Hemochromatosis

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  Subject Areas on Research

  • A mouse model of familial porphyria cutanea tarda. 
  • A mouse model of juvenile hemochromatosis. 
  • A study of pituitary function in patients with idiopathic hemochromatosis. 
  • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. 
  • Animal models of hereditary iron transport disorders. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Case records of the Massachusetts General Hospital. Case 21-2005. A four-week-old male infant with jaundice and thrombocytopenia. 
  • Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. 
  • Closing the iron gate. 
  • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. 
  • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. 
  • Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Disorders of iron metabolism. 
  • Distribution of transferrin saturations in the African-American population. 
  • Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease. 
  • Evaluating the role of blood collection centers in public health: a status report. 
  • Evaluation of a workplace hemochromatosis screening program. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Haptoglobin modifies the hemochromatosis phenotype in mice. 
  • Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort. 
  • Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis. 
  • Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. 
  • Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. 
  • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. 
  • Hereditary hemochromatosis: gene discovery and its implications for population-based screening. 
  • Hungry irony. 
  • Identification of a novel mutation (C321X) in HJV. 
  • Inherited iron overload disorders. 
  • Iron homeostasis and erythropoiesis. 
  • Iron in skin of mice with three etiologies of systemic iron overload. 
  • Iron is hot: an update on the pathophysiology of hemochromatosis. 
  • Iron metabolism in mice with partial frataxin deficiency. 
  • Magnetic resonance imaging in hemochromatosis: extrahepatic iron deposition. 
  • Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. 
  • Molecular control of iron metabolism. 
  • Molecular insights into mechanisms of iron transport. 
  • Pathophysiologic mechanisms of anemia of chronic disease. 
  • Prevalence of heterozygotes for hemochromatosis in the white population of the United States. 
  • Regulation of iron absorption in Hfe mutant mice. 
  • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. 
  • Reversible retinal edema in an infant with neonatal hemochromatosis and liver failure. 
  • Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis. 
  • Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders. 
  • The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. 
  • The molecular regulation of iron metabolism. 
  • Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. 
  • Understanding heme transport. 
  • Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda.