Phosphorylases

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  Subject Areas on Research

  • Adenovirus-mediated delivery into myocytes of muscle glycogen phosphorylase, the enzyme deficient in patients with glycogen-storage disease type V. 
  • Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. 
  • Agonist versus antagonist binding to alpha-adrenergic receptors. 
  • An engineered liver glycogen phosphorylase with AMP allosteric activation. 
  • Asymptomatic McArdle's disease associated with hyper-creatine kinase-emia and absence of myophosphorylase. 
  • Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases. 
  • Developmental expression of glycogenolytic enzymes in rabbit tissues: possible relationship to fetal lung maturation. 
  • Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes. 
  • Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage. 
  • Follicle-stimulating hormone activation of glycogen phosphorylase in the Sertoli cell-enriched rat testis. 
  • Glycogen storage disease type Ia in two littermate Maltese puppies. 
  • Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. 
  • Insulin replacement therapy in diabetic rats using an osmotic pump normalizes expression of enzymes key to hepatic carbohydrate metabolism. 
  • Metabolic variation among rat lumbosacral alpha-motoneurons. 
  • Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. 
  • Noncardiogenic pulmonary edema and rhabdomyolsis after protamine administration in a patient with unrecognized McArdle's disease. 
  • Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels. 
  • Quantitation and significance of 125I-calmodulin binding to myosin light chain kinase and phosphorylase distributed on polyacrylamide gels. 
  • Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage. 
  • Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition. 
  • Structural relationships in glycogen phosphorylases. 
  • The family of glycogen phosphorylases: structure and function. 
  • The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14.