T-Lymphocytes, Helper-Inducer

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  Subject Areas on Research

  • A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques. 
  • A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection. 
  • AIDS-associated Kaposi's sarcoma: variables associated with survival. 
  • Activation of interleukin 4- and interleukin 6-secreting cells by HIV-specific synthetic peptides. 
  • Adenovirus F protein as a delivery vehicle for botulinum B. 
  • Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. 
  • Adoptively transferred immunity persists in human marrow graft recipients. 
  • Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology. 
  • Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes. 
  • Association of the CCR5 gene with juvenile idiopathic arthritis. 
  • Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. 
  • B cell depletion in HIV-1 subtype A infected Ugandan adults: relationship to CD4 T cell count, viral load and humoral immune responses. 
  • Biologic predictors of clinical improvement in rituximab-treated refractory myositis. 
  • Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. 
  • Brain abscess caused by a variety of cladosporium trichoides. 
  • CD4 T follicular helper cell dynamics during SIV infection. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Characterization of T lymphocyte and monocyte populations in HLA B8/DRw3 normal individuals and in patients with dermatitis herpetiformis. 
  • Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques. 
  • Combined immunodeficiency due to the selective absence of CD4 inducer T lymphocytes. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. 
  • Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity. 
  • Dietary Methionine in T Cell Biology and Autoimmune Disease. 
  • Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein. 
  • Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. 
  • Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. 
  • Endothelial antigen presentation: stimulation of previously activated but not naïve TCR-transgenic mouse T cells. 
  • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. 
  • Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases. 
  • Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. 
  • Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo. 
  • Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. 
  • Gamma-irradiation reduces the allogenicity of donor corneas. 
  • Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis. 
  • Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice. 
  • Germinal center responses to complex antigens. 
  • HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth. 
  • HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition. 
  • HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. 
  • HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound. 
  • Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. 
  • Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. 
  • Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation. 
  • Human interleukin-2 and lymphoproliferative (T-helper cell) responses to soluble HLA class I antigens in vitro: I. Specificity for polymorphic domains. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations. 
  • Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro. 
  • IFN-beta inhibits human Th17 cell differentiation. 
  • IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation. 
  • IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. 
  • Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis. 
  • Immune checkpoint modulation enhances HIV-1 antibody induction. 
  • Immunization against SIVmne in macaques using multigenic DNA vaccines. 
  • Immunodominant sites of human T cell lymphotropic virus type 1 envelope protein for murine helper T cells. 
  • Immunogenicity of HIV-1 Env and Gag in baboons using a DNA prime/protein boost regimen. 
  • Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules. 
  • In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye. 
  • Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. 
  • Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. 
  • Induction of HIVMN neutralizing antibodies in primates using a prime-boost regimen of hybrid synthetic gp120 envelope peptides. 
  • Induction of neutralizing antibodies and cytotoxic T lymphocytes in Balb/c mice immunized with virus-like particles presenting a gp120 molecule from a HIV-1 isolate of clade A. 
  • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. 
  • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. 
  • Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo. 
  • LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function. 
  • Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. 
  • Liposomes as antigen delivery systems in viral immunity. 
  • Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. 
  • Lymphocyte subsets in Chediak-Higashi patients. 
  • Mismatched dsRNA (ampligen) induces protection against genomic variants of the human immunodeficiency virus type 1 (HIV-1) in a multiplicity of target cells. 
  • Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. 
  • Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies. 
  • Molecular analysis of highly enriched populations of T-cell-depleted monocytes. 
  • Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine. 
  • Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells. 
  • Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner. 
  • Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization. 
  • Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses. 
  • Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. 
  • Optimal priming of poxvirus vector (NYVAC)-based HIV vaccine regimens for T cell responses requires three DNA injections. Results of the randomized multicentre EV03/ANRS VAC20 Phase I/II Trial. 
  • Oral vaccine models: multiple delivery systems employing tetanus toxoid. 
  • Pathogenic Correlates of Simian Immunodeficiency Virus-Associated B Cell Dysfunction. 
  • Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles. 
  • Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. 
  • Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. 
  • Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients. 
  • Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. 
  • Prospects for treatment of human retrovirus-associated diseases. 
  • Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization. 
  • Regulation of T-helper-cell lineage development by osteopontin: the inside story. 
  • Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. 
  • Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. 
  • Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection. 
  • Rheumatoid arthritis and sterile corneal ulceration. Analysis of tissue immune effector cells and ocular epithelial antigens using monoclonal antibodies. 
  • Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection. 
  • Split tolerance induced by immunotoxin in a rhesus kidney allograft model. 
  • Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins. 
  • Suppressor function of T lymphocytes in the acquired immunodeficiency syndrome as assessed by allogeneic mixed lymphocyte culture. 
  • Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus. 
  • T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis. 
  • T cells and T-cell subsets in a large population of patients with primary immunodeficiency. 
  • T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. 
  • T helper subsets in allergic eye disease. 
  • T-cell receptor α enhancer is inactivated in αβ T lymphocytes. 
  • TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures. 
  • Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. 
  • The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. 
  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. 
  • The pathologic and clinical intersection of atopic and autoimmune disease. 
  • The role of functionally distinct helper T lymphocyte subpopulations in the induction of human B cell differentiation. 
  • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. 
  • The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation. 
  • Vaccination establishes clonal relatives of germinal center T cells in the blood of humans. 
  • Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys. 
  • Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways. 
  • mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology