Cyclic GMP

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  Subject Areas on Research

  • A metabolic study of patients with lung cancer and hyponatremia of malignancy. 
  • A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. 
  • A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. 
  • Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase. 
  • Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. 
  • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. 
  • An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. 
  • Ancient origins of nitric oxide signaling in biological systems. 
  • Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. 
  • Antiplatelet effects of a novel antianginal agent, nicorandil. 
  • Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. 
  • Atrial natriuretic factor: pharmacokinetics and cyclic GMP response in relation to biologic effects in severe heart failure. 
  • Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism. 
  • Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans. 
  • Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells. 
  • Attenuation of the effect of punishment by thyrotropin-releasing hormone: comparisons with chlordiazepoxide. 
  • Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells. 
  • Beta-adrenergic receptors: recognition and regulation. 
  • Biochemistry of soluble guanylate cyclase. 
  • Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy. 
  • CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels. 
  • Cell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation. 
  • Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell. 
  • Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance. 
  • Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy. 
  • Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. 
  • Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility. 
  • Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). 
  • Cyclic GMP is a second messenger by which nitric oxide inhibits diaphragm contraction. 
  • Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. 
  • Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. 
  • Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. 
  • Dibutyryl cyclic GMP, morphine and Met-enkephalin: lack of common actions on neuronal firing. 
  • Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells. 
  • Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. 
  • Dual actions of S-nitrosylated derivative of vasoactive intestinal peptide as a vasoactive intestinal peptide-like mediator and a nitric oxide carrier. 
  • Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin. 
  • Effect of prostaglandin E 1 on leukocyte migration. 
  • Effects of atrial natriuretic peptide on the coronary arterial vasculature in humans. 
  • Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction. 
  • Exploring New Cardiovascular Pathways: Are Soluble Guanylate Cyclase Stimulators the Right Direction? 
  • Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). 
  • Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. 
  • Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. 
  • Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. 
  • Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. 
  • High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue. 
  • Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. 
  • Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line. 
  • In intact cone photoreceptors, a Ca2+-dependent, diffusible factor modulates the cGMP-gated ion channels differently than in rods. 
  • In intact mammalian photoreceptors, Ca2+-dependent modulation of cGMP-gated ion channels is detectable in cones but not in rods. 
  • Interaction between cyclic nucleotides and herpes simplex viruses: productive infection. 
  • Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. 
  • MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. 
  • Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors. 
  • Methylene blue reverses endotoxin-induced hypotension. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. 
  • N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. 
  • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. 
  • Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. 
  • Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide. 
  • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. 
  • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. 
  • Nitric oxide in plant immunity. 
  • Nitric oxide in skeletal muscle. 
  • Nitric oxide inhibition of human sperm motility. 
  • Nitric oxide inhibits Fas-induced apoptosis. 
  • Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. 
  • Nitric oxide modulates HIV-1 replication. 
  • Nitric oxide modulates branching morphogenesis in fetal rat lung explants. 
  • Nitric oxide signaling: no longer simply on or off. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Nitrosative stress-induced apoptosis through inhibition of NF-kappa B. 
  • Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse. 
  • Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity. 
  • OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons. 
  • Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation. 
  • Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs. 
  • Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice. 
  • Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen. 
  • Phosphorylation of the cystic fibrosis transmembrane conductance regulator. 
  • Photoreceptor light adaptation. Untangling desensitization and sensitization. 
  • Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits. 
  • Pilot Study Evaluating a Rat Model of Radiation-induced Erectile Dysfunction Using an Image-guided Microirradiator. 
  • Predicted effects of nitric oxide and superoxide on the vasoactivity of the afferent arteriole. 
  • Pregnancy and estradiol decrease GTPase activity in the guinea pig uterine artery. 
  • Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins. 
  • Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension. 
  • Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways. 
  • Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S. 
  • Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. 
  • Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP. 
  • Regulation of ryanodine receptors by reactive nitrogen species. 
  • Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. 
  • Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. 
  • Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model. 
  • S-nitrosylation in cardiovascular signaling. 
  • S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme. 
  • Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. 
  • Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Sodium nitroprusside, an endothelium-derived relaxing factor congener, increases platelet cyclic GMP levels and inhibits epinephrine-exacerbated in vivo platelet thrombus formation in stenosed canine coronary arteries. 
  • Soluble guanylate cyclase: a potential therapeutic target for heart failure. 
  • Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro. 
  • Structure and regulation of soluble guanylate cyclase. 
  • Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding. 
  • Studies leading to the isolation of a cDNA for the gene causing retinal degeneration in the rd mouse. 
  • Techniques for the study of the biochemical basis of drug action. 
  • Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. 
  • The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes. 
  • The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. 
  • The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction. 
  • The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements. 
  • The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915. 
  • The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level. 
  • Time course and Ca(2+) dependence of sensitivity modulation in cyclic GMP-gated currents of intact cone photoreceptors. 
  • Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments. 
  • Treatment-related biomarkers in pulmonary hypertension. 
  • Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. 
  • Tuning outer segment Ca2+ homeostasis to phototransduction in rods and cones. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
  • YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function. 
  • cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction. 
  • cGMP signal termination. 
  • cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse. 
  • cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. 
  • mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse. 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology