitting smoking raises whole blood glutathione.
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Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure.
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Regulation of mitochondrial processes by protein S-nitrosylation.
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Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels.
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Role of glutathione in cellular resistance to alkylating agents.
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Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones.
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S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets.
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S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action.
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S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system.
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Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis.
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Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study.
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Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury.
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Stability of Metal-Glutathione Complexes During Oxidation by Hydrogen Peroxide and Cu(II)-Catalysis
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Strong hg(II) complexation in municipal wastewater effluent and surface waters.
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Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.
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Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.
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Synergistic cytotoxicity between menadione and dicumarol vs. murine leukemia L1210.
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Ternary complex formation facilitates a redox mechanism for iron release from a siderophore.
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The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
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The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation.
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The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.
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The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose.
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The use of UW solution in clinical transplantation. A 4-year experience.
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Toxicological effects of methylmercury on walleye (Sander vitreus) and perch (Perca flavescens) from lakes of the boreal forest.
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Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.
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Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
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Trout liver slices for metabolism and toxicity studies.
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Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro.
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Update on preservation of liver grafts.
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Utilization of pediatric donors for pancreas transplantation.
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Visible light photochemical release of nitric oxide from S-nitrosoglutathione: potential photochemotherapeutic applications.
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XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.
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cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
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microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.
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pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
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Keywords of People