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Subject Areas on Research
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(1)H MRS detection of glycine residue of reduced glutathione in vivo.
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3-Hydroxyisovalerylcarnitine in patients with deficiency of 3-methylcrotonyl CoA carboxylase.
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A Convenient Synthesis of Cis and Trans 4-tert-Butoxycarbonyl-Substituted Cyclohexylglycine
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A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism.
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A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
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A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain.
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A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout.
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A review of molecular mechanisms linked to potential renal injury agents in tropical rural farming communities.
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A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents.
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Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury.
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An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor.
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An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.
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An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
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Analysis of abnormal urinary metabolites in the newborn period in medium-chain acyl-CoA dehydrogenase deficiency.
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Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers.
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Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort.
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Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia.
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Benzoate treatment and the glycine index in nonketotic hyperglycinaemia.
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Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel.
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Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position.
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Blue Vision (Cyanopsia) Associated With TURP Syndrome: A Case Report.
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C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis.
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Can Glycine Mitigate COVID-19 Associated Tissue Damage and Cytokine Storm?
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Cerebrospinal fluid amino acids glycine, serine, and threonine in nonketotic hyperglycinemia.
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Characterization of the usage of the serine metabolic network in human cancer.
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Chronopharmacology of strychnine and allylglycine in the mouse.
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Collagenase in bone of man.
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Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds.
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Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.
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Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries.
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Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
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Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis.
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Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis.
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Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats.
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Developmental changes of glycine transport in the dog.
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Dietary glycine inhibits angiogenesis during wound healing and tumor growth.
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Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).
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Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.
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Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes.
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Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.
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Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial.
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Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency.
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Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia.
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Ethanol inhibition of NMDA mediated depolarizations is increased in the presence of Mg2+.
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Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding.
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Expression level is a key determinant of E2F1-mediated cell fate.
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G proteins. Visual differences.
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Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank.
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Glucosamine dependence of Huntington's chorea fibroblasts in culture.
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Glycine and L-carnitine therapy in 3-methylcrotonyl-CoA carboxylase deficiency.
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Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics.
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Glycine metabolism. I. Properties of the system catalyzing the exchange of bicarbonate with the carboxyl group of glycine in Peptococcus glycinophilus.
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Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes.
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Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.
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High-performance liquid chromatographic separation and quantification of alanopine and strombine in crude tissue extracts.
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Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin.
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Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.
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Identification of two novel mutations in families with X-linked ocular albinism.
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Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions.
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Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.
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In silico experimentation with a model of hepatic mitochondrial folate metabolism.
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Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.
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Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
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Inhibition of HIF prolyl-hydroxylase domain to correct anemia in patients with chronic kidney disease.
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Inhibition, Not Excitation, Drives Rhythmic Whisking.
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Inhibitors of metalloendoprotease activity prevent K+-stimulated neurotransmitter release from the retina of Xenopus laevis.
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Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
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Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia.
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Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.
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Kinetic role of helix caps in protein folding is context-dependent.
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L-carnitine therapy in isovaleric acidemia.
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Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations.
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Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro.
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Mapping of a ligand-binding site for the human thromboxane A2 receptor protein.
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Mechanical unfolding of ubiquitin molecules.
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Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.
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Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
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Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity.
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Missense mutation in a von Willebrand factor type A domain of the alpha 3(VI) collagen gene (COL6A3) in a family with Bethlem myopathy.
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Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.
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Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.
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Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
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Mutation of bcl-x gene in non-Hodgkin's lymphoma.
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N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.
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N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis.
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NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P.
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Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
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Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled.
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Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration.
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Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
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Nitroxyl anion regulation of the NMDA receptor.
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Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog.
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Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.
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Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka.
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One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
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Opposite modulation of capsaicin-evoked substance P release by glutamate receptors.
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Outcomes of patients with IDH1-mutant relapsed or refractory acute myeloid leukemia receiving ivosidenib who proceeded to hematopoietic stem cell transplant.
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Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%).
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Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies.
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Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast.
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Quantification of creatine and guanidinoacetate using GC-MS and LC-MS/MS for the detection of cerebral creatine deficiency syndromes.
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Radiohistochemical demonstration of NMDA/glycine-channel activation in rat hippocampus.
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Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate.
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Reactivation of Epstein-Barr Virus by HIF-1α Requires p53.
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Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding.
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Serine, glycine and one-carbon units: cancer metabolism in full circle.
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Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online.
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Short-chain acyl-coenzyme A dehydrogenase deficiency in mice.
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Silver ions increase auxin efflux independently of effects on ethylene response.
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Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase.
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Site-directed mutagenesis of glycine-14 and two "critical" cysteinyl residues in Drosophila alcohol dehydrogenase.
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Structural conservation of ion conduction pathways in K channels and glutamate receptors.
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Structure validation by Calpha geometry: phi,psi and Cbeta deviation.
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Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.
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Surface loop dynamics in adeno-associated virus capsid assembly.
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TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling.
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Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.
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The G185R mutation disrupts function of the iron transporter Nramp2.
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The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
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The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants.
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The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening.
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The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions.
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The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene.
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The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout.
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The kinetics of intramolecular distribution of 15N in uric acid following administration of 15N-glycine: preferential labeling of N-(3+9) of uric acid in primary gout and a reappraisal of the "glutamine hypothesis".
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Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit.
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Transport studies and enzyme assays in mice infected with human Giardia lamblia.
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Treatment outcome of creatine transporter deficiency: international retrospective cohort study.
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Twenty-four hour rhythms in the glycine content of rat hindbrain and spinal cord.
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Ultrasonic absorption measurements in aqueous solutions of glycine, diglycine, and triglycine.
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Uptake of proline by brushborder vesicles isolated from human kidney cortex.
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Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms.
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mGluR modulation of post-traumatic neuronal death: role of NMDA receptors.
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Keywords of People
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Charles, Hal Cecil,
Adjunct Associate Professor in the Department of Radiology,
Radiology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Muir, Kelly Walton,
Associate Professor of Ophthalmology,
Ophthalmology, Glaucoma