-
Subject Areas on Research
-
A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors.
-
A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
-
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
-
A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.
-
A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics.
-
A metabolic signature of colon cancer initiating cells.
-
A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.
-
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
-
Acetate Metabolism in Physiology, Cancer, and Beyond.
-
Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.
-
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
-
Activation of glycolysis and apoptosis in glycogen storage disease type Ia.
-
Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.
-
Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion.
-
Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.
-
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
-
Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.
-
Altered metabolism in cancer.
-
Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.
-
Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.
-
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.
-
Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.
-
Biochemical and structural changes in cultured heart cells induced by metabolic inhibition.
-
Biochemistry. A glucose-to-gene link.
-
Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.
-
Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
-
Carbohydrate metabolism in transforming lymphocytes from the aged.
-
Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.
-
ChREBP regulates fructose-induced glucose production independently of insulin signaling.
-
Changes on Midchemoradiation Therapy Fluorodeoxyglucose Positron Emission Tomography for Cervical Cancer Are Associated with Prognosis.
-
Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.
-
Common responses of tumors and wounds to hypoxia.
-
Computational approaches for understanding energy metabolism.
-
Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.
-
Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes.
-
Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life.
-
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
-
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.
-
Decreased autophagy and fuel switching occur in a senescent hepatic cell model system.
-
Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age.
-
Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.
-
Differential induction of mRNAs for the glycolytic and ethanolic fermentative pathways by hypoxia and anoxia in maize seedlings.
-
Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes.
-
Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity.
-
Dysfunctional T cell metabolism in the tumor microenvironment.
-
Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.
-
EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
-
Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.
-
Epigenetics and cancer metabolism.
-
Erythrocytes of the human neonate.
-
Estimating relative changes of metabolic fluxes.
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
-
Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.
-
Exercise training for competitive tennis.
-
Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.
-
Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines.
-
Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.
-
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
-
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
-
From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.
-
Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.
-
Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.
-
Genetic selection for enhanced serine metabolism in cancer development.
-
Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.
-
Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues.
-
Glucose availability and glycolytic metabolism dictate glycosphingolipid levels.
-
Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
-
Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase.
-
Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production.
-
Glycolytic reprogramming in cancer cells: PKM2 dimer predominance induced by pulsatile PFK-1 activity.
-
Growth factors can influence cell growth and survival through effects on glucose metabolism.
-
HIF-1α in heart: protective mechanisms.
-
Hedgehog controls hepatic stellate cell fate by regulating metabolism.
-
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
-
Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.
-
Heterogeneity of glycolysis in cancers and therapeutic opportunities.
-
Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
-
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
-
IL-7 is essential for homeostatic control of T cell metabolism in vivo.
-
Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.
-
In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction.
-
Inhibiting glycolysis to reduce seizures: how it might work.
-
Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.
-
Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.
-
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.
-
Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells.
-
Ionic basis of phenytoin sodium inhibition of insulin secretion in pancreatic islets.
-
Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices.
-
Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity.
-
Leptin metabolically licenses T cells for activation to link nutrition and immunity.
-
Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens.
-
Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.
-
LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism.
-
Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.
-
Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.
-
Metabolic Teamwork in the Stem Cell Niche.
-
Metabolic coupling factors in pancreatic beta-cell signal transduction.
-
Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes.
-
Metabolic landscape of the tumor microenvironment at single cell resolution.
-
Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment.
-
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
-
Metabolic regulation of Akt: roles reversed.
-
Metabolic regulation of T lymphocytes.
-
Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury.
-
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.
-
Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.
-
Metabolism: A new layer of glycolysis.
-
Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C.
-
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.
-
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.
-
Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
-
Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.
-
Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase.
-
New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system.
-
Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue.
-
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.
-
Novel therapeutic targets of tumor metabolism.
-
Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS.
-
Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane.
-
Organization of enzyme concentration across the metabolic network in cancer cells.
-
Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.
-
Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.
-
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
-
Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment.
-
Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice.
-
Prognostic value of midtreatment FDG-PET in oropharyngeal cancer.
-
Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.
-
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.
-
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.
-
Radiation induces aerobic glycolysis through reactive oxygen species.
-
Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies.
-
Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation.
-
Regulatory elements governing transcription in specialized myofiber subtypes.
-
Revisiting the Warburg Effect: Some Tumors Hold Their Breath.
-
Rewiring of glycolysis in cancer cell metabolism.
-
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.
-
Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models.
-
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
-
Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
-
Sweet nothings: sensing of sugar metabolites controls T cell function.
-
Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.
-
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
-
The CD28 signaling pathway regulates glucose metabolism.
-
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
-
The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.
-
The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.
-
The consequences of enhanced cell-autonomous glucose metabolism.
-
The effect of age on the accumulation of labile triosephosphate isomerase and thymidine incorporation in pokeweed mitogen stimulated human lymphocytes.
-
The effect of irrigation solution at different temperatures on articular cartilage metabolism.
-
The engine driving the ship: metabolic steering of cell proliferation and death.
-
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.
-
The protein synthetic surge in response to mitogen triggers high glycolytic enzyme levels in human lymphocytes and occurs prior to DNA synthesis.
-
The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.
-
Thermodynamic constraints on the regulation of metabolic fluxes.
-
Use of an isolated heart model to test the utilization of substrates for inclusion in cardioplegic solutions.
-
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
-
p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.
-
Keywords of People