Cyclic GMP
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Subject Areas on Research
- A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.
- Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase.
- An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
- Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.
- Atrial natriuretic factor: pharmacokinetics and cyclic GMP response in relation to biologic effects in severe heart failure.
- Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism.
- Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans.
- Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells.
- Attenuation of the effect of punishment by thyrotropin-releasing hormone: comparisons with chlordiazepoxide.
- Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells.
- Beta-adrenergic receptors: recognition and regulation.
- Biochemistry of soluble guanylate cyclase.
- Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy.
- Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis.
- CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels.
- Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial.
- Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell.
- Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.
- Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy.
- Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.
- Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility.
- Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs).
- Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells.
- Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
- Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.
- Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells.
- Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
- Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin.
- Effects of atrial natriuretic peptide on the coronary arterial vasculature in humans.
- Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction.
- Evolution of a σ-(c-di-GMP)-anti-σ switch.
- Exploring New Cardiovascular Pathways: Are Soluble Guanylate Cyclase Stimulators the Right Direction?
- Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).
- Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice.
- Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.
- Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate.
- High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue.
- Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
- Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line.
- Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.
- MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure.
- Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors.
- Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
- Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins.
- N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin.
- NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression.
- Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity.
- Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.
- Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle.
- Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission.
- Nitric oxide inhibition of human sperm motility.
- Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum.
- Nitric oxide modulates branching morphogenesis in fetal rat lung explants.
- Nitric oxide signaling: no longer simply on or off.
- Nitric oxide-generating hydrogels inhibit neointima formation.
- Nitrosative stress-induced apoptosis through inhibition of NF-kappa B.
- Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse.
- Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity.
- Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation.
- Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs.
- Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice.
- Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen.
- Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
- Photoreceptor light adaptation. Untangling desensitization and sensitization.
- Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits.
- Pilot Study Evaluating a Rat Model of Radiation-induced Erectile Dysfunction Using an Image-guided Microirradiator.
- Pregnancy and estradiol decrease GTPase activity in the guinea pig uterine artery.
- Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension.
- Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle.
- Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways.
- Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S.
- Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.
- Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP.
- Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.
- SEMA3A signaling controls layer-specific interneuron branching in the cerebellum.
- Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.
- Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle.
- Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
- Soluble guanylate cyclase: a potential therapeutic target for heart failure.
- Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro.
- Structure and regulation of soluble guanylate cyclase.
- Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding.
- Studies leading to the isolation of a cDNA for the gene causing retinal degeneration in the rd mouse.
- Techniques for the study of the biochemical basis of drug action.
- Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
- The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes.
- The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
- The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction.
- The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.
- The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase.
- The vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level.
- Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments.
- Treatment-related biomarkers in pulmonary hypertension.
- Voltage-gated ion channels in nociceptors: modulation by cGMP.
- YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function.
- c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.
- cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction.
- cGMP signal termination.
- cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.
- cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
- mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse.
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Keywords of People
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
- Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology