Glycine

• 

  Subject Areas on Research

  • (1)H MRS detection of glycine residue of reduced glutathione in vivo. 
  • 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells. 
  • 3-Hydroxyisovalerylcarnitine in patients with deficiency of 3-methylcrotonyl CoA carboxylase. 
  • A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. 
  • A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution. 
  • A convenient synthesis of cis and trans 4-tert-butoxycarbonyl-substituted cyclohexylglycine. 
  • A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. 
  • A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. 
  • A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain. 
  • A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout. 
  • A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents. 
  • Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. 
  • An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor. 
  • An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. 
  • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. 
  • Analysis of abnormal urinary metabolites in the newborn period in medium-chain acyl-CoA dehydrogenase deficiency. 
  • Anti-brain autoantibodies and altered excitatory neurotransmitters in obsessive-compulsive disorder. 
  • Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. 
  • Assessment of the endogenous allergens in glyphosate-tolerant and commercial soybean varieties. 
  • Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort. 
  • Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. 
  • Benzoate treatment and the glycine index in nonketotic hyperglycinaemia. 
  • Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. 
  • Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel. 
  • Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position. 
  • Blue Vision (Cyanopsia) Associated With TURP Syndrome: A Case Report. 
  • C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis. 
  • Characterization of the usage of the serine metabolic network in human cancer. 
  • Chronopharmacology of strychnine and allylglycine in the mouse. 
  • Clinical experience with excitatory amino acid antagonist drugs. 
  • Collagenase in bone of man. 
  • Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds. 
  • Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. 
  • Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats. 
  • Developmental changes of glycine transport in the dog. 
  • Dietary glycine inhibits angiogenesis during wound healing and tumor growth. 
  • Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs). 
  • Dual actions of S-nitrosylated derivative of vasoactive intestinal peptide as a vasoactive intestinal peptide-like mediator and a nitric oxide carrier. 
  • Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. 
  • Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML. 
  • Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lung. 
  • Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effects of glycine receptor antagonism on spreading depression in the rat. 
  • Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency. 
  • Elongation by Escherichia coli RNA polymerase is blocked in vitro by a site-specific DNA binding protein. 
  • Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia. 
  • Ethanol inhibition of NMDA mediated depolarizations is increased in the presence of Mg2+. 
  • Evidence for donor strand complementation in the biogenesis of Haemophilus influenzae haemagglutinating pili. 
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. 
  • Expression level is a key determinant of E2F1-mediated cell fate. 
  • Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. 
  • G proteins. Visual differences. 
  • Glucosamine dependence of Huntington's chorea fibroblasts in culture. 
  • Glycine and L-carnitine therapy in 3-methylcrotonyl-CoA carboxylase deficiency. 
  • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. 
  • Glycine metabolism. I. Properties of the system catalyzing the exchange of bicarbonate with the carboxyl group of glycine in Peptococcus glycinophilus. 
  • Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat. 
  • Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes. 
  • Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice. 
  • High-performance liquid chromatographic separation and quantification of alanopine and strombine in crude tissue extracts. 
  • Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin. 
  • Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia. 
  • Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. 
  • Identification of two novel mutations in families with X-linked ocular albinism. 
  • Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. 
  • In silico experimentation with a model of hepatic mitochondrial folate metabolism. 
  • Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Inhibition of HIF prolyl-hydroxylase domain to correct anemia in patients with chronic kidney disease. 
  • Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. 
  • Inhibition, Not Excitation, Drives Rhythmic Whisking. 
  • Inhibitors of metalloendoprotease activity prevent K+-stimulated neurotransmitter release from the retina of Xenopus laevis. 
  • Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect? 
  • Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia. 
  • Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • L-carnitine therapy in isovaleric acidemia. 
  • Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations. 
  • Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro. 
  • Local calcium release in dendritic spines required for long-term synaptic depression. 
  • Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics. 
  • Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity. 
  • Missense mutation in a von Willebrand factor type A domain of the alpha 3(VI) collagen gene (COL6A3) in a family with Bethlem myopathy. 
  • Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. 
  • Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth. 
  • Mutation of bcl-x gene in non-Hodgkin's lymphoma. 
  • Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease. 
  • Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity. 
  • N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex. 
  • N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis. 
  • NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. 
  • Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate. 
  • Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled. 
  • Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration. 
  • Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. 
  • Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog. 
  • Normal glycine-C14-incorporation into uric acid in primary gout. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. 
  • Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. 
  • Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%). 
  • Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies. 
  • Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast. 
  • Purification of, generation of monoclonal antibodies to, and mapping of phosphoribosyl N-formylglycinamide amidotransferase. 
  • Quantification of creatine and guanidinoacetate using GC-MS and LC-MS/MS for the detection of cerebral creatine deficiency syndromes. 
  • RFLPs of the gene for the human glycine receptor on the X-chromosome. 
  • Radiohistochemical demonstration of NMDA/glycine-channel activation in rat hippocampus. 
  • Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate. 
  • Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding. 
  • Relative contributions of a single-admission 12-lead electrocardiogram and early 24-hour continuous electrocardiographic monitoring for early risk stratification in patients with unstable coronary artery disease. 
  • Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats. 
  • Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. 
  • Serine, glycine and one-carbon units: cancer metabolism in full circle. 
  • Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. 
  • Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. 
  • Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase. 
  • Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. 
  • Stroke Impact Scale-16: A brief assessment of physical function. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Structure validation by Calpha geometry: phi,psi and Cbeta deviation. 
  • Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3. 
  • Surface loop dynamics in adeno-associated virus capsid assembly. 
  • TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling. 
  • Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. 
  • The G185R mutation disrupts function of the iron transporter Nramp2. 
  • The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition. 
  • The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions. 
  • The high concentration of Arg213-->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities. 
  • The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene. 
  • The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. 
  • The kinetics of intramolecular distribution of 15N in uric acid following administration of 15N-glycine: preferential labeling of N-(3+9) of uric acid in primary gout and a reappraisal of the "glutamine hypothesis". 
  • Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. 
  • Transport studies and enzyme assays in mice infected with human Giardia lamblia. 
  • Treatment outcome of creatine transporter deficiency: international retrospective cohort study. 
  • Twenty-four hour rhythms in the glycine content of rat hindbrain and spinal cord. 
  • Two dosing regimens of tosedostat in elderly patients with relapsed or refractory acute myeloid leukaemia (OPAL): a randomised open-label phase 2 study. 
  • Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies. 
  • Ultrasonic absorption measurements in aqueous solutions of glycine, diglycine, and triglycine. 
  • Uptake of proline by brushborder vesicles isolated from human kidney cortex. 
  • Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms. 
  • mGluR modulation of post-traumatic neuronal death: role of NMDA receptors. 
• 

  Keywords of People

  • Charles, Hal Cecil, Associate Professor of Radiology, Radiology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology