Granulosa Cells
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Subject Areas on Research
- 2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator.
- A grafted ovarian fragment rescues host fertility after chemotherapy.
- A model system for the biochemical study of luteinizing hormone/chorionic gonadotropin receptor synthesis.
- A nonradioactive assay for transfected chloramphenicol acetyltransferase activity using fluorescent substrates.
- A serum-free defined culture system which maintains follicle-stimulating hormone responsiveness and differentiation of porcine granulosa cells.
- Androgens amplify beta-adrenergic and FSH stimulation of granulosa cells.
- Binding of progesterone to cell surfaces of human granulosa-lutein cells.
- Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia.
- Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3',5'-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells.
- Changes in (125I) labeled human chorionic gonadotropin (hCG) binding to porcine granulosa cells during follicle development and cell culture.
- Compartmental ovarian steroidogenesis in polycystic ovary syndrome.
- Decreased intracellular potassium levels underlie increased progesterone synthesis during ovarian follicular atresia.
- Developmental coordination of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and acute hCG responsiveness in cultured and freshly harvested porcine granulosa cells.
- Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation.
- Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.
- Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro.
- Effects of atrial natriuretic peptide on rat ovarian granulosa cell steroidogenesis in vitro.
- Effects of cytokines on porcine granulosa cell steroidogenesis in vitro.
- Effects of diethylstilbestrol on rat granulosa cell and thecal/interstitial cell transforming growth factor-beta 2 mRNA expression in vivo: analysis by reverse transcription-polymerase chain reaction.
- Effects of partially and more highly purified platelet-derived growth factor preparations on luteinizing hormone receptor induction in granulosa cell cultures.
- Epidermal growth factor enhances [125I]iodo-follicle-stimulating hormone binding by cultured porcine granulosa cells.
- Estrogen and progesterone production by granulosa cell monolayers derived from in vitro fertilization procedures: lack of evidence for modulation by androgen.
- Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells.
- Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.
- Follicle-stimulating hormone-mediated induction of functional luteinizing hormone/human chorionic gonadotropin receptors during monolayer culture of porcine granulosa cells.
- Gonadotropin regulation of the rat proopiomelanocortin promoter: characterization by transfection of primary ovarian granulosa cells.
- Granulosa cell differentiation in vitro: effect of insulin on growth and functional integrity.
- Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.
- Human granulosa-luteal and cumulus cells express transforming growth factors-beta type 1 and type 2 mRNA.
- Human platelet-derived growth factor preparations contain a separate activity which potentiates follicle-stimulating hormone-mediated induction of luteinizing hormone receptor in cultured rat granulosa cells: evidence for transforming growth factor-beta.
- Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells.
- Influence of vitamin A injection before mating on oocyte development, follicular hormones, and ovulation in gilts fed high-energy diets.
- Interactions between hormones and growth factors in the regulation of granulosa cell differentiation in vitro.
- Interleukin-6: effects on and production by rat granulosa cells in vitro.
- Intracellular mechanisms of gonadotropin-stimulated gene expression in granulosa cells.
- Modulation of progestin secretion in ovarian cells by 17beta-hydroxy-5alpha-androstan-3-one (dihydrotestosterone): a direct demonstration in monolayer culture.
- Monolayer growth and differentiated function of porcine and rat granulosa cells following cryopreservation.
- Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease.
- Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by follicle-stimulating hormone and serum.
- Porcine granulosa cells do not express transforming growth factor-beta 2 (TGF-beta 2) messenger ribonucleic acid: molecular basis for their inability to produce TGF-beta activity comparable to that of rat granulosa cells.
- Production of progestin-stimulatory factor(s) by enriched populations of rat T and B lymphocytes.
- RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.
- Rat granulosa cells express transforming growth factor-beta type 2 messenger ribonucleic acid which is regulatable by follicle-stimulating hormone in vitro.
- Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen.
- Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence.
- Screening of potential reproductive toxicants by use of porcine granulosa cell cultures.
- Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter.
- Steroidal modulation of progesterone secretion by granulosa cells from large porcine follicles: a role for androgens and estrogens in controlling steroidogenesis.
- Steroidal modulation of steroid secretion in vitro: an experimental approach to intra-follicular regulatory mechanisms.
- Steroidogenesis in porcine atretic follicles: loss of aromatase activity in isolated granulosa and theca.
- Synergistic effect of insulin and follicle-stimulating hormone on biochemical and morphological differentiation of porcine granulosa cells in vitro.
- Synthetic estrogens suppress granulosa cell progesterone production in vitro.
- Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.
- The effect of plating density on granulosa cell growth and differentiation in vitro.
- The effect of transforming growth factor-beta on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells.
- The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.
- The production of transforming growth factor-beta activity by rat granulosa cell cultures.
- The regulation of granulosa cell proopiomelanocortin messenger ribonucleic acid by androgens and gonadotropins.
- Toxicity of methoxyacetic acid in cultured human luteal cells.
- Transforming growth factor beta modulates gonadotropin receptor expression in porcine and rat granulosa cells differently.
- Use of human cumulus granulosa cells for in vitro screening of reproductive toxicants.
- Water permeability of an ovarian antral follicle is predominantly transcellular and mediated by aquaporins.
- [125I]iodo-epidermal growth factor binding and mitotic responsiveness of porcine granulosa cells are modulated by differentiation and follicle-stimulating hormone.