Heme

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  Subject Areas on Research

  • A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection. 
  • Adjustment of iron intake for dietary enhancers and inhibitors in population studies: bioavailable iron in rural and urban residing Russian women and children. 
  • Altered ligand rebinding kinetics due to distal-side effects in hemoglobin chico (Lysbeta66(E10) --> thr). 
  • An investigation of hemopexin redox properties by spectroelectrochemistry: biological relevance for heme uptake. 
  • Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'. 
  • Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide. 
  • Carbon monoxide actuates O(2)-limited heme degradation in the rat brain. 
  • Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function. 
  • Carbon monoxide-driven reduction of ferric heme and heme proteins. 
  • Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. 
  • Characterization of complexes between Escherichia coli sulfite reductase hemoprotein subunit and its substrates sulfite and nitrite. 
  • Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. 
  • Coculturing of Mosquito-Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis. 
  • Cofactor Dynamics Couples the Protein Surface to the Heme in Cytochrome c , Facilitating Electron Transfer. 
  • Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. 
  • Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). 
  • Connecting genetic risk to disease end points through the human blood plasma proteome. 
  • Critical redox and allosteric aspects of nitric oxide interactions with hemoglobin. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex. 
  • Differentiation of erythroleukemia cells in vitro: properties of chemical inducers. 
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 
  • Distance-independent charge recombination kinetics in cytochrome c-cytochrome c peroxidase complexes: compensating changes in the electronic coupling and reorganization energies. 
  • Dynamic docking and electron-transfer between cytochrome b5 and a suite of myoglobin surface-charge mutants. Introduction of a functional-docking algorithm for protein-protein complexes. 
  • Effect of heme and non-heme ligands on subunit dissociation of normal and carboxypeptidase-digested hemoglobin. Gel filtration and flash photolysis studies. 
  • Electron paramagnetic resonance and optical evidence for interaction between siroheme and Fe4S4 prosthetic groups in complexes of Escherichia coli sulfite reductase hemoprotein with added ligands. 
  • Electron paramagnetic resonance and optical spectroscopic evidence for interaction between siroheme and Fe4S4 prosthetic groups in Escherichia coli sulfite reductase hemoprotein subunit. 
  • Evidence for siroheme-Fe4S4 interaction in spinach ferredoxin-sulfite reductase. 
  • Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite. 
  • Functional properties of carboxypeptidase-digested hemoglobins. 
  • Globin attenuates the innate immune response to endotoxin. 
  • Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. 
  • Heme redox properties of S-nitrosated hemoglobin A0 and hemoglobin S: implications for interactions of nitric oxide with normal and sickle red blood cells. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • Heme-copper oxidases use tunneling pathways. 
  • Hemoglobin Raleigh (beta1 valine replaced by acetylalanine). Structural and functional characterization. 
  • High-level expression of Escherichia coli NADPH-sulfite reductase: requirement for a cloned cysG plasmid to overcome limiting siroheme cofactor. 
  • Human sulfite oxidase deficiency. Characterization of the molecular defect in a multicomponent system. 
  • Identification of a human heme exporter that is essential for erythropoiesis. 
  • Incorporation of methionine-derived methyl groups into sirohaem by Escherichia coli. 
  • Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. 
  • Inhibitor of marrow thymidine incorporation from sera of patients with uremia. 
  • Inter- and intra-molecular electron transfer in the cytochrome bc(1) complex. 
  • Internal electron transfer between hemes and Cu(II) bound at cysteine beta93 promotes methemoglobin reduction by carbon monoxide. 
  • Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme. 
  • Invertebrate hemoglobins and nitric oxide: how heme pocket structure controls reactivity. 
  • Iron and copper in mitochondrial diseases. 
  • Isolation of polypeptide chains with heme from the extracellular hemoglobin of Amphitrite ornata (Polychaeta, Annelida). 
  • Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. 
  • Mössbauer evidence for exchange-coupled siroheme and [4Fe-4S] prosthetic groups in Escherichia coli sulfite reductase. Studies of the reduced states and of a nitrite turnover complex. 
  • Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups. 
  • Mössbauer studies of Escherichia coli sulfite reductase complexes with carbon monoxide and cyanide. Exchange coupling and intrinsic properties of the [4Fe-4S] cluster. 
  • Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. 
  • New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease. 
  • Nitric oxide signaling: no longer simply on or off. 
  • On the reaction of ferric heme proteins with nitrite and sulfite. 
  • Oxygen affinity and amino acid sequence of myoglobins from endothermic and ectothermic fish. 
  • Oxygen binding to partially nitrosylated hemoglobin. 
  • Partial restoration of normal functional properties in carboxypeptidase A-digested hemoglobin. 
  • Probing domain interactions in soluble guanylate cyclase. 
  • Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. 
  • Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. 
  • Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. 
  • Protein phosphorylation and intermolecular electron transfer: a joint experimental and computational study of a hormone biosynthesis pathway. 
  • Proton NMR of Escherichia coli sulfite reductase: studies of the heme protein subunit with added ligands. 
  • Purification and properties of sulfite oxidase from human liver. 
  • RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms. 
  • Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme. 
  • Reprioritization of biofilm metabolism is associated with nutrient adaptation and long-term survival of Haemophilus influenzae. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes. 
  • Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease. 
  • Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase. 
  • S-Nitrosohemoglobin: an allosteric mediator of NO group function in mammalian vasculature. 
  • S-nitrosylation in health and disease. 
  • Siroheme: a prosthetic group of the Neurospora crassa assimilatory nitrite reductase. 
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. 
  • Structural studies of the heme domain of sulfite oxidase: CNBr fragments. 
  • Structure and regulation of the chicken erythroid delta-aminolevulinate synthase gene. 
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. 
  • Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy. 
  • Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. 
  • Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity. 
  • The case of the missing NO-hemoglobin: spectral changes suggestive of heme redox reactions reflect changes in NO-heme geometry. 
  • The construction of metal centers in proteins by rational design. 
  • The domains of rat liver sulfite oxidase. Proteolytic separation and characterization. 
  • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. 
  • The heme and Fe4S4 cluster in the crystallographic structure of Escherichia coli sulfite reductase. 
  • The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches. 
  • Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms. 
  • Transfusion-related biologic effects and free hemoglobin, heme, and iron. 
  • Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development. 
  • Tryptic cleavage of rat liver sulfite oxidase. Isolation and characterization of molybdenum and heme domains. 
  • Understanding heme transport. 
  • Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study. 
  • Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation. 
  • What happens in lead poisoning? 
  • When is a heme transporter not a heme transporter? When it's a folate transporter.