Glycosaminoglycans

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  Subject Areas on Research

  • "Heparin-free" cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass. 
  • ^* CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments. 
  • A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke. 
  • A straightforward, quantitative ultra-performance liquid chromatography-tandem mass spectrometric method for heparan sulfate, dermatan sulfate and chondroitin sulfate in urine: an improved clinical screening test for the mucopolysaccharidoses. 
  • Acid mucopolysaccharides in the outflow apparatus. 
  • Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction. 
  • An improved method for glycosaminoglycan analysis by LC-MS/MS of urine samples collected on filter paper. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Carbohydrate cytochemistry by transmission and scanning electron microscopy. 
  • Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing. 
  • Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture. 
  • Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. 
  • Characterization of corneal proteoglycans under vitamin A deficiency. 
  • Comparison of T1ρ, dGEMRIC, and quantitative T2 MRI in preoperative ACL rupture patients. 
  • Comparison of dermatan sulfate and heparan sulfate concentrations in serum, cerebrospinal fluid and urine in patients with mucopolysaccharidosis type I receiving intravenous and intrathecal enzyme replacement therapy. 
  • Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury. 
  • Composition and transport properties of human ankle and knee cartilage. 
  • Diagnosis of diffuse malignant mesothelioma: experience of a US/Canadian Mesothelioma Panel. 
  • Differential inhibition of HIV-1 cell binding and HIV-1-induced syncytium formation by low molecular weight sulphated polysaccharides. 
  • Distributing a fixed amount of cyclic loading to tendon explants over longer periods induces greater cellular and mechanical responses. 
  • Distribution and significance of hyaluronidase-sensitive materials in the trabecular wall of Schlemm's canal. 
  • Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1. 
  • Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds. 
  • Effects of cell damage and glycosaminoglycan degradation on available extravascular space of different dextrans in a rat fibrosarcoma. 
  • Efficient analysis of urinary glycosaminoglycans by LC-MS/MS in mucopolysaccharidoses type I, II and VI. 
  • Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. 
  • Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation. 
  • Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. 
  • Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. 
  • Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. 
  • Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria. 
  • Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria. 
  • Glycosaminoglycan binding properties of natural venezuelan equine encephalitis virus isolates. 
  • Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C. 
  • Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. 
  • Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans. 
  • Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-1alpha. 
  • Immunoinhibition of intracellular protein digestion in macrophages. 
  • Influence of physical properties of biomaterials on cellular behavior. 
  • Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. 
  • Ionic modulation of the effects of heparin on plasminogen activation by tissue plasminogen activator: the effects of ionic strength, divalent cations, and chloride. 
  • Kinetic analysis of the effects of glycosaminoglycans and lipoproteins on urokinase-mediated plasminogen activation. 
  • Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. 
  • Large-dose infusions of heparinoid ORG 10172 in ischemic stroke. 
  • Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. 
  • Mechanism of shortened bones in mucopolysaccharidosis VII. 
  • Medusa cells: the morphology and cytochemistry of common amoeboid variants of eosinophils. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Murine parietal endoderm cells synthesise heparan sulphate and 170K and 145K sulphated glycoproteins as components of Reichert's membrane. 
  • Myotonic muscular dystrophy: morphology, histochemistry, and growth characteristics of cultured skin fibroblasts. 
  • Parenteral anticoagulation with the heparinoid Lomoparan (Org 10172) in patients with heparin induced thrombocytopenia and thrombosis. 
  • Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). 
  • Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate. 
  • Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. 
  • Product comparison model in otolaryngology: Equivalency analysis of absorbable hemostatic agents after endoscopic sinus surgery. 
  • Quantification of Glycosaminoglycans in Urine by Isotope-Dilution Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry. 
  • Quantification of glycosaminoglycans in urine by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry. 
  • RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Receptor Switching in Newly Evolved Adeno-associated Viruses. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress. 
  • Role of pericellular matrix in development of a mechanically functional neocartilage. 
  • Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta. 
  • Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. 
  • Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration. 
  • The North Carolina Experience with Mucopolysaccharidosis Type I Newborn Screening. 
  • The appearance of the outflow apparatus of the eye after staining with ruthenium red. 
  • The carbohydrates in frog retinal rod outer segments. 
  • The effect of irrigation solution at different temperatures on articular cartilage metabolism. 
  • The effects of adipokines on cartilage and meniscus catabolism. 
  • The effects of exposure of articular cartilage to air. A histochemical and ultrastructural investigation. 
  • The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. 
  • The gelatinous bone marrow (serous atrophy) in patients with acquired immunodeficiency syndrome. Evidence of excess sulfated glycosaminoglycan. 
  • The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development. 
  • The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants. 
  • The uveal effusion syndrome and trans-scleral flow. 
  • Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. 
  • Triiodothyronine stimulates cartilage growth and maturation by different mechanisms. 
  • Urinary glycosaminoglycans in normal subjects and patients with stones. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology