Haploidy

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  Subject Areas on Research

  • A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. 
  • A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. 
  • A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. 
  • A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line. 
  • Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. 
  • Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans. 
  • Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae. 
  • Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. 
  • Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. 
  • Comparative linkage maps suggest that fission, not polyploidy, underlies near-doubling of chromosome number within monkeyflowers (Mimulus; Phrymaceae). 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Delineating the requirements for spontaneous DNA damage resistance pathways in genome maintenance and viability in Saccharomyces cerevisiae. 
  • Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation. 
  • Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. 
  • Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating. 
  • Efficient purging of deleterious mutations in plants with haploid selfing. 
  • Gene conversion occurs within the mating-type locus of Cryptococcus neoformans during sexual reproduction. 
  • Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae. 
  • Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. 
  • Genetic diversity of the Cryptococcus species complex suggests that Cryptococcus gattii deserves to have varieties. 
  • Genetic structure and genealogy in the Sphagnum subsecundum complex (Sphagnaceae: Bryophyta). 
  • Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production. 
  • HLA antigens in primary immunodeficiency diseases. 
  • Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombination. 
  • Haploidy and androgenesis in Drosophila. 
  • Improving indel detection specificity of the Ion Torrent PGM benchtop sequencer. 
  • Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic. 
  • Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. 
  • Mating-Type-Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in Cryptococcus neoformans. 
  • Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. 
  • Maximal stimulation of meiotic recombination by a yeast transcription factor requires the transcription activation domain and a DNA-binding domain. 
  • Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans. 
  • Meiotic recombination between dispersed repeated genes is associated with heteroduplex formation. 
  • Mitotic and meiotic gene conversion of Ty elements and other insertions in Saccharomyces cerevisiae. 
  • Monolayer absorption of human cytotoxic T cells: evidence for clonality. 
  • Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces genome deletion project, have an additional mutation in the mismatch repair gene MSH3. 
  • One haploid parent contributes 100% of the gene pool for a widespread species in northwest North America. 
  • P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. 
  • Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. 
  • Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection. 
  • Preferential synthesis of yeast mitochondrial DNA in alpha factor-arrested cells. 
  • Preparation and screening of an arrayed human genomic library generated with the P1 cloning system. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast. 
  • Selection is no more efficient in haploid than in diploid life stages of an angiosperm and a moss. 
  • Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. 
  • Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. 
  • Spatial Genetic Structure of the Abundant and Widespread Peatmoss Sphagnum magellanicum Brid. 
  • The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. 
  • The effects of quantitative fecundity in the haploid stage on reproductive success and diploid fitness in the aquatic peat moss Sphagnum macrophyllum. 
  • Towards a genetic theory for the evolution of the sex ratio. III. Parental and sibling control of brood investment ratio under partial sib-mating. 
  • Triplet repeats form secondary structures that escape DNA repair in yeast. 
  • alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness. 
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  Keywords of People

  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology