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Subject Areas on Research
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A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.
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Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase.
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Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.
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Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.
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An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
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Ancient origins of nitric oxide signaling in biological systems.
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Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.
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Antiplatelet effects of a novel antianginal agent, nicorandil.
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Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor.
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Atrial natriuretic factor: pharmacokinetics and cyclic GMP response in relation to biologic effects in severe heart failure.
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Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism.
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Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans.
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Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells.
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Attenuation of the effect of punishment by thyrotropin-releasing hormone: comparisons with chlordiazepoxide.
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Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells.
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Beta-adrenergic receptors: recognition and regulation.
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Biochemistry of soluble guanylate cyclase.
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Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy.
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CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels.
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Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial.
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Cell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation.
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Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell.
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Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.
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Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy.
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Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.
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Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility.
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Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs).
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Cyclic GMP is a second messenger by which nitric oxide inhibits diaphragm contraction.
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Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells.
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Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
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Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.
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Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells.
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Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
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Dual actions of S-nitrosylated derivative of vasoactive intestinal peptide as a vasoactive intestinal peptide-like mediator and a nitric oxide carrier.
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Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin.
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Effects of atrial natriuretic peptide on the coronary arterial vasculature in humans.
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Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction.
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Exploring New Cardiovascular Pathways: Are Soluble Guanylate Cyclase Stimulators the Right Direction?
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Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).
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Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice.
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Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.
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Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate.
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High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue.
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Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
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Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line.
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Interaction between cyclic nucleotides and herpes simplex viruses: productive infection.
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Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.
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MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure.
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Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors.
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Methylene blue reverses endotoxin-induced hypotension.
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Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
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Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins.
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N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin.
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N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.
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NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression.
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Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity.
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Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.
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Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide.
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Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle.
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Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission.
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Nitric oxide in plant immunity.
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Nitric oxide in skeletal muscle.
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Nitric oxide inhibition of human sperm motility.
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Nitric oxide inhibits Fas-induced apoptosis.
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Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum.
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Nitric oxide modulates HIV-1 replication.
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Nitric oxide modulates branching morphogenesis in fetal rat lung explants.
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Nitric oxide signaling: no longer simply on or off.
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Nitric oxide-generating hydrogels inhibit neointima formation.
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Nitrosative stress-induced apoptosis through inhibition of NF-kappa B.
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Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse.
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Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity.
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OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons.
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Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation.
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Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs.
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Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice.
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Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen.
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Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
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Photoreceptor light adaptation. Untangling desensitization and sensitization.
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Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits.
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Pilot Study Evaluating a Rat Model of Radiation-induced Erectile Dysfunction Using an Image-guided Microirradiator.
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Pregnancy and estradiol decrease GTPase activity in the guinea pig uterine artery.
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Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension.
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Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle.
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Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways.
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Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S.
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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.
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Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP.
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Regulation of ryanodine receptors by reactive nitrogen species.
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Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro.
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Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.
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Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model.
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S-nitrosylation in cardiovascular signaling.
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S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.
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Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.
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Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle.
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Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
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Sodium nitroprusside, an endothelium-derived relaxing factor congener, increases platelet cyclic GMP levels and inhibits epinephrine-exacerbated in vivo platelet thrombus formation in stenosed canine coronary arteries.
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Soluble guanylate cyclase: a potential therapeutic target for heart failure.
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Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro.
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Structure and regulation of soluble guanylate cyclase.
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Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding.
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Studies leading to the isolation of a cDNA for the gene causing retinal degeneration in the rd mouse.
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Techniques for the study of the biochemical basis of drug action.
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Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
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The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes.
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The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
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The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction.
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The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.
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The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase.
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The vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level.
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Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments.
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Treatment-related biomarkers in pulmonary hypertension.
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Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro.
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Voltage-gated ion channels in nociceptors: modulation by cGMP.
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YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function.
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c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.
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cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction.
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cGMP signal termination.
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cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.
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cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
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mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse.
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