Guanylyl Imidodiphosphate

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  Subject Areas on Research

  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A novel radioiodinated high affinity ligand for the D2-dopamine receptor. Characterization of its binding in bovine anterior pituitary membranes. 
  • Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors. 
  • Agonist versus antagonist binding to alpha-adrenergic receptors. 
  • Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study. 
  • Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. 
  • Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling. 
  • Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization. 
  • Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. 
  • Developmental changes in the hormonal regulation of rat testis Sertoli cell adenylyl cyclase. 
  • Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists. 
  • Guanine nucleotides and alpha 1 adrenergic receptors in the heart. 
  • Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary. 
  • Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides. 
  • Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes. 
  • Identification and initial characterization of translational initiation factor 2 from bovine mitochondria. 
  • Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. 
  • Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. 
  • Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. 
  • Secretin receptors in a new preparation of plasma membranes from intrahepatic biliary epithelium. 
  • Specific photoaffinity labelling of inhibitory adenosine receptors. 
  • The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. 
  • The porcine heart M2 muscarinic receptor: agonist-induced phosphorylation and comparison of properties with the chick heart receptor. 
  • The rat testicular A1 adenosine receptor-adenylate cyclase system. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems.