Gram-Negative Bacteria

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  Subject Areas on Research

  • 10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America. 
  • A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058. 
  • A comparison of neonatal Gram-negative rod and Gram-positive cocci meningitis. 
  • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. 
  • A novel secretion apparatus for the assembly of adhesive bacterial pili. 
  • Analysis of bacterial cultures in infectious keratitis, 1997 to 2004. 
  • Antibacterial Resistance Leadership Group 2.0: Back to Business. 
  • Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514. 
  • Bacteremia in lung transplant recipients in the current era. 
  • Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate. 
  • Bacterial outer membrane vesicles and the host-pathogen interaction. 
  • Bacteriologic features of surgical site infections following breast surgery. 
  • Bacteriophages that infect Gram-negative bacteria as source of signal-arrest-release motif lysins. 
  • Biological functions and biogenesis of secreted bacterial outer membrane vesicles. 
  • Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. 
  • Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis. 
  • Ceftaroline for complicated skin and skin-structure infections. 
  • Central line-associated bloodstream infection in hospitalized children with peripherally inserted central venous catheters: extending risk analyses outside the intensive care unit. 
  • Clinical Outcomes and Healthcare Utilization Related to Multidrug-Resistant Gram-Negative Infections in Community Hospitals. 
  • Clinical importance of "breakthrough" bacteremia. 
  • Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria. 
  • Crossing a biological velvet rope. 
  • Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. 
  • Defining wound microbial flora: molecular microbiology opening new horizons. 
  • Diagnostic methods to determine microbiology of postpartum endometritis in South Asia: laboratory methods protocol used in the Postpartum Sepsis Study: a prospective cohort study. 
  • Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin*. 
  • Drug design from the cryptic inhibitor envelope. 
  • Early and late onset sepsis in late preterm infants. 
  • Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. 
  • Envelope control of outer membrane vesicle production in Gram-negative bacteria. 
  • Environmentally controlled bacterial vesicle-mediated export. 
  • Establishing communication via gram-negative bacterial pili. 
  • Expanded Gram-Negative Antimicrobial Prophylaxis Reduces Surgical Site Infections in Hip Arthroplasty. 
  • Expanding the Database of Signal-Anchor-Release Domain Endolysins Through Metagenomics. 
  • Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals. 
  • Fluoroquinolone resistance during 2000-2005: an observational study. 
  • Functionality of the TOL plasmid under varying environmental conditions following conjugal transfer. 
  • Genetically engineered probiotic competition. 
  • Gram-Negative Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group. 
  • High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors. 
  • How bacterial cell division might cheat turgor pressure - a unified mechanism of septal division in Gram-positive and Gram-negative bacteria. 
  • Hyperkeratotic rim of gram-negative toe web infections. 
  • Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. 
  • Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit. 
  • In vitro assembly and GTP hydrolysis by bacterial tubulins BtubA and BtubB. 
  • In vitro efficacy of a polyhexamethylene biguanide-impregnated gauze dressing against bacteria found in veterinary patients. 
  • Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. 
  • Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. 
  • Mast cell modulation of immune responses to bacteria. 
  • Microbiology of ventilator-associated pneumonia compared with that of hospital-acquired pneumonia. 
  • Multicountry Distribution and Characterization of Extended-spectrum β-Lactamase-associated Gram-negative Bacteria From Bloodstream Infections in Sub-Saharan Africa. 
  • New nitrogen-fixing microorganisms detected in oligotrophic oceans by amplification of Nitrogenase (nifH) genes. 
  • Noise reduction by diffusional dissipation in a minimal quorum sensing motif. 
  • Non-HACEK gram-negative bacillus endocarditis. 
  • Offense and defense: microbial membrane vesicles play both ways. 
  • Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions. 
  • Overview of first-line amikacin therapy for urologic infections. 
  • Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. 
  • Phospholipid distribution in the cytoplasmic membrane of Gram-negative bacteria is highly asymmetric, dynamic, and cell shape-dependent. 
  • Plasma concentrations of tumour necrosis factor-alpha and interleukin-6 during burn wound surgery or dressing. 
  • Preliminary study using species-specific oligonucleotide probe for rRNA of Bilophila wadsworthia. 
  • Protein selection and export via outer membrane vesicles. 
  • Quantitative and qualitative preparations of bacterial outer membrane vesicles. 
  • Recent Advances in Lipopolysaccharide Recognition Systems. 
  • Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. 
  • Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response. 
  • Results from a 13-Year Prospective Cohort Study Show Increased Mortality Associated with Bloodstream Infections Caused by Pseudomonas aeruginosa Compared to Other Bacteria. 
  • Risk factors for gram-negative bacterial surgical site infection: do allergies to antibiotics increase risk? 
  • Specificity and immunochemical properties of antibodies to bacterial DNA in sera of normal human subjects and patients with systemic lupus erythematosus (SLE). 
  • Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance. 
  • Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. 
  • Structure, inhibition, and regulation of essential lipid A enzymes. 
  • Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria. 
  • Sutterella wadsworthensis gen. nov., sp. nov., bile-resistant microaerophilic Campylobacter gracilis-like clinical isolates. 
  • The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis. 
  • The North American component (the United States and Canada) of an International Comparative MIC trial monitoring ofloxacin resistance. 
  • The Vitek analyser for routine bacterial identification and susceptibility testing: protocols, problems, and pitfalls. 
  • The development and evaluation of a community-based clinical diagnosis tool and treatment regimen for postpartum sepsis in Bangladesh and Pakistan. 
  • The etiology of febrile illness in adults presenting to Patan hospital in Kathmandu, Nepal. 
  • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. 
  • The extracellular vesicle generation paradox: a bacterial point of view. 
  • The role of lipid rafts in the pathogenesis of bacterial infections. 
  • Treatment of multidrug-resistant gram-negative bacilli after solid organ transplant: Outcomes and complications. 
  • Type III protein secretion mechanism in mammalian and plant pathogens. 
  • Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis. 
  • United States geographic bacteria susceptibility patterns. 1997 ASCP Susceptibility Testing Group. 
  • VA/Q abnormalities during gram negative sepsis. 
  • Virulence and immunomodulatory roles of bacterial outer membrane vesicles. 
  • “A robust platform for the synthesis of new tetracycline antibiotics 
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  Keywords of People

  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Cell Biology