Glycolysis

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  Subject Areas on Research

  • A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. 
  • A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. 
  • A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. 
  • A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. 
  • A metabolic signature of colon cancer initiating cells. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. 
  • Acetate Metabolism in Physiology, Cancer, and Beyond. 
  • Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. 
  • Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. 
  • Activation of glycolysis and apoptosis in glycogen storage disease type Ia. 
  • Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide. 
  • Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion. 
  • Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat. 
  • Altered metabolism in cancer. 
  • Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. 
  • Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. 
  • Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. 
  • Biochemical and structural changes in cultured heart cells induced by metabolic inhibition. 
  • Biochemical changes during graded brain ischemia in gerbils. Part 1. Global biochemical alterations. 
  • Biochemistry. A glucose-to-gene link. 
  • Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis. 
  • Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia. 
  • Carbohydrate metabolism in transforming lymphocytes from the aged. 
  • Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. 
  • ChREBP regulates fructose-induced glucose production independently of insulin signaling. 
  • Changes on Midchemoradiation Therapy Fluorodeoxyglucose Positron Emission Tomography for Cervical Cancer Are Associated with Prognosis. 
  • Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans. 
  • Common responses of tumors and wounds to hypoxia. 
  • Computational approaches for understanding energy metabolism. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes. 
  • Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. 
  • Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age. 
  • Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. 
  • Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. 
  • Differential induction of mRNAs for the glycolytic and ethanolic fermentative pathways by hypoxia and anoxia in maize seedlings. 
  • Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes. 
  • Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. 
  • Dysfunctional T cell metabolism in the tumor microenvironment. 
  • Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. 
  • Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. 
  • Epigenetics and cancer metabolism. 
  • Erythrocytes of the human neonate. 
  • Estimating relative changes of metabolic fluxes. 
  • Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 
  • Exercise training for competitive tennis. 
  • Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. 
  • Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines. 
  • Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. 
  • Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans. 
  • Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression. 
  • Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. 
  • Genetic selection for enhanced serine metabolism in cancer development. 
  • Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats. 
  • Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. 
  • Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. 
  • Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. 
  • Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Glycolytic reprogramming in cancer cells: PKM2 dimer predominance induced by pulsatile PFK-1 activity. 
  • Growth factors can influence cell growth and survival through effects on glucose metabolism. 
  • Hedgehog controls hepatic stellate cell fate by regulating metabolism. 
  • Hepatic HKDC1 Expression Contributes to Liver Metabolism. 
  • Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma. 
  • Heterogeneity of glycolysis in cancers and therapeutic opportunities. 
  • Heterogeneity of tumor-induced gene expression changes in the human metabolic network. 
  • IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. 
  • IL-7 is essential for homeostatic control of T cell metabolism in vivo. 
  • Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. 
  • In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. 
  • In vitro biochemistry of trabecular meshwork. 
  • Inhibiting glycolysis to reduce seizures: how it might work. 
  • Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. 
  • Inhibition of p38 MAPK alpha/beta reduces ischemic injury and does not block protective effects of preconditioning. 
  • Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo. 
  • Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. 
  • Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells. 
  • Ionic basis of phenytoin sodium inhibition of insulin secretion in pancreatic islets. 
  • Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. 
  • Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens. 
  • Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis. 
  • LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. 
  • Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. 
  • Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. 
  • Metabolic Teamwork in the Stem Cell Niche. 
  • Metabolic coupling factors in pancreatic beta-cell signal transduction. 
  • Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes. 
  • Metabolic landscape of the tumor microenvironment at single cell resolution. 
  • Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment. 
  • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. 
  • Metabolic regulation of Akt: roles reversed. 
  • Metabolic regulation of T lymphocytes. 
  • Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. 
  • Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. 
  • Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. 
  • Metabolism: A new layer of glycolysis. 
  • Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C. 
  • MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. 
  • Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. 
  • Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. 
  • Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells. 
  • Molecular stability and function of Hb C-Harlem. 
  • Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase. 
  • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. 
  • Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Novel therapeutic targets of tumor metabolism. 
  • Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS. 
  • Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane. 
  • Organization of enzyme concentration across the metabolic network in cancer cells. 
  • Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. 
  • Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. 
  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. 
  • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. 
  • Plasmodium berghei: glycolytic enzymes of the infected mouse erythrocyte. 
  • Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment. 
  • Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. 
  • Prognostic value of midtreatment FDG-PET in oropharyngeal cancer. 
  • Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment. 
  • Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells. 
  • Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. 
  • Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. 
  • Radiation induces aerobic glycolysis through reactive oxygen species. 
  • Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies. 
  • Regional metabolism of experimental brain tumors. 
  • Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. 
  • Regulation of carbohydrate and fatty acid utilization by L-carnitine during cardiac development and hypoxia. 
  • Regulatory elements governing transcription in specialized myofiber subtypes. 
  • Revisiting the Warburg Effect: Some Tumors Hold Their Breath. 
  • Rewiring of glycolysis in cancer cell metabolism. 
  • Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. 
  • Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models. 
  • Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. 
  • Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. 
  • Sweet nothings: sensing of sugar metabolites controls T cell function. 
  • Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. 
  • Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. 
  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. 
  • The CD28 signaling pathway regulates glucose metabolism. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma. 
  • The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. 
  • The consequences of enhanced cell-autonomous glucose metabolism. 
  • The effect of age on the accumulation of labile triosephosphate isomerase and thymidine incorporation in pokeweed mitogen stimulated human lymphocytes. 
  • The effect of irrigation solution at different temperatures on articular cartilage metabolism. 
  • The effects of aging and training on skeletal muscle. 
  • The engine driving the ship: metabolic steering of cell proliferation and death. 
  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. 
  • The mechanisms of citrate on regulating the distribution of carbon flux in the biosynthesis of uridine 5'-monophosphate by Saccharomyces cerevisiae. 
  • The protein synthetic surge in response to mitogen triggers high glycolytic enzyme levels in human lymphocytes and occurs prior to DNA synthesis. 
  • The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. 
  • Thermodynamic constraints on the regulation of metabolic fluxes. 
  • Use of an isolated heart model to test the utilization of substrates for inclusion in cardioplegic solutions. 
  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. 
  • WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. 
  • p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology