Hematopoiesis

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  Subject Areas on Research

  • 4-hydroperoxycyclophosphamide--purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A functional tethered ligand thrombin receptor is present on human hematopoietic progenitor cells. 
  • A mouse model of adult-onset anaemia due to erythropoietin deficiency. 
  • Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia. 
  • Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. 
  • Analysis of the human thymic perivascular space during aging. 
  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. 
  • Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7. 
  • CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation. 
  • CNS inflammation and bone marrow neuropathy in type 1 diabetes. 
  • Chemotherapy dose intensity and quality cancer care. 
  • Clinical implications for the administration of colony stimulating factors. 
  • Clinical manifestations of paroxysmal nocturnal hemoglobinuria: present state and future problems. 
  • Colony-stimulating factors: clinical applications. 
  • Comparative effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy. 
  • Concise review: role of DEK in stem/progenitor cell biology. 
  • Controlling lymphopoiesis with a combinatorial E-protein code. 
  • Cyclophosphamide plus ATG conditioning is insufficient for sustained hematopoietic reconstitution in patients with severe aplastic anemia transplanted with marrow from HLA-A, B, DRB matched unrelated donors. 
  • DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). 
  • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. 
  • Double unrelated umbilical cord blood vs HLA-haploidentical bone marrow transplantation: the BMT CTN 1101 trial. 
  • Dyshematopoiesis in combined immune deficiency with congenital neutropenia. 
  • Early hematopoiesis inhibition under chronic radiation exposure in humans. 
  • Early hematopoietic effects of chronic radiation exposure in humans. 
  • Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. 
  • Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. 
  • Effect of xenogeneic chimerism in a human/sheep model on natural antibody. 
  • Effects of acute and chronic inflammation on B-cell development and differentiation. 
  • Effects of hematopoietic growth factors following myeloablation in a primate model. 
  • Effects of interleukin-1 on hematopoietic progenitors: evidence of stimulatory and inhibitory activities in a primate model. 
  • Effects of interleukin-3 on hematopoietic recovery after 5-fluorouracil or cyclophosphamide treatment of cynomolgus primates. 
  • Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. 
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. 
  • Engraftment in 86 with patients lymphoid malignancy after autologous marrow transplantation. 
  • Enhanced HIV-1 activity in bone marrow can lead to myelopoietic suppression partially contributed by gag p24. 
  • Enhancement of human hematopoiesis by mast cell growth factor in human-sheep chimeras created by the in utero transplantation of human fetal hematopoietic cells. 
  • Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythroleukemia: a study of 15 cases and literature review. 
  • Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. 
  • Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development. 
  • Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. 
  • Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study. 
  • Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia. 
  • From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. 
  • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. 
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. 
  • Generation of normal lymphocyte populations following transplantation of adenosine-deaminase-deficient fetal liver cells. 
  • Hematopoietic growth factors in the older cancer patient. 
  • Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors: G-CSF, GM-CSF, IL-1, IL-2, M-CSF. 
  • Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. 
  • Hemopoiesis and aging. 
  • Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition. 
  • IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. 
  • Immune reconstitution in children after unrelated cord blood transplantation. 
  • In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice. 
  • Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice. 
  • Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. 
  • Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation. 
  • Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. 
  • Introduction to the hematopoietic growth factors. 
  • Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques. 
  • Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia. 
  • Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. 
  • Long-term outcome after marrow transplantation for severe aplastic anemia. 
  • Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. 
  • Long-term survival and cure after marrow transplantation for congenital hypoplastic anaemia (Diamond-Blackfan syndrome). 
  • Mammalian and Drosophila blood: JAK of all trades? 
  • Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures. 
  • Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome. 
  • Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. 
  • Minireview: Nuclear receptors, hematopoiesis, and stem cells. 
  • Modeling hematopoietic system response caused by chronic exposure to ionizing radiation. 
  • Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. 
  • Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis. 
  • Multiple gamma c-dependent cytokines regulate T-cell development. 
  • Myelotoxicity and dose intensity of chemotherapy: reporting practices from randomized clinical trials. 
  • Omidubicel vs standard myeloablative umbilical cord blood transplantation: results of a phase 3 randomized study. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning. 
  • PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy. 
  • Pancreatic islet cell carcinoma associated with multiple hormone secretion and pancytopenia. Evidence of a serum factor suppressing hematopoiesis. 
  • Phase I trial and pharmacokinetic (PK) and pharmacodynamics (PD) study of topotecan using a five-day course in children with refractory solid tumors: a pediatric oncology group study. 
  • Pleiotrophin mediates hematopoietic regeneration via activation of RAS. 
  • Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery. 
  • Practical murine hematopathology: a comparative review and implications for research. 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Preliminary analysis of a randomized comparison of 5-fluorouracil versus 5-fluorouracil and high-dose continuous-infusion folinic acid in disseminated colorectal cancer. 
  • Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. 
  • RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. 
  • Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. 
  • Regulation of hematopoietic cell development and activation by adapter proteins. 
  • Regulation of steady-state neutrophil homeostasis by macrophages. 
  • Releasing the block: setting differentiation free with mutant IDH inhibitors. 
  • Renal allograft cell infiltrates associated with irreversible rejection. 
  • Requirement of MIP-1 alpha for an inflammatory response to viral infection. 
  • Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia. 
  • Role of transforming growth factor-beta in hematologic malignancies. 
  • Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. 
  • Severe aplastic anemia associated with chronic mucocutaneous candidiasis. Immunologic and hematologic reconstitution after allogeneic bone marrow transplantation. 
  • Sources of human and murine hematopoietic stem cells. 
  • Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia. 
  • Stem cell factor is a potent synergistic factor in hematopoiesis. 
  • Stem cell transplantation (cord blood transplants). 
  • Supportive care of the marrow transplant recipient: the Seattle Experience. 
  • Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development. 
  • T cell receptor excision circle assessment of thymopoiesis in aging mice. 
  • T lymphocyte depletion of human peripheral blood and bone marrow using monoclonal antibodies and magnetic microspheres. 
  • T-Cell recovery in adults and children following umbilical cord blood transplantation. 
  • Technology evaluation: Stem-cell therapy, Aastrom Biosciences Inc. 
  • The NF-E2 transcription factor. 
  • The Polygenic and Monogenic Basis of Blood Traits and Diseases. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The diversity and plasticity of adult hepatic progenitor cells and their niche. 
  • The economics of the hematopoietic growth factors. 
  • The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. 
  • The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. 
  • The impact of Filgrastim schedule variation on hematopoietic recovery post-chemotherapy. 
  • The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. 
  • The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells. 
  • Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. 
  • Topoisomerase II levels during granulocytic maturation in vitro and in vivo. 
  • Transcriptional diversity during lineage commitment of human blood progenitors. 
  • Transferrin receptor 1 is differentially required in lymphocyte development. 
  • Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma. 
  • Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. 
  • Treatment of patients with pineoblastoma with high dose cyclophosphamide. 
  • Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. 
  • Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation. 
  • Unrelated umbilical cord blood transplantation in adult patients. 
  • Utilizing Low Oxygen Tension to Reduce Hematopoietic Cells in Murine Bone Marrow Stromal Cell Cultures. 
  • Wild-type Kras expands and exhausts hematopoietic stem cells. 
  • Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. 
  • Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. 
  • Xenotransplantation of baboon bone marrow cells: a historical review of the protocols as a possible treatment modality for HIV/AIDS. 
  • Xist exerts gene-specific silencing during XCI maintenance and impacts lineage-specific cell differentiation and proliferation during hematopoiesis. 
  • Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. 
  • Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. 
  • p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. 
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  Keywords of People

  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Doan, Phuong Linh, Associate Professor of Medicine, Duke Cancer Institute
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology