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Subject Areas on Research
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A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.
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A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.
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A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity.
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A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes.
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A serum-free defined culture system which maintains follicle-stimulating hormone responsiveness and differentiation of porcine granulosa cells.
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Activation of protein kinase C inhibits human keratinocyte migration.
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Activin expression by cultured human retinal pigment epithelial cells.
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Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes.
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Acute radiation injury: contingency planning for triage, supportive care, and transplantation.
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Adenosine 3',5'-monophosphate: a modulator of embryonic chick cartilage growth.
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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.
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Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer.
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Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
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An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide.
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Angiogenesis.
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Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.
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Angiogenic therapy for coronary artery and peripheral arterial disease.
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Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants.
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Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.
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Antisense technology to block autocrine growth factors.
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Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats.
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Arterial homeostasis, inflammation, and erythropoietic growth factors.
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Autocrine-paracrine mechanisms of vascular myocytes in systemic hypertension.
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Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF).
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Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules.
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Biology of small cell lung cancer.
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Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).
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Bombyxin is a growth factor for wing imaginal disks in Lepidoptera.
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Bone morphogenetic protein induces bone in the squirrel monkey, but bone matrix does not.
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Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos.
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CCK-releasing activity of rat intestinal secretion: effect of atropine and comparison with monitor peptide.
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Calmodulin, cell growth and gene expression.
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Cell biology of vascular hypertrophy in systemic hypertension.
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Cell growth regulation in epithelial ovarian cancer.
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Cellular and molecular studies in brain and nervous system oncology.
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Changes in the distribution of GAP-43 during the development of neuronal polarity.
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Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro.
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Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium.
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Chronic ethanol intoxication enhances the production of cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein-2 by hepatocytes after human immunodeficiency virus-1 glycoprotein 120 vaccination.
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Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies.
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Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth.
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Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc.
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Controlled evaluation of blood culture medium containing gelatin and V-factor-analog for detection of septicemia in children.
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DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
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Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression.
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Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones.
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Development of the coronary blood supply: changing concepts and current ideas.
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Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation.
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Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival.
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Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract.
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Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
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Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation.
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Effects of hematopoietic growth factors following myeloablation in a primate model.
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Effects of keratinocyte growth factor-2 (KGF-2) on wound healing in an ischaemia-impaired rabbit ear model and on scar formation.
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Embryonic germ cell lines and their derivation from mouse primordial germ cells.
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Emergence of the keratinocyte growth factor multigene family during the great ape radiation.
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Endocrine therapy in metastatic breast cancer.
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Endothelium and growth factors in vascular remodeling of hypertension.
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Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.
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Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity.
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Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain.
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Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathology.
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Expression of TGFalpha in meningiomas.
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Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick.
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Expression of differentiation antigens by hybrids of human lymphoblastoid cells.
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Expression of growth factor and growth factor receptor RNA in rat pleural mesothelial cells in culture.
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Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines.
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Expression of nonphagocytic NADPH oxidase system in the ocular lens.
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Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells.
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Fate of GAP-43 in ascending spinal axons of DRG neurons after peripheral nerve injury: delayed accumulation and correlation with regenerative potential.
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Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide.
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Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
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Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans.
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Future directions in toxicity prevention.
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Future directions in toxicity prevention.
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GAP-43 as a 'calmodulin sponge' and some implications for calcium signalling in axon terminals.
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Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.
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Global analysis of gene expression in renal ischemia-reperfusion in the mouse.
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Graft hyporeactivity induced by donor-derived dendritic cell progenitors.
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Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells.
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Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors.
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Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover.
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Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells.
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Growth factor-regulated proteases and extracellular matrix remodeling during mammalian development.
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Growth factors in development: the role of TGF-beta related polypeptide signalling molecules in embryogenesis.
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Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.
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Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing.
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Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein.
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Hemopoiesis and aging.
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High levels of granulocyte and granulocyte-macrophage colony-stimulating factors in cord blood of normal full-term neonates.
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Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations.
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Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors.
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Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung.
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In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.
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Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning.
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Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1.
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Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways.
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Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture.
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Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis.
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Intercellular growth factor signaling and the development of mouse tracheal submucosal glands.
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Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells.
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Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse.
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Keratinocyte growth factor--just another mitogen or the "Holy Grail" that regulates liver regeneration?
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Local contractile and growth modulators in the myocardium.
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Long-term healing of bone using recombinant human bone morphogenetic protein 2.
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Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells.
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MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.
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Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration.
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Mechanical load stimulates expression of novel genes in vivo and in vitro in avian flexor tendon cells.
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Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding.
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Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.
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Molecular biology of gastrointestinal peptides and growth factors: relevance to intestinal adaptation.
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Molecular biology of hypertension.
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Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications.
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Monitor peptide binding sites are expressed in the rat liver and small intestine.
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Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors.
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Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells.
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NIEHS/EPA Workshops. Growth and differentiation factors.
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NIEHS/EPA Workshops. Pattern formation.
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Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons.
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Neural selective activation and temporal regulation of a mammalian GAP-43 promoter in zebrafish.
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Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.
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Neutrophil growth factors.
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Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans.
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New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor.
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Nutrition, hormones, metabolism, and liver regeneration.
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Optimization and characterization of the capillary human tumor clonogenic cell assay.
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Oxidized alpha2-macroglobulin (alpha2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation.
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PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.
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Pathogenesis of ovarian cancers.
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Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.
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Peripheral blood stem cell harvesting and CD34-positive cell selection.
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Phenotypic and cell cycle properties of human oligodendrocytes in vitro.
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Plasticity in the adult human oligodendrocyte lineage.
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Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by follicle-stimulating hormone and serum.
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Possible cellular and molecular mechanisms for asbestos carcinogenicity.
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Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.
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Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals.
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Quantitative assessment of growth stimulating activity of the vitreous during PVR.
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Recombinant human granulocyte-macrophage colony-stimulating factor produces fever.
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Regulation of cholecystokinin secretion by intraluminal releasing factors.
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Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies.
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Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog.
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Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells.
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SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.
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Selective conservation of GAP-43 structure in vertebrate evolution.
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Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.
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Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina.
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Stimulation of endothelial cell prostacyclin release by retina-derived factors.
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Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor.
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T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis.
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Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
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The B cell surface molecule B1 is functionally linked with B cell activation and differentiation.
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The aromatase enzyme: from cloning to cancer.
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The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.
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The role of hematopoietic growth factors and oncogenes in leukemogenesis.
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The role of peptide growth factors in epithelial ovarian cancer.
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The use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous bone marrow transplantation.
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The uterine myometrium is a target for increased levels of activin A during pregnancy.
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Tissue engineering for meniscus repair.
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Transforming growth factor beta3 promotes fascial wound healing in a new animal model.
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Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles.
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Transient requirement for ganglion cells during assembly of retinal synaptic layers.
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Tyrosine phosphorylation in human neutrophil.
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UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
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Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.
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What keeps a resting T cell alive?
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alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation.
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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.
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p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Erickson, Harold Paul,
James B. Duke Distinguished Professor of Cell Biology,
Cell Biology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Liton, Paloma Borrajo,
Associate Professor in Ophthalmology,
Pathology
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Olson, Steven Arthur,
Professor of Orthopaedic Surgery,
Orthopaedics
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Taylor, Gregory Alan,
Professor in Medicine,
Immunology
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Velkey, John Matthew,
Assistant Professor of the Practice of Medical Education in the Department of Cell Biology,
Cell Biology
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Warner, David Samuel,
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine,
Neurobiology