Guanylate Cyclase

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  Subject Areas on Research

  • A loss-of-function RNA interference screen for molecular targets in cancer. 
  • A new activating role for CO in cardiac mitochondrial biogenesis. 
  • A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. 
  • Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. 
  • Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C. 
  • An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. 
  • Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. 
  • Biochemical and cytochemical comparison of surface membranes from normal and dystrophic chickens. 
  • Biochemistry of soluble guanylate cyclase. 
  • Biogenesis, cellular localization, and functional activation of the heat-stable enterotoxin receptor (guanylyl cyclase C). 
  • Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide. 
  • Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase. 
  • Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. 
  • Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. 
  • Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility. 
  • Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). 
  • Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. 
  • Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. 
  • Diarrhea, demography and cell signaling: lessons from microbial toxins. 
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 
  • Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial. 
  • Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial. 
  • Effect of the isoflavone genistein against galactose-induced cataracts in rats. 
  • Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking. 
  • Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. 
  • Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. 
  • Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. 
  • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. 
  • Nitric oxide signaling: no longer simply on or off. 
  • Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event. 
  • Nucleotide regulation of soluble guanylate cyclase substrate specificity. 
  • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. 
  • Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation. 
  • PSORS2 is due to mutations in CARD14. 
  • Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen. 
  • Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. 
  • Probing domain interactions in soluble guanylate cyclase. 
  • Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways. 
  • Regulation of mitochondrial processes by protein S-nitrosylation. 
  • Relative quantification based on logistic models for individual polymerase chain reactions. 
  • Role of guanylate cyclase modulators in decompensated heart failure. 
  • S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery. 
  • SEMA3A signaling controls layer-specific interneuron branching in the cerebellum. 
  • Selection of optimal reference genes for normalization in quantitative RT-PCR. 
  • Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. 
  • Soluble guanylate cyclase: a potential therapeutic target for heart failure. 
  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. 
  • Structure and regulation of soluble guanylate cyclase. 
  • Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. 
  • Techniques for the study of the biochemical basis of drug action. 
  • The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. 
  • The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. 
  • The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes. 
  • The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. 
  • The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. 
  • The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology