Hematopoietic Stem Cells

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  Subject Areas on Research

  • miR-146a -Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression. 
  • A Combination of Ontogeny and CNS Environment Establishes Microglial Identity. 
  • A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A functional tethered ligand thrombin receptor is present on human hematopoietic progenitor cells. 
  • A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. 
  • A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. 
  • A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. 
  • A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A novel role for activation-induced cytidine deaminase: central B-cell tolerance. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation. 
  • A phase II trial of high dose carboplatin and paclitaxel with G-CSF and peripheral blood stem cell support followed by surgery and/or chest radiation in patients with stage III non-small cell lung cancer: CALGB 9531. 
  • A randomized phase 3 study of peripheral blood progenitor cell mobilization with stem cell factor and filgrastim in high-risk breast cancer patients. 
  • A role for cFLIP in B cell proliferation and stress MAPK regulation. 
  • A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. 
  • A yeast expression system for human galactose-1-phosphate uridylyltransferase. 
  • ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors. 
  • Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia. 
  • Abnormalities in S-adenosylhomocysteine hydrolysis, ATP catabolism, and lymphoid differentiation in adenosine deaminase deficiency. 
  • Absence of phosphatidylinositol (PI)-linked proteins in a very early human multipotential haematopoietic marrow cell. 
  • Absolute values of dendritic cell subsets in bone marrow, cord blood, and peripheral blood enumerated by a novel method. 
  • Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. 
  • Acute myeloid leukemia arising from polycythemia vera underwent reversion to chronic phase of myeloproliferative neoplasm status post chemotherapy: Biclonal myeloid neoplasms with genomic evidence of a common early hematopoietic progenitor. 
  • Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation. 
  • Adolescent/Young Adult Perspectives of a Therapeutic Music Video Intervention to Improve Resilience During Hematopoietic Stem Cell Transplant for Cancer. 
  • Adoptive transfer of cytotoxic T lymphocytes for the treatment of transplant-associated lymphoma. 
  • Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide. 
  • Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene. 
  • An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells. 
  • An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. 
  • An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Antithymocyte globulin stimulates human hematopoietic progenitor cells. 
  • Apheresis. New opportunities. 
  • Aplastic anemia in a patient with Rothmund-Thomson syndrome. 
  • Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia. 
  • Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture. 
  • Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System. 
  • Autologous bone marrow transplantation in acute myelogenous leukemia: in vitro treatment with myeloid-specific monoclonal antibodies and drugs in combination. 
  • BP1, a new homeobox gene, is frequently expressed in acute leukemias. 
  • Banking and transplantation of unrelated donor umbilical cord blood: status of the National Heart, Lung, and Blood Institute-sponsored trial. 
  • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. 
  • Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche. 
  • Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. 
  • Biochemical characterization of antibodies submitted as reactive with glycophorin species. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. 
  • Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease. 
  • CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation. 
  • CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. 
  • Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Cellular events in the differentiation of antibody-secreting cells. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. 
  • Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells. 
  • Characterization of human CD7 transgenic mice. 
  • Characterization of multiple CD34+ cell populations in cord blood. 
  • Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas. 
  • Chronic myelogenous leukemia. 
  • Circulating CD34+ cell counts are predictive of CD34+ peripheral blood progenitor cell yields. 
  • Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. 
  • Combined chemoseparation and immunoseparation of clonogenic T lymphoma cells from human bone marrow using 2'-deoxycoformycin, deoxyadenosine, 3A1 monoclonal antibody, and complement. 
  • Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. 
  • Comparative effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy. 
  • Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells. 
  • Concise review: role of DEK in stem/progenitor cell biology. 
  • Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin. 
  • Cord blood is the optimal graft source for the treatment of pediatric patients with lysosomal storage diseases: clinical outcomes and future directions. 
  • Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells. 
  • Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • DEK regulates hematopoietic stem engraftment and progenitor cell proliferation. 
  • Deletion of carboxy-terminal residues of murine granulocyte-macrophage colony-stimulating factor results in a loss of biologic activity and altered glycosylation. 
  • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants. 
  • Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. 
  • Depletion of circulating progenitor cells precedes overt diabetes: a substudy from the VA enhanced fitness trial. 
  • Detection of Hypoxic Regions in the Bone Microenvironment. 
  • Development and validation of a rapid, aldehyde dehydrogenase bright-based cord blood potency assay. 
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. 
  • Differential effects of nitric oxide on erythroid and myeloid colony growth from CD34+ human bone marrow cells. 
  • Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro. 
  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. 
  • Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells. 
  • Direct-to-Consumer Advertising of Stem Cell Clinics: Ethical Considerations and Recommendations for the Health-Care Community. 
  • Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34. 
  • Dyshematopoiesis in combined immune deficiency with congenital neutropenia. 
  • E2A promotes the survival of precursor and mature B lymphocytes. 
  • Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues. 
  • Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment. 
  • Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation. 
  • Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis. 
  • Effect os xid on anti-DNA B-cell precursors. 
  • Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy. 
  • Effects of granulocyte-macrophage colony stimulating factor produced in Chinese hamster ovary cells (regramostim), Escherichia coli (molgramostim) and yeast (sargramostim) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy. 
  • Effects of interleukin-1 on hematopoietic progenitors: evidence of stimulatory and inhibitory activities in a primate model. 
  • Effects of interleukin-3 on hematopoietic recovery after 5-fluorouracil or cyclophosphamide treatment of cynomolgus primates. 
  • Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model. 
  • Elimination of malignant clonogenic T cells from human bone marrow using chemoimmunoseparation with 2'-deoxycoformycin, deoxyadenosine and an immunotoxin. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury. 
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. 
  • Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. 
  • Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. 
  • Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. 
  • Enhancement of human hematopoiesis by mast cell growth factor in human-sheep chimeras created by the in utero transplantation of human fetal hematopoietic cells. 
  • Enrichment of peripheral blood stem cells in a primate model following administration of a single dose of rh-IL-1 beta. 
  • Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Erythroleukemia: a study of 15 cases and literature review. 
  • Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. 
  • Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. 
  • Establishment of the DU.528 human lymphohemopoietic stem cell line. 
  • Evidence for susceptibility of intrathymic T cell precursors to human immunodeficiency virus infection: a mechanism for T4 (CD4) lymphocyte depletion. 
  • Ex Vivo Expansion or Manipulation of Stem Cells to Improve Outcome of Umbilical Cord Blood Transplantation. 
  • Ex vivo expansion of murine and human hematopoietic stem cells. 
  • Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. 
  • Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells. 
  • Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. 
  • Expression of protooncogene c-myb in normal human hematopoietic cells. 
  • Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. 
  • Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes. 
  • Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma. 
  • From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • G-CSF and peripheral blood progenitor cells. 
  • Gene expression analysis of purified hematopoietic stem cells and committed progenitors. 
  • Generation of normal lymphocyte populations following transplantation of adenosine-deaminase-deficient fetal liver cells. 
  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. 
  • Graft hyporeactivity induced by donor-derived dendritic cell progenitors. 
  • Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. 
  • Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. 
  • Growth inhibition by thymidine of leukemic HL-60 and normal human myeloid progenitor cells. 
  • Guanine arabinoside as a bone marrow-purging agent. 
  • Hematopoietic cell transplantation for Chediak-Higashi syndrome. 
  • Hematopoietic chimerism achieved by in utero hematopoietic stem cell injection does not induce donor-specific tolerance for renal allografts in sheep. 
  • Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. 
  • Hematopoietic stem cell transplantation. 
  • Hematopoietic stem cells convert into liver cells within days without fusion. 
  • Hematopoietic stem cells. 
  • Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect. 
  • Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. 
  • Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity. 
  • Human fetal liver hematopoietic cell expansion with a novel bioreactor system. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression. 
  • Hydroxyethyl starch as a substitute for dextran 40 for thawing peripheral blood progenitor cell products. 
  • Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. 
  • Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. 
  • IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia. 
  • IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp). 
  • Identification of a human heme exporter that is essential for erythropoiesis. 
  • Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells. 
  • Immunomagnetic purging of breast cancer from bone marrow for autologous transplantation. 
  • Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. 
  • Immunotherapy reverses glioma-driven dysfunction of immune system homeostasis. 
  • Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation. 
  • In utero transplantation of rat hematopoietic stem cells induces xenogeneic chimerism in mice. 
  • In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice. 
  • Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. 
  • Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism. 
  • Influence of preparatory regimen and source of hematopoietic cells on outcome of autotransplantation for non-Hodgkin's lymphoma. 
  • Inherited causes of clonal haematopoiesis in 97,691 whole genomes. 
  • Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. 
  • Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 
  • Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. 
  • Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. 
  • Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation. 
  • Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. 
  • Isolation of early hematopoietic cells, including megakaryocyte progenitors, in the ALDH-bright cell population of cryopreserved, banked UC blood. 
  • KDM1 class flavin-dependent protein lysine demethylases. 
  • Lack of circulating megakaryoblasts in newborn peripheral blood: development and validation of a sensitive flow cytometric detection method. 
  • Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. 
  • Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. 
  • Levels of p53 protein increase with maturation in human hematopoietic cells. 
  • Lineage-specific trisomy 21 in a neonate with resolving transient myeloproliferative syndrome. 
  • Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers. 
  • Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. 
  • Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. 
  • Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration. 
  • Manufacture of Autologous CD34+ Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases. 
  • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. 
  • Microdosimetric and Biological Effects of Photon Irradiation at Different Energies in Bone Marrow. 
  • Minireview: Nuclear receptors, hematopoiesis, and stem cells. 
  • Mitogenic and adhesive effects of tenascin-C on human hematopoietic cells are mediated by various functional domains. 
  • Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression. 
  • Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy. 
  • Mobilization of peripheral blood progenitor cells by hematopoietic growth factors. 
  • Modeling hematopoietic system response caused by chronic exposure to ionizing radiation. 
  • Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow. 
  • Molecular evidence for arterial repair in atherosclerosis. 
  • Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis. 
  • Multiparameter-fluorescence activated cell sorting analysis of retroviral vector gene transfer into primitive umbilical cord blood cells. 
  • Myelopoiesis during Solid Cancers and Strategies for Immunotherapy. 
  • NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response. 
  • Neonatal W-mutant mice are favorable hosts for tracking development of marked hematopoietic stem cells. 
  • Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells. 
  • Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. 
  • Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferative status of normal human hematopoietic cells. 
  • Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells. 
  • Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. 
  • Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. 
  • Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning. 
  • Outcomes of transplantation using various hematopoietic cell sources in children with Hurler syndrome after myeloablative conditioning. 
  • Outside influence: TLRs direct hematopoietic cell fates. 
  • P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. 
  • Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency. 
  • Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. 
  • Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks. 
  • Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer. 
  • Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease. 
  • Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells. 
  • Planning and response to radiation exposures. 
  • Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. 
  • Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. 
  • Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells. 
  • Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA. 
  • Preclinical efficacy of MEK inhibition in Nras-mutant AML. 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. 
  • Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. 
  • Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. 
  • Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. 
  • Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis. 
  • Purification and partial characterization of a human hematopoietic precursor population. 
  • Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. 
  • Randomized clinical trial of therapeutic music video intervention for resilience outcomes in adolescents/young adults undergoing hematopoietic stem cell transplant: a report from the Children's Oncology Group. 
  • Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models. 
  • Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor. 
  • Regulation of E2A gene expression in B-lymphocyte development. 
  • Rendering the leukemia cell susceptible to attack. 
  • Rewiring the niche: sympathetic neuropathy drives malignant niche transformation. 
  • Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations. 
  • Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development. 
  • Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. 
  • Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model. 
  • Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. 
  • Small-molecule nicotinamide for ex vivo expansion of umbilical cord blood. 
  • Sources of human and murine hematopoietic stem cells. 
  • Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. 
  • Stem cell factor is a potent synergistic factor in hematopoiesis. 
  • Stem cell transplantation (cord blood transplants). 
  • Storage of newborn stem cells for future use. 
  • Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. 
  • Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity. 
  • Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. 
  • Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development. 
  • Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. 
  • Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease. 
  • Technology evaluation: Stem-cell therapy, Aastrom Biosciences Inc. 
  • The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies. 
  • The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. 
  • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. 
  • The In Vitro Differentiation of Human CD141+CLEC9A+ Dendritic Cells from Mobilized Peripheral Blood CD34+ Hematopoietic Stem Cells. 
  • The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The Role of the Immune Cells in Fracture Healing. 
  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. 
  • The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. 
  • The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells. 
  • The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell. 
  • The effects of leukemosuppressive immunotherapy on bone marrow infectious cell centers in AKR mice. 
  • The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments. 
  • The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. 
  • The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. 
  • The in vitro growth of murine high proliferative potential-colony forming cells is not enhanced by growth in a low oxygen atmosphere. 
  • The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. 
  • The role of CD45RO in antithymocyte globulin's stimulation of primitive haemopoietic cells. 
  • The role of hematopoietic growth factors and oncogenes in leukemogenesis. 
  • The role of ion fluxes in hematopoietic cell differentiation. 
  • The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. 
  • The use of in vitro technics to study drug-induced pancytopenia. 
  • The vascular niche: home for normal and malignant hematopoietic stem cells. 
  • Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. 
  • Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. 
  • Topical lineage-negative progenitor-cell therapy for diabetic wounds. 
  • Transcriptional diversity during lineage commitment of human blood progenitors. 
  • Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. 
  • Transplantation of cord-blood cells. 
  • Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose. 
  • Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. 
  • Tumor stem cell cloning in agar-containing capillaries. 
  • Umbilical cord blood: a novel alternative source of hematopoietic stem cells for bone marrow transplantation. 
  • Update on umbilical cord blood transplantation. 
  • Utilizing Low Oxygen Tension to Reduce Hematopoietic Cells in Murine Bone Marrow Stromal Cell Cultures. 
  • Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury. 
  • Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor. 
  • Wild-type Kras expands and exhausts hematopoietic stem cells. 
  • Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. 
  • Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. 
  • Xist RNA is a potent suppressor of hematologic cancer in mice. 
  • Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. 
  • iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors. 
  • zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. 
  • β-Arrestin2 mediates progression of murine primary myelofibrosis. 
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  Keywords of People

  • Allori, Alexander C, Associate Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Doan, Phuong Linh, Associate Professor of Medicine, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Yildirim, Eda, Assistant Professor of Cell Biology, Cell Biology