Growth Substances

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  Subject Areas on Research

  • A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 
  • A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. 
  • A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity. 
  • A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes. 
  • A serum-free defined culture system which maintains follicle-stimulating hormone responsiveness and differentiation of porcine granulosa cells. 
  • Activation of protein kinase C inhibits human keratinocyte migration. 
  • Activin expression by cultured human retinal pigment epithelial cells. 
  • Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. 
  • Acute radiation injury: contingency planning for triage, supportive care, and transplantation. 
  • Adenosine 3',5'-monophosphate: a modulator of embryonic chick cartilage growth. 
  • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. 
  • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide. 
  • An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. 
  • Angiogenesis. 
  • Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. 
  • Angiogenic therapy for coronary artery and peripheral arterial disease. 
  • Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. 
  • Antisense technology to block autocrine growth factors. 
  • Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats. 
  • Arterial homeostasis, inflammation, and erythropoietic growth factors. 
  • Autocrine-paracrine mechanisms of vascular myocytes in systemic hypertension. 
  • Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. 
  • Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF). 
  • Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules. 
  • Biology of small cell lung cancer. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. 
  • Bombyxin is a growth factor for wing imaginal disks in Lepidoptera. 
  • Bone morphogenetic protein induces bone in the squirrel monkey, but bone matrix does not. 
  • Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. 
  • CCK-releasing activity of rat intestinal secretion: effect of atropine and comparison with monitor peptide. 
  • Calmodulin, cell growth and gene expression. 
  • Cell biology of vascular hypertrophy in systemic hypertension. 
  • Cell growth regulation in epithelial ovarian cancer. 
  • Cellular and molecular studies in brain and nervous system oncology. 
  • Changes in the distribution of GAP-43 during the development of neuronal polarity. 
  • Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro. 
  • Characterization of the hematopoietic defect in paroxysmal nocturnal hemoglobinuria. 
  • Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium. 
  • Chronic ethanol intoxication enhances the production of cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein-2 by hepatocytes after human immunodeficiency virus-1 glycoprotein 120 vaccination. 
  • Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies. 
  • Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. 
  • Comparative effects of growth factors on fibroblasts of Dupuytren's tissue and normal palmar fascia. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. 
  • Controlled evaluation of blood culture medium containing gelatin and V-factor-analog for detection of septicemia in children. 
  • DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. 
  • Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. 
  • Deletion of carboxy-terminal residues of murine granulocyte-macrophage colony-stimulating factor results in a loss of biologic activity and altered glycosylation. 
  • Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones. 
  • Development of the coronary blood supply: changing concepts and current ideas. 
  • Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. 
  • Differential properties among clones of simian virus 40-transformed human epithelial cells. 
  • Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival. 
  • Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract. 
  • Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. 
  • Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. 
  • Effects of hematopoietic growth factors following myeloablation in a primate model. 
  • Effects of keratinocyte growth factor-2 (KGF-2) on wound healing in an ischaemia-impaired rabbit ear model and on scar formation. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Emergence of the keratinocyte growth factor multigene family during the great ape radiation. 
  • Endocrine therapy in metastatic breast cancer. 
  • Endothelium and growth factors in vascular remodeling of hypertension. 
  • Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. 
  • Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathology. 
  • Expression of TGFalpha in meningiomas. 
  • Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick. 
  • Expression of differentiation antigens by hybrids of human lymphoblastoid cells. 
  • Expression of growth factor and growth factor receptor RNA in rat pleural mesothelial cells in culture. 
  • Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. 
  • Expression of nonphagocytic NADPH oxidase system in the ocular lens. 
  • Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells. 
  • Fate of GAP-43 in ascending spinal axons of DRG neurons after peripheral nerve injury: delayed accumulation and correlation with regenerative potential. 
  • Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide. 
  • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. 
  • Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans. 
  • Future directions in toxicity prevention. 
  • Future directions in toxicity prevention. 
  • GAP-43 as a 'calmodulin sponge' and some implications for calcium signalling in axon terminals. 
  • Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. 
  • Global analysis of gene expression in renal ischemia-reperfusion in the mouse. 
  • Graft hyporeactivity induced by donor-derived dendritic cell progenitors. 
  • Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. 
  • Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. 
  • Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • Growth factor-regulated proteases and extracellular matrix remodeling during mammalian development. 
  • Growth factors in development: the role of TGF-beta related polypeptide signalling molecules in embryogenesis. 
  • Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. 
  • Hemopoiesis and aging. 
  • High levels of granulocyte and granulocyte-macrophage colony-stimulating factors in cord blood of normal full-term neonates. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations. 
  • Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors. 
  • Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages. 
  • Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung. 
  • Idiopathic pulmonary fibrosis. New insights into classification and pathogenesis usher in a new era therapeutic approaches. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning. 
  • Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. 
  • Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways. 
  • Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. 
  • Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. 
  • Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. 
  • Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. 
  • Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells. 
  • Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. 
  • Isolation and purification of morphogenic autoregulatory substance produced by Candida albicans. 
  • Keratinocyte growth factor--just another mitogen or the "Holy Grail" that regulates liver regeneration? 
  • Local contractile and growth modulators in the myocardium. 
  • Long-term healing of bone using recombinant human bone morphogenetic protein 2. 
  • Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells. 
  • Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration. 
  • Mechanical load stimulates expression of novel genes in vivo and in vitro in avian flexor tendon cells. 
  • Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding. 
  • Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II. 
  • Molecular biology of gastrointestinal peptides and growth factors: relevance to intestinal adaptation. 
  • Molecular biology of hypertension. 
  • Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications. 
  • Monitor peptide binding sites are expressed in the rat liver and small intestine. 
  • Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors. 
  • Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells. 
  • NH2-terminal amino acid sequence of rabbit hepatopoietin A, a heparin-binding polypeptide growth factor for hepatocytes. 
  • NIEHS/EPA Workshops. Growth and differentiation factors. 
  • NIEHS/EPA Workshops. Pattern formation. 
  • Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. 
  • Neural crest and cardiovascular development: a 20-year perspective. 
  • Neural selective activation and temporal regulation of a mammalian GAP-43 promoter in zebrafish. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • Neutrophil growth factors. 
  • Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans. 
  • New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. 
  • Nutrition, hormones, metabolism, and liver regeneration. 
  • Optimization and characterization of the capillary human tumor clonogenic cell assay. 
  • Oxidized alpha2-macroglobulin (alpha2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation. 
  • PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation. 
  • Pathogenesis of ovarian cancers. 
  • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. 
  • Peripheral blood stem cell harvesting and CD34-positive cell selection. 
  • Phenotypic and cell cycle properties of human oligodendrocytes in vitro. 
  • Plasticity in the adult human oligodendrocyte lineage. 
  • Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by follicle-stimulating hormone and serum. 
  • Poly(alpha-hydroxy acids): carriers for bone morphogenetic proteins. 
  • Possible cellular and molecular mechanisms for asbestos carcinogenicity. 
  • Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43. 
  • Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals. 
  • Quantitative assessment of growth stimulating activity of the vitreous during PVR. 
  • Recombinant human granulocyte-macrophage colony-stimulating factor produces fever. 
  • Regulation of cholecystokinin secretion by intraluminal releasing factors. 
  • Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies. 
  • Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog. 
  • Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells. 
  • SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. 
  • Selective conservation of GAP-43 structure in vertebrate evolution. 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. 
  • Stimulation of endothelial cell prostacyclin release by retina-derived factors. 
  • Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. 
  • The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. 
  • The aromatase enzyme: from cloning to cancer. 
  • The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. 
  • The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer. 
  • The granulin-epithelin precursor: a putative new growth factor for ovarian cancer. 
  • The role of hematopoietic growth factors and oncogenes in leukemogenesis. 
  • The role of peptide growth factors in epithelial ovarian cancer. 
  • The use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous bone marrow transplantation. 
  • The uterine myometrium is a target for increased levels of activin A during pregnancy. 
  • Tissue engineering for meniscus repair. 
  • Transforming growth factor beta3 promotes fascial wound healing in a new animal model. 
  • Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. 
  • Transient requirement for ganglion cells during assembly of retinal synaptic layers. 
  • Tyrosine phosphorylation in human neutrophil. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. 
  • Viral oncogenes and signal transduction. 
  • What keeps a resting T cell alive? 
  • Wnt proteins are lipid-modified and can act as stem cell growth factors. 
  • alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. 
  • c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. 
  • c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors. 
  • p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Olson, Steven Arthur, Professor of Orthopaedic Surgery, Orthopaedics
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology