Gout

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  Subject Areas on Research

  • A histopathologic study of retinal arterial aneurysms. 
  • A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout. 
  • Acute gout presenting in the manubriosternal joint. 
  • Agency and structure in the sociology of sickness. 
  • An examination of the relationship between serum uric acid level, a clinical history of gout, and cardiovascular outcomes among patients with acute coronary syndrome. 
  • Antihypertensive effectiveness of very low doses of hydrochlorothiazide: results of the PHICOG Trial. 
  • Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid. 
  • Aspiration of the asymptomatic metatarsophalangeal joint in gout patients and hyperuricemic controls. 
  • Association of Gout With Long-Term Cardiovascular Outcomes Among Patients With Obstructive Coronary Artery Disease. 
  • Biochemical profile of stone-forming patients with diabetes mellitus. 
  • Circulating galectin-3 in infections and non-infectious inflammatory diseases. 
  • Clinical Images: a not-so crystal-clear ankle mass. 
  • Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing. 
  • Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation. 
  • Colchicine--Update on mechanisms of action and therapeutic uses. 
  • Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout. 
  • Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. 
  • Cost-effectiveness analysis of genotyping for HLA-B*5801 and an enhanced safety program in gout patients starting allopurinol in Singapore. 
  • Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. 
  • Editorial Commentary: Prevention and treatment of atrial fibrillation: Is hyperuricemia the next target? 
  • Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. 
  • Ethnic background has minimal impact on the etiology of nephrolithiasis. 
  • Familial hyperuricemia and renal insufficiency. 
  • Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol study. 
  • Fine-needle aspiration cytology of articular and periarticular lesions. 
  • Gout and the regulation of purine biosynthesis. 
  • Gout as a source of sesamoid pain. 
  • Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. 
  • Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in Gout. 
  • Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? 
  • Gout, tophi and the wonders of NETs. 
  • Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients. 
  • Long-term colchicine administration leading to colchicine toxicity and death. 
  • Migration and gout: the Tokelau Island migrant study. 
  • Molecular abnormalities of human plasminogen isolated from synovial fluid of rheumatoid arthritis patients. 
  • Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis? 
  • Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout. 
  • Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout. 
  • Reassessing serum urate targets in the management of refractory gout: can you go too low? 
  • Renal calculi: pathogenesis, diagnosis, and medical therapy. 
  • Rheumatologic manifestations of cancer. 
  • The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. 
  • The kinetics of intramolecular distribution of 15N in uric acid following administration of 15N-glycine: preferential labeling of N-(3+9) of uric acid in primary gout and a reappraisal of the "glutamine hypothesis". 
  • Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. 
  • Uricase and other novel agents for the management of patients with treatment-failure gout. 
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  Keywords of People

  • Allen, Nancy Bates, Professor Emeritus of Medicine, Medicine, Rheumatology and Immunology
  • Ostbye, Truls, Professor of Family Medicine and Community Health, Family Medicine and Community Health
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology