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Subject Areas on Research
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(1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.
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A comparison of glutathione-dependent enzymes in liver, gills and posterior kidney of channel catfish (Ictalurus punctatus).
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A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits.
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A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity.
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A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state.
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A role for the Ppz Ser/Thr protein phosphatases in the regulation of translation elongation factor 1Balpha.
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A spectrophotometric glutathione S-transferase assay displaying alpha-class selectivity utilizing 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide.
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ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation.
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Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
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Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.
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Accumulation and debromination of decabromodiphenyl ether (BDE-209) in juvenile fathead minnows (Pimephales promelas) induces thyroid disruption and liver alterations.
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Activation-dependent conformational changes in {beta}-arrestin 2.
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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.
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Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli.
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Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.
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Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
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Antioxidant responses and oxidative stress in sheepshead minnow larvae exposed to Corexit 9500®
or its component surfactant, DOSS.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.
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Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study.
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Association between polymorphisms in the GSTA4 gene and risk of lung cancer: a case-control study in a Southeastern Chinese population.
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Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers.
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Bacteriophage T4 UvsW protein is a helicase involved in recombination, repair and the regulation of DNA replication origins.
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Binding of G protein beta gamma-subunits to pleckstrin homology domains.
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Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.
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Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
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Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).
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Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
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Calmodulin mediates Ca2+ sensitivity of sodium channels.
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Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.
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Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines.
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Characterization of RanBP2-associated molecular components in neuroretina.
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Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins.
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Characterizing the in vitro hepatic biotransformation of the flame retardant BDE 99 by common carp.
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Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States).
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Clinical pharmacology of melphalan and its implications for clinical resistance to anticancer agents.
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Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation.
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Collision-induced dissociative chemical cross-linking reagents and methodology: Applications to protein structural characterization using tandem mass spectrometry analysis.
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Comparative metabolism and excretion of benzo(a)pyrene in 2 species of ictalurid catfish.
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Contemplating genetic feedback regarding lung cancer susceptibility.
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Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.
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Cyclophosphamide resistance in medulloblastoma.
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Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma.
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DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma.
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DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.
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Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione.
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Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism.
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Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells.
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Distribution of antioxidant enzymes in the normal aged human conjunctiva: an immunocytochemical study.
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Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.
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EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor.
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Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats.
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Effects of 2,4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish (Ictalurus punctatus).
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Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences.
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Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck.
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Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95.
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Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.
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Ethanol interferes with regeneration-associated changes in biotransforming enzymes: a potential mechanism underlying ethanol's carcinogenicity?
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Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.
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Evolution of graded refractive index in squid lenses.
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Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.
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Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome.
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Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.
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GSTM1 polymorphism, GSTT1 polymorphism, and cervical cancer risk: a meta-analysis.
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GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis.
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GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis.
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Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.
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Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier.
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Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas.
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Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer.
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Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements.
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Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours.
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Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunity.
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Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk.
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Glutathione S-transferase M1, T1, and P1 polymorphisms and ovarian cancer risk: a meta-analysis.
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Glutathione S-transferase fusion proteins mimic receptor dimerization in permeabilized cells.
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Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer.
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Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.
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Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis.
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Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck.
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Glutathione S-transferase polymorphisms and survival in primary malignant glioma.
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Glutathione S-transferase-mediated chlorothalonil metabolism in liver and gill subcellular fractions of channel catfish.
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Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues.
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Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines.
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Glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and idiopathic male infertility: novel perspectives versus facts.
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Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction.
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Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck.
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HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.
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High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer.
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High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population.
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Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney.
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Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits.
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Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
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Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.
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In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck.
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In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.
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In-transit melanoma: the role of alkylating-agent resistance in regional therapy.
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Induction of hepatic drug metabolizing enzymes by coal fly ash in rats.
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Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.
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Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.
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Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate.
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Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
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Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling.
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Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.
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Interpretation of genetic risk feedback among African American smokers with low socioeconomic status.
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Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
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Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
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Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.
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Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.
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Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3.
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Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma.
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Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
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Methodological remarks on the recent meta-analysis examining the association between glutathione-S-transferase M1 polymorphism and sporadic colorectal cancer risk.
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Methylomics of gene expression in human monocytes.
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Microsomal and cytosolic epoxide hydrolase and glutathione S-transferase activities in the gill, liver, and kidney of the rainbow trout, Salmo gairdneri. Baseline levels and optimization of assay conditions.
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Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ.
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Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction.
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Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.
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Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells.
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Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker.
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Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.
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Ontogeny and oncogenesis balance the transcriptional profile of renal cell cancer.
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Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy.
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Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.
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PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA.
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Phosphorylation of O6-alkylguanine-DNA alkyltransferase: experience with a GST-fusion protein and a new pull-down assay.
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Preliminary examination of polymorphisms of GSTM1, GSTT1, and GSTZ1 in relation to semen quality.
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Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas.
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Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain.
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Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking.
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Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.
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Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
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Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle.
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Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.
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Regulation of arrestin-3 phosphorylation by casein kinase II.
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Responses to online GSTM1 genetic test results among smokers related to patients with lung cancer: a pilot study.
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Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.
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Role of glutathione in cellular resistance to alkylating agents.
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Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study.
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Species-specific differences and structure-activity relationships in the debromination of PBDE congeners in three fish species.
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Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling.
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Structural basis for the proinflammatory cytokine activity of high mobility group box 1.
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Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.
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Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line.
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Testing different communication formats on responses to imagined risk of having versus missing the GSTM1 gene.
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The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
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The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression.
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The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.
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The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
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The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
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The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
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The feasibility of online genetic testing for lung cancer susceptibility: uptake of a web-based protocol and decision outcomes.
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The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells.
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The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.
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The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus.
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The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer.
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The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
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The role of glutathione S-transferase P1-1 in colorectal cancer: friend or foe?
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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
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Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.
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Toxicity of expanded polyglutamine-domain proteins in Escherichia coli.
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Toxicological effects of methylmercury on walleye (Sander vitreus) and perch (Perca flavescens) from lakes of the boreal forest.
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Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.
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Translational inhibition of messenger RNA of the human pi class glutathione S-transferase by antisense oligodeoxyribonucleotides.
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Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.
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Two-dimensional tracking of ncd motility by back focal plane interferometry.
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Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study.
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Young smokers' interpretations of the estimated lung cancer risk associated with a common genetic variant of low penetrance.
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[The relationship between drug sensitivity and expression of drug resistance gene mutations in non-small cell lung cancer].
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beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
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Keywords of People
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology