Guanylyl Imidodiphosphate

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  Subject Areas on Research

  • A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. 
  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A novel radioiodinated high affinity ligand for the D2-dopamine receptor. Characterization of its binding in bovine anterior pituitary membranes. 
  • A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using turkey erythrocyte membranes as the acceptor preparation. 
  • Activation of adenylate cyclase by beta-adrenergic receptors: investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release. 
  • Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization. 
  • Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors. 
  • Agonist versus antagonist binding to alpha-adrenergic receptors. 
  • Agonist-induced increase in apparent beta-adrenergic receptor size. 
  • Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands. 
  • Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study. 
  • Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. 
  • Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling. 
  • Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization. 
  • Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. 
  • Developmental changes in the hormonal regulation of rat testis Sertoli cell adenylyl cyclase. 
  • Differential regulation of the alpha 2-adrenergic receptor by Na+ and guanine nucleotides. 
  • Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists. 
  • Endogenous proteinases modulate the function of the beta-adrenergic receptor-adenylate cyclase system. 
  • Glucagon receptor-mediated activation of Gs is accompanied by subunit dissociation. 
  • Guanine nucleotides and alpha 1 adrenergic receptors in the heart. 
  • Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary. 
  • Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes. 
  • Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment. 
  • Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides. 
  • Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes. 
  • Identification and initial characterization of translational initiation factor 2 from bovine mitochondria. 
  • Interactions of agonists with platelet alpha 2-adrenergic receptors. 
  • Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. 
  • Multiple effects of guanine nucleotides on human platelet adenylated cyclase. 
  • Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. 
  • Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. 
  • Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets. 
  • Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide. 
  • Secretin receptors in a new preparation of plasma membranes from intrahepatic biliary epithelium. 
  • Specific photoaffinity labelling of inhibitory adenosine receptors. 
  • The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. 
  • The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. 
  • The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor. 
  • The rat testicular A1 adenosine receptor-adenylate cyclase system. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. 
  • Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo. 
  • Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. 
  • cGMP signal termination.