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Subject Areas on Research
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3-Deazaguanine: report of a phase I trial and drug-related cardiac toxicity.
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A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study.
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A phase II study of biweekly pemetrexed and gemcitabine in patients with metastatic breast cancer.
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A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
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A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma.
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Activity of temozolomide in the treatment of central nervous system tumor xenografts.
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Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B.
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Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.
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Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir.
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An artificial intelligence model to predict hepatocellular carcinoma risk in Korean and Caucasian patients with chronic hepatitis B.
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Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
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Base modifications in plasmid DNA caused by potassium permanganate.
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Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
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Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
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CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer.
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Can O6-alkylguanine-DNA alkyltransferase depletion enhance alkylator activity in the clinic?
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Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop 'G4 Kissing' interaction.
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Charge splitters and charge transport junctions based on guanine quadruplexes.
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Cisplatin versus carboplatin-based regimens for the treatment of patients with metastatic lung cancer. An analysis of Veterans Health Administration data.
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Comparative Effectiveness of Lamivudine versus Entecavir in Patients with Hepatocellular Carcinoma: Watch out for Confounders!
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Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA.
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Coordinate regulation of the proximal and distal steps of the pathway of purine synthesis de nono in WI-L2 human lymphoblasts.
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Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide.
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Correlation between Charge Transport and Base Excision Repair in the MutY-DNA Glycosylase.
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Cost-effectiveness of epidermal growth factor receptor mutation testing and first-line treatment with gefitinib for patients with advanced adenocarcinoma of the lung.
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Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
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Crystal structure of the promutagen O4-methylthymidine: importance of the anti conformation of the O(4) methoxy group and possible mispairing of O4-methylthymidine with guanine.
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DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes.
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Defining best supportive care.
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Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs.
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Direct evidence for (G)O6···H2-N4(C)+ hydrogen bonding in transient G(syn)-C+ and G(syn)-m5C+ Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R1ρ relaxation dispersion measurements.
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Discontinuation of nucleos(t)ide analogues is not associated with a higher risk of HBsAg seroreversion after antiviral-induced HBsAg seroclearance: a nationwide multicentre study.
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Dynamic basis for dG•dT misincorporation via tautomerization and ionization.
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Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
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Efficacy and safety of entecavir plus carnitine complex (GODEX®) compared to entecavir monotherapy in patient with ALT elevated chronic hepatitis B: randomized, multicenter open-label trials. The GOAL study.
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Engineering nanometre-scale coherence in soft matter.
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Enhanced catalytic DNAzyme for label-free colorimetric detection of DNA.
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Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
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Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
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Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.
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Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs.
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Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.
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Essential role of an active-site guanine in glmS ribozyme catalysis.
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Gene markers in brain tumors: what the epileptologist should know.
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Gout and the regulation of purine biosynthesis.
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Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast.
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Guanine to inosine substitution leads to large increases in the population of a transient G·C Hoogsteen base pair.
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Hepatitis B virus viral load and treatment decision.
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Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
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Identification of the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans as bis(molybdopterin guanine dinucleotide)molybdenum.
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In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.
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Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice.
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Infrared Spectroscopic Observation of a G-C+ Hoogsteen Base Pair in the DNA:TATA-Box Binding Protein Complex Under Solution Conditions.
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Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
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Mapping of peroxyl radical induced damage on genomic DNA.
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Mathematical modeling: epidemiology meets systems biology.
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Mechanism of corepressor-mediated specific DNA binding by the purine repressor.
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Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
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Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts.
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Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration.
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Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
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Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism.
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O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase.
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O6-benzylguanine-mediated enhancement of chemotherapy.
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O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
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PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes.
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Pemetrexed Plus Cisplatin Versus Gemcitabine Plus Cisplatin According to Thymidylate Synthase Expression in Nonsquamous Non-Small-Cell Lung Cancer: A Biomarker-Stratified Randomized Phase II Trial.
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Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer.
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Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.
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Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium.
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Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
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Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
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Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.
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Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.
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Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
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Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.
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Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
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Phase II trial of pemetrexed-based induction chemotherapy followed by concomitant chemoradiotherapy in previously irradiated patients with squamous cell carcinoma of the head and neck.
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Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.
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Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes.
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Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine.
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Radioiodinated O(6)-Benzylguanine derivatives containing an azido function.
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Randomized phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and Leukemia Group B trial 30407.
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Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.
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Re-design of Rhodobacter sphaeroides dimethyl sulfoxide reductase. Enhancement of adenosine N1-oxide reductase activity.
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Regulation of de novo purine biosynthesis in human lymphoblasts. Coordinate control of proximal (rate-determining) steps and the inosinic acid branch point.
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Resolving the motional modes that code for RNA adaptation.
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Results of a phase II study of pemetrexed as first-line chemotherapy in patients with advanced or metastatic breast cancer.
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Revisiting the Hole Size in Double Helical DNA with Localized Orbital Scaling Corrections.
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Risk score model for the development of hepatocellular carcinoma in treatment-naïve patients receiving oral antiviral treatment for chronic hepatitis B.
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Robust IR-based detection of stable and fractionally populated G-C+ and A-T Hoogsteen base pairs in duplex DNA.
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Simultaneous determination of guanine, uric acid, hypoxanthine and xanthine in human plasma by reversed-phase high-performance liquid chromatography with amperometric detection.
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Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
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Structure of a Z-DNA with two different backbone chain conformations. Stabilization of the decadeoxyoligonucleotide d(CGTACGTACG) by [Co(NH3)6]3+ binding to the guanine.
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Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
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Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
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Tenofovir versus entecavir in lowering the risk of hepatocellular carcinoma development in patients with chronic hepatitis B: a critical systematic review and meta-analysis.
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The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase.
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The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates.
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The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha.
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The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity.
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The conserved dinucleotide AG of the 3' splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors.
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The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans.
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The hydrogen bonding of cytosine with guanine: calorimetric and 1H-nmr analysis of the molecular interactions of nucleic acid bases.
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The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors.
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The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout.
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The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast.
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The structural basis for the mutagenicity of O(6)-methyl-guanine lesions.
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Therapy of acute and fulminant hepatitis B.
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Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence.
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Transposon Tn5 target specificity: preference for insertion at G/C pairs.
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Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Variable temperature infrared spectroscopy of cytosine-guanine base pairs: tautomerism versus polarization.
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Keywords of People
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
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Zafar, Syed Yousuf,
Adjunct Professor in the Department of Medicine,
Duke Science & Society