Glycolipids

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  Subject Areas on Research

  • A comprehensive testing algorithm for the diagnosis of Fabry disease in males and females. 
  • A new ganglioside of the lactotetraose series, GalNAc-3'-isoLM1, detected in human meconium. 
  • A phase II prospective multi-institutional trial of adjuvant active specific immunotherapy following curative resection of colorectal cancer hepatic metastases: cancer and leukemia group B study 89903. 
  • A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii. 
  • Accumulation of glycolipids containing N-acetylglucosamine in erythrocyte stroma of patients with congenital dyserythropoietic anemia type II (HEMPAS). 
  • An ethanolamine-phosphate modified glycolipid in Clostridium acetobutylicum that responds to membrane stress. 
  • Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514. 
  • Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. 
  • Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. 
  • Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid. 
  • Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. 
  • Circulating glycoconjugates in CSF of meningioma patients. 
  • Combined analysis of plasma or serum glucosylsphingosine and globotriaosylsphingosine by UPLC-MS/MS. 
  • Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis. 
  • Dr(a-) polymorphism of decay accelerating factor. Biochemical, functional, and molecular characterization and production of allele-specific transfectants. 
  • Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas. 
  • Glycosylation of serum HDL and LDL in rats given excess retinol. 
  • Hepatic monoacylglycerol acyltransferase: ontogeny and characterization of an activity associated with the chick embryo. 
  • How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? 
  • Human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function. 
  • Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis. 
  • Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. 
  • Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma. 
  • Inhibition of protein synthesis also inhibits synthesis of lipid-linked oligosaccharides. 
  • Isolation and characterization of biliary epithelial cells from rainbow trout liver. 
  • Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. 
  • Metastatic behavior and cell surface properties of HT-29 human colon carcinoma variant cells selected for their differential expression of sialyl-dimeric Le(x)-antigen. 
  • Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. 
  • Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli. 
  • Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia. 
  • Phenylalanine 30 plays an important role in receptor binding of verotoxin-1. 
  • Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging. 
  • Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use. 
  • Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. 
  • Relationship between insulin-mediated turnover of glucosamine-labeled lipids and activity of the insulin receptor tyrosine kinase. 
  • Streptococcus pneumoniae, S. mitis, and S. oralis Produce a Phosphatidylglycerol-Dependent, ltaS-Independent Glycerophosphate-Linked Glycolipid. 
  • Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis. 
  • Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay. 
  • T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents. 
  • The footprint of antibody bound to pig cells: evidence of complex surface topology. 
  • The inflammatory response and resistance to endotoxin in mice. 
  • Time to treatment benefit for adult patients with Fabry disease receiving agalsidase β: data from the Fabry Registry.