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Subject Areas on Research
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A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas.
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A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2.
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A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.
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A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity.
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A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity.
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A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats.
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A novel GALNT3 mutation in a pseudoautosomal dominant form of tumoral calcinosis: evidence that the disorder is autosomal recessive.
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A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum.
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A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
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A transcription factor links growth rate and metabolism in the hypersaline adapted archaeon Halobacterium salinarum.
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Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.
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Advanced glycation end products contribute to amyloidosis in Alzheimer disease.
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Advances in enzymology and related areas of molecular biology. Preface.
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AglJ adds the first sugar of the N-linked pentasaccharide decorating the Haloferax volcanii S-layer glycoprotein.
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AglQ is a novel component of the Haloferax volcanii N-glycosylation pathway.
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AglR is required for addition of the final mannose residue of the N-linked glycan decorating the Haloferax volcanii S-layer glycoprotein.
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Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization.
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Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.
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An important role of l-fucose biosynthesis and protein fucosylation genes in Arabidopsis immunity.
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Antibody responses to the HIV-1 envelope high mannose patch.
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Antibody-independent, complement-mediated enhancement of HIV-1 infection by mannosidase I and II inhibitors.
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Antigenicity and Immunogenicity of HIV-1 Envelope Trimers Complexed to a Small-Molecule Viral Entry Inhibitor.
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Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate.
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Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer.
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Association of the Novel Inflammatory Marker GlycA and Incident Heart Failure and Its Subtypes of Preserved and Reduced Ejection Fraction: The Multi-Ethnic Study of Atherosclerosis.
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Behçet's disease patients present high levels of deglycosylated anti-lipoteichoic acid IgG and high IL-8 production after lipoteichoic acid stimulation.
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Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits.
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Broad Analysis of Vicinal Disulfides: Occurrences, Conformations with Cis or with Trans Peptides, and Functional Roles Including Sugar Binding.
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Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.
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Cell adhesion molecule L1 in folded (horseshoe) and extended conformations.
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Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair.
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Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.
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Characterization of glycosylation profiles of HIV-1 transmitted/founder envelopes by mass spectrometry.
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Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins.
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Characterization of the PMT gene family in Cryptococcus neoformans.
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Chemoenzymatic Assembly of Bacterial Glycoconjugates for Site-Specific Orthogonal Labeling.
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Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.
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Cloning, expression, and cellular localization of a human prenylcysteine lyase.
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Coming together at the hinges: Therapeutic prospects of IgG3.
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Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140.
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Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein.
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Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin.
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Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design.
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Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21).
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Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death.
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Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration.
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Determinants of Tenascin-C and HIV-1 envelope binding and neutralization.
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Different routes to the same ending: comparing the N-glycosylation processes of Haloferax volcanii and Haloarcula marismortui, two halophilic archaea from the Dead Sea.
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Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations.
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Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2.
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Distinct glycan-charged phosphodolichol carriers are required for the assembly of the pentasaccharide N-linked to the Haloferax volcanii S-layer glycoprotein.
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Distinct patterns of glycosylation of colligin, a collagen-binding glycoprotein, and SPARC (osteonectin), a secreted Ca2+-binding glycoprotein. Evidence for the localisation of colligin in the endoplasmic reticulum.
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Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid.
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Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway.
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Early AGEing and Alzheimer's.
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Eliminating antibody polyreactivity through addition of N-linked glycosylation.
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Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.
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Erythrocyte Webb-type glycophorin C variant lacks N-glycosylation due to an asparagine to serine substitution.
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Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure.
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Evidence against posttranslational glycosylation of rat glucocorticoid receptors.
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Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.
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Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation.
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Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.
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Ex Vivo Expansion or Manipulation of Stem Cells to Improve Outcome of Umbilical Cord Blood Transplantation.
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Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells.
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Expression analysis of endoglin missense and truncation mutations: insights into protein structure and disease mechanisms.
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Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
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Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.
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Functional analysis of the lipoglycodepsipeptide antibiotic ramoplanin.
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Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa.
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Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant.
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Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment
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GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
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Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity.
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Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1.
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Glycated AAV vectors: chemical redirection of viral tissue tropism.
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Glyco-engineering in Archaea: differential N-glycosylation of the S-layer glycoprotein in a transformed Haloferax volcanii strain.
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Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.
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Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments.
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Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity.
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Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers.
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Glycosylation influences intracellular transit time and secretion rate of human prorenin in transfected cells.
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Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.
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Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis.
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Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility.
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Glycosylation site-specific analysis of clade C HIV-1 envelope proteins.
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HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.
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HIV-1 intrapatient sequence diversity in the immunogenic V3 region.
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Heterogeneity in the B1 (CD20) cell surface molecule expressed by human B-lymphocytes.
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Human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function.
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Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells.
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Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis.
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Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of Ranvier.
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Increased nonenzymatically glycosylated proteins in the vitreous humor of diabetic animals.
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Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.
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Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.
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Involvement of histo-blood-group antigens in the susceptibility of colon carcinoma cells to natural killer-mediated cytotoxicity.
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Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.
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Is amyloid beta-protein glycated in Alzheimer's disease?
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Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.
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L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity.
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Life with too much polyprenol: polyprenol reductase deficiency.
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Lipid modification gives rise to two distinct Haloferax volcanii S-layer glycoprotein populations.
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Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation.
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Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells.
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Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system.
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Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.
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Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.
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Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis.
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Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation.
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Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41.
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Myelodysplasia and deficiency of uridine diphosphate-galactose 4-epimerase.
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N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus.
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N-glycosylation in the thermoacidophilic archaeon Sulfolobus acidocaldarius involves a short dolichol pyrophosphate carrier.
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N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.
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Neonatal plasminogen displays altered cell surface binding and activation kinetics. Correlation with increased glycosylation of the protein.
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NgBR is essential for endothelial cell glycosylation and vascular development.
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Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1.
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Novel nucleocytoplasmic protein O-fucosylation by SPINDLY regulates diverse developmental processes in plants.
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Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock.
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O-glycosylation as a sorting determinant for cell surface delivery in yeast.
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Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries.
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Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex.
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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
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Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.
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Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.
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Potential pathogenicity of deglycosylated IgG cross reactive with streptokinase and fibronectin in the serum of patients with rheumatoid arthritis.
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Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features.
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Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation.
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Purification and partial molecular characterization of GRP94, an ER resident chaperone.
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Purification, characterization, and immunogenicity of a soluble trimeric envelope protein containing a partial deletion of the V2 loop derived from SF162, an R5-tropic human immunodeficiency virus type 1 isolate.
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Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
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Quaternary epitope specificities of anti-HIV-1 neutralizing antibodies generated in rhesus macaques infected by the simian/human immunodeficiency virus SHIVSF162P4.
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Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections.
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Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers.
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Revisiting N-glycosylation in Halobacterium salinarum: Characterizing a dolichol phosphate- and glycoprotein-bound tetrasaccharide.
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RoBo-1, a novel member of the urokinase plasminogen activator receptor/CD59/Ly-6/snake toxin family selectively expressed in rat bone and growth plate cartilage.
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Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.
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Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure.
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SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.
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Safety and immunogenicity of a fully glycosylated recombinant gp160 human immunodeficiency virus type 1 vaccine in subjects at low risk of infection. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group Network.
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Salt stress increases abundance and glycosylation of CFTR localized at apical surfaces of salt gland secretory cells.
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Self-organization of apical membrane protein sorting in epithelial cells.
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Sialic acid content of plasminogen 2 glycoforms as a regulator of fibrinolytic activity. Isolation, carbohydrate analysis, and kinetic characterization of six glycoforms of plasminogen.
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Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton.
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Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from nonmucinous pancreatic cysts.
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Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.
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Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
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Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein.
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Substrate promiscuity: AglB, the archaeal oligosaccharyltransferase, can process a variety of lipid-linked glycans.
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Synthesis and bioactivity of carbohydrate derivatives of indigo, its isomers and heteroanalogues.
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Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211At via a tin precursor.
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Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition.
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TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44.
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Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma.
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Terminal N-linked galactose is the primary receptor for adeno-associated virus 9.
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The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template.
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The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization.
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The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans.
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The SARS-CoV-2 Spike variant D614G favors an open conformational state.
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The acceptor substrate specificity of porcine submaxillary UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is dependent on the amino acid sequences adjacent to serine and threonine residues.
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The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge.
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The loss of a polymorphic glycosylation site caused by Thr-927-->Ile is linked to a second polymorphic Val-816-->Ile substitution in lysosomal alpha-glucosidase of American blacks.
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The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation.
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Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells.
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Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.
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Total synthesis of cyanolide A and confirmation of its absolute configuration.
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Two distinct N-glycosylation pathways process the Haloferax volcanii S-layer glycoprotein upon changes in environmental salinity.
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