Halothane

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  Subject Areas on Research

  • A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia. 
  • A comparison of cerebral ischemic flow thresholds during halothane/N2O and isoflurane/N2O anesthesia in rats. 
  • A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. 
  • A comparison of the vasodilating effects of halothane and isoflurane on the isolated rabbit basilar artery with and without intact endothelium. 
  • A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats. 
  • AMPA receptor competitive antagonism reduces halothane MAC in rats. 
  • Adverse drug reactions with halogenated anesthetics. 
  • Anaesthesia and intra-ocular pressure in young children. A study of three different techniques of anaesthesia. 
  • Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat. 
  • Behavioral effects of chronic exposure to low concentrations of halothane during development in rats. 
  • Cerebral blood flow in a rat glioma model during halothane anesthesia. 
  • Cerebrovascular adaptation to prolonged halothane anesthesia is not related to cerebrospinal fluid pH. 
  • Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat. 
  • Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. 
  • Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. 
  • Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography. 
  • Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat. 
  • Distribution of cerebral blood flow during halothane versus isoflurane anesthesia in rats. 
  • Does anesthetic technique make a difference? Augmentation of systolic blood pressure during carotid endarterectomy: effects of phenylephrine versus light anesthesia and of isoflurane versus halothane on the incidence of myocardial ischemia. 
  • Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate. 
  • Effects of anaesthesia and recent surgery on diastolic function. 
  • Effects of halothane on synaptogenesis and learning behavior in rats. 
  • Effects of halothane on the development of rat brain: a golgi study of dendritic growth. 
  • Effects of ketamine on outcome from temporary middle cerebral artery occlusion in the spontaneously hypertensive rat. 
  • Effects of nitrous oxide and volatile anaesthetics on cerebral blood flow. 
  • Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat. 
  • Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat. 
  • Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat. 
  • Halothane reduces focal ischemic injury in the rat when brain temperature is controlled. 
  • High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat. 
  • Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. 
  • Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms. 
  • Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. 
  • Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. 
  • Interaction of halothane with lipid bilayers. 
  • Interactions between NMDA and AMPA glutamate receptor antagonists during halothane anesthesia in the rat. 
  • Intramuscular rapacuronium in infants and children: a comparative multicenter study to confirm the efficacy and safety of the age-related tracheal intubating doses of intramuscular rapacuronium (ORG 9487) in two groups of pediatric subjects. 
  • Ischemic depolarization during halothane-nitrous oxide and isoflurane-nitrous oxide anesthesia. An examination of cerebral blood flow threshold and times to depolarization. 
  • Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels. 
  • Long-term effects of developmental halothane exposure on radial arm maze performance in rats. 
  • Minimum alveolar concentration for halothane in the rat is resistant to effects of forebrain ischemia and reperfusion. 
  • Mitochondrial and immunoallergic injury increase risk of positive drug rechallenge after drug-induced liver injury: a systematic review. 
  • Myocardial depression by anesthetic agents (halothane, enflurane and nitrous oxide): quantitation based on end-systolic pressure-dimension relations. 
  • Neurobehavioral effects of chronic halothane exposure during developmental and juvenile periods in the rat. 
  • Neurobehavioral toxicology of halothane in rats. 
  • Neuromuscular effects of rapacuronium in pediatric patients during nitrous oxide-halothane anesthesia: comparison with mivacurium. 
  • Onset and duration of neuromuscular blockade following high-dose vecuronium administration. 
  • Onset and recovery of neuromuscular blockade after two doses of rocuronium in children. 
  • Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction. 
  • Reversible focal ischemia in the rat: effects of halothane, isoflurane, and methohexital anesthesia. 
  • Sevoflurane and halothane reduce focal ischemic brain damage in the rat. Possible influence on thermoregulation. 
  • Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats. 
  • The effect of halothane on cultured fibroblasts and neuroblastoma cells. 
  • The esophageal temperature gradient in anesthetized children. 
  • The influence of different concentrations of volatile anesthetics on the threshold for cortical spreading depression in rats. 
  • The influence of halothane, isoflurane, and pentobarbital on cerebral plasma volume in hypocapnic and normocapnic rats. 
  • The influence of inhalational anesthetics on in vivo and in vitro benzodiazepine receptor binding in the rat cerebral cortex. 
  • The mechanism of halothane-induced myocardial depression. Altered diastolic mechanics versus impaired contractility. 
  • The role of cerebral metabolism in determining the local cerebral blood flow effects of volatile anesthetics: evidence for persistent flow-metabolism coupling. 
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  Keywords of People

  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology